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The map label for this gene is rnr [H]

Identifier: 148828044

GI number: 148828044

Start: 1440427

End: 1442775

Strand: Reverse

Name: rnr [H]

Synonym: CGSHiGG_07825

Alternate gene names: 148828044

Gene position: 1442775-1440427 (Counterclockwise)

Preceding gene: 148828045

Following gene: 148828043

Centisome position: 76.45

GC content: 40.4

Gene sequence:

>2349_bases
ATGACAAAAAAACATAAAAACTTAATCAACCAAGATCCAAATTACAAACGAGAATTGGAAAAATACGGCAATCCAATCCC
GAGCCGTGAATTTATTTTAAGCGTTATTCGAGACAATAATGCACCGATGAATCGGGATGAAATTTTGACCGCACTTTCCA
TTCGAAATGAAGATCAAATAGAGGCGATGCGTCGCCGATTACGCGCGATGGAAAATGACGGACAATTAGTGTTCACCAAA
CGTAAACGCTATGCCTTACCAGAAAAATTAGATTTATTTAAAGGCACGGTAATTGGTCATCGCGAAGGTTTTGGTTTTTT
ACAGGTCGATGGCAAAAAGGATGATTTATTCATTCCGAACCATCAAATGCAAAGAGTCATGCATGGAGATTTTGTCTTAG
CGCAACCTGCTGGATTAGATCGTCGTGGTCGCCGTGAAGTGCGAATTGTGCGCGTATTAGAAAGCCGTAAAAAACAAATT
GTGGGTCGCTTTTTCTTAGAAAACGGTTTTAGCTATGTGGTGCCTGATGACAGTAGAATTGGCCGAGATATTCTCGTGCC
AAATGAACATCGTAATGGTGCTCGAATGGGACAAGTTGTCGTTGTCGAATTGCAAGAACGATCTGCTAGTTTTAACCAGC
CAATTGGCGTAATCACTGAGATCCTAGGCGATAATATGGCGAAAGGAATGGAAGTGGAAATCGCCTTGCGTAACCACGAT
ATTCCCCATAAGTTTCCAAGTGCGGTGGAAAAATATGTTAAAAAATTCACTGAAGAAGTGCCTGAAGAAGCAAAAAAAGG
GCGTGTGGATTTACGAAATTTACCGCTTGTGACCATTGATGGTGAAGATGCTCGCGATTTTGATGATGCCGTTTATTGTG
AAAAACACGGCAAAGGCTGGAAACTTTGGGTGGCGATTGCGGATGTTAGTTATTACGTACGTTTACGTTCCGCTTTGGAT
GTAGAAGCGCATAATCGTGGTAACTCGGTCTATTTTCCAAACCGAGTTGTACCAATGCTACCTGAAATTTTATCGAACGG
ATTATGCTCTCTAAACCCACAAGTGGATCGTTTGTGTATGGTGTGTGAGATGCAAATTTCTGCCAAAGGTAAGCTCACAG
ATTATCGCTTTTATGAAGCAGTGATGAATTCTCACGCCCGCCTCACTTATACCAAAGTCGCAAAAATGCTTGAAGGCGAT
GAAGAATTACGCGCTCGTTATTCTACGCTTGTGCCTCATTTAGAAGATCTTTATAAACTCTATCAAGCCTTGCTTGGTGC
ACGTCATCAACGTGGTGCGATCGATTTTGAAACCATTGAAACTAAGTTTATTTTCAATGCAATGGGGAGAATTGAGCGTA
TTGAACCCGTTGTTCGCAATGATGCCCACAAAATCATTGAGGAATGTATGATTCTTGCGAATATCGCAGCAGCCAATTTT
ATGGAAAAACATAAAGAGCCAGCGTTATATCGCATTCATGCCACCCCGAGCGAAGAAAAATTAACATCGTTCCGCACTTT
CTTAAGTGAGTTTGGTTTAACTTTAGAAGGTGGCTTAAAACCAACTACAAAAGACTATGCTGCTCTCTTAGAAAAAGTTA
AAGAACGGCCTGATCATGAACTTATTCAAACAATGTTGCTACGTTCATTAAGTCAAGCCGACTATCATGCTGATAATATT
GGGCATTTTGGTTTGGCTTTGGAAGAATATGCACACTTTACTTCGCCAATTCGCCGTTATCCAGACTTAACACTTCATCG
AGGTATCAAATATTTACTCGCTAAAGAACAAGGCGCAAAACGTAAAACTACCGATACAGGCGGTTATCATTACTCTTTTG
ATGAAATGGATTTACTTGGCAATCACTGTTCAATGACGGAACGCCGTGCCGACGACGCTACTCGTGAAGTGGCAGATTGG
CTGAAATGCGAATATATGCAAGATCATGTCGGTGGAGAATTTAGCGGTGTTATTTCATCTGTGACGGGATTTGGTTTATT
TGTACGCTTAGATGATTTATTCATCGATGGTTTAGTCCATATTTCCACCTTAGAAAACGATTATTACCAATTCGATGCAA
CAAAACAGCGTTTAATTGGCGAAAATAGCGGAATGCAATATCGCTTAGGCGATAAAGTTCGCATCAAAGTTGAAGCAGTA
CATTTAGAAAATAAAATGGTCGATTTCTCGCTAATAGGTAGTGAACGTAAACCTCGTCGAGCTGGAAAAACGGCGAAAGA
AAAAGCTAAGAAAGTTTTTAAAGAGCTACCGTCCAAAGCCTCCAAAAAACGAAAAAGTGCGGTAAAAAAGAAAGAAGTTT
CGAAGAAAACATCTAGAAAACAAAAATAA

Upstream 100 bases:

>100_bases
TAAAATATCCTTAAAATATACAGTGATAATTTTATCCCCATCTTGCATTATCCCCCTTACAGTGTCAAACTCTCCGCACT
TTTTAAAACTGTAAAAAATA

Downstream 100 bases:

>100_bases
TTCACTTCCTATTGTAAGAATGAATTAAAAATTCAAATAAGAAAAAGAGAAATTTATGTCAGAACAAATCTACGGCATTC
ATGCTGTTAATAGTATTTTA

Product: 23S rRNA (guanosine-2'-O-)-methyltransferase

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 782; Mature: 781

Protein sequence:

>782_residues
MTKKHKNLINQDPNYKRELEKYGNPIPSREFILSVIRDNNAPMNRDEILTALSIRNEDQIEAMRRRLRAMENDGQLVFTK
RKRYALPEKLDLFKGTVIGHREGFGFLQVDGKKDDLFIPNHQMQRVMHGDFVLAQPAGLDRRGRREVRIVRVLESRKKQI
VGRFFLENGFSYVVPDDSRIGRDILVPNEHRNGARMGQVVVVELQERSASFNQPIGVITEILGDNMAKGMEVEIALRNHD
IPHKFPSAVEKYVKKFTEEVPEEAKKGRVDLRNLPLVTIDGEDARDFDDAVYCEKHGKGWKLWVAIADVSYYVRLRSALD
VEAHNRGNSVYFPNRVVPMLPEILSNGLCSLNPQVDRLCMVCEMQISAKGKLTDYRFYEAVMNSHARLTYTKVAKMLEGD
EELRARYSTLVPHLEDLYKLYQALLGARHQRGAIDFETIETKFIFNAMGRIERIEPVVRNDAHKIIEECMILANIAAANF
MEKHKEPALYRIHATPSEEKLTSFRTFLSEFGLTLEGGLKPTTKDYAALLEKVKERPDHELIQTMLLRSLSQADYHADNI
GHFGLALEEYAHFTSPIRRYPDLTLHRGIKYLLAKEQGAKRKTTDTGGYHYSFDEMDLLGNHCSMTERRADDATREVADW
LKCEYMQDHVGGEFSGVISSVTGFGLFVRLDDLFIDGLVHISTLENDYYQFDATKQRLIGENSGMQYRLGDKVRIKVEAV
HLENKMVDFSLIGSERKPRRAGKTAKEKAKKVFKELPSKASKKRKSAVKKKEVSKKTSRKQK

Sequences:

>Translated_782_residues
MTKKHKNLINQDPNYKRELEKYGNPIPSREFILSVIRDNNAPMNRDEILTALSIRNEDQIEAMRRRLRAMENDGQLVFTK
RKRYALPEKLDLFKGTVIGHREGFGFLQVDGKKDDLFIPNHQMQRVMHGDFVLAQPAGLDRRGRREVRIVRVLESRKKQI
VGRFFLENGFSYVVPDDSRIGRDILVPNEHRNGARMGQVVVVELQERSASFNQPIGVITEILGDNMAKGMEVEIALRNHD
IPHKFPSAVEKYVKKFTEEVPEEAKKGRVDLRNLPLVTIDGEDARDFDDAVYCEKHGKGWKLWVAIADVSYYVRLRSALD
VEAHNRGNSVYFPNRVVPMLPEILSNGLCSLNPQVDRLCMVCEMQISAKGKLTDYRFYEAVMNSHARLTYTKVAKMLEGD
EELRARYSTLVPHLEDLYKLYQALLGARHQRGAIDFETIETKFIFNAMGRIERIEPVVRNDAHKIIEECMILANIAAANF
MEKHKEPALYRIHATPSEEKLTSFRTFLSEFGLTLEGGLKPTTKDYAALLEKVKERPDHELIQTMLLRSLSQADYHADNI
GHFGLALEEYAHFTSPIRRYPDLTLHRGIKYLLAKEQGAKRKTTDTGGYHYSFDEMDLLGNHCSMTERRADDATREVADW
LKCEYMQDHVGGEFSGVISSVTGFGLFVRLDDLFIDGLVHISTLENDYYQFDATKQRLIGENSGMQYRLGDKVRIKVEAV
HLENKMVDFSLIGSERKPRRAGKTAKEKAKKVFKELPSKASKKRKSAVKKKEVSKKTSRKQK
>Mature_781_residues
TKKHKNLINQDPNYKRELEKYGNPIPSREFILSVIRDNNAPMNRDEILTALSIRNEDQIEAMRRRLRAMENDGQLVFTKR
KRYALPEKLDLFKGTVIGHREGFGFLQVDGKKDDLFIPNHQMQRVMHGDFVLAQPAGLDRRGRREVRIVRVLESRKKQIV
GRFFLENGFSYVVPDDSRIGRDILVPNEHRNGARMGQVVVVELQERSASFNQPIGVITEILGDNMAKGMEVEIALRNHDI
PHKFPSAVEKYVKKFTEEVPEEAKKGRVDLRNLPLVTIDGEDARDFDDAVYCEKHGKGWKLWVAIADVSYYVRLRSALDV
EAHNRGNSVYFPNRVVPMLPEILSNGLCSLNPQVDRLCMVCEMQISAKGKLTDYRFYEAVMNSHARLTYTKVAKMLEGDE
ELRARYSTLVPHLEDLYKLYQALLGARHQRGAIDFETIETKFIFNAMGRIERIEPVVRNDAHKIIEECMILANIAAANFM
EKHKEPALYRIHATPSEEKLTSFRTFLSEFGLTLEGGLKPTTKDYAALLEKVKERPDHELIQTMLLRSLSQADYHADNIG
HFGLALEEYAHFTSPIRRYPDLTLHRGIKYLLAKEQGAKRKTTDTGGYHYSFDEMDLLGNHCSMTERRADDATREVADWL
KCEYMQDHVGGEFSGVISSVTGFGLFVRLDDLFIDGLVHISTLENDYYQFDATKQRLIGENSGMQYRLGDKVRIKVEAVH
LENKMVDFSLIGSERKPRRAGKTAKEKAKKVFKELPSKASKKRKSAVKKKEVSKKTSRKQK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=443, Percent_Identity=31.8284424379233, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI190014625, Length=443, Percent_Identity=31.8284424379233, Blast_Score=179, Evalue=8e-45,
Organism=Homo sapiens, GI134288890, Length=503, Percent_Identity=28.0318091451292, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI19115966, Length=454, Percent_Identity=27.3127753303965, Blast_Score=142, Evalue=2e-33,
Organism=Homo sapiens, GI219521928, Length=454, Percent_Identity=27.3127753303965, Blast_Score=142, Evalue=2e-33,
Organism=Homo sapiens, GI156105693, Length=228, Percent_Identity=28.9473684210526, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI156105695, Length=228, Percent_Identity=28.9473684210526, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI87082383, Length=740, Percent_Identity=67.1621621621622, Blast_Score=1046, Evalue=0.0,
Organism=Escherichia coli, GI1787542, Length=657, Percent_Identity=28.310502283105, Blast_Score=182, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI212645896, Length=423, Percent_Identity=30.2600472813239, Blast_Score=173, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17553506, Length=461, Percent_Identity=29.2841648590022, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324552, Length=565, Percent_Identity=24.7787610619469, Blast_Score=151, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24649634, Length=476, Percent_Identity=28.9915966386555, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI19922976, Length=386, Percent_Identity=26.4248704663212, Blast_Score=131, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24654597, Length=386, Percent_Identity=26.4248704663212, Blast_Score=131, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24654592, Length=386, Percent_Identity=26.4248704663212, Blast_Score=131, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 89772; Mature: 89641

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKHKNLINQDPNYKRELEKYGNPIPSREFILSVIRDNNAPMNRDEILTALSIRNEDQI
CCCHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHH
EAMRRRLRAMENDGQLVFTKRKRYALPEKLDLFKGTVIGHREGFGFLQVDGKKDDLFIPN
HHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCEEECCCCCEEEEECCCCCCEECCC
HQMQRVMHGDFVLAQPAGLDRRGRREVRIVRVLESRKKQIVGRFFLENGFSYVVPDDSRI
HHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCC
GRDILVPNEHRNGARMGQVVVVELQERSASFNQPIGVITEILGDNMAKGMEVEIALRNHD
CCCCCCCCCCCCCCCCCCEEEEEEHHHCCCCCCCHHHHHHHHCCHHCCCCEEEEEECCCC
IPHKFPSAVEKYVKKFTEEVPEEAKKGRVDLRNLPLVTIDGEDARDFDDAVYCEKHGKGW
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEECCCCCCCCCCHHHHHCCCCCE
KLWVAIADVSYYVRLRSALDVEAHNRGNSVYFPNRVVPMLPEILSNGLCSLNPQVDRLCM
EEEEEEEHHHHHHHHHHHHCCHHCCCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHH
VCEMQISAKGKLTDYRFYEAVMNSHARLTYTKVAKMLEGDEELRARYSTLVPHLEDLYKL
HHHHHCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
YQALLGARHQRGAIDFETIETKFIFNAMGRIERIEPVVRNDAHKIIEECMILANIAAANF
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
MEKHKEPALYRIHATPSEEKLTSFRTFLSEFGLTLEGGLKPTTKDYAALLEKVKERPDHE
HHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCCHH
LIQTMLLRSLSQADYHADNIGHFGLALEEYAHFTSPIRRYPDLTLHRGIKYLLAKEQGAK
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCC
RKTTDTGGYHYSFDEMDLLGNHCSMTERRADDATREVADWLKCEYMQDHVGGEFSGVISS
CCCCCCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VTGFGLFVRLDDLFIDGLVHISTLENDYYQFDATKQRLIGENSGMQYRLGDKVRIKVEAV
HHHCEEEEEEHHHHHCCHHEEEECCCCCEEECCHHHHHHCCCCCCEEECCCEEEEEEEEE
HLENKMVDFSLIGSERKPRRAGKTAKEKAKKVFKELPSKASKKRKSAVKKKEVSKKTSRK
EECCCEEEEEEECCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QK
CC
>Mature Secondary Structure 
TKKHKNLINQDPNYKRELEKYGNPIPSREFILSVIRDNNAPMNRDEILTALSIRNEDQI
CCHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHH
EAMRRRLRAMENDGQLVFTKRKRYALPEKLDLFKGTVIGHREGFGFLQVDGKKDDLFIPN
HHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCEEECCCCCEEEEECCCCCCEECCC
HQMQRVMHGDFVLAQPAGLDRRGRREVRIVRVLESRKKQIVGRFFLENGFSYVVPDDSRI
HHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCC
GRDILVPNEHRNGARMGQVVVVELQERSASFNQPIGVITEILGDNMAKGMEVEIALRNHD
CCCCCCCCCCCCCCCCCCEEEEEEHHHCCCCCCCHHHHHHHHCCHHCCCCEEEEEECCCC
IPHKFPSAVEKYVKKFTEEVPEEAKKGRVDLRNLPLVTIDGEDARDFDDAVYCEKHGKGW
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEECCCCCCCCCCHHHHHCCCCCE
KLWVAIADVSYYVRLRSALDVEAHNRGNSVYFPNRVVPMLPEILSNGLCSLNPQVDRLCM
EEEEEEEHHHHHHHHHHHHCCHHCCCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHH
VCEMQISAKGKLTDYRFYEAVMNSHARLTYTKVAKMLEGDEELRARYSTLVPHLEDLYKL
HHHHHCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
YQALLGARHQRGAIDFETIETKFIFNAMGRIERIEPVVRNDAHKIIEECMILANIAAANF
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
MEKHKEPALYRIHATPSEEKLTSFRTFLSEFGLTLEGGLKPTTKDYAALLEKVKERPDHE
HHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCCHH
LIQTMLLRSLSQADYHADNIGHFGLALEEYAHFTSPIRRYPDLTLHRGIKYLLAKEQGAK
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCC
RKTTDTGGYHYSFDEMDLLGNHCSMTERRADDATREVADWLKCEYMQDHVGGEFSGVISS
CCCCCCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VTGFGLFVRLDDLFIDGLVHISTLENDYYQFDATKQRLIGENSGMQYRLGDKVRIKVEAV
HHHCEEEEEEHHHHHCCHHEEEECCCCCEEECCHHHHHHCCCCCCEEECCCEEEEEEEEE
HLENKMVDFSLIGSERKPRRAGKTAKEKAKKVFKELPSKASKKRKSAVKKKEVSKKTSRK
EECCCEEEEEEECCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]