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The map label for this gene is clpP [H]

Identifier: 150396095

GI number: 150396095

Start: 930911

End: 931537

Strand: Direct

Name: clpP [H]

Synonym: Smed_0872

Alternate gene names: 150396095

Gene position: 930911-931537 (Clockwise)

Preceding gene: 150396094

Following gene: 150396096

Centisome position: 24.61

GC content: 58.69

Gene sequence:

>627_bases
ATGAGAAATCCAGTTGATACGGCCATGGCGCTGGTGCCGATGGTTGTTGAGCAGACCAATCGCGGTGAGCGATCCTACGA
TATCTATTCGCGGCTGCTGAAGGAGCGCATCATCTTTCTCACGGGTCCGGTCGAAGATCACATGGCGACGCTTGTCTGCG
CGCAGTTGCTGTTCCTCGAGGCGGAAAATCCGAAAAAGGAAATCGCACTCTACATCAACTCGCCCGGCGGGGTCGTGACG
GCCGGCATGGCGATCTACGACACGATGCAGTTCATTAAGCCTGCAGTTTCGACGCTCTGCATCGGTCAGGCGGCATCCAT
GGGTTCGCTGCTGCTCGCGGCCGGACACAAGGACATGCGCTTCGCAACGCCGAATTCCCGCATCATGGTGCACCAGCCTT
CCGGCGGGTTCCAGGGGCAGGCCTCCGACATCGAGCGGCATGCACGCGACATTCTCAAGATGAAGCGCCGGTTGAACGAG
GTTTACGTCAAGCATTGCGGCCGCACCTATGAGGAGGTGGAGCAGACGCTTGATCGCGATCACTTCATGAGTTCGGATGA
AGCGCTCGACTGGGGTCTGATCGACAAGGTGATCACGTCGCGCGATGCGGTCGAGGGCATGGAATAG

Upstream 100 bases:

>100_bases
GACTTGAAGTGCAGGGCATTGACACTCTATGTAAGGTCTGAGGCTTTTCCGATGATTCCGGTCCGCGCAGGGATGCGGTC
CCGATTGATGAAGGTTCGAT

Downstream 100 bases:

>100_bases
CCCGAACACGGGCTTTTGTGTCGCCACAGATGTAATTGTGACACATTTGTAATGGCGAAGGGGCTTTATCCGAGGGGTAA
AGCCGTTAATATGAATCCTT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2 [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MRNPVDTAMALVPMVVEQTNRGERSYDIYSRLLKERIIFLTGPVEDHMATLVCAQLLFLEAENPKKEIALYINSPGGVVT
AGMAIYDTMQFIKPAVSTLCIGQAASMGSLLLAAGHKDMRFATPNSRIMVHQPSGGFQGQASDIERHARDILKMKRRLNE
VYVKHCGRTYEEVEQTLDRDHFMSSDEALDWGLIDKVITSRDAVEGME

Sequences:

>Translated_208_residues
MRNPVDTAMALVPMVVEQTNRGERSYDIYSRLLKERIIFLTGPVEDHMATLVCAQLLFLEAENPKKEIALYINSPGGVVT
AGMAIYDTMQFIKPAVSTLCIGQAASMGSLLLAAGHKDMRFATPNSRIMVHQPSGGFQGQASDIERHARDILKMKRRLNE
VYVKHCGRTYEEVEQTLDRDHFMSSDEALDWGLIDKVITSRDAVEGME
>Mature_208_residues
MRNPVDTAMALVPMVVEQTNRGERSYDIYSRLLKERIIFLTGPVEDHMATLVCAQLLFLEAENPKKEIALYINSPGGVVT
AGMAIYDTMQFIKPAVSTLCIGQAASMGSLLLAAGHKDMRFATPNSRIMVHQPSGGFQGQASDIERHARDILKMKRRLNE
VYVKHCGRTYEEVEQTLDRDHFMSSDEALDWGLIDKVITSRDAVEGME

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=191, Percent_Identity=59.1623036649215, Blast_Score=246, Evalue=7e-66,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=68.0412371134021, Blast_Score=293, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI17538017, Length=188, Percent_Identity=61.7021276595745, Blast_Score=245, Evalue=9e-66,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=63.8297872340426, Blast_Score=260, Evalue=5e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23263; Mature: 23263

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNPVDTAMALVPMVVEQTNRGERSYDIYSRLLKERIIFLTGPVEDHMATLVCAQLLFLE
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHC
AENPKKEIALYINSPGGVVTAGMAIYDTMQFIKPAVSTLCIGQAASMGSLLLAAGHKDMR
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FATPNSRIMVHQPSGGFQGQASDIERHARDILKMKRRLNEVYVKHCGRTYEEVEQTLDRD
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
HFMSSDEALDWGLIDKVITSRDAVEGME
HCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRNPVDTAMALVPMVVEQTNRGERSYDIYSRLLKERIIFLTGPVEDHMATLVCAQLLFLE
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHC
AENPKKEIALYINSPGGVVTAGMAIYDTMQFIKPAVSTLCIGQAASMGSLLLAAGHKDMR
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FATPNSRIMVHQPSGGFQGQASDIERHARDILKMKRRLNEVYVKHCGRTYEEVEQTLDRD
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
HFMSSDEALDWGLIDKVITSRDAVEGME
HCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]