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The map label for this gene is eccE1

Identifier: 148663749

GI number: 148663749

Start: 4370478

End: 4371866

Strand: Reverse

Name: eccE1

Synonym: MRA_3921

Alternate gene names: 148663749

Gene position: 4371866-4370478 (Counterclockwise)

Preceding gene: 148663750

Following gene: 148663748

Centisome position: 98.91

GC content: 66.23

Gene sequence:

>1389_bases
ATGAGAAATCCTTTAGGGCTGCGGTTCAGCACCGGGCACGCCTTGCTTGCCTCCGCGTTGGCCCCGCCATGCATCATCGC
ATTCTTGGAGACGCGCTACTGGTGGGCGGGGATTGCGCTGGCCTCGTTGGGCGTCATCGTGGCCACGGTCACTTTCTACG
GCCGCCGGATCACCGGCTGGGTGGCGGCGGTGTACGCGTGGTTGCGGCGGCGCCGACGGCCCCCGGATTCCTCGTCAGAA
CCTGTGGTCGGGGCCACCGTGAAGCCAGGAGATCACGTTGCGGTGCGCTGGCAAGGCGAGTTTCTGGTCGCCGTAATCGA
GCTCATTCCCCGACCATTCACGCCGACGGTCATCGTCGACGGGCAAGCCCACACCGACGACATGCTGGACACCGGACTGG
TGGAGGAGCTCCTGTCGGTGCACTGTCCCGACTTGGAGGCCGATATCGTCTCAGCCGGCTACCGCGTCGGCAATACCGCA
GCGCCGGACGTGGTGAGTCTGTATCAGCAGGTGATCGGGACAGACCCGGCGCCGGCGAACCGCCGGACCTGGATCGTGCT
GCGCGCCGACCCGGAACGCACCCGCAAATCGGCGCAGCGCCGCGATGAAGGCGTCGCAGGACTGGCCCGGTATTTGGTGG
CGTCCGCGACGCGCATTGCCGATCGACTGGCTAGCCATGGTGTCGACGCGGTGTGTGGCCGCAGCTTCGATGACTACGAC
CACGCCACCGACATCGGCTTTGTGCGGGAGAAATGGTCGATGATCAAGGGGCGCGATGCCTACACTGCCGCCTACGCGGC
GCCCGGAGGTCCGGATGTATGGTGGTCGGCGCGCGCGGACCACACCATCACCAGAGTCCGGGTCGCGCCGGGGATGGCCC
CGCAGTCCACGGTGTTGCTGACCACGGCGGACAAGCCCAAGACACCCAGGGGCTTCGCCCGCCTATTTGGCGGGCAGCGG
CCCGCGCTGCAAGGCCAGCATCTGGTGGCCAACCGCCACTGCCAGCTGCCGATCGGGTCAGCTGGGGTACTGGTCGGCGA
GACGGTGAACCGATGCCCGGTCTACATGCCCTTCGACGATGTCGACATCGCCCTCAACCTGGGTGACGCTCAGACATTCA
CCCAGTTCGTGGTGCGTGCGGCGGCGGCAGGTGCGATGGTCACAGTCGGGCCACAGTTCGAGGAATTTGCCCGGTTGATC
GGCGCACACATCGGGCAGGAGGTAAAGGTGGCGTGGCCGAATGCGACGACCTATCTCGGCCCGCATCCCGGTATTGACCG
GGTGATTCTGCGGCACAATGTGATCGGTACCCCGCGGCATCGGCAGCTGCCGATTCGCCGGGTTTCCCCACCCGAGGAAA
GCCGCTACCAGATGGCGCTGCCGAAGTAG

Upstream 100 bases:

>100_bases
GTCCCGATCGTCGCCCGATTACGGCTGTGGCGTTGGTGGCCGTCGGCCTTACGTTGGCCCTGGGCCTGGGCGCGCTGGCT
AGACGGGCGCTGAGCCGCCG

Downstream 100 bases:

>100_bases
GGCGATCCGTTCGCGATGCCGGCATGAACGGGCGGCATCAAATTAGTGCAGGAACCTTTCAGTTTAGCGACGATAATGGC
TATAGCACTAAGGAGGATGA

Product: hypothetical protein

Products: NA

Alternate protein names: ESX conserved component E1; Type VII secretion system protein EccE1; T7SS protein EccE1

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MRNPLGLRFSTGHALLASALAPPCIIAFLETRYWWAGIALASLGVIVATVTFYGRRITGWVAAVYAWLRRRRRPPDSSSE
PVVGATVKPGDHVAVRWQGEFLVAVIELIPRPFTPTVIVDGQAHTDDMLDTGLVEELLSVHCPDLEADIVSAGYRVGNTA
APDVVSLYQQVIGTDPAPANRRTWIVLRADPERTRKSAQRRDEGVAGLARYLVASATRIADRLASHGVDAVCGRSFDDYD
HATDIGFVREKWSMIKGRDAYTAAYAAPGGPDVWWSARADHTITRVRVAPGMAPQSTVLLTTADKPKTPRGFARLFGGQR
PALQGQHLVANRHCQLPIGSAGVLVGETVNRCPVYMPFDDVDIALNLGDAQTFTQFVVRAAAAGAMVTVGPQFEEFARLI
GAHIGQEVKVAWPNATTYLGPHPGIDRVILRHNVIGTPRHRQLPIRRVSPPEESRYQMALPK

Sequences:

>Translated_462_residues
MRNPLGLRFSTGHALLASALAPPCIIAFLETRYWWAGIALASLGVIVATVTFYGRRITGWVAAVYAWLRRRRRPPDSSSE
PVVGATVKPGDHVAVRWQGEFLVAVIELIPRPFTPTVIVDGQAHTDDMLDTGLVEELLSVHCPDLEADIVSAGYRVGNTA
APDVVSLYQQVIGTDPAPANRRTWIVLRADPERTRKSAQRRDEGVAGLARYLVASATRIADRLASHGVDAVCGRSFDDYD
HATDIGFVREKWSMIKGRDAYTAAYAAPGGPDVWWSARADHTITRVRVAPGMAPQSTVLLTTADKPKTPRGFARLFGGQR
PALQGQHLVANRHCQLPIGSAGVLVGETVNRCPVYMPFDDVDIALNLGDAQTFTQFVVRAAAAGAMVTVGPQFEEFARLI
GAHIGQEVKVAWPNATTYLGPHPGIDRVILRHNVIGTPRHRQLPIRRVSPPEESRYQMALPK
>Mature_462_residues
MRNPLGLRFSTGHALLASALAPPCIIAFLETRYWWAGIALASLGVIVATVTFYGRRITGWVAAVYAWLRRRRRPPDSSSE
PVVGATVKPGDHVAVRWQGEFLVAVIELIPRPFTPTVIVDGQAHTDDMLDTGLVEELLSVHCPDLEADIVSAGYRVGNTA
APDVVSLYQQVIGTDPAPANRRTWIVLRADPERTRKSAQRRDEGVAGLARYLVASATRIADRLASHGVDAVCGRSFDDYD
HATDIGFVREKWSMIKGRDAYTAAYAAPGGPDVWWSARADHTITRVRVAPGMAPQSTVLLTTADKPKTPRGFARLFGGQR
PALQGQHLVANRHCQLPIGSAGVLVGETVNRCPVYMPFDDVDIALNLGDAQTFTQFVVRAAAAGAMVTVGPQFEEFARLI
GAHIGQEVKVAWPNATTYLGPHPGIDRVILRHNVIGTPRHRQLPIRRVSPPEESRYQMALPK

Specific function: Could be part of a complex that is involved in secretion of ESX-1 substrates, such as EsxA (ESAT-6) and EsxB (CFP-10)

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EccE family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECCE1_MYCTU (O05462)

Other databases:

- EMBL:   BX842584
- EMBL:   AE000516
- PIR:   C70597
- RefSeq:   NP_218399.1
- RefSeq:   NP_338551.1
- ProteinModelPortal:   O05462
- EnsemblBacteria:   EBMYCT00000000265
- EnsemblBacteria:   EBMYCT00000071734
- GeneID:   886208
- GeneID:   922541
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3997
- KEGG:   mtu:Rv3882c
- TIGR:   MT3997
- TubercuList:   Rv3882c
- GeneTree:   EBGT00050000014761
- HOGENOM:   HBG568425
- OMA:   WIMLRAD
- ProtClustDB:   CLSK792784
- InterPro:   IPR021368

Pfam domain/function: PF11203 DUF2984

EC number: NA

Molecular weight: Translated: 50397; Mature: 50397

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x229c0fc0)-; HASH(0x21d97f48)-;

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNPLGLRFSTGHALLASALAPPCIIAFLETRYWWAGIALASLGVIVATVTFYGRRITGW
CCCCCCCEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VAAVYAWLRRRRRPPDSSSEPVVGATVKPGDHVAVRWQGEFLVAVIELIPRPFTPTVIVD
HHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHHCCCCCCEEEEC
GQAHTDDMLDTGLVEELLSVHCPDLEADIVSAGYRVGNTAAPDVVSLYQQVIGTDPAPAN
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
RRTWIVLRADPERTRKSAQRRDEGVAGLARYLVASATRIADRLASHGVDAVCGRSFDDYD
CEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCC
HATDIGFVREKWSMIKGRDAYTAAYAAPGGPDVWWSARADHTITRVRVAPGMAPQSTVLL
CHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEECCCCCEEEEEEECCCCCCCCEEEE
TTADKPKTPRGFARLFGGQRPALQGQHLVANRHCQLPIGSAGVLVGETVNRCPVYMPFDD
EECCCCCCCHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCEEECCCCCCCEEECCCCC
VDIALNLGDAQTFTQFVVRAAAAGAMVTVGPQFEEFARLIGAHIGQEVKVAWPNATTYLG
CEEEEECCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCCEEEECCCCCEECC
PHPGIDRVILRHNVIGTPRHRQLPIRRVSPPEESRYQMALPK
CCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCH
>Mature Secondary Structure
MRNPLGLRFSTGHALLASALAPPCIIAFLETRYWWAGIALASLGVIVATVTFYGRRITGW
CCCCCCCEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VAAVYAWLRRRRRPPDSSSEPVVGATVKPGDHVAVRWQGEFLVAVIELIPRPFTPTVIVD
HHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHHCCCCCCEEEEC
GQAHTDDMLDTGLVEELLSVHCPDLEADIVSAGYRVGNTAAPDVVSLYQQVIGTDPAPAN
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
RRTWIVLRADPERTRKSAQRRDEGVAGLARYLVASATRIADRLASHGVDAVCGRSFDDYD
CEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCC
HATDIGFVREKWSMIKGRDAYTAAYAAPGGPDVWWSARADHTITRVRVAPGMAPQSTVLL
CHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEECCCCCEEEEEEECCCCCCCCEEEE
TTADKPKTPRGFARLFGGQRPALQGQHLVANRHCQLPIGSAGVLVGETVNRCPVYMPFDD
EECCCCCCCHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCEEECCCCCCCEEECCCCC
VDIALNLGDAQTFTQFVVRAAAAGAMVTVGPQFEEFARLIGAHIGQEVKVAWPNATTYLG
CEEEEECCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCCEEEECCCCCEECC
PHPGIDRVILRHNVIGTPRHRQLPIRRVSPPEESRYQMALPK
CCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036