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The map label for this gene is cytR [H]

Identifier: 150008191

GI number: 150008191

Start: 1819476

End: 1820489

Strand: Reverse

Name: cytR [H]

Synonym: BDI_1557

Alternate gene names: 150008191

Gene position: 1820489-1819476 (Counterclockwise)

Preceding gene: 150008195

Following gene: 150008190

Centisome position: 37.84

GC content: 43.39

Gene sequence:

>1014_bases
ATGAAAAAGCGTCAAATCACGATAAAGGATATAGCGAAAGCCTTGCATATTTCCCCGTCAACAGTCTCTCGTTCCTTGGC
TGATCATCCGGATATCAGCCAAGAAACCAAGAATATAGTGAATGCTTACGCTCGTGAACATAAATATAAGCCCAATGCCT
TAGCCTTGAGTTTACGGACAAATAATACGAAAACAATCGGTGTTATTTTACCGCAGATCGTACATTATTTCTTTTCTTCT
GTTTTATCCGGTATAGAGGATGAGGCGGAAAAGGGAGGGTATCGTGTTATTATTTGTCAAAGTAATGAGAATTATGAGAA
AGAAGTAAAAGGTGCGCAAGCTTTATTGGAAGCACGTGTTTGCGGTGTCTTGGCTTCTGTCGCTAAAACAACGACGATCT
ACAATCATTTCCAAGAACTAATCGATAGCGATATACCTATGGTGTTTTTTGATCGTATATGCACGGGGATCTTGACAGAC
CGGGTGGTCGTTGATGATTATGCCGGGGTTTGTTCCGCTGTTGAATACTTGATTCGTAGCGGTTGCCGGCGAATCGCCTT
TTTCGGATCTCCTTCTCATTTAGCGATCTCTAATAATCGTAGGATGGGATATGAGGATGCTTTGCGTAAAAATGGATTAC
CGGTAGATAAAGAGTTAATTAAGATTTGTGATAATTATACCGAGGCGCTTCGGTTGACCCCGGAATTATTGTCGTTGCCC
AATCGTCCGGATGCGTTCTTCGCCGTAAATGATGAGACTGCTATAGGGGTGCTGAATGTTGTCAAGGCCAAGGGATTGAG
GATACCCGATGAGGTTTCGATTTGTGGGTTTACGAATAATAGCTTAGCGGAAGTTAGTGATCCCCTGCTGACCTCCGTGG
ATCAACATGGTTATGAGTTGGGAGCTATCGCTATGCGTTTACTGATAGAACGTTTGAATGGCGTGCGTGACGGGGATCGT
ATCGTGAGCAAGATTATCAAGACAAATCTGGTGGTGAGACAGTCTACCCGTTAA

Upstream 100 bases:

>100_bases
AATGTTTGTCGATACCCCTATAAATTTACGCAAACGTTCTCGCAAACGTTTGCATTGTATGACCTAAATACATATCTTTG
ATTTTATAAAAAAGAGAACC

Downstream 100 bases:

>100_bases
AAAAGTAGCTTCCGAAAACGTTTGCTCTACTTCTTTGCATGAATTTGAATAGGGACGACGTCCTGTTTCGGAATAATTCC
GTATGTTTGTCACCAAACAA

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKKRQITIKDIAKALHISPSTVSRSLADHPDISQETKNIVNAYAREHKYKPNALALSLRTNNTKTIGVILPQIVHYFFSS
VLSGIEDEAEKGGYRVIICQSNENYEKEVKGAQALLEARVCGVLASVAKTTTIYNHFQELIDSDIPMVFFDRICTGILTD
RVVVDDYAGVCSAVEYLIRSGCRRIAFFGSPSHLAISNNRRMGYEDALRKNGLPVDKELIKICDNYTEALRLTPELLSLP
NRPDAFFAVNDETAIGVLNVVKAKGLRIPDEVSICGFTNNSLAEVSDPLLTSVDQHGYELGAIAMRLLIERLNGVRDGDR
IVSKIIKTNLVVRQSTR

Sequences:

>Translated_337_residues
MKKRQITIKDIAKALHISPSTVSRSLADHPDISQETKNIVNAYAREHKYKPNALALSLRTNNTKTIGVILPQIVHYFFSS
VLSGIEDEAEKGGYRVIICQSNENYEKEVKGAQALLEARVCGVLASVAKTTTIYNHFQELIDSDIPMVFFDRICTGILTD
RVVVDDYAGVCSAVEYLIRSGCRRIAFFGSPSHLAISNNRRMGYEDALRKNGLPVDKELIKICDNYTEALRLTPELLSLP
NRPDAFFAVNDETAIGVLNVVKAKGLRIPDEVSICGFTNNSLAEVSDPLLTSVDQHGYELGAIAMRLLIERLNGVRDGDR
IVSKIIKTNLVVRQSTR
>Mature_337_residues
MKKRQITIKDIAKALHISPSTVSRSLADHPDISQETKNIVNAYAREHKYKPNALALSLRTNNTKTIGVILPQIVHYFFSS
VLSGIEDEAEKGGYRVIICQSNENYEKEVKGAQALLEARVCGVLASVAKTTTIYNHFQELIDSDIPMVFFDRICTGILTD
RVVVDDYAGVCSAVEYLIRSGCRRIAFFGSPSHLAISNNRRMGYEDALRKNGLPVDKELIKICDNYTEALRLTPELLSLP
NRPDAFFAVNDETAIGVLNVVKAKGLRIPDEVSICGFTNNSLAEVSDPLLTSVDQHGYELGAIAMRLLIERLNGVRDGDR
IVSKIIKTNLVVRQSTR

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=332, Percent_Identity=32.8313253012048, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI1787948, Length=332, Percent_Identity=29.5180722891566, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1790194, Length=308, Percent_Identity=28.5714285714286, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789202, Length=288, Percent_Identity=27.7777777777778, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1788474, Length=310, Percent_Identity=28.0645161290323, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1789068, Length=334, Percent_Identity=28.4431137724551, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1787580, Length=317, Percent_Identity=28.391167192429, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI48994940, Length=315, Percent_Identity=25.0793650793651, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1790715, Length=316, Percent_Identity=24.3670886075949, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1786268, Length=334, Percent_Identity=23.0538922155689, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787906, Length=309, Percent_Identity=26.8608414239482, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789456, Length=341, Percent_Identity=24.9266862170088, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1786540, Length=344, Percent_Identity=22.6744186046512, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790192, Length=310, Percent_Identity=24.8387096774194, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37395; Mature: 37395

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRQITIKDIAKALHISPSTVSRSLADHPDISQETKNIVNAYAREHKYKPNALALSLRT
CCCCEEEHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEC
NNTKTIGVILPQIVHYFFSSVLSGIEDEAEKGGYRVIICQSNENYEKEVKGAQALLEARV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
CGVLASVAKTTTIYNHFQELIDSDIPMVFFDRICTGILTDRVVVDDYAGVCSAVEYLIRS
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
GCRRIAFFGSPSHLAISNNRRMGYEDALRKNGLPVDKELIKICDNYTEALRLTPELLSLP
CCCEEEEECCCCEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHCCC
NRPDAFFAVNDETAIGVLNVVKAKGLRIPDEVSICGFTNNSLAEVSDPLLTSVDQHGYEL
CCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHCCHHHHHHHHCCHHH
GAIAMRLLIERLNGVRDGDRIVSKIIKTNLVVRQSTR
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCC
>Mature Secondary Structure
MKKRQITIKDIAKALHISPSTVSRSLADHPDISQETKNIVNAYAREHKYKPNALALSLRT
CCCCEEEHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEC
NNTKTIGVILPQIVHYFFSSVLSGIEDEAEKGGYRVIICQSNENYEKEVKGAQALLEARV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
CGVLASVAKTTTIYNHFQELIDSDIPMVFFDRICTGILTDRVVVDDYAGVCSAVEYLIRS
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
GCRRIAFFGSPSHLAISNNRRMGYEDALRKNGLPVDKELIKICDNYTEALRLTPELLSLP
CCCEEEEECCCCEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHCCC
NRPDAFFAVNDETAIGVLNVVKAKGLRIPDEVSICGFTNNSLAEVSDPLLTSVDQHGYEL
CCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHCCHHHHHHHHCCHHH
GAIAMRLLIERLNGVRDGDRIVSKIIKTNLVVRQSTR
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]