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The map label for this gene is panE [C]

Identifier: 148823768

GI number: 148823768

Start: 2911273

End: 2912100

Strand: Direct

Name: panE [C]

Synonym: TBFG_12593

Alternate gene names: 148823768

Gene position: 2911273-2912100 (Clockwise)

Preceding gene: 148823765

Following gene: 148823769

Centisome position: 65.8

GC content: 70.41

Gene sequence:

>828_bases
TTGCACAAGGCCGGGTATTCGCCGCTGTTGTGCGGCCACACTCCGCGCGCCGGGATCGAGCTCCGGCGAGACGGCGCAGA
CCCCATCGTGGTGCCCGGTCCGGTGCACACCAGTCCTCGGGAGGTTGCCGGCCCGGTCGATGTGCTGATCCTGGCGGTCA
AGGCCACTCAGAACGACGCCGCACGTCCCTGGCTGACCCGCCTGTGCGACGAGCGCACCGTGGTGGCCGTGCTGCAAAAC
GGTGTCGAACAGGTCGAGCAGGTCCAGCCGCATTGTCCGTCCTCGGCCGTGGTTCCCGCGATCGTGTGGTGTTCGGCCGA
GACCCAGCCGCAAGGGTGGGTGCGCTTGCGCGGTGAAGCCGCACTGGTCGTTCCCACCGGGCCCGCGGCCGAGCAGTTCG
CCGGGCTGCTGCGCGGTGCCGGCGCCACGGTGGACTGCGACCCCGACTTCACCACGGCGGCCTGGCGCAAACTACTGGTC
AACGCGCTGGCGGGATTTATGGTGCTGTCCGGACGGCGGTCGGCAATGTTCCGCCGCGACGACGTCGCGGCATTGTCGCG
CCGCTATGTCGCCGAATGCCTGGCGGTGGCGCGCGCTGAGGGTGCCCGACTCGATGACGACGTCGTCGACGAAGTGGTCC
GCCTCGTCCGGTCGGCCCCGCAGGACATGGGCACCTCGATGCTGGCCGACCGGGCAGCCCACCGGCCACTGGAATGGGAT
TTGCGCAATGGGGTGATCGTCCGCAAGGCCCGCGCCCACGGCCTGGCCACCCCGATCAGCGACGTGCTGGTGCCGCTGCT
GGCGGCTGCCAGCGACGGTCCCGGATAG

Upstream 100 bases:

>100_bases
CATCGGTCACGCAGGATAATTTCGGCTCATCTCAACAAACATTGCAACAGGCATTGCCCTAGTCGGACCCGGTGCCGTCG
GAACGACGGTCGCCGCGCTG

Downstream 100 bases:

>100_bases
CAATGTAGCTAATGTCTAGATCATGTACCCCTGCGAGCGGGTAGGCCTGAGCTTCACCGAGACCGCGCCTTACCTCTTCC
GCAACACCGTCGACCTGGCC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MHKAGYSPLLCGHTPRAGIELRRDGADPIVVPGPVHTSPREVAGPVDVLILAVKATQNDAARPWLTRLCDERTVVAVLQN
GVEQVEQVQPHCPSSAVVPAIVWCSAETQPQGWVRLRGEAALVVPTGPAAEQFAGLLRGAGATVDCDPDFTTAAWRKLLV
NALAGFMVLSGRRSAMFRRDDVAALSRRYVAECLAVARAEGARLDDDVVDEVVRLVRSAPQDMGTSMLADRAAHRPLEWD
LRNGVIVRKARAHGLATPISDVLVPLLAAASDGPG

Sequences:

>Translated_275_residues
MHKAGYSPLLCGHTPRAGIELRRDGADPIVVPGPVHTSPREVAGPVDVLILAVKATQNDAARPWLTRLCDERTVVAVLQN
GVEQVEQVQPHCPSSAVVPAIVWCSAETQPQGWVRLRGEAALVVPTGPAAEQFAGLLRGAGATVDCDPDFTTAAWRKLLV
NALAGFMVLSGRRSAMFRRDDVAALSRRYVAECLAVARAEGARLDDDVVDEVVRLVRSAPQDMGTSMLADRAAHRPLEWD
LRNGVIVRKARAHGLATPISDVLVPLLAAASDGPG
>Mature_275_residues
MHKAGYSPLLCGHTPRAGIELRRDGADPIVVPGPVHTSPREVAGPVDVLILAVKATQNDAARPWLTRLCDERTVVAVLQN
GVEQVEQVQPHCPSSAVVPAIVWCSAETQPQGWVRLRGEAALVVPTGPAAEQFAGLLRGAGATVDCDPDFTTAAWRKLLV
NALAGFMVLSGRRSAMFRRDDVAALSRRYVAECLAVARAEGARLDDDVVDEVVRLVRSAPQDMGTSMLADRAAHRPLEWD
LRNGVIVRKARAHGLATPISDVLVPLLAAASDGPG

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 29299; Mature: 29299

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKAGYSPLLCGHTPRAGIELRRDGADPIVVPGPVHTSPREVAGPVDVLILAVKATQNDA
CCCCCCCCEEECCCCCCCCEEECCCCCCEEECCCCCCCCHHHCCCCEEEEEEEECCCCCC
ARPWLTRLCDERTVVAVLQNGVEQVEQVQPHCPSSAVVPAIVWCSAETQPQGWVRLRGEA
CCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCEEEECCCE
ALVVPTGPAAEQFAGLLRGAGATVDCDPDFTTAAWRKLLVNALAGFMVLSGRRSAMFRRD
EEEEECCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DVAALSRRYVAECLAVARAEGARLDDDVVDEVVRLVRSAPQDMGTSMLADRAAHRPLEWD
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEE
LRNGVIVRKARAHGLATPISDVLVPLLAAASDGPG
CCCCEEEEEHHHCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MHKAGYSPLLCGHTPRAGIELRRDGADPIVVPGPVHTSPREVAGPVDVLILAVKATQNDA
CCCCCCCCEEECCCCCCCCEEECCCCCCEEECCCCCCCCHHHCCCCEEEEEEEECCCCCC
ARPWLTRLCDERTVVAVLQNGVEQVEQVQPHCPSSAVVPAIVWCSAETQPQGWVRLRGEA
CCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCEEEECCCE
ALVVPTGPAAEQFAGLLRGAGATVDCDPDFTTAAWRKLLVNALAGFMVLSGRRSAMFRRD
EEEEECCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DVAALSRRYVAECLAVARAEGARLDDDVVDEVVRLVRSAPQDMGTSMLADRAAHRPLEWD
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEE
LRNGVIVRKARAHGLATPISDVLVPLLAAASDGPG
CCCCEEEEEHHHCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]