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The map label for this gene is pyrG [H]

Identifier: 150005857

GI number: 150005857

Start: 4188490

End: 4190088

Strand: Direct

Name: pyrG [H]

Synonym: BVU_3353

Alternate gene names: 150005857

Gene position: 4188490-4190088 (Clockwise)

Preceding gene: 150005855

Following gene: 150005858

Centisome position: 81.12

GC content: 42.15

Gene sequence:

>1599_bases
GTGGGAGAAACTAAGTATATCTTCGTAACTGGTGGTGTTGCCTCCTCATTAGGTAAAGGTATTATTTCATCATCAATAGG
TAAATTACTGCAAGCCAGAGGCTATAATGTAACAATTCAGAAGTTCGATCCGTATATCAATATTGATCCGGGAACTTTGA
ATCCTTATGAACATGGTGAATGTTATGTAACGGTAGACGGACACGAAGCCGACCTCGATTTGGGACATTACGAACGTTTT
TTGGGCATCCAAACAACTAAAGCCAATAACATTACAACAGGACGTATTTACAAAAGTGTTATTGACAAAGAACGCCGTGG
TGACTATTTGGGAAAGACTATTCAGGTTATCCCCCATATCACCGATGAGATCAAACGCAATGTAAAATTATTGGGAAGCA
AATATAAATTTGATTTTGTCATTACCGAAATCGGTGGTACCGTAGGTGATATTGAATCACTTCCTTATTTGGAAAGTATC
CGCCAATTGAAATGGGAAATGGGACGTAATGCGTTGTGCGTACACCTTACTTATGTTCCTTATCTGGCAGCAGCAGGCGA
ATTGAAGACCAAACCTACCCAGCACTCTGTAAAAGAGCTGCAATCTGTTGGTATTCAACCAGATGTATTGGTATTGCGTA
CCGAGCACGAATTGAGCACAAACTTGAAAAAGAAAGTTGCTCTGTTCTGTAACGTAGATGAAAATGCTGTGGTGCAGTCT
ATCGATATGCCCACCATTTATGAAGTACCTTTGCGTATGCAAGAGCAGGGACTGGATGTAACCATTCTCCAAAAGATGGG
ATTGCCCGTGGGTGAAACTCCAACCCTCGGTCCATGGAGAGATTTTCTAGATCGCCGTCATAAGGCAACTGAGAAAGTAA
AAATTGGATTGGTTGGTAAATACGATTTGCAAGACGCTTATAAATCTATCCTTGAAGCCTTGTCACAAGCCGCCACTTAC
AATGACCGCAAAGCGGATATCCACTTCATAAACAGCGAGAAACTGACAGATGCTAATGTAGAAGAGCAGATTAAGGATAT
GGATGGTATCATCATCTGCCCGGGATTCGGACAACGTGGCATAGAAGGTAAGTTCGTTGCTATCAAATATGCACGTACAC
ACAATGTGCCGACTTTTGGTATCTGTCTAGGTATGCAGTGCATGGCTATTGAGTTTGCCCGTAACGTGCTAGGTTATACA
GATGCCAACAGCCGCGAAATGGATGAAAAAACGCCACACAACGTGATAGACATTATGGAAGAACAGAAAGCTATCACCAA
TATGGGCGGCACTATGCGCCTGGGAGCCTATGAATGTATCCTTGACCAACACTCAAAGACTTTTGAAGCCTATAAAAGCG
AACACATACAGGAACGCCACCGTCACCGCTACGAATTCAATAATGACTATAAGCAGGAGTACGAAAAGGCGGGTATGAAA
TGCGTGGGTATCAATCCGGAATCCGATTTAGTGGAAATAATTGAAATCCCGACATTAAAATGGTTCATCGGAGTACAGTT
CCATCCCGAGTACAGCAGTACAGTATTGAAACCACATCCTTTATTCCTGTCATTTATCAAAGCGGCAATAGACAAATAA

Upstream 100 bases:

>100_bases
AGCATATCCGACAATATTGAAAAAGATTTTGTAATTTTGCAACTTTGATAAATATTGCGATTTTGATAATTAAGAAAATA
ACATTTAAAAATATTAAGTC

Downstream 100 bases:

>100_bases
GAAACGAGAATTATAATATAATAAGGTAAACAAGTAAAAATGGACAAAAACACTTTAGTGGGATTCGCCCTGATTGGTGC
AGTTGTGATAGGCTTCAGCA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MGETKYIFVTGGVASSLGKGIISSSIGKLLQARGYNVTIQKFDPYINIDPGTLNPYEHGECYVTVDGHEADLDLGHYERF
LGIQTTKANNITTGRIYKSVIDKERRGDYLGKTIQVIPHITDEIKRNVKLLGSKYKFDFVITEIGGTVGDIESLPYLESI
RQLKWEMGRNALCVHLTYVPYLAAAGELKTKPTQHSVKELQSVGIQPDVLVLRTEHELSTNLKKKVALFCNVDENAVVQS
IDMPTIYEVPLRMQEQGLDVTILQKMGLPVGETPTLGPWRDFLDRRHKATEKVKIGLVGKYDLQDAYKSILEALSQAATY
NDRKADIHFINSEKLTDANVEEQIKDMDGIIICPGFGQRGIEGKFVAIKYARTHNVPTFGICLGMQCMAIEFARNVLGYT
DANSREMDEKTPHNVIDIMEEQKAITNMGGTMRLGAYECILDQHSKTFEAYKSEHIQERHRHRYEFNNDYKQEYEKAGMK
CVGINPESDLVEIIEIPTLKWFIGVQFHPEYSSTVLKPHPLFLSFIKAAIDK

Sequences:

>Translated_532_residues
MGETKYIFVTGGVASSLGKGIISSSIGKLLQARGYNVTIQKFDPYINIDPGTLNPYEHGECYVTVDGHEADLDLGHYERF
LGIQTTKANNITTGRIYKSVIDKERRGDYLGKTIQVIPHITDEIKRNVKLLGSKYKFDFVITEIGGTVGDIESLPYLESI
RQLKWEMGRNALCVHLTYVPYLAAAGELKTKPTQHSVKELQSVGIQPDVLVLRTEHELSTNLKKKVALFCNVDENAVVQS
IDMPTIYEVPLRMQEQGLDVTILQKMGLPVGETPTLGPWRDFLDRRHKATEKVKIGLVGKYDLQDAYKSILEALSQAATY
NDRKADIHFINSEKLTDANVEEQIKDMDGIIICPGFGQRGIEGKFVAIKYARTHNVPTFGICLGMQCMAIEFARNVLGYT
DANSREMDEKTPHNVIDIMEEQKAITNMGGTMRLGAYECILDQHSKTFEAYKSEHIQERHRHRYEFNNDYKQEYEKAGMK
CVGINPESDLVEIIEIPTLKWFIGVQFHPEYSSTVLKPHPLFLSFIKAAIDK
>Mature_531_residues
GETKYIFVTGGVASSLGKGIISSSIGKLLQARGYNVTIQKFDPYINIDPGTLNPYEHGECYVTVDGHEADLDLGHYERFL
GIQTTKANNITTGRIYKSVIDKERRGDYLGKTIQVIPHITDEIKRNVKLLGSKYKFDFVITEIGGTVGDIESLPYLESIR
QLKWEMGRNALCVHLTYVPYLAAAGELKTKPTQHSVKELQSVGIQPDVLVLRTEHELSTNLKKKVALFCNVDENAVVQSI
DMPTIYEVPLRMQEQGLDVTILQKMGLPVGETPTLGPWRDFLDRRHKATEKVKIGLVGKYDLQDAYKSILEALSQAATYN
DRKADIHFINSEKLTDANVEEQIKDMDGIIICPGFGQRGIEGKFVAIKYARTHNVPTFGICLGMQCMAIEFARNVLGYTD
ANSREMDEKTPHNVIDIMEEQKAITNMGGTMRLGAYECILDQHSKTFEAYKSEHIQERHRHRYEFNNDYKQEYEKAGMKC
VGINPESDLVEIIEIPTLKWFIGVQFHPEYSSTVLKPHPLFLSFIKAAIDK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=550, Percent_Identity=43.2727272727273, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI28559085, Length=547, Percent_Identity=43.1444241316271, Blast_Score=453, Evalue=1e-127,
Organism=Homo sapiens, GI28559083, Length=547, Percent_Identity=43.1444241316271, Blast_Score=453, Evalue=1e-127,
Organism=Homo sapiens, GI221316689, Length=547, Percent_Identity=43.1444241316271, Blast_Score=453, Evalue=1e-127,
Organism=Escherichia coli, GI1789142, Length=538, Percent_Identity=49.4423791821561, Blast_Score=509, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI25148299, Length=607, Percent_Identity=39.7034596375618, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6322563, Length=561, Percent_Identity=40.1069518716578, Blast_Score=404, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6319432, Length=560, Percent_Identity=40, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24664469, Length=551, Percent_Identity=44.2831215970962, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI21357815, Length=496, Percent_Identity=41.9354838709677, Blast_Score=371, Evalue=1e-103,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 60079; Mature: 59947

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGETKYIFVTGGVASSLGKGIISSSIGKLLQARGYNVTIQKFDPYINIDPGTLNPYEHGE
CCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCE
CYVTVDGHEADLDLGHYERFLGIQTTKANNITTGRIYKSVIDKERRGDYLGKTIQVIPHI
EEEEECCCCCCCCHHHHHHHHCEEECCCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHH
TDEIKRNVKLLGSKYKFDFVITEIGGTVGDIESLPYLESIRQLKWEMGRNALCVHLTYVP
HHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHCCHHHHHHHHHHHHHCCCEEEEEEEHHH
YLAAAGELKTKPTQHSVKELQSVGIQPDVLVLRTEHELSTNLKKKVALFCNVDENAVVQS
HHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECHHHHHCCCEEEEEEEECCCCHHEEE
IDMPTIYEVPLRMQEQGLDVTILQKMGLPVGETPTLGPWRDFLDRRHKATEKVKIGLVGK
CCCCEEEECCCHHHHCCCCEEEHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEC
YDLQDAYKSILEALSQAATYNDRKADIHFINSEKLTDANVEEQIKDMDGIIICPGFGQRG
CCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCEEEECCCCCCC
IEGKFVAIKYARTHNVPTFGICLGMQCMAIEFARNVLGYTDANSREMDEKTPHNVIDIME
CCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
EQKAITNMGGTMRLGAYECILDQHSKTFEAYKSEHIQERHRHRYEFNNDYKQEYEKAGMK
HHHHHHHCCCCEEECHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCE
CVGINPESDLVEIIEIPTLKWFIGVQFHPEYSSTVLKPHPLFLSFIKAAIDK
EEECCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
GETKYIFVTGGVASSLGKGIISSSIGKLLQARGYNVTIQKFDPYINIDPGTLNPYEHGE
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCE
CYVTVDGHEADLDLGHYERFLGIQTTKANNITTGRIYKSVIDKERRGDYLGKTIQVIPHI
EEEEECCCCCCCCHHHHHHHHCEEECCCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHH
TDEIKRNVKLLGSKYKFDFVITEIGGTVGDIESLPYLESIRQLKWEMGRNALCVHLTYVP
HHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHCCHHHHHHHHHHHHHCCCEEEEEEEHHH
YLAAAGELKTKPTQHSVKELQSVGIQPDVLVLRTEHELSTNLKKKVALFCNVDENAVVQS
HHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECHHHHHCCCEEEEEEEECCCCHHEEE
IDMPTIYEVPLRMQEQGLDVTILQKMGLPVGETPTLGPWRDFLDRRHKATEKVKIGLVGK
CCCCEEEECCCHHHHCCCCEEEHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEC
YDLQDAYKSILEALSQAATYNDRKADIHFINSEKLTDANVEEQIKDMDGIIICPGFGQRG
CCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCEEEECCCCCCC
IEGKFVAIKYARTHNVPTFGICLGMQCMAIEFARNVLGYTDANSREMDEKTPHNVIDIME
CCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
EQKAITNMGGTMRLGAYECILDQHSKTFEAYKSEHIQERHRHRYEFNNDYKQEYEKAGMK
HHHHHHHCCCCEEECHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCE
CVGINPESDLVEIIEIPTLKWFIGVQFHPEYSSTVLKPHPLFLSFIKAAIDK
EEECCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]