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The map label for this gene is livH [H]

Identifier: 150396002

GI number: 150396002

Start: 836577

End: 837473

Strand: Direct

Name: livH [H]

Synonym: Smed_0778

Alternate gene names: 150396002

Gene position: 836577-837473 (Clockwise)

Preceding gene: 150395999

Following gene: 150396008

Centisome position: 22.12

GC content: 62.88

Gene sequence:

>897_bases
ATGGCTTACTTTCTTCAGCAGATCGCCAATGCCGTGCCCGTGGCCGCGCTCTATGCGGCGCTCGCCTTCGGCTACGCGAT
AGCCTTTGCGGTTACCCGGCGGGCAGACCTGACCTATGGCGCACTATTTGCCTTCGCCGGGCAGATGTTCGTGCTGTTTG
CAGATGTCGGCTGGAACCGGCTTTGGCTGGTGTTGCCGGCGGCACTGGGGCTCGGGGCGGCGGCGGCGCTGACATTCGGC
ATCGGTGCCGGTCTCATTGCCGGACGCTACATAATGCGGCCGTTGGCATTCTCCTCAGCCAATGCGGTGGTCGTCGCCTC
TCTAGGATGCCTGCTGGTGCTGATGGAAACGGCCCGGCTTGCCTCCGAAACCAGGAGTTTGTGGCTGCCGCCTTTTCTGA
ACGGCGTGGTCGTGTTCTGGCCGAACCCCGCCTTTCCGGTCGCGCTGACGGTCGTCCAGCTCGTCAACACTGCACTCATG
GTCACCCTTGTTGCCGGGGGGCACTGGCTGCTGACCCATTCCTATGCCGGCCGCTATTGGCGCGCTGTCTCGGAAGACCG
CGAGGCTGCCGCACTTTGCGGTGTCGATCCGGGATCGGTTTACATCGCCGCCTATGGCGTGGCATCGCTGATCGCCGCTT
TCTGCGGGATTCTCGCGGCATCCTATTACGGCAACATGGATTTCGGCACCGGCCTGACCTTCGGCGTCAAGGTCCTGTTC
ATTGCCGCCATCGGCGGGCAGACCGCGCCGCTATTCGCGGCCCTTGGCGCGGCCGGCATCGGCCTCATCGAAACGCTGTG
GAGTGCCTATGGACCGATTCTCTGGCGGGATTTCGCCATATTCGGCTTCCTCGTCGTCGTGCTTGTGATAACGCGCCGTG
AAAAGTTCATTCCCTGA

Upstream 100 bases:

>100_bases
GAAAGCCGCACGCATTTTTCCACATCGCTCCAGGCCGAATTACTAACTGGTAAAACCCAGTTTACCAGTTATAGTGAGCT
TGTCACTACGCGGATGAGCC

Downstream 100 bases:

>100_bases
AGGCTGCAAACTTCGAGCGTGCTTGCGGACGGAAAGATCACCCACGCGCCCAGCGATCGCGGGCGTCGTCGTCCGCATCC
TTCGCGCTGATCCAATCGCC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MAYFLQQIANAVPVAALYAALAFGYAIAFAVTRRADLTYGALFAFAGQMFVLFADVGWNRLWLVLPAALGLGAAAALTFG
IGAGLIAGRYIMRPLAFSSANAVVVASLGCLLVLMETARLASETRSLWLPPFLNGVVVFWPNPAFPVALTVVQLVNTALM
VTLVAGGHWLLTHSYAGRYWRAVSEDREAAALCGVDPGSVYIAAYGVASLIAAFCGILAASYYGNMDFGTGLTFGVKVLF
IAAIGGQTAPLFAALGAAGIGLIETLWSAYGPILWRDFAIFGFLVVVLVITRREKFIP

Sequences:

>Translated_298_residues
MAYFLQQIANAVPVAALYAALAFGYAIAFAVTRRADLTYGALFAFAGQMFVLFADVGWNRLWLVLPAALGLGAAAALTFG
IGAGLIAGRYIMRPLAFSSANAVVVASLGCLLVLMETARLASETRSLWLPPFLNGVVVFWPNPAFPVALTVVQLVNTALM
VTLVAGGHWLLTHSYAGRYWRAVSEDREAAALCGVDPGSVYIAAYGVASLIAAFCGILAASYYGNMDFGTGLTFGVKVLF
IAAIGGQTAPLFAALGAAGIGLIETLWSAYGPILWRDFAIFGFLVVVLVITRREKFIP
>Mature_297_residues
AYFLQQIANAVPVAALYAALAFGYAIAFAVTRRADLTYGALFAFAGQMFVLFADVGWNRLWLVLPAALGLGAAAALTFGI
GAGLIAGRYIMRPLAFSSANAVVVASLGCLLVLMETARLASETRSLWLPPFLNGVVVFWPNPAFPVALTVVQLVNTALMV
TLVAGGHWLLTHSYAGRYWRAVSEDREAAALCGVDPGSVYIAAYGVASLIAAFCGILAASYYGNMDFGTGLTFGVKVLFI
AAIGGQTAPLFAALGAAGIGLIETLWSAYGPILWRDFAIFGFLVVVLVITRREKFIP

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=292, Percent_Identity=25.6849315068493, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 31490; Mature: 31359

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYFLQQIANAVPVAALYAALAFGYAIAFAVTRRADLTYGALFAFAGQMFVLFADVGWNR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEECCCCH
LWLVLPAALGLGAAAALTFGIGAGLIAGRYIMRPLAFSSANAVVVASLGCLLVLMETARL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
ASETRSLWLPPFLNGVVVFWPNPAFPVALTVVQLVNTALMVTLVAGGHWLLTHSYAGRYW
HHHHHCEECCHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHH
RAVSEDREAAALCGVDPGSVYIAAYGVASLIAAFCGILAASYYGNMDFGTGLTFGVKVLF
HHHHCCCHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
IAAIGGQTAPLFAALGAAGIGLIETLWSAYGPILWRDFAIFGFLVVVLVITRREKFIP
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AYFLQQIANAVPVAALYAALAFGYAIAFAVTRRADLTYGALFAFAGQMFVLFADVGWNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEECCCCH
LWLVLPAALGLGAAAALTFGIGAGLIAGRYIMRPLAFSSANAVVVASLGCLLVLMETARL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
ASETRSLWLPPFLNGVVVFWPNPAFPVALTVVQLVNTALMVTLVAGGHWLLTHSYAGRYW
HHHHHCEECCHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHH
RAVSEDREAAALCGVDPGSVYIAAYGVASLIAAFCGILAASYYGNMDFGTGLTFGVKVLF
HHHHCCCHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
IAAIGGQTAPLFAALGAAGIGLIETLWSAYGPILWRDFAIFGFLVVVLVITRREKFIP
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]