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The map label for this gene is clpB [H]

Identifier: 150005806

GI number: 150005806

Start: 4133119

End: 4135635

Strand: Direct

Name: clpB [H]

Synonym: BVU_3299

Alternate gene names: 150005806

Gene position: 4133119-4135635 (Clockwise)

Preceding gene: 150005802

Following gene: 150005807

Centisome position: 80.05

GC content: 42.59

Gene sequence:

>2517_bases
ATGAACAATCAATTTACACAAAGAGTGTCCGATATCATCATGTATAGCAAGGAAGAAGCCAACAGGCTGCGAAATAGCTA
TATTGGTCCCGAACACTTGTTGTTGGGACTGATACGTGAAGGTGAAGGAAAAGCTATCGAGATTTTGTTTAATTTGCAAA
TAAACTTACAGGACATAAAAAATCAGTTGGAGGCCATTGTGAAAAACAATGCAGAAAATGACACCACCTATGACGAGAAT
ATTAGCTTTAATGACAAAGCATCCAAAGTGTTAAAGCTATGTATTCTAGAGGCTAAGTTATTGAGAAACATTGCGGCTGA
CTCTGAACATATTTTGTTAGCAATTATGAAGGTCAAGGATAATGCAGCTTTCCACGTCTTGGAAAGCAATGGCGTAACAT
ACGAAAAAATCAAACTCACTTTACAACCAGACACCCATGCAGGTCTGGGGTTCAGTGAGGACGAGGATGAAGACGAGGAT
ATACGTCAGAGTCCAAGTGGCAATAAATCAAATGCAGCACAACAGCAGGCACGCCCGGCACAAAAAAAGCCGGCTAATGA
CACTCCTGTACTCGACAATTTCGGCACAGACATGACAAAAGCTGCCGAAGAAGGAAAACTAGATCCTGTAGTTGGCCGGG
TGAAGGAAATAGAGCGACTGGCACAAATATTGAGCCGTCGCAAGAAAAACAACCCAATTTTGATTGGCGAACCGGGAGTC
GGCAAATCTGCCATTGTTGAGGGACTTGCATTACGGATTGTGGAAAAGAAAGTATCACGTATCTTATTTGACAAACGAGT
GATAGCTCTTGATATGACTGCCGTTGTCGCAGGCACTAAATATCGTGGACAATTCGAGGAACGTATTCGTTCTATCTTAA
ACGAGTTGAAGAAGAATCCTAACATCATTCTTTTCATCGATGAAATCCACACTATTGTGGGAGCAGGTTCTGCAGCGGGC
TCAATGGATGCAGCCAATATGTTGAAACCCGCATTGGCCAGAGGCGAGATTCAATGCATCGGAGCGACGACGTTGGACGA
ATACCGCCAAAACATTGAAAAAGACGGTGCATTGGAACGTCGGTTCCAAAAGGTTATTGTAGAACCAACAACTGCAGAAG
AGACACTTCAGATATTGAAAAATATCAAGGATAAATACGAGGATCATCATAATGTGAACTATACAGATGCAGCCCTTGAA
GCTTGTGTGAAACTAACAGACCGATATATCACAGACCGTAACTTCCCCGATAAAGCGATAGATGCTTTAGATGAAGCCGG
CTCGCGCGTACATCTTACTAATATCACTGCTCCTAAAGAAATAGAAGAACAGGAAAAACTGATTGATGAGATGAAATCTC
TTAAAAATGAAGCTGTCAGGCTACAGAATTTCGAACTGGCCGCCAGTTATCGTGACAAAGAGAAAGAATATACGAATCAG
CTTGATACCCTGAAGGAAGAATGGGAAAAAAGTCTGAAGGAAAACCGGGAAACGGTAGATGACGAACAAATAGCTGAAGT
CGTTTCCATGATGTCAGGCGTACCTGTACAAAGAATGGCACAGGCTGAAGGAATGAAATTATTAGGAATGAAAGACGATC
TGCTTTCTAAAGTTATCGGTCAGGACAAAGCAATCGCCACACTGGTAAAAGCTATTCAAAGAAGCCGTGTAGGCCTGAAA
GATCCTAATAAGCCGATTGGTACATTCATGTTTCTAGGTCCGACAGGTGTCGGCAAGACTCATTTGGCCAAGGAGTTAGC
GAAACTAATGTTCGGTTCAGCAGATGCACTTATCCGCATTGACATGAGTGAATATATGGAAAAATTCACCGTATCCCGTC
TGGTAGGAGCACCTCCCGGATACGTAGGTTATGAAGAAGGTGGGCAGCTGACGGAGAAAGTAAGGCGTAAACCCTACTCT
ATCGTTTTATTGGATGAAATTGAAAAAGCGCATCCCGATGTATTCAACATATTGTTGCAAGTGATGGATGAAGGTCGGTT
GACTGACAGTTATGGCAGAACTGTAGACTTTAAAAATACCATAGTCATCATGACATCTAATATTGGAACCCGCCAACTGA
AAGAATTCGGAAAAGGAATCGGATTTGCCGCCCAGGTCCGTACTGATGACAAAGAATACTCGCGCAGCGTGATTACAAAA
GCTTTGAATAAGTCTTTTGCGCCCGAATTCATCAATCGTTTGGACGAAATAATAACTTTCGACCAACTCGATCTGGATGC
ACTGACCCGGATTATTGATATTGAACTTAAGGGCCTTTACAGTCGTGTGAAAAACATTGGTTACAAGCTTGTTATTGACG
AAGATGCCAAAAAGTTTGTAGCCACCAAAGGTTACGATGTACAGTTTGGAGCACGCCCATTGAAACGTGCCATCCAAAAC
AACTTGGAGGATGGCATCTCCGAGCTGATACTTGGATCAGAAATGGCAGCTGGTGACACGATCAAGGTAAGCTATGACAA
AGAAAAAGACCTCATTGTCATGACTGTGGAAAAGTAA

Upstream 100 bases:

>100_bases
TTATGCTAATATAAATAAGAAAACAATGGTATGCATTGTTATTATGTGTATCTTTGCACACTGGGAAATAAATACTATAC
TTTAGGAGGACGATAAATTT

Downstream 100 bases:

>100_bases
AGAGTCCAAAGTTATTCAAAAAATAACAGACAAAATGTCAGATATCACTGTATCTGGCATTTTTTTTGCCCATCATCCAA
CAAAAAGACGATTCAAACGT

Product: negative regulator of genetic competence

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 838; Mature: 838

Protein sequence:

>838_residues
MNNQFTQRVSDIIMYSKEEANRLRNSYIGPEHLLLGLIREGEGKAIEILFNLQINLQDIKNQLEAIVKNNAENDTTYDEN
ISFNDKASKVLKLCILEAKLLRNIAADSEHILLAIMKVKDNAAFHVLESNGVTYEKIKLTLQPDTHAGLGFSEDEDEDED
IRQSPSGNKSNAAQQQARPAQKKPANDTPVLDNFGTDMTKAAEEGKLDPVVGRVKEIERLAQILSRRKKNNPILIGEPGV
GKSAIVEGLALRIVEKKVSRILFDKRVIALDMTAVVAGTKYRGQFEERIRSILNELKKNPNIILFIDEIHTIVGAGSAAG
SMDAANMLKPALARGEIQCIGATTLDEYRQNIEKDGALERRFQKVIVEPTTAEETLQILKNIKDKYEDHHNVNYTDAALE
ACVKLTDRYITDRNFPDKAIDALDEAGSRVHLTNITAPKEIEEQEKLIDEMKSLKNEAVRLQNFELAASYRDKEKEYTNQ
LDTLKEEWEKSLKENRETVDDEQIAEVVSMMSGVPVQRMAQAEGMKLLGMKDDLLSKVIGQDKAIATLVKAIQRSRVGLK
DPNKPIGTFMFLGPTGVGKTHLAKELAKLMFGSADALIRIDMSEYMEKFTVSRLVGAPPGYVGYEEGGQLTEKVRRKPYS
IVLLDEIEKAHPDVFNILLQVMDEGRLTDSYGRTVDFKNTIVIMTSNIGTRQLKEFGKGIGFAAQVRTDDKEYSRSVITK
ALNKSFAPEFINRLDEIITFDQLDLDALTRIIDIELKGLYSRVKNIGYKLVIDEDAKKFVATKGYDVQFGARPLKRAIQN
NLEDGISELILGSEMAAGDTIKVSYDKEKDLIVMTVEK

Sequences:

>Translated_838_residues
MNNQFTQRVSDIIMYSKEEANRLRNSYIGPEHLLLGLIREGEGKAIEILFNLQINLQDIKNQLEAIVKNNAENDTTYDEN
ISFNDKASKVLKLCILEAKLLRNIAADSEHILLAIMKVKDNAAFHVLESNGVTYEKIKLTLQPDTHAGLGFSEDEDEDED
IRQSPSGNKSNAAQQQARPAQKKPANDTPVLDNFGTDMTKAAEEGKLDPVVGRVKEIERLAQILSRRKKNNPILIGEPGV
GKSAIVEGLALRIVEKKVSRILFDKRVIALDMTAVVAGTKYRGQFEERIRSILNELKKNPNIILFIDEIHTIVGAGSAAG
SMDAANMLKPALARGEIQCIGATTLDEYRQNIEKDGALERRFQKVIVEPTTAEETLQILKNIKDKYEDHHNVNYTDAALE
ACVKLTDRYITDRNFPDKAIDALDEAGSRVHLTNITAPKEIEEQEKLIDEMKSLKNEAVRLQNFELAASYRDKEKEYTNQ
LDTLKEEWEKSLKENRETVDDEQIAEVVSMMSGVPVQRMAQAEGMKLLGMKDDLLSKVIGQDKAIATLVKAIQRSRVGLK
DPNKPIGTFMFLGPTGVGKTHLAKELAKLMFGSADALIRIDMSEYMEKFTVSRLVGAPPGYVGYEEGGQLTEKVRRKPYS
IVLLDEIEKAHPDVFNILLQVMDEGRLTDSYGRTVDFKNTIVIMTSNIGTRQLKEFGKGIGFAAQVRTDDKEYSRSVITK
ALNKSFAPEFINRLDEIITFDQLDLDALTRIIDIELKGLYSRVKNIGYKLVIDEDAKKFVATKGYDVQFGARPLKRAIQN
NLEDGISELILGSEMAAGDTIKVSYDKEKDLIVMTVEK
>Mature_838_residues
MNNQFTQRVSDIIMYSKEEANRLRNSYIGPEHLLLGLIREGEGKAIEILFNLQINLQDIKNQLEAIVKNNAENDTTYDEN
ISFNDKASKVLKLCILEAKLLRNIAADSEHILLAIMKVKDNAAFHVLESNGVTYEKIKLTLQPDTHAGLGFSEDEDEDED
IRQSPSGNKSNAAQQQARPAQKKPANDTPVLDNFGTDMTKAAEEGKLDPVVGRVKEIERLAQILSRRKKNNPILIGEPGV
GKSAIVEGLALRIVEKKVSRILFDKRVIALDMTAVVAGTKYRGQFEERIRSILNELKKNPNIILFIDEIHTIVGAGSAAG
SMDAANMLKPALARGEIQCIGATTLDEYRQNIEKDGALERRFQKVIVEPTTAEETLQILKNIKDKYEDHHNVNYTDAALE
ACVKLTDRYITDRNFPDKAIDALDEAGSRVHLTNITAPKEIEEQEKLIDEMKSLKNEAVRLQNFELAASYRDKEKEYTNQ
LDTLKEEWEKSLKENRETVDDEQIAEVVSMMSGVPVQRMAQAEGMKLLGMKDDLLSKVIGQDKAIATLVKAIQRSRVGLK
DPNKPIGTFMFLGPTGVGKTHLAKELAKLMFGSADALIRIDMSEYMEKFTVSRLVGAPPGYVGYEEGGQLTEKVRRKPYS
IVLLDEIEKAHPDVFNILLQVMDEGRLTDSYGRTVDFKNTIVIMTSNIGTRQLKEFGKGIGFAAQVRTDDKEYSRSVITK
ALNKSFAPEFINRLDEIITFDQLDLDALTRIIDIELKGLYSRVKNIGYKLVIDEDAKKFVATKGYDVQFGARPLKRAIQN
NLEDGISELILGSEMAAGDTIKVSYDKEKDLIVMTVEK

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=333, Percent_Identity=36.3363363363363, Blast_Score=201, Evalue=2e-51,
Organism=Escherichia coli, GI1788943, Length=880, Percent_Identity=43.5227272727273, Blast_Score=673, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=820, Percent_Identity=37.8048780487805, Blast_Score=533, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6320464, Length=729, Percent_Identity=41.5637860082305, Blast_Score=550, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6323002, Length=402, Percent_Identity=38.5572139303483, Blast_Score=276, Evalue=1e-74,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 93873; Mature: 93873

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNQFTQRVSDIIMYSKEEANRLRNSYIGPEHLLLGLIREGEGKAIEILFNLQINLQDIK
CCCHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEEEEECHHHHH
NQLEAIVKNNAENDTTYDENISFNDKASKVLKLCILEAKLLRNIAADSEHILLAIMKVKD
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECC
NAAFHVLESNGVTYEKIKLTLQPDTHAGLGFSEDEDEDEDIRQSPSGNKSNAAQQQARPA
CCEEEEEECCCCEEEEEEEEECCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHCCCC
QKKPANDTPVLDNFGTDMTKAAEEGKLDPVVGRVKEIERLAQILSRRKKNNPILIGEPGV
CCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
GKSAIVEGLALRIVEKKVSRILFDKRVIALDMTAVVAGTKYRGQFEERIRSILNELKKNP
CHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
NIILFIDEIHTIVGAGSAAGSMDAANMLKPALARGEIQCIGATTLDEYRQNIEKDGALER
CEEEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCHHHH
RFQKVIVEPTTAEETLQILKNIKDKYEDHHNVNYTDAALEACVKLTDRYITDRNFPDKAI
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
DALDEAGSRVHLTNITAPKEIEEQEKLIDEMKSLKNEAVRLQNFELAASYRDKEKEYTNQ
HHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LDTLKEEWEKSLKENRETVDDEQIAEVVSMMSGVPVQRMAQAEGMKLLGMKDDLLSKVIG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHCCCEEECCCHHHHHHHHC
QDKAIATLVKAIQRSRVGLKDPNKPIGTFMFLGPTGVGKTHLAKELAKLMFGSADALIRI
CCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEE
DMSEYMEKFTVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSIVLLDEIEKAHPDVFNILLQ
CHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHH
VMDEGRLTDSYGRTVDFKNTIVIMTSNIGTRQLKEFGKGIGFAAQVRTDDKEYSRSVITK
HHHCCCCCCCCCCEEECCCEEEEEECCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHH
ALNKSFAPEFINRLDEIITFDQLDLDALTRIIDIELKGLYSRVKNIGYKLVIDEDAKKFV
HHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHH
ATKGYDVQFGARPLKRAIQNNLEDGISELILGSEMAAGDTIKVSYDKEKDLIVMTVEK
HCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEECC
>Mature Secondary Structure
MNNQFTQRVSDIIMYSKEEANRLRNSYIGPEHLLLGLIREGEGKAIEILFNLQINLQDIK
CCCHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEEEEECHHHHH
NQLEAIVKNNAENDTTYDENISFNDKASKVLKLCILEAKLLRNIAADSEHILLAIMKVKD
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECC
NAAFHVLESNGVTYEKIKLTLQPDTHAGLGFSEDEDEDEDIRQSPSGNKSNAAQQQARPA
CCEEEEEECCCCEEEEEEEEECCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHCCCC
QKKPANDTPVLDNFGTDMTKAAEEGKLDPVVGRVKEIERLAQILSRRKKNNPILIGEPGV
CCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
GKSAIVEGLALRIVEKKVSRILFDKRVIALDMTAVVAGTKYRGQFEERIRSILNELKKNP
CHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
NIILFIDEIHTIVGAGSAAGSMDAANMLKPALARGEIQCIGATTLDEYRQNIEKDGALER
CEEEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCHHHH
RFQKVIVEPTTAEETLQILKNIKDKYEDHHNVNYTDAALEACVKLTDRYITDRNFPDKAI
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
DALDEAGSRVHLTNITAPKEIEEQEKLIDEMKSLKNEAVRLQNFELAASYRDKEKEYTNQ
HHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LDTLKEEWEKSLKENRETVDDEQIAEVVSMMSGVPVQRMAQAEGMKLLGMKDDLLSKVIG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHCCCEEECCCHHHHHHHHC
QDKAIATLVKAIQRSRVGLKDPNKPIGTFMFLGPTGVGKTHLAKELAKLMFGSADALIRI
CCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEE
DMSEYMEKFTVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSIVLLDEIEKAHPDVFNILLQ
CHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHH
VMDEGRLTDSYGRTVDFKNTIVIMTSNIGTRQLKEFGKGIGFAAQVRTDDKEYSRSVITK
HHHCCCCCCCCCCEEECCCEEEEEECCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHH
ALNKSFAPEFINRLDEIITFDQLDLDALTRIIDIELKGLYSRVKNIGYKLVIDEDAKKFV
HHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHH
ATKGYDVQFGARPLKRAIQNNLEDGISELILGSEMAAGDTIKVSYDKEKDLIVMTVEK
HCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]