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The map label for this gene is dut [H]

Identifier: 150009759

GI number: 150009759

Start: 3839083

End: 3839517

Strand: Direct

Name: dut [H]

Synonym: BDI_3174

Alternate gene names: 150009759

Gene position: 3839083-3839517 (Clockwise)

Preceding gene: 150009758

Following gene: 150009760

Centisome position: 79.79

GC content: 51.72

Gene sequence:

>435_bases
ATGAAAGTAAGAATTATCAATAAATCGCATCACCCGCTGCCGGGTTATGCGACTCCTTTATCTGCCGGGATGGATATCCG
GGCGAATTTGTCGGAATCGGTTGTGTTGAAACCGTTGGAACGTAAATTAATCCCGACCGGACTTTATATCTCGCTGCCGG
AAGGCTATGAGGCCCAGATGCGTCCGCGTAGCGGGCTGGCTTTAAAGCATGGGATAACCCTGCTGAATACGCCGGGTACG
ATCGACGCCGATTATCGGGGGGAGATCGGCATTATTCTCGTGAATCTATCTTCGGAGCCTTTTACGGTGAATGATGGTGA
GCGTATCTGCCAAATGGTTATAGCCGCTCATAGCCATGTGGATTGGGAGCCCGTGGAGACGTTGGATGATACCGAGCGGG
GAGCCGGGGGATTCGGTCATACCGGAAAAGAATAA

Upstream 100 bases:

>100_bases
CCCCGAGGAAGACGCTGTAGAACGTTTAGTTCAGTTAATAAAAGAGAACGGGGATTGGGTTAATTGATTGACTATTGACA
ATTTGTTTATCTTTGCAAGT

Downstream 100 bases:

>100_bases
GAATAATAAGGTTAACAAGAATAATAGGATGTTTAAGCAACTGATATATCTCATCTCTTTCCTCTCGTTGGTCGCTGTGC
TCCCGGCTGGTGCTACAGAA

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MKVRIINKSHHPLPGYATPLSAGMDIRANLSESVVLKPLERKLIPTGLYISLPEGYEAQMRPRSGLALKHGITLLNTPGT
IDADYRGEIGIILVNLSSEPFTVNDGERICQMVIAAHSHVDWEPVETLDDTERGAGGFGHTGKE

Sequences:

>Translated_144_residues
MKVRIINKSHHPLPGYATPLSAGMDIRANLSESVVLKPLERKLIPTGLYISLPEGYEAQMRPRSGLALKHGITLLNTPGT
IDADYRGEIGIILVNLSSEPFTVNDGERICQMVIAAHSHVDWEPVETLDDTERGAGGFGHTGKE
>Mature_144_residues
MKVRIINKSHHPLPGYATPLSAGMDIRANLSESVVLKPLERKLIPTGLYISLPEGYEAQMRPRSGLALKHGITLLNTPGT
IDADYRGEIGIILVNLSSEPFTVNDGERICQMVIAAHSHVDWEPVETLDDTERGAGGFGHTGKE

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=144, Percent_Identity=39.5833333333333, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI4503423, Length=144, Percent_Identity=39.5833333333333, Blast_Score=106, Evalue=6e-24,
Organism=Homo sapiens, GI70906441, Length=144, Percent_Identity=39.5833333333333, Blast_Score=105, Evalue=2e-23,
Organism=Escherichia coli, GI1790071, Length=134, Percent_Identity=47.0149253731343, Blast_Score=121, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71988561, Length=131, Percent_Identity=40.4580152671756, Blast_Score=99, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6319729, Length=134, Percent_Identity=35.8208955223881, Blast_Score=83, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19921126, Length=139, Percent_Identity=35.9712230215827, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24583610, Length=139, Percent_Identity=35.9712230215827, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15682; Mature: 15682

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVRIINKSHHPLPGYATPLSAGMDIRANLSESVVLKPLERKLIPTGLYISLPEGYEAQM
CEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCEEECCHHHHCCCCCEEEECCCCCCCCC
RPRSGLALKHGITLLNTPGTIDADYRGEIGIILVNLSSEPFTVNDGERICQMVIAAHSHV
CCCCCCEEECCEEEEECCCCCCCCCCCCEEEEEEEECCCCEEECCHHHHHHHHHHHHCCC
DWEPVETLDDTERGAGGFGHTGKE
CCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKVRIINKSHHPLPGYATPLSAGMDIRANLSESVVLKPLERKLIPTGLYISLPEGYEAQM
CEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCEEECCHHHHCCCCCEEEECCCCCCCCC
RPRSGLALKHGITLLNTPGTIDADYRGEIGIILVNLSSEPFTVNDGERICQMVIAAHSHV
CCCCCCEEECCEEEEECCCCCCCCCCCCEEEEEEEECCCCEEECCHHHHHHHHHHHHCCC
DWEPVETLDDTERGAGGFGHTGKE
CCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA