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The map label for this gene is mmgC [H]

Identifier: 148823977

GI number: 148823977

Start: 3109661

End: 3110893

Strand: Reverse

Name: mmgC [H]

Synonym: TBFG_12802

Alternate gene names: 148823977

Gene position: 3110893-3109661 (Counterclockwise)

Preceding gene: 148823978

Following gene: 148823974

Centisome position: 70.31

GC content: 63.18

Gene sequence:

>1233_bases
ATGTTCGAGTGGTCCGACACCGATCTAATGGTGCGCGACGCCGTTCGCCAGTTCATCGACAAGGAGATCCGCCCGCACCA
AGACGCATTGGAAACCGGTGAACTGTCGCCGTATCCGATCGCGCGCAAGCTGTTCAGCCAGTTCGGTCTGGACGTGCTGC
TTGCCGAGTCGGTCAACCAGATGCTGGATGGGGAGCGGGCTAAGCGGGAAAAGCGGGACAGCTCAGGCAGTTTCGGGCTG
GCTGACCAGGCTTCGATGGTCGCGGTGCTGGTGTCCGAACTGGCCGGGGTCAGCATCGGATTGCTGAGCACGGTGGCCGT
CAGCCTCGGGTTGGGCGCGGCGACGATCATGAGCCGCGGCACCCTGGCCCAACAGGAGCGCTGGGTGCCCACGCTGGTGA
CGCTGGAAAAGATCGCGGCCTGGGCCATTACCGAGCCAGACTCCGGCTCGGATGCGTTCGGCGGCATGAAGACTCACGTG
ACCCGCGACGGTGAAGACTACATCCTCAACGGGCACAAGACCTTCATCACCAACGGGCCGTACGCTGATGTCCTGGTGGT
CTACGCCAAGCTCGCCGACGGTGAGCCCGCCTCAGATTGGCGTAACCGCCCGGTGCTGGTCTTTGTGCTCGATGCCGGCA
TGCCGGGCCTGACGCAGGGCAAGCCGTTCAAGAAGATGGGCATGATGTCTTCGCCGACCGGCGAGTTGTTCTTCGACAAC
GTGCGGCTGACCCCGGATCGCCTGCTTTGCGCCGAGGGGGACGGCCGCGACAGCGCCCGCGCCAATTTCGCCGTCGAACG
CCTCGGCGTGGCGCTCATGTCGTTGGGCATCATCAACGAATGCCACCGGCTGTGTGTGGATTACGCAAAGACCCGCACGC
TGTGGGGCCGTAACATCGGGCAGTTCCAACTGATCCAGTTGAAGTTGGCGAAAATGGAAGTTGCGCGGATCAACGTGCAG
AACATGGTATTTCAGGCCATCGAGCGGCTCAAAGCCGGCAAACAGCTGACGCTGGCCGAGGCCTCGGCGATCAAGCTGTA
TTCCTCGGAGGCCGCCACCGATGTCGCGATGGAGGCCGTCCAGCTGTTCGGCGGCAACGGCTACATGGCCGAATATCGGG
TGGAGCAGCTGGCTCGCGATGCCAAGTCGCTGATGATCTACGCCGGCAGCAACGAGGTCCAGGTAACCCACATCGCCAAG
GGCCTGCTGGGCGAACCGGCTTCGCGAGCGTAA

Upstream 100 bases:

>100_bases
ACCGCCGCGCTGCAACACAACATCGGGCTGGGCGGCGCCGCCGTGGTCACCGCATACCAACGGGCCGAACGTTGAGCCAC
GCGATCGGAGGGAGCACGCC

Downstream 100 bases:

>100_bases
CCGGACTGCGAAAATCCGTGCCGAAAATCGCAGCCACGTTACGCTCGCGGGCCAAAGCCGTCAGCTCACCACCCAGATTG
CCTGGGCGGCCGGGCTCCCC

Product: acyl-CoA dehydrogenase fadE21

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MFEWSDTDLMVRDAVRQFIDKEIRPHQDALETGELSPYPIARKLFSQFGLDVLLAESVNQMLDGERAKREKRDSSGSFGL
ADQASMVAVLVSELAGVSIGLLSTVAVSLGLGAATIMSRGTLAQQERWVPTLVTLEKIAAWAITEPDSGSDAFGGMKTHV
TRDGEDYILNGHKTFITNGPYADVLVVYAKLADGEPASDWRNRPVLVFVLDAGMPGLTQGKPFKKMGMMSSPTGELFFDN
VRLTPDRLLCAEGDGRDSARANFAVERLGVALMSLGIINECHRLCVDYAKTRTLWGRNIGQFQLIQLKLAKMEVARINVQ
NMVFQAIERLKAGKQLTLAEASAIKLYSSEAATDVAMEAVQLFGGNGYMAEYRVEQLARDAKSLMIYAGSNEVQVTHIAK
GLLGEPASRA

Sequences:

>Translated_410_residues
MFEWSDTDLMVRDAVRQFIDKEIRPHQDALETGELSPYPIARKLFSQFGLDVLLAESVNQMLDGERAKREKRDSSGSFGL
ADQASMVAVLVSELAGVSIGLLSTVAVSLGLGAATIMSRGTLAQQERWVPTLVTLEKIAAWAITEPDSGSDAFGGMKTHV
TRDGEDYILNGHKTFITNGPYADVLVVYAKLADGEPASDWRNRPVLVFVLDAGMPGLTQGKPFKKMGMMSSPTGELFFDN
VRLTPDRLLCAEGDGRDSARANFAVERLGVALMSLGIINECHRLCVDYAKTRTLWGRNIGQFQLIQLKLAKMEVARINVQ
NMVFQAIERLKAGKQLTLAEASAIKLYSSEAATDVAMEAVQLFGGNGYMAEYRVEQLARDAKSLMIYAGSNEVQVTHIAK
GLLGEPASRA
>Mature_410_residues
MFEWSDTDLMVRDAVRQFIDKEIRPHQDALETGELSPYPIARKLFSQFGLDVLLAESVNQMLDGERAKREKRDSSGSFGL
ADQASMVAVLVSELAGVSIGLLSTVAVSLGLGAATIMSRGTLAQQERWVPTLVTLEKIAAWAITEPDSGSDAFGGMKTHV
TRDGEDYILNGHKTFITNGPYADVLVVYAKLADGEPASDWRNRPVLVFVLDAGMPGLTQGKPFKKMGMMSSPTGELFFDN
VRLTPDRLLCAEGDGRDSARANFAVERLGVALMSLGIINECHRLCVDYAKTRTLWGRNIGQFQLIQLKLAKMEVARINVQ
NMVFQAIERLKAGKQLTLAEASAIKLYSSEAATDVAMEAVQLFGGNGYMAEYRVEQLARDAKSLMIYAGSNEVQVTHIAK
GLLGEPASRA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=300, Percent_Identity=35.6666666666667, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI226958414, Length=300, Percent_Identity=35.6666666666667, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI4557235, Length=319, Percent_Identity=34.7962382445141, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI76496475, Length=320, Percent_Identity=34.6875, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI4557233, Length=401, Percent_Identity=32.1695760598504, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI4501857, Length=395, Percent_Identity=30.379746835443, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4501859, Length=406, Percent_Identity=29.064039408867, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI21361497, Length=299, Percent_Identity=32.4414715719064, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI7656849, Length=311, Percent_Identity=31.8327974276527, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI187960098, Length=404, Percent_Identity=27.970297029703, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4557231, Length=404, Percent_Identity=27.970297029703, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4503943, Length=419, Percent_Identity=26.491646778043, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI7669494, Length=402, Percent_Identity=27.1144278606965, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI48976061, Length=290, Percent_Identity=23.7931034482759, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI211971008, Length=290, Percent_Identity=23.7931034482759, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI38505218, Length=296, Percent_Identity=20.2702702702703, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786223, Length=340, Percent_Identity=29.7058823529412, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI87081958, Length=273, Percent_Identity=32.2344322344322, Blast_Score=121, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17538396, Length=402, Percent_Identity=30.8457711442786, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17569725, Length=409, Percent_Identity=30.8068459657702, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71985184, Length=315, Percent_Identity=32.6984126984127, Blast_Score=157, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17508101, Length=316, Percent_Identity=31.3291139240506, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17534899, Length=404, Percent_Identity=28.2178217821782, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17534353, Length=330, Percent_Identity=31.2121212121212, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17570075, Length=411, Percent_Identity=28.4671532846715, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17506239, Length=401, Percent_Identity=26.9326683291771, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17533517, Length=396, Percent_Identity=27.020202020202, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71985192, Length=268, Percent_Identity=32.089552238806, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17505929, Length=398, Percent_Identity=25.6281407035176, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI71990804, Length=266, Percent_Identity=30.4511278195489, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17551932, Length=403, Percent_Identity=25.0620347394541, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI32563615, Length=217, Percent_Identity=28.5714285714286, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17531909, Length=255, Percent_Identity=26.6666666666667, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI86563381, Length=273, Percent_Identity=27.8388278388278, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI86563383, Length=273, Percent_Identity=27.8388278388278, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71982178, Length=212, Percent_Identity=26.4150943396226, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562446, Length=292, Percent_Identity=24.6575342465753, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI281363737, Length=303, Percent_Identity=32.3432343234323, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI21356377, Length=404, Percent_Identity=29.9504950495049, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI21355753, Length=402, Percent_Identity=28.1094527363184, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24660351, Length=402, Percent_Identity=27.8606965174129, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24646207, Length=401, Percent_Identity=29.1770573566085, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24666513, Length=318, Percent_Identity=30.5031446540881, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI19920834, Length=421, Percent_Identity=27.3159144893112, Blast_Score=128, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 44744; Mature: 44744

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEWSDTDLMVRDAVRQFIDKEIRPHQDALETGELSPYPIARKLFSQFGLDVLLAESVNQ
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHH
MLDGERAKREKRDSSGSFGLADQASMVAVLVSELAGVSIGLLSTVAVSLGLGAATIMSRG
HHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHCC
TLAQQERWVPTLVTLEKIAAWAITEPDSGSDAFGGMKTHVTRDGEDYILNGHKTFITNGP
CHHHHHCCCHHHHHHHHHHHEEECCCCCCCCCCCCCEEEEECCCCCEEECCCEEEEECCC
YADVLVVYAKLADGEPASDWRNRPVLVFVLDAGMPGLTQGKPFKKMGMMSSPTGELFFDN
HHHHHHHHHHHCCCCCCHHHCCCCEEEEEEECCCCCCCCCCCHHHHCCCCCCCCCEEECC
VRLTPDRLLCAEGDGRDSARANFAVERLGVALMSLGIINECHRLCVDYAKTRTLWGRNIG
EEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QFQLIQLKLAKMEVARINVQNMVFQAIERLKAGKQLTLAEASAIKLYSSEAATDVAMEAV
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHEEECCHHHHHHHHHHH
QLFGGNGYMAEYRVEQLARDAKSLMIYAGSNEVQVTHIAKGLLGEPASRA
HHHCCCCCHHHHHHHHHHHHHHEEEEEECCCCEEEHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFEWSDTDLMVRDAVRQFIDKEIRPHQDALETGELSPYPIARKLFSQFGLDVLLAESVNQ
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHH
MLDGERAKREKRDSSGSFGLADQASMVAVLVSELAGVSIGLLSTVAVSLGLGAATIMSRG
HHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHCC
TLAQQERWVPTLVTLEKIAAWAITEPDSGSDAFGGMKTHVTRDGEDYILNGHKTFITNGP
CHHHHHCCCHHHHHHHHHHHEEECCCCCCCCCCCCCEEEEECCCCCEEECCCEEEEECCC
YADVLVVYAKLADGEPASDWRNRPVLVFVLDAGMPGLTQGKPFKKMGMMSSPTGELFFDN
HHHHHHHHHHHCCCCCCHHHCCCCEEEEEEECCCCCCCCCCCHHHHCCCCCCCCCEEECC
VRLTPDRLLCAEGDGRDSARANFAVERLGVALMSLGIINECHRLCVDYAKTRTLWGRNIG
EEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QFQLIQLKLAKMEVARINVQNMVFQAIERLKAGKQLTLAEASAIKLYSSEAATDVAMEAV
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHEEECCHHHHHHHHHHH
QLFGGNGYMAEYRVEQLARDAKSLMIYAGSNEVQVTHIAKGLLGEPASRA
HHHCCCCCHHHHHHHHHHHHHHEEEEEECCCCEEEHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]