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The map label for this gene is ndk [H]

Identifier: 150395999

GI number: 150395999

Start: 834856

End: 835278

Strand: Direct

Name: ndk [H]

Synonym: Smed_0775

Alternate gene names: 150395999

Gene position: 834856-835278 (Clockwise)

Preceding gene: 150395998

Following gene: 150396002

Centisome position: 22.08

GC content: 60.05

Gene sequence:

>423_bases
ATGGCGATTGAACGTACCTTTTCGATGATCAAGCCGGATGCGACGAAGCGTAACCTGACCGGCGCCATCACCAAGATGCT
GGAAGACGCCGGCCTGCGCGTCGTCGCTTCGAAGCGCGTCTGGATGAGCCGCCGCGAAGCCGAAGGCTTTTACGCTGTCC
ACAAGGATCGCCCGTTCTTCGGCGAACTGGTCGAATTCATGTCCTCCGGCCCGACCGTCGTTCAGGTCCTCGAAGGCGAG
AATGCCATTGCCAAGAACCGTGAAGTGATGGGTGCCACCAATCCGGCAAACGCCGCCGAAGGCACGATCCGCAAGGTCCA
TGCGCTTTCGATCGGCGAAAACTCCGTTCACGGTTCCGATGCGCCGGAAACCGCTGCCGAAGAAATCGCCTATTGGTTCT
CGGGCACCGAGATCGTCGGCTGA

Upstream 100 bases:

>100_bases
AACTGAGGCGCAAGCGGCCGAATCGTGGCCACGCCCCCTTGTTTTGCACGGAATTGGCGGCTAATGAACCGCCACTTCTC
AAGAGCAAGGAATTGAGCCC

Downstream 100 bases:

>100_bases
TCAAATAAGCGAGTGATTTTCAGGCTGGGGTGGTGACACCCCGGCTTTTTACGTCGGGCAGGCGGCGGTTTCGAAGCGCA
CCGGTGCCTTGCCATTCTTG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MAIERTFSMIKPDATKRNLTGAITKMLEDAGLRVVASKRVWMSRREAEGFYAVHKDRPFFGELVEFMSSGPTVVQVLEGE
NAIAKNREVMGATNPANAAEGTIRKVHALSIGENSVHGSDAPETAAEEIAYWFSGTEIVG

Sequences:

>Translated_140_residues
MAIERTFSMIKPDATKRNLTGAITKMLEDAGLRVVASKRVWMSRREAEGFYAVHKDRPFFGELVEFMSSGPTVVQVLEGE
NAIAKNREVMGATNPANAAEGTIRKVHALSIGENSVHGSDAPETAAEEIAYWFSGTEIVG
>Mature_139_residues
AIERTFSMIKPDATKRNLTGAITKMLEDAGLRVVASKRVWMSRREAEGFYAVHKDRPFFGELVEFMSSGPTVVQVLEGEN
AIAKNREVMGATNPANAAEGTIRKVHALSIGENSVHGSDAPETAAEEIAYWFSGTEIVG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=44.5255474452555, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI37693993, Length=138, Percent_Identity=43.4782608695652, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=44.5255474452555, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=44.5255474452555, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=44.5255474452555, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=44.5255474452555, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=44.5255474452555, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=44.5255474452555, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=36.7647058823529, Blast_Score=97, Evalue=3e-21,
Organism=Homo sapiens, GI37574614, Length=136, Percent_Identity=31.6176470588235, Blast_Score=83, Evalue=6e-17,
Organism=Homo sapiens, GI7019465, Length=136, Percent_Identity=31.6176470588235, Blast_Score=83, Evalue=7e-17,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=33.0882352941176, Blast_Score=73, Evalue=8e-14,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=29.7101449275362, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=53.9568345323741, Blast_Score=158, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=45.1851851851852, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=41.1764705882353, Blast_Score=115, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=47.0588235294118, Blast_Score=132, Evalue=7e-32,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=30.5970149253731, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15228; Mature: 15097

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTFSMIKPDATKRNLTGAITKMLEDAGLRVVASKRVWMSRREAEGFYAVHKDRPFF
CCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCEEEEECCCCHH
GELVEFMSSGPTVVQVLEGENAIAKNREVMGATNPANAAEGTIRKVHALSIGENSVHGSD
HHHHHHHCCCCEEEEEECCCCCHHCCCCEECCCCCCCCCCCHHHHHEEEECCCCCCCCCC
APETAAEEIAYWFSGTEIVG
CCHHHHHHHHHHHCCCEECC
>Mature Secondary Structure 
AIERTFSMIKPDATKRNLTGAITKMLEDAGLRVVASKRVWMSRREAEGFYAVHKDRPFF
CCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCEEEEECCCCHH
GELVEFMSSGPTVVQVLEGENAIAKNREVMGATNPANAAEGTIRKVHALSIGENSVHGSD
HHHHHHHCCCCEEEEEECCCCCHHCCCCEECCCCCCCCCCCHHHHHEEEECCCCCCCCCC
APETAAEEIAYWFSGTEIVG
CCHHHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]