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The map label for this gene is echA17

Identifier: 148824230

GI number: 148824230

Start: 3411129

End: 3411893

Strand: Reverse

Name: echA17

Synonym: TBFG_13055

Alternate gene names: 148824230

Gene position: 3411893-3411129 (Counterclockwise)

Preceding gene: 148824231

Following gene: 148824229

Centisome position: 77.11

GC content: 69.8

Gene sequence:

>765_bases
GTGCCCGAGTTCGTCAACGTCGTGGTCAGTGACGGCTCCCAGGATGCCGGCCTGGCCATGTTGCTCCTATCGCGACCGCC
TACCAACGCGATGACCCGCCAGGTCTACCGGGAAGTGGTCGCCGCGGCCAACGAGCTGGGGCGACGCGACGACGTGGCCG
CAGTGATCCTGTATGGCGGCCACGAAATCTTCTCCGCCGGCGACGACATGCCCGAACTGCGGACATTGAGCGCGCAGGAG
GCCGACACCGCCGCCCGGATTCGGCAGCAGGCCGTCGACGCCGTTGCGGCGATCCCCAAGCCGACCGTGGCCGCCATCAC
CGGATACGCGTTGGGTGCCGGCCTTACGCTGGCCCTAGCCGCCGATTGGCGAGTCAGCGGTGACAACGTGAAATTCGGCG
CGACCGAGATCCTGGCCGGCCTGATCCCCAGCGGCGACGGAATGGCCCGGCTGACCCGTGCGGCCGGTCCGAGCAGAGCC
AAGGAGCTGGTGTTCAGCGGGCGCTTCTTCGACGCCGAGGAGGCCTTGGCGCTGGGCCTGATCGACGACATGGTGGCCCC
CGACGACGTTTACGACGCCGCGGCGGCCTGGGCGAGGCGCTTTCTTGACGGCCCGCCGCACGCGCTGGCCGCGGCCAAAG
CCGGGATCAGCGACGTCTACGAGCTGGCGCCGGCCGAGCGGATCGCCGCTGAGCGTCGGCGCTATGTCGAGGTGTTCGCC
GCTGGTCAAGGTGGTGGCAGCAAGGGTGACCGGGGCGGCCGTTAG

Upstream 100 bases:

>100_bases
GCAACGGCGACAACTGGGAGATCGAGTTCTTCGATTCCGACCGCTATAACCAGGCCCGGAGATCGGGCGGATCGACCGGG
TGGCCGCTGTGACGCCAACG

Downstream 100 bases:

>100_bases
GCTCGCCTATATGACGAGGAGTTCAAACATCCCCGCCGACGCCACTCCCAATCCACATGCCACGGCCGAGCAGGTGGCCG
CAGCTCGGCACGACAGCAAG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MPEFVNVVVSDGSQDAGLAMLLLSRPPTNAMTRQVYREVVAAANELGRRDDVAAVILYGGHEIFSAGDDMPELRTLSAQE
ADTAARIRQQAVDAVAAIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILAGLIPSGDGMARLTRAAGPSRA
KELVFSGRFFDAEEALALGLIDDMVAPDDVYDAAAAWARRFLDGPPHALAAAKAGISDVYELAPAERIAAERRRYVEVFA
AGQGGGSKGDRGGR

Sequences:

>Translated_254_residues
MPEFVNVVVSDGSQDAGLAMLLLSRPPTNAMTRQVYREVVAAANELGRRDDVAAVILYGGHEIFSAGDDMPELRTLSAQE
ADTAARIRQQAVDAVAAIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILAGLIPSGDGMARLTRAAGPSRA
KELVFSGRFFDAEEALALGLIDDMVAPDDVYDAAAAWARRFLDGPPHALAAAKAGISDVYELAPAERIAAERRRYVEVFA
AGQGGGSKGDRGGR
>Mature_253_residues
PEFVNVVVSDGSQDAGLAMLLLSRPPTNAMTRQVYREVVAAANELGRRDDVAAVILYGGHEIFSAGDDMPELRTLSAQEA
DTAARIRQQAVDAVAAIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILAGLIPSGDGMARLTRAAGPSRAK
ELVFSGRFFDAEEALALGLIDDMVAPDDVYDAAAAWARRFLDGPPHALAAAKAGISDVYELAPAERIAAERRRYVEVFAA
GQGGGSKGDRGGR

Specific function: Could possibly oxidize fatty acids using specific components

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family

Homologues:

Organism=Homo sapiens, GI194097323, Length=238, Percent_Identity=28.5714285714286, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI68989263, Length=188, Percent_Identity=34.5744680851064, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI4502327, Length=232, Percent_Identity=34.051724137931, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI157694516, Length=224, Percent_Identity=25.8928571428571, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI213417737, Length=224, Percent_Identity=25.8928571428571, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI157694520, Length=206, Percent_Identity=26.2135922330097, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI70995211, Length=179, Percent_Identity=32.4022346368715, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI20127408, Length=163, Percent_Identity=30.0613496932515, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI45643119, Length=220, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI260275230, Length=220, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI260274832, Length=220, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI31542718, Length=199, Percent_Identity=26.6331658291457, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787659, Length=224, Percent_Identity=34.375, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI221142681, Length=227, Percent_Identity=31.2775330396476, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788597, Length=206, Percent_Identity=29.126213592233, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788682, Length=176, Percent_Identity=34.6590909090909, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1790281, Length=192, Percent_Identity=26.5625, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI87082183, Length=187, Percent_Identity=25.668449197861, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=240, Percent_Identity=31.25, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17540714, Length=227, Percent_Identity=29.9559471365639, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI25145438, Length=227, Percent_Identity=28.1938325991189, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17560910, Length=221, Percent_Identity=27.1493212669683, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17534483, Length=171, Percent_Identity=29.8245614035088, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17536985, Length=175, Percent_Identity=29.1428571428571, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17558304, Length=176, Percent_Identity=25.5681818181818, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508951, Length=194, Percent_Identity=25.2577319587629, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144276, Length=194, Percent_Identity=25.2577319587629, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508953, Length=194, Percent_Identity=25.2577319587629, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17549921, Length=195, Percent_Identity=28.2051282051282, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI20129971, Length=243, Percent_Identity=29.6296296296296, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653477, Length=243, Percent_Identity=29.6296296296296, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653139, Length=193, Percent_Identity=31.6062176165803, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI19920382, Length=215, Percent_Identity=27.906976744186, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921018, Length=195, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24583165, Length=189, Percent_Identity=27.5132275132275, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550169, Length=211, Percent_Identity=25.5924170616114, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECH17_MYCBO (Q7TXE1)

Other databases:

- EMBL:   BX248344
- RefSeq:   NP_856710.1
- HSSP:   Q13825
- ProteinModelPortal:   Q7TXE1
- SMR:   Q7TXE1
- EnsemblBacteria:   EBMYCT00000016377
- GeneID:   1093520
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3065c
- GeneTree:   EBGT00070000031721
- HOGENOM:   HBG748731
- OMA:   EGIGTIR
- ProtClustDB:   PRK05869
- BioCyc:   MBOV233413:MB3065C-MONOMER
- InterPro:   IPR001753

Pfam domain/function: PF00378 ECH

EC number: =4.2.1.17

Molecular weight: Translated: 26538; Mature: 26407

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEFVNVVVSDGSQDAGLAMLLLSRPPTNAMTRQVYREVVAAANELGRRDDVAAVILYGG
CCCCEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECC
HEIFSAGDDMPELRTLSAQEADTAARIRQQAVDAVAAIPKPTVAAITGYALGAGLTLALA
CEEECCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEEE
ADWRVSGDNVKFGATEILAGLIPSGDGMARLTRAAGPSRAKELVFSGRFFDAEEALALGL
ECEEECCCCEECCHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHH
IDDMVAPDDVYDAAAAWARRFLDGPPHALAAAKAGISDVYELAPAERIAAERRRYVEVFA
HHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHCCHHHHHHHHHHHEEEEE
AGQGGGSKGDRGGR
ECCCCCCCCCCCCC
>Mature Secondary Structure 
PEFVNVVVSDGSQDAGLAMLLLSRPPTNAMTRQVYREVVAAANELGRRDDVAAVILYGG
CCCEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECC
HEIFSAGDDMPELRTLSAQEADTAARIRQQAVDAVAAIPKPTVAAITGYALGAGLTLALA
CEEECCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEEE
ADWRVSGDNVKFGATEILAGLIPSGDGMARLTRAAGPSRAKELVFSGRFFDAEEALALGL
ECEEECCCCEECCHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHH
IDDMVAPDDVYDAAAAWARRFLDGPPHALAAAKAGISDVYELAPAERIAAERRRYVEVFA
HHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHCCHHHHHHHHHHHEEEEE
AGQGGGSKGDRGGR
ECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972