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The map label for this gene is lexA

Identifier: 148827939

GI number: 148827939

Start: 1342147

End: 1342770

Strand: Direct

Name: lexA

Synonym: CGSHiGG_07240

Alternate gene names: 148827939

Gene position: 1342147-1342770 (Clockwise)

Preceding gene: 148827937

Following gene: 148827940

Centisome position: 71.12

GC content: 38.46

Gene sequence:

>624_bases
ATGAGACCATTAACCGCACGCCAACAAGAAGTGTTGGATTTATTAAAACGCCATTTGGAAACAACAGGTATGCCACCAAC
ACGAGCAGAAATATCTCGAGAATTAGGTTTCAAATCTGCAAATGCCGCAGAAGAACATTTGAAAGCACTTTCACGTAAAG
GTGCAATCGAAATCATTCCCGGCGCATCTCGTGGTATTCGTATTTTAGACAATAGTTCGAATGATGAATTTGACGGTTTA
CCGCTTGTAGGGCGCGTGGCTGCTGGAGAACCGATTCTTGCAGAGCAGCATATTGAAGCGACATATCGAGTAGATGCAGA
TATGTTTAAACCACAGGCTGATTTCTTACTTAAAGTTTATGGTCTATCAATGAAAAATGTTGGTATCTTAGATGGTGATT
TACTAGCTGTGCATAGTACTAAGGATGTACGTAACGGACAAATTGTGGTTGCACGTATTGAAGATGAAGTAACAGTAAAA
CGTCTTGAGAAAAAAGGTTCTATCATTTATCTACACGCAGAAAATGAAGAATTTGATCCTATAGTAGTCAATCTTGAAGA
ACAAAAAAATTTTGAAATTGAAGGTATTGCAGTAGGCATTATTCGCAATAACGCTTGGATGTAA

Upstream 100 bases:

>100_bases
CAAAAATGTGACTTAATACACAGATTTAAAAAATAACAGTTGCAACTTTACACAATCTGTATACAATGCCAGTTATCTGT
ATTTAAAAACAGGAGTGTAT

Downstream 100 bases:

>100_bases
TCTGATACCAAGAATGAATAAAGTGCGGTAAAAATTTACGGTATTTTTACCGCACTTTGCTTATACTAGAGTTCTTTATT
TGCCATGATTTTTGCTGCTC

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MRPLTARQQEVLDLLKRHLETTGMPPTRAEISRELGFKSANAAEEHLKALSRKGAIEIIPGASRGIRILDNSSNDEFDGL
PLVGRVAAGEPILAEQHIEATYRVDADMFKPQADFLLKVYGLSMKNVGILDGDLLAVHSTKDVRNGQIVVARIEDEVTVK
RLEKKGSIIYLHAENEEFDPIVVNLEEQKNFEIEGIAVGIIRNNAWM

Sequences:

>Translated_207_residues
MRPLTARQQEVLDLLKRHLETTGMPPTRAEISRELGFKSANAAEEHLKALSRKGAIEIIPGASRGIRILDNSSNDEFDGL
PLVGRVAAGEPILAEQHIEATYRVDADMFKPQADFLLKVYGLSMKNVGILDGDLLAVHSTKDVRNGQIVVARIEDEVTVK
RLEKKGSIIYLHAENEEFDPIVVNLEEQKNFEIEGIAVGIIRNNAWM
>Mature_207_residues
MRPLTARQQEVLDLLKRHLETTGMPPTRAEISRELGFKSANAAEEHLKALSRKGAIEIIPGASRGIRILDNSSNDEFDGL
PLVGRVAAGEPILAEQHIEATYRVDADMFKPQADFLLKVYGLSMKNVGILDGDLLAVHSTKDVRNGQIVVARIEDEVTVK
RLEKKGSIIYLHAENEEFDPIVVNLEEQKNFEIEGIAVGIIRNNAWM

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=207, Percent_Identity=67.6328502415459, Blast_Score=288, Evalue=1e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA_HAEI8 (Q4QME9)

Other databases:

- EMBL:   CP000057
- RefSeq:   YP_248458.1
- ProteinModelPortal:   Q4QME9
- SMR:   Q4QME9
- STRING:   Q4QME9
- GeneID:   3430217
- GenomeReviews:   CP000057_GR
- KEGG:   hit:NTHI0905
- eggNOG:   COG1974
- HOGENOM:   HBG679610
- PhylomeDB:   Q4QME9
- ProtClustDB:   PRK00215
- BioCyc:   HINF281310:NTHI0905-MONOMER
- GO:   GO:0006508
- GO:   GO:0006350
- HAMAP:   MF_00015
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 23021; Mature: 23021

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: ACT_SITE 123-123 ACT_SITE 160-160

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPLTARQQEVLDLLKRHLETTGMPPTRAEISRELGFKSANAAEEHLKALSRKGAIEIIP
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEC
GASRGIRILDNSSNDEFDGLPLVGRVAAGEPILAEQHIEATYRVDADMFKPQADFLLKVY
CCCCCEEEEECCCCCCCCCCCEEEEECCCCCEEHHHHCCEEEEECHHHCCCHHHHEEHEE
GLSMKNVGILDGDLLAVHSTKDVRNGQIVVARIEDEVTVKRLEKKGSIIYLHAENEEFDP
CCCCCCCEEECCCEEEEECCCCCCCCCEEEEEECCHHHHHHHHHCCCEEEEEECCCCCCC
IVVNLEEQKNFEIEGIAVGIIRNNAWM
EEEEEECCCCEEEEEEEEEEEECCCCC
>Mature Secondary Structure
MRPLTARQQEVLDLLKRHLETTGMPPTRAEISRELGFKSANAAEEHLKALSRKGAIEIIP
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEC
GASRGIRILDNSSNDEFDGLPLVGRVAAGEPILAEQHIEATYRVDADMFKPQADFLLKVY
CCCCCEEEEECCCCCCCCCCCEEEEECCCCCEEHHHHCCEEEEECHHHCCCHHHHEEHEE
GLSMKNVGILDGDLLAVHSTKDVRNGQIVVARIEDEVTVKRLEKKGSIIYLHAENEEFDP
CCCCCCCEEECCCEEEEECCCCCCCCCEEEEEECCHHHHHHHHHCCCEEEEEECCCCCCC
IVVNLEEQKNFEIEGIAVGIIRNNAWM
EEEEEECCCCEEEEEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA