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The map label for this gene is emrA [H]

Identifier: 148828078

GI number: 148828078

Start: 1485355

End: 1486527

Strand: Reverse

Name: emrA [H]

Synonym: CGSHiGG_08050

Alternate gene names: 148828078

Gene position: 1486527-1485355 (Counterclockwise)

Preceding gene: 148828079

Following gene: 148828064

Centisome position: 78.77

GC content: 38.36

Gene sequence:

>1173_bases
ATGACGCAAATTGCAACTGAAAACCCATCAACTAAATCTGTATCAAATAAAACTAACCGTAAAAAAGGCTTAAGCATTTT
TATTCTTCTCCTGCTTATTATTGGTATTGCTTGTGCTTTGTATTGGTTTTTCTTCTTGAAGGATTTTGAAGAAACAGAAG
ATGCTTATGTGGGTGGAAATCAAGTAATGGTATCATCACAAGTTGCAGGTAATGTAGCGAAGATTAATGCTGACAATATG
GATAAAGTCCATGCAGGTGATATTCTAGTTGAATTGGATGATACCAATGCGAAACTTAGTTTCGAACAGGCCAAAAGCAA
TCTCGCCAATGCTGTACGTCAGATAGAACAACTGGGTTTTACTGTGCAGCAATTGCAATCAGCTGTGCACGCCAATGAAA
TTTCTTTAGCTCAAGCACAAGGCAATTTGGCGCGCCGAGTTCAACTTGAAAAAATGGGTGCGATTGATAAAGAATCTTTC
CAACACGCAAAAGAAGCTGTCGAGCTTGCCAAAGCAAATTTAAATGCCTCTAAAAATCAATTGGCTGCTAATCAGGCTTT
ATTGCGTAACGTTCCATTACGTGAACAACCGCAAATACAAAATGCAATGAGTTCACTCAAACAGGCTTGGTTAAATTTGC
AACGTACAAAAATTAGAAGTCCAATTGATGGCTATGTGGCGCGTCGTAATGTTCAAGTTGGGCAAGCCGTTTCAGTGGGT
GGCGCGTTAATGGCGGTGGTATCTAATGAACAAATGTGGCTAGAAGCTAACTTCAAAGAAACCCAATTAACGAATATGCG
CATTGGTCAGCCAGTAAAAATCCATTTTGATTTATACGGTAAAAATAAAGAATTTGATGGCGTGATAAATGGTATTGAAA
TGGGGACTGGCAATGCATTTTCTCTTTTGCCTTCACAAAATGCTACGGGTAACTGGATTAAAGTGGTGCAACGCGTACCT
GTGCGAATTAAATTAGATCCACAACAATTTACAGAAACGCCATTGAGAATTGGTCTTTCTGCAACGGCAAAAGTAAGAAT
TTCAGATTCATCAGGCGCAATGCTACGAGAAAAAACAGAACCGAAAACGTTATTTTCTACTGATACACTTAAATATGATG
AAAGTGCGGTAGAAAATTTGATTGAATCTATCATTCAGCAAAACAGCCATTAA

Upstream 100 bases:

>100_bases
TTTAAAGTTTCATAATGACCTTTCATTTTATTTTTGATAGTTTTAAAGGTTATCTCAAATATCTCATTTTTAAACATTAT
CCCAGCTTAGGGAAGGCATT

Downstream 100 bases:

>100_bases
GGCGGCGTTATGGACAATTCCGCAAAAAAATTCCCGCCTATTCAAGGTGGTGCCCTGATTTTATTAACACTGGCTTTATC
TCTCGCCACCTTTATGCAGG

Product: multidrug resistance protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MTQIATENPSTKSVSNKTNRKKGLSIFILLLLIIGIACALYWFFFLKDFEETEDAYVGGNQVMVSSQVAGNVAKINADNM
DKVHAGDILVELDDTNAKLSFEQAKSNLANAVRQIEQLGFTVQQLQSAVHANEISLAQAQGNLARRVQLEKMGAIDKESF
QHAKEAVELAKANLNASKNQLAANQALLRNVPLREQPQIQNAMSSLKQAWLNLQRTKIRSPIDGYVARRNVQVGQAVSVG
GALMAVVSNEQMWLEANFKETQLTNMRIGQPVKIHFDLYGKNKEFDGVINGIEMGTGNAFSLLPSQNATGNWIKVVQRVP
VRIKLDPQQFTETPLRIGLSATAKVRISDSSGAMLREKTEPKTLFSTDTLKYDESAVENLIESIIQQNSH

Sequences:

>Translated_390_residues
MTQIATENPSTKSVSNKTNRKKGLSIFILLLLIIGIACALYWFFFLKDFEETEDAYVGGNQVMVSSQVAGNVAKINADNM
DKVHAGDILVELDDTNAKLSFEQAKSNLANAVRQIEQLGFTVQQLQSAVHANEISLAQAQGNLARRVQLEKMGAIDKESF
QHAKEAVELAKANLNASKNQLAANQALLRNVPLREQPQIQNAMSSLKQAWLNLQRTKIRSPIDGYVARRNVQVGQAVSVG
GALMAVVSNEQMWLEANFKETQLTNMRIGQPVKIHFDLYGKNKEFDGVINGIEMGTGNAFSLLPSQNATGNWIKVVQRVP
VRIKLDPQQFTETPLRIGLSATAKVRISDSSGAMLREKTEPKTLFSTDTLKYDESAVENLIESIIQQNSH
>Mature_389_residues
TQIATENPSTKSVSNKTNRKKGLSIFILLLLIIGIACALYWFFFLKDFEETEDAYVGGNQVMVSSQVAGNVAKINADNMD
KVHAGDILVELDDTNAKLSFEQAKSNLANAVRQIEQLGFTVQQLQSAVHANEISLAQAQGNLARRVQLEKMGAIDKESFQ
HAKEAVELAKANLNASKNQLAANQALLRNVPLREQPQIQNAMSSLKQAWLNLQRTKIRSPIDGYVARRNVQVGQAVSVGG
ALMAVVSNEQMWLEANFKETQLTNMRIGQPVKIHFDLYGKNKEFDGVINGIEMGTGNAFSLLPSQNATGNWIKVVQRVPV
RIKLDPQQFTETPLRIGLSATAKVRISDSSGAMLREKTEPKTLFSTDTLKYDESAVENLIESIIQQNSH

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=384, Percent_Identity=46.875, Blast_Score=355, Evalue=4e-99,
Organism=Escherichia coli, GI1788711, Length=379, Percent_Identity=47.4934036939314, Blast_Score=341, Evalue=5e-95,
Organism=Escherichia coli, GI1790519, Length=309, Percent_Identity=27.831715210356, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87081951, Length=311, Percent_Identity=26.0450160771704, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1789637, Length=326, Percent_Identity=25.7668711656442, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43067; Mature: 42936

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQIATENPSTKSVSNKTNRKKGLSIFILLLLIIGIACALYWFFFLKDFEETEDAYVGGN
CCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCC
QVMVSSQVAGNVAKINADNMDKVHAGDILVELDDTNAKLSFEQAKSNLANAVRQIEQLGF
EEEEEHHHCCCEEEECCCCCCCEECCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCC
TVQQLQSAVHANEISLAQAQGNLARRVQLEKMGAIDKESFQHAKEAVELAKANLNASKNQ
HHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHH
LAANQALLRNVPLREQPQIQNAMSSLKQAWLNLQRTKIRSPIDGYVARRNVQVGQAVSVG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHC
GALMAVVSNEQMWLEANFKETQLTNMRIGQPVKIHFDLYGKNKEFDGVINGIEMGTGNAF
CEEEEEECCCEEEEECCCCHHEECCCCCCCCEEEEEEEECCCCCCCHHHCCEEECCCCEE
SLLPSQNATGNWIKVVQRVPVRIKLDPQQFTETPLRIGLSATAKVRISDSSGAMLREKTE
EECCCCCCCCHHHHHHHHCCEEEEECHHHHHCCCHHCCCCCEEEEEEECCCCCEEECCCC
PKTLFSTDTLKYDESAVENLIESIIQQNSH
CCEEEECCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQIATENPSTKSVSNKTNRKKGLSIFILLLLIIGIACALYWFFFLKDFEETEDAYVGGN
CCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCC
QVMVSSQVAGNVAKINADNMDKVHAGDILVELDDTNAKLSFEQAKSNLANAVRQIEQLGF
EEEEEHHHCCCEEEECCCCCCCEECCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCC
TVQQLQSAVHANEISLAQAQGNLARRVQLEKMGAIDKESFQHAKEAVELAKANLNASKNQ
HHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHH
LAANQALLRNVPLREQPQIQNAMSSLKQAWLNLQRTKIRSPIDGYVARRNVQVGQAVSVG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHC
GALMAVVSNEQMWLEANFKETQLTNMRIGQPVKIHFDLYGKNKEFDGVINGIEMGTGNAF
CEEEEEECCCEEEEECCCCHHEECCCCCCCCEEEEEEEECCCCCCCHHHCCEEECCCCEE
SLLPSQNATGNWIKVVQRVPVRIKLDPQQFTETPLRIGLSATAKVRISDSSGAMLREKTE
EECCCCCCCCHHHHHHHHCCEEEEECHHHHHCCCHHCCCCCEEEEEEECCCCCEEECCCC
PKTLFSTDTLKYDESAVENLIESIIQQNSH
CCEEEECCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]