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The map label for this gene is eccE2

Identifier: 148663752

GI number: 148663752

Start: 4375354

End: 4376967

Strand: Reverse

Name: eccE2

Synonym: MRA_3924

Alternate gene names: 148663752

Gene position: 4376967-4375354 (Counterclockwise)

Preceding gene: 148663753

Following gene: 148663751

Centisome position: 99.03

GC content: 65.8

Gene sequence:

>1614_bases
TTGACGTCCAAGCTGACCGGGTTCAGCCCGCGCAGTGCGAGGCGGGTCGCCGGGGTGTGGACAGTGTTCGTGCTCGCGTC
GGCGGGCTGGGCGCTGGGCGGCCAGCTAGGTGCGGTCATGGCTGTCGTGGTCGGCGTCGCCTTGGTGTTCGTACAGTGGT
GGGGTCAGCCGGCGTGGTCGTGGGCGGTACTGGGGCTGCGGGGTCGGCGTCCCGTCAAATGGAATGACCCAATTACCTTG
GCCAACAACCGATCCGGGGGTGGCGTCCGCGTGCAAGACGGTGTCGCGGTGGTGGCGGTGCAACTTCTCGGCCGAGCGCA
CCGGGCGACTACGGTCACCGGGTCGGTGACCGTAGAAAGCGACAACGTGATTGACGTCGTTGAGCTCGCGCCGTTGCTGC
GCCACCCGCTGGACCTGGAACTCGATTCAATCAGCGTCGTCACCTTCGGCTCGCGAACCGGCACCGTCGGCGATTACCCG
CGGGTGTATGACGCGGAGATCGGTACGCCGCCGTATGCCGGGCGGCGCGAAACGTGGCTGATCATGCGGCTTCCGGTGAT
CGGCAACACCCAAGCTTTACGCTGGCGTACCAGCGTTGGGGCCGCTGCCATTTCGGTCGCCCAACGCGTTGCCAGCTCCC
TGCGCTGTCAGGGCTTGCGCGCCAAACTGGCCACCGCAACAGACTTGGCTGAGCTTGATCGCCGGCTGGGGTCGGACGCG
GTAGCCGGGAGTGCGCAGCGCTGGAAAGCTATCCGCGGTGAAGCCGGGTGGATGACGACGTATGCGTACCCGGCTGAGGC
GATTTCGTCGCGGGTTCTCTCGCAAGCCTGGACGCTGCGTGCCGATGAGGTCATCCAGAACGTAACGGTGTATCCGGACG
CGACGTGCACCGCGACCATCACCGTGCGCACACCGACGCCGGCGCCTACCCCGCCCAGTGTGATCTTGCGTCGGCTCAAT
GGTGAGCAAGCCGCCGCGGCTGCGGCCAACATGTGCGGGCCACGTCCACACCTACGCGGACAGCGGCGCTGCCCGTTGCC
GGCGCAGCTAGTCACCGAGATCGGACCGTCGGGGGTGTTGATTGGCAAGCTGAGCAACGGGGACCGGCTGATGATTCCCG
TTACCGACGCCGGTGAGCTGTCGCGCGTCTTCGTGGCCGCGGACGACACGATCGCCAAGAGGATCGTGATTCGCGTCGTC
GGTGCCGGTGAGCGGGTGTGTGTGCACACTCGCGACCAAGAGCGTTGGGCCAGCGTACGCATGCCGCAGTTGAGCATCGT
CGGCACACCACGGCCCGCGCCGCGCACCACTGTCGGCGTCGTGGAGTACGTGCGGCGGCGCAAGAACGGCGATGACGGCA
AATCTGAAGGCAGCGGTGTCGATGTCGCGATTTCGCCCACGCCACGGCCAGCCAGTGTCATCACCATTGCCCGACCCGGT
ACCTCGCTGTCCGAGAGCGATCGGCATGGCTTCGAGGTGACCATCGAACAAATCGATCGGGCAACGGTGAAAGTCGGTGC
GGCAGGACAAAACTGGCTGGTTGAGATGGAAATGTTCCGTGCGGAGAACCGCTATGTCAGCCTTGAGCCGGTCACGATGT
CGATAGGCCGGTAG

Upstream 100 bases:

>100_bases
CGCCCGATCACCGGGCGCGCAATATCGCTATCGGGTTCGTCGGCGCAGTGGCCACCGGTGTGCTGGCAATGGCAATCGGG
GCTCGGCTACGGAGGGCGCG

Downstream 100 bases:

>100_bases
AACGTTGCCAACGGAATTTGAGGCACAGAGTGACAGACACACGTTGCAACCGCGGTGACAGCGGCGGCGATGTCGAGAAT
GGTGGACACGATGGGTGATT

Product: hypothetical protein

Products: NA

Alternate protein names: ESX conserved component E2; Type VII secretion system protein EccE2; T7SS protein EccE2

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MTSKLTGFSPRSARRVAGVWTVFVLASAGWALGGQLGAVMAVVVGVALVFVQWWGQPAWSWAVLGLRGRRPVKWNDPITL
ANNRSGGGVRVQDGVAVVAVQLLGRAHRATTVTGSVTVESDNVIDVVELAPLLRHPLDLELDSISVVTFGSRTGTVGDYP
RVYDAEIGTPPYAGRRETWLIMRLPVIGNTQALRWRTSVGAAAISVAQRVASSLRCQGLRAKLATATDLAELDRRLGSDA
VAGSAQRWKAIRGEAGWMTTYAYPAEAISSRVLSQAWTLRADEVIQNVTVYPDATCTATITVRTPTPAPTPPSVILRRLN
GEQAAAAAANMCGPRPHLRGQRRCPLPAQLVTEIGPSGVLIGKLSNGDRLMIPVTDAGELSRVFVAADDTIAKRIVIRVV
GAGERVCVHTRDQERWASVRMPQLSIVGTPRPAPRTTVGVVEYVRRRKNGDDGKSEGSGVDVAISPTPRPASVITIARPG
TSLSESDRHGFEVTIEQIDRATVKVGAAGQNWLVEMEMFRAENRYVSLEPVTMSIGR

Sequences:

>Translated_537_residues
MTSKLTGFSPRSARRVAGVWTVFVLASAGWALGGQLGAVMAVVVGVALVFVQWWGQPAWSWAVLGLRGRRPVKWNDPITL
ANNRSGGGVRVQDGVAVVAVQLLGRAHRATTVTGSVTVESDNVIDVVELAPLLRHPLDLELDSISVVTFGSRTGTVGDYP
RVYDAEIGTPPYAGRRETWLIMRLPVIGNTQALRWRTSVGAAAISVAQRVASSLRCQGLRAKLATATDLAELDRRLGSDA
VAGSAQRWKAIRGEAGWMTTYAYPAEAISSRVLSQAWTLRADEVIQNVTVYPDATCTATITVRTPTPAPTPPSVILRRLN
GEQAAAAAANMCGPRPHLRGQRRCPLPAQLVTEIGPSGVLIGKLSNGDRLMIPVTDAGELSRVFVAADDTIAKRIVIRVV
GAGERVCVHTRDQERWASVRMPQLSIVGTPRPAPRTTVGVVEYVRRRKNGDDGKSEGSGVDVAISPTPRPASVITIARPG
TSLSESDRHGFEVTIEQIDRATVKVGAAGQNWLVEMEMFRAENRYVSLEPVTMSIGR
>Mature_536_residues
TSKLTGFSPRSARRVAGVWTVFVLASAGWALGGQLGAVMAVVVGVALVFVQWWGQPAWSWAVLGLRGRRPVKWNDPITLA
NNRSGGGVRVQDGVAVVAVQLLGRAHRATTVTGSVTVESDNVIDVVELAPLLRHPLDLELDSISVVTFGSRTGTVGDYPR
VYDAEIGTPPYAGRRETWLIMRLPVIGNTQALRWRTSVGAAAISVAQRVASSLRCQGLRAKLATATDLAELDRRLGSDAV
AGSAQRWKAIRGEAGWMTTYAYPAEAISSRVLSQAWTLRADEVIQNVTVYPDATCTATITVRTPTPAPTPPSVILRRLNG
EQAAAAAANMCGPRPHLRGQRRCPLPAQLVTEIGPSGVLIGKLSNGDRLMIPVTDAGELSRVFVAADDTIAKRIVIRVVG
AGERVCVHTRDQERWASVRMPQLSIVGTPRPAPRTTVGVVEYVRRRKNGDDGKSEGSGVDVAISPTPRPASVITIARPGT
SLSESDRHGFEVTIEQIDRATVKVGAAGQNWLVEMEMFRAENRYVSLEPVTMSIGR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EccE family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECCE2_MYCTU (O05459)

Other databases:

- EMBL:   BX842584
- EMBL:   AE000516
- PIR:   F70597
- RefSeq:   NP_218402.1
- RefSeq:   NP_338554.1
- EnsemblBacteria:   EBMYCT00000000011
- EnsemblBacteria:   EBMYCT00000071070
- GeneID:   886220
- GeneID:   926548
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT4000
- KEGG:   mtu:Rv3885c
- TIGR:   MT4000
- TubercuList:   Rv3885c
- GeneTree:   EBGT00050000014761
- HOGENOM:   HBG565402
- OMA:   SGCGQLI
- ProtClustDB:   CLSK792787
- InterPro:   IPR021368

Pfam domain/function: PF11203 DUF2984

EC number: NA

Molecular weight: Translated: 57657; Mature: 57526

Theoretical pI: Translated: 10.68; Mature: 10.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x2293c7a0)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSKLTGFSPRSARRVAGVWTVFVLASAGWALGGQLGAVMAVVVGVALVFVQWWGQPAWS
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHCHHHHHHHHHHHHHHHHHHHHCCCCCCE
WAVLGLRGRRPVKWNDPITLANNRSGGGVRVQDGVAVVAVQLLGRAHRATTVTGSVTVES
EEEEECCCCCCCCCCCCEEEECCCCCCCEEEECCHHHHHHHHHCCCCCCEEEEEEEEECC
DNVIDVVELAPLLRHPLDLELDSISVVTFGSRTGTVGDYPRVYDAEIGTPPYAGRRETWL
CCCCHHHHHHHHHCCCCCCEECCEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCEEE
IMRLPVIGNTQALRWRTSVGAAAISVAQRVASSLRCQGLRAKLATATDLAELDRRLGSDA
EEEECCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCH
VAGSAQRWKAIRGEAGWMTTYAYPAEAISSRVLSQAWTLRADEVIQNVTVYPDATCTATI
HCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHCEEECCCCCEEEEE
TVRTPTPAPTPPSVILRRLNGEQAAAAAANMCGPRPHLRGQRRCPLPAQLVTEIGPSGVL
EEECCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCEE
IGKLSNGDRLMIPVTDAGELSRVFVAADDTIAKRIVIRVVGAGERVCVHTRDQERWASVR
EEEECCCCEEEEEECCCCCCEEEEEECCHHHHEEEEEEEECCCCEEEEECCCHHHHHHCC
MPQLSIVGTPRPAPRTTVGVVEYVRRRKNGDDGKSEGSGVDVAISPTPRPASVITIARPG
CCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCC
TSLSESDRHGFEVTIEQIDRATVKVGAAGQNWLVEMEMFRAENRYVSLEPVTMSIGR
CCCCCCCCCCCEEEHHHHCCEEEEECCCCCCEEEEEEEHHCCCCEEEEEEEEEECCH
>Mature Secondary Structure 
TSKLTGFSPRSARRVAGVWTVFVLASAGWALGGQLGAVMAVVVGVALVFVQWWGQPAWS
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHCHHHHHHHHHHHHHHHHHHHHCCCCCCE
WAVLGLRGRRPVKWNDPITLANNRSGGGVRVQDGVAVVAVQLLGRAHRATTVTGSVTVES
EEEEECCCCCCCCCCCCEEEECCCCCCCEEEECCHHHHHHHHHCCCCCCEEEEEEEEECC
DNVIDVVELAPLLRHPLDLELDSISVVTFGSRTGTVGDYPRVYDAEIGTPPYAGRRETWL
CCCCHHHHHHHHHCCCCCCEECCEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCEEE
IMRLPVIGNTQALRWRTSVGAAAISVAQRVASSLRCQGLRAKLATATDLAELDRRLGSDA
EEEECCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCH
VAGSAQRWKAIRGEAGWMTTYAYPAEAISSRVLSQAWTLRADEVIQNVTVYPDATCTATI
HCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHCEEECCCCCEEEEE
TVRTPTPAPTPPSVILRRLNGEQAAAAAANMCGPRPHLRGQRRCPLPAQLVTEIGPSGVL
EEECCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCEE
IGKLSNGDRLMIPVTDAGELSRVFVAADDTIAKRIVIRVVGAGERVCVHTRDQERWASVR
EEEECCCCEEEEEECCCCCCEEEEEECCHHHHEEEEEEEECCCCEEEEECCCHHHHHHCC
MPQLSIVGTPRPAPRTTVGVVEYVRRRKNGDDGKSEGSGVDVAISPTPRPASVITIARPG
CCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCC
TSLSESDRHGFEVTIEQIDRATVKVGAAGQNWLVEMEMFRAENRYVSLEPVTMSIGR
CCCCCCCCCCCEEEHHHHCCEEEEECCCCCCEEEEEEEHHCCCCEEEEEEEEEECCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036