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The map label for this gene is ethR [H]

Identifier: 148824250

GI number: 148824250

Start: 3430422

End: 3431102

Strand: Reverse

Name: ethR [H]

Synonym: TBFG_13075

Alternate gene names: 148824250

Gene position: 3431102-3430422 (Counterclockwise)

Preceding gene: 148824252

Following gene: 148824249

Centisome position: 77.55

GC content: 63.44

Gene sequence:

>681_bases
ATGGTGCAAGGTCAAGGGGGTGATCAAAAGGTGACCAGTCATGCCGCAGACGAGAAGCAGGCTGCGCCGCCGATGCGACG
GCGTGGTGACAGGCATCGCCAGGCGATTCTGCGGGCCGCACGCGAACTGCTGGAGGAGACACCGTTCGCGGAATTGTCGG
TGCGCGCTATCAGCCTTCGCGCAGGGGTAGCCCGCTCCGGTTTCTACTTCTACTTCGATTCCAAATACTCGGTGCTCGCC
CAGATCTTGGCCGAGGCCACCGAAGAACTCGAAGAAGCCAGCCAGCATTTCTCCGCCCGTCAGCCAGGGGAGTCACCCGA
GCAGTTCGTCAACCGGATGATCGGCAGCGTCGCCGCCGTTTACGCGAACAACGACCCGGTGCTGCGGGCCTGTAATGCGG
CACGCCAGAGCGACATGGAGATCCGCGATATTCTCGAGCGGCAGTTCCAAGTGCTGTTGCGTGAAACCATCGGCGTCTTC
GAGGCTGAGGTGAAGGCCGGCACTGCGCATCCGATCAGCGAAGACCTCCCGACGCTCGTCCGCACCCTGGCAGCTACCAC
CGCGCTGATGCTGACCGGTGACGCTTTGCTCGTCGGCCCCGACAGTGACGCAGCGCGCCGGGTTCGGGTGCTTGAACAGA
TGTGGCTCAACGCGCTTTGGGGTGGCGGCAAGGCCCCATAG

Upstream 100 bases:

>100_bases
GTGGATCGTCGCCATTGGCGCTCCTTACCGGTGGTGGCTGTAACTGAAATCTATCCTTCTGGTCAATTTGACGGCTACCG
ATGTTCCGTTTTCAGACGCC

Downstream 100 bases:

>100_bases
CTATCGGGGCGCATCGATCGTCCTACCGGAGGGGGTGTCGGTACCGCCGGTATCGTCACGACCATGTTGCAGAGGGGAGC
CGGACAGTATTTCGCGGGTA

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MVQGQGGDQKVTSHAADEKQAAPPMRRRGDRHRQAILRAARELLEETPFAELSVRAISLRAGVARSGFYFYFDSKYSVLA
QILAEATEELEEASQHFSARQPGESPEQFVNRMIGSVAAVYANNDPVLRACNAARQSDMEIRDILERQFQVLLRETIGVF
EAEVKAGTAHPISEDLPTLVRTLAATTALMLTGDALLVGPDSDAARRVRVLEQMWLNALWGGGKAP

Sequences:

>Translated_226_residues
MVQGQGGDQKVTSHAADEKQAAPPMRRRGDRHRQAILRAARELLEETPFAELSVRAISLRAGVARSGFYFYFDSKYSVLA
QILAEATEELEEASQHFSARQPGESPEQFVNRMIGSVAAVYANNDPVLRACNAARQSDMEIRDILERQFQVLLRETIGVF
EAEVKAGTAHPISEDLPTLVRTLAATTALMLTGDALLVGPDSDAARRVRVLEQMWLNALWGGGKAP
>Mature_226_residues
MVQGQGGDQKVTSHAADEKQAAPPMRRRGDRHRQAILRAARELLEETPFAELSVRAISLRAGVARSGFYFYFDSKYSVLA
QILAEATEELEEASQHFSARQPGESPEQFVNRMIGSVAAVYANNDPVLRACNAARQSDMEIRDILERQFQVLLRETIGVF
EAEVKAGTAHPISEDLPTLVRTLAATTALMLTGDALLVGPDSDAARRVRVLEQMWLNALWGGGKAP

Specific function: Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24832; Mature: 24832

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQGQGGDQKVTSHAADEKQAAPPMRRRGDRHRQAILRAARELLEETPFAELSVRAISLR
CCCCCCCCHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AGVARSGFYFYFDSKYSVLAQILAEATEELEEASQHFSARQPGESPEQFVNRMIGSVAAV
HHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
YANNDPVLRACNAARQSDMEIRDILERQFQVLLRETIGVFEAEVKAGTAHPISEDLPTLV
HCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RTLAATTALMLTGDALLVGPDSDAARRVRVLEQMWLNALWGGGKAP
HHHHHHHHHHEECCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVQGQGGDQKVTSHAADEKQAAPPMRRRGDRHRQAILRAARELLEETPFAELSVRAISLR
CCCCCCCCHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AGVARSGFYFYFDSKYSVLAQILAEATEELEEASQHFSARQPGESPEQFVNRMIGSVAAV
HHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
YANNDPVLRACNAARQSDMEIRDILERQFQVLLRETIGVFEAEVKAGTAHPISEDLPTLV
HCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RTLAATTALMLTGDALLVGPDSDAARRVRVLEQMWLNALWGGGKAP
HHHHHHHHHHEECCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]