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The map label for this gene is eccA2

Identifier: 148663751

GI number: 148663751

Start: 4373425

End: 4375284

Strand: Reverse

Name: eccA2

Synonym: MRA_3923

Alternate gene names: 148663751

Gene position: 4375284-4373425 (Counterclockwise)

Preceding gene: 148663752

Following gene: 148663750

Centisome position: 98.99

GC content: 62.69

Gene sequence:

>1860_bases
ATGTCGAGAATGGTGGACACGATGGGTGATTTACTCACTGCGCGCCGGCATTTCGATCGGGCGATGACGATCAAGAATGG
CCAGGGATGCGTGGCGGCGTTGCCTGAGTTTGTGGCTGCCACCGAGGCCGATCCGTCGATGGCCGACGCGTGGCTGGGTC
GTATCGCCTGCGGTGACCGCGATCTGGCCTCGCTTAAGCAGCTCAACGCCCATAGCGAGTGGCTGCACCGCGAGACCACG
CGGATCGGCCGGACGTTGGCCGCTGAGGTCCAGCTGGGACCATCCATCGGGATCACGGTGACCGACGCATCTCAGGTGGG
GCTGGCGCTGTCGTCGGCGTTGACGATCGCGGGGGAGTATGCGAAGGCCGATGCCCTGTTAGCAAACCGCGAGCTATTGG
ATTCGTGGCGCAACTACCAGTGGCATCAGCTGGCTCGGGCGTTCCTGATGTACGTCACGCAGCGATGGCCCGACGTGTTG
TCGACGGCCGCCGAGGATCTGCCGCCACAGGCGATCGTCATGCCGGCGGTGACCGCGTCGATTTGTGCGCTGGCAGCCCA
CGCCGCCGCCCATCTCGGGCAGGGGCGAGTGGCCCTGGACTGGCTGGACCGGGTGGACGTGATCGGACACAGCAGGTCAT
CGGAGCGGTTCGGCGCCGACGTGCTCACCGCGGCGATCGGACCGGCCGATATTCCGCTGCTGGTCGCCGACTTGGCGTAT
GTGCGGGGGATGGTGTACCGGCAACTGCATGAGGAGGACAAGGCCCAGATCTGGCTGTCGAAGGCCACCATCAACGGGGT
GCTCACCGACGCCGCCAAAGAAGCCCTGGCGGACCCGAACCTGCGCTTGATTGTTACCGATGAACGAACCATCGCCAGCC
GCTCCGACCGTTGGGATGCTTCGACGGCGAAAAGCCGCGACCAGCTCGATGACGACAATGCAGCGCAGCGGCGCGGCGAG
CTGCTAGCCGAGGGCCGGGAACTGCTGGCCAAACAGGTGGGCCTGGCGGCGGTCAAGCAAGCGGTATCGGCGCTGGAAGA
CCAACTCGAGGTGCGCATGATGCGCCTAGAGCACGGCCTACCGGTGGAGGGGCAGACCAACCACATGTTGCTGGTGGGGC
CACCAGGCACAGGTAAGACAACCACCGCTGAAGCGCTCGGCAAGATCTACGCCGGCATGGGGATCGTGCGTCACCCCGAA
ATTCGAGAAGTTCGCCGATCGGACTTCTGTGGGCACTACATCGGGGAGTCAGGACCCAAGACGAACGAGCTGATCGAAAA
GTCACTCGGGCGAATCATTTTCATGGACGAGTTCTACTCGCTGATCGAACGTCATCAAGACGGAACACCGGACATGATCG
GCATGGAGGCGGTCAATCAACTCCTGGTTCAATTGGAAACACACCGATTCGACTTCTGTTTCATCGGGGCCGGCTATGAG
GATCAGGTGGATGAATTCCTCACCGTGAACCCGGGTTTGGCTGGCCGGTTCAACCGAAAGCTGCGGTTCGAGTCTTATTC
GCCGGTGGAGATCGTCGAGATTGGACACCGCTACGCTACACCGCGCGCCAGCCAGCTCGATGACGCCGCACGGGAGGTAT
TCCTCGACGCGGTCACCACCATCCGTAACTACACCACCCCTAGTGGGCAGCACGGTATCGACGCTATGCAAAACGGTCGG
TTCGCCCGCAACGTGATCGAACGCGCCGAAGGGTTCCGGGACACCCGGGTGGTTGCGCAAAAACGTGCGGGCCAACCGGT
ATCGGTTCAGGATCTGCAGATCATCACCGCCACCGACATCGATGCCGCGATACGCAGCGTGTGCTCAGACAACCGAGACA
TGGCCGCGATCGTTTGGTAG

Upstream 100 bases:

>100_bases
TGAGCCGGTCACGATGTCGATAGGCCGGTAGAACGTTGCCAACGGAATTTGAGGCACAGAGTGACAGACACACGTTGCAA
CCGCGGTGACAGCGGCGGCG

Downstream 100 bases:

>100_bases
CAGCCGCATATCGGCTAGTGCGGTAGCAAAACCGTTGAGTCCCGGCGTGGTCCAGGTACAGCGCCTACGCGCCCTGGTCG
GCGCGGCGGACCAGCCCAGG

Product: putative CbxX/CfqX family protein

Products: NA

Alternate protein names: ESX conserved component A2; Type VII secretion system protein EccA2; T7SS protein EccA2

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MSRMVDTMGDLLTARRHFDRAMTIKNGQGCVAALPEFVAATEADPSMADAWLGRIACGDRDLASLKQLNAHSEWLHRETT
RIGRTLAAEVQLGPSIGITVTDASQVGLALSSALTIAGEYAKADALLANRELLDSWRNYQWHQLARAFLMYVTQRWPDVL
STAAEDLPPQAIVMPAVTASICALAAHAAAHLGQGRVALDWLDRVDVIGHSRSSERFGADVLTAAIGPADIPLLVADLAY
VRGMVYRQLHEEDKAQIWLSKATINGVLTDAAKEALADPNLRLIVTDERTIASRSDRWDASTAKSRDQLDDDNAAQRRGE
LLAEGRELLAKQVGLAAVKQAVSALEDQLEVRMMRLEHGLPVEGQTNHMLLVGPPGTGKTTTAEALGKIYAGMGIVRHPE
IREVRRSDFCGHYIGESGPKTNELIEKSLGRIIFMDEFYSLIERHQDGTPDMIGMEAVNQLLVQLETHRFDFCFIGAGYE
DQVDEFLTVNPGLAGRFNRKLRFESYSPVEIVEIGHRYATPRASQLDDAAREVFLDAVTTIRNYTTPSGQHGIDAMQNGR
FARNVIERAEGFRDTRVVAQKRAGQPVSVQDLQIITATDIDAAIRSVCSDNRDMAAIVW

Sequences:

>Translated_619_residues
MSRMVDTMGDLLTARRHFDRAMTIKNGQGCVAALPEFVAATEADPSMADAWLGRIACGDRDLASLKQLNAHSEWLHRETT
RIGRTLAAEVQLGPSIGITVTDASQVGLALSSALTIAGEYAKADALLANRELLDSWRNYQWHQLARAFLMYVTQRWPDVL
STAAEDLPPQAIVMPAVTASICALAAHAAAHLGQGRVALDWLDRVDVIGHSRSSERFGADVLTAAIGPADIPLLVADLAY
VRGMVYRQLHEEDKAQIWLSKATINGVLTDAAKEALADPNLRLIVTDERTIASRSDRWDASTAKSRDQLDDDNAAQRRGE
LLAEGRELLAKQVGLAAVKQAVSALEDQLEVRMMRLEHGLPVEGQTNHMLLVGPPGTGKTTTAEALGKIYAGMGIVRHPE
IREVRRSDFCGHYIGESGPKTNELIEKSLGRIIFMDEFYSLIERHQDGTPDMIGMEAVNQLLVQLETHRFDFCFIGAGYE
DQVDEFLTVNPGLAGRFNRKLRFESYSPVEIVEIGHRYATPRASQLDDAAREVFLDAVTTIRNYTTPSGQHGIDAMQNGR
FARNVIERAEGFRDTRVVAQKRAGQPVSVQDLQIITATDIDAAIRSVCSDNRDMAAIVW
>Mature_618_residues
SRMVDTMGDLLTARRHFDRAMTIKNGQGCVAALPEFVAATEADPSMADAWLGRIACGDRDLASLKQLNAHSEWLHRETTR
IGRTLAAEVQLGPSIGITVTDASQVGLALSSALTIAGEYAKADALLANRELLDSWRNYQWHQLARAFLMYVTQRWPDVLS
TAAEDLPPQAIVMPAVTASICALAAHAAAHLGQGRVALDWLDRVDVIGHSRSSERFGADVLTAAIGPADIPLLVADLAYV
RGMVYRQLHEEDKAQIWLSKATINGVLTDAAKEALADPNLRLIVTDERTIASRSDRWDASTAKSRDQLDDDNAAQRRGEL
LAEGRELLAKQVGLAAVKQAVSALEDQLEVRMMRLEHGLPVEGQTNHMLLVGPPGTGKTTTAEALGKIYAGMGIVRHPEI
REVRRSDFCGHYIGESGPKTNELIEKSLGRIIFMDEFYSLIERHQDGTPDMIGMEAVNQLLVQLETHRFDFCFIGAGYED
QVDEFLTVNPGLAGRFNRKLRFESYSPVEIVEIGHRYATPRASQLDDAAREVFLDAVTTIRNYTTPSGQHGIDAMQNGRF
ARNVIERAEGFRDTRVVAQKRAGQPVSVQDLQIITATDIDAAIRSVCSDNRDMAAIVW

Specific function: Shows ATPase activity. Could provide energy for export of ESX-2 substrates

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cbxX/cfxQ family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECCA2_MYCTU (O05460)

Other databases:

- EMBL:   BX842584
- EMBL:   AE000516
- PIR:   E70597
- RefSeq:   NP_218401.1
- RefSeq:   NP_338553.1
- ProteinModelPortal:   O05460
- SMR:   O05460
- EnsemblBacteria:   EBMYCT00000000836
- EnsemblBacteria:   EBMYCT00000071703
- GeneID:   886210
- GeneID:   922533
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3999
- KEGG:   mtu:Rv3884c
- TIGR:   MT3999
- TubercuList:   Rv3884c
- GeneTree:   EBGT00050000015038
- HOGENOM:   HBG564739
- OMA:   RAMAIMS
- ProtClustDB:   CLSK792786
- GO:   GO:0005737
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR000641
- PRINTS:   PR00819
- SMART:   SM00382

Pfam domain/function: PF00004 AAA

EC number: NA

Molecular weight: Translated: 68042; Mature: 67911

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRMVDTMGDLLTARRHFDRAMTIKNGQGCVAALPEFVAATEADPSMADAWLGRIACGDR
CCHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
DLASLKQLNAHSEWLHRETTRIGRTLAAEVQLGPSIGITVTDASQVGLALSSALTIAGEY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEECHHHHHHHHHHHHHHHHHH
AKADALLANRELLDSWRNYQWHQLARAFLMYVTQRWPDVLSTAAEDLPPQAIVMPAVTAS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHH
ICALAAHAAAHLGQGRVALDWLDRVDVIGHSRSSERFGADVLTAAIGPADIPLLVADLAY
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHCHHHHHHHCCCCCHHHHHHHHHH
VRGMVYRQLHEEDKAQIWLSKATINGVLTDAAKEALADPNLRLIVTDERTIASRSDRWDA
HHHHHHHHHHHCCHHHEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHCCCCCCCC
STAKSRDQLDDDNAAQRRGELLAEGRELLAKQVGLAAVKQAVSALEDQLEVRMMRLEHGL
HHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PVEGQTNHMLLVGPPGTGKTTTAEALGKIYAGMGIVRHPEIREVRRSDFCGHYIGESGPK
CCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHCCCCCCC
TNELIEKSLGRIIFMDEFYSLIERHQDGTPDMIGMEAVNQLLVQLETHRFDFCFIGAGYE
HHHHHHHHHCCEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCH
DQVDEFLTVNPGLAGRFNRKLRFESYSPVEIVEIGHRYATPRASQLDDAAREVFLDAVTT
HHCCCEEECCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
IRNYTTPSGQHGIDAMQNGRFARNVIERAEGFRDTRVVAQKRAGQPVSVQDLQIITATDI
HHCCCCCCCCCCCHHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEEEECCH
DAAIRSVCSDNRDMAAIVW
HHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure 
SRMVDTMGDLLTARRHFDRAMTIKNGQGCVAALPEFVAATEADPSMADAWLGRIACGDR
CHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
DLASLKQLNAHSEWLHRETTRIGRTLAAEVQLGPSIGITVTDASQVGLALSSALTIAGEY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEECHHHHHHHHHHHHHHHHHH
AKADALLANRELLDSWRNYQWHQLARAFLMYVTQRWPDVLSTAAEDLPPQAIVMPAVTAS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHH
ICALAAHAAAHLGQGRVALDWLDRVDVIGHSRSSERFGADVLTAAIGPADIPLLVADLAY
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHCHHHHHHHCCCCCHHHHHHHHHH
VRGMVYRQLHEEDKAQIWLSKATINGVLTDAAKEALADPNLRLIVTDERTIASRSDRWDA
HHHHHHHHHHHCCHHHEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHCCCCCCCC
STAKSRDQLDDDNAAQRRGELLAEGRELLAKQVGLAAVKQAVSALEDQLEVRMMRLEHGL
HHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PVEGQTNHMLLVGPPGTGKTTTAEALGKIYAGMGIVRHPEIREVRRSDFCGHYIGESGPK
CCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHCCCCCCC
TNELIEKSLGRIIFMDEFYSLIERHQDGTPDMIGMEAVNQLLVQLETHRFDFCFIGAGYE
HHHHHHHHHCCEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCH
DQVDEFLTVNPGLAGRFNRKLRFESYSPVEIVEIGHRYATPRASQLDDAAREVFLDAVTT
HHCCCEEECCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
IRNYTTPSGQHGIDAMQNGRFARNVIERAEGFRDTRVVAQKRAGQPVSVQDLQIITATDI
HHCCCCCCCCCCCHHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEEEECCH
DAAIRSVCSDNRDMAAIVW
HHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036