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The map label for this gene is serA [H]

Identifier: 150005749

GI number: 150005749

Start: 4070227

End: 4071147

Strand: Direct

Name: serA [H]

Synonym: BVU_3242

Alternate gene names: 150005749

Gene position: 4070227-4071147 (Clockwise)

Preceding gene: 150005748

Following gene: 150005750

Centisome position: 78.83

GC content: 43.21

Gene sequence:

>921_bases
ATGAAAGTATTAGTAGCAACAGACAAGCCGTTTGCAAAAGTTGCAGTAGACGGTATCCGTAAAGAAATAGAAGCAGCAGG
TTATGAACTGGTATTGCTGGAAAAATATGGTGAAAAAGCTAAACTACTGGAAGCTGTAAAGGACGTTAACGCAATCATTA
TCCGCAGTGATATTATTGATGCCGAAGTATTGGATGCGGCAAAAGAACTGAAAATCGTAGTACGTGCAGGAGCAGGTTAT
GATAACGTGGATTTGGCGGCTGCTACGGCACACAATGTGTGTGTTATGAATACTCCGGGACAGAACTCCAATGCAGTAGC
CGAACTGGCTTTTGGCATGATGGTGATGGCTGTCCGCAATTTCTATAACGGGACTTCGGGTACTGAACTGATGGGCAAGA
AGTTAGGTATCCATGCATACGGCAATGTAGGTCGTAATGTGGCTCGTATCGCTAAAGGTTTTGGCATGGATATTTATGCT
TTTGACGCTTTCTGCCCGAAAGAAGTGATCGAAAAAGATGGTGTGAAAGCTGTTTCTTCTGCTGAGGAACTGTATGCTGC
TTGTAATATAGTGTCCCTGCATATTCCTGCTACGGCTGAAACTAAAAATTCCATCAACTATGAATTGGTCAACAAGATGC
CTAAAGGAGGAGTATTGGTAAATACTGCCCGTAAGGAAGTGATCAATGAAGCGGAATTAATCAAACTGATGGAAGAACGC
ACCGACTTAAAGTATGTTACTGATATCATGCCGGTTGCCCATGCAGAGTTCTCGGAAAAATTTGCCGGCCGTTATTTCGC
TACACCGAAAAAGATGGGGGCCCAGACGGCTGAAGCAAATATCAACGCAGGTATCGCTGCTGCCAGACAAATAGTAGGCT
TCCTGAAAGATGGTTGTGAAAAATTCAGAGTAAATAAATAA

Upstream 100 bases:

>100_bases
GTTCACCACAGATTATACGAATTGCACAGATAGGAACAATAAATGGAATCTGTGATAATCCGTGATAATCTGTGGTGAAC
CTTTTTAATACAATAAGACC

Downstream 100 bases:

>100_bases
GTAATCCAATAACCGCAGGGGCGGATTGAATCCGACCGGATGCATATAGCTTATGTTTTCGGGCGAATGCAATTCGCCCC
TGCAAGTAAAATCTAATACC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKVLVATDKPFAKVAVDGIRKEIEAAGYELVLLEKYGEKAKLLEAVKDVNAIIIRSDIIDAEVLDAAKELKIVVRAGAGY
DNVDLAAATAHNVCVMNTPGQNSNAVAELAFGMMVMAVRNFYNGTSGTELMGKKLGIHAYGNVGRNVARIAKGFGMDIYA
FDAFCPKEVIEKDGVKAVSSAEELYAACNIVSLHIPATAETKNSINYELVNKMPKGGVLVNTARKEVINEAELIKLMEER
TDLKYVTDIMPVAHAEFSEKFAGRYFATPKKMGAQTAEANINAGIAAARQIVGFLKDGCEKFRVNK

Sequences:

>Translated_306_residues
MKVLVATDKPFAKVAVDGIRKEIEAAGYELVLLEKYGEKAKLLEAVKDVNAIIIRSDIIDAEVLDAAKELKIVVRAGAGY
DNVDLAAATAHNVCVMNTPGQNSNAVAELAFGMMVMAVRNFYNGTSGTELMGKKLGIHAYGNVGRNVARIAKGFGMDIYA
FDAFCPKEVIEKDGVKAVSSAEELYAACNIVSLHIPATAETKNSINYELVNKMPKGGVLVNTARKEVINEAELIKLMEER
TDLKYVTDIMPVAHAEFSEKFAGRYFATPKKMGAQTAEANINAGIAAARQIVGFLKDGCEKFRVNK
>Mature_306_residues
MKVLVATDKPFAKVAVDGIRKEIEAAGYELVLLEKYGEKAKLLEAVKDVNAIIIRSDIIDAEVLDAAKELKIVVRAGAGY
DNVDLAAATAHNVCVMNTPGQNSNAVAELAFGMMVMAVRNFYNGTSGTELMGKKLGIHAYGNVGRNVARIAKGFGMDIYA
FDAFCPKEVIEKDGVKAVSSAEELYAACNIVSLHIPATAETKNSINYELVNKMPKGGVLVNTARKEVINEAELIKLMEER
TDLKYVTDIMPVAHAEFSEKFAGRYFATPKKMGAQTAEANINAGIAAARQIVGFLKDGCEKFRVNK

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=296, Percent_Identity=32.4324324324324, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI145580575, Length=266, Percent_Identity=27.0676691729323, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI61743967, Length=266, Percent_Identity=27.8195488721804, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4557497, Length=266, Percent_Identity=27.8195488721804, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI145580578, Length=266, Percent_Identity=27.0676691729323, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4557499, Length=266, Percent_Identity=27.0676691729323, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1789279, Length=315, Percent_Identity=26.6666666666667, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787645, Length=257, Percent_Identity=29.1828793774319, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=310, Percent_Identity=29.6774193548387, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25147481, Length=205, Percent_Identity=28.2926829268293, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320925, Length=309, Percent_Identity=26.537216828479, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6322116, Length=306, Percent_Identity=25.8169934640523, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=178, Percent_Identity=33.1460674157303, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324964, Length=242, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921140, Length=297, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28574286, Length=316, Percent_Identity=25.3164556962025, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45552429, Length=215, Percent_Identity=28.8372093023256, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585514, Length=215, Percent_Identity=28.8372093023256, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574282, Length=215, Percent_Identity=28.8372093023256, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574284, Length=215, Percent_Identity=28.8372093023256, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45551003, Length=215, Percent_Identity=28.8372093023256, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646446, Length=205, Percent_Identity=28.2926829268293, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646448, Length=205, Percent_Identity=28.2926829268293, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646452, Length=205, Percent_Identity=28.2926829268293, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646450, Length=205, Percent_Identity=28.2926829268293, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI62472511, Length=205, Percent_Identity=28.2926829268293, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24585516, Length=292, Percent_Identity=25.6849315068493, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 33086; Mature: 33086

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVATDKPFAKVAVDGIRKEIEAAGYELVLLEKYGEKAKLLEAVKDVNAIIIRSDIID
CEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCEEEEECCCCC
AEVLDAAKELKIVVRAGAGYDNVDLAAATAHNVCVMNTPGQNSNAVAELAFGMMVMAVRN
HHHHHHHHHEEEEEEECCCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHH
FYNGTSGTELMGKKLGIHAYGNVGRNVARIAKGFGMDIYAFDAFCPKEVIEKDGVKAVSS
HCCCCCCHHHHHHHCCEEECCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCHHHHH
AEELYAACNIVSLHIPATAETKNSINYELVNKMPKGGVLVNTARKEVINEAELIKLMEER
HHHHHHHHCEEEEECCCCCCCCCCCCHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
TDLKYVTDIMPVAHAEFSEKFAGRYFATPKKMGAQTAEANINAGIAAARQIVGFLKDGCE
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHH
KFRVNK
HHCCCC
>Mature Secondary Structure
MKVLVATDKPFAKVAVDGIRKEIEAAGYELVLLEKYGEKAKLLEAVKDVNAIIIRSDIID
CEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCEEEEECCCCC
AEVLDAAKELKIVVRAGAGYDNVDLAAATAHNVCVMNTPGQNSNAVAELAFGMMVMAVRN
HHHHHHHHHEEEEEEECCCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHH
FYNGTSGTELMGKKLGIHAYGNVGRNVARIAKGFGMDIYAFDAFCPKEVIEKDGVKAVSS
HCCCCCCHHHHHHHCCEEECCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCHHHHH
AEELYAACNIVSLHIPATAETKNSINYELVNKMPKGGVLVNTARKEVINEAELIKLMEER
HHHHHHHHCEEEEECCCCCCCCCCCCHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
TDLKYVTDIMPVAHAEFSEKFAGRYFATPKKMGAQTAEANINAGIAAARQIVGFLKDGCE
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHH
KFRVNK
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]