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The map label for this gene is ethA [H]

Identifier: 148663607

GI number: 148663607

Start: 4200625

End: 4201299

Strand: Reverse

Name: ethA [H]

Synonym: MRA_3779

Alternate gene names: 148663607

Gene position: 4201299-4200625 (Counterclockwise)

Preceding gene: 148663608

Following gene: 148663606

Centisome position: 95.05

GC content: 65.04

Gene sequence:

>675_bases
ATGATAGGCCGCGATCGGGCCTACGCCGTCACCCGGCGCAAAGACATCGCCAAGCAACGGTTGGTGTGGCGGTTATGCCA
ACGGTATCCGAGAGCCGCCCGGCGACTGATCCGTCATCTCAACGCCAAGCAGCTGGCCGCCGGATATCCGGCCGACGAGC
ACTTCAAGCCGGTCTACAACCCATGGGACCAACGCCTGTGCGCGGTGCCAGATGCCGACATGTTCAAGGCCATCCGCGAC
GGCCGGGCCTCGGTGGTCACCGAGGCGATCGATACTTTTACCGAAAACGGAATCCGGCTGCAATCCGGACGCGAATTGGC
GGCCGACATCAGCATCACTGCCACCGGCCTCAATCTGCTGGCCTTCGGTGGCATCAACCTCTCGGTCGACGGAGTCGCCG
TGGACGTTGCCGAGAAGGTGGCATTCAAGGGTTTCCTGCTCAGCGACGTGTCCAACTTCGCCGGCCCACATGGACGCACC
CGGGCACACCATCTGCTGTCCGCAGCTGCCCGCAGCCATGCCGACCCGGCCGCTGCAGGGCGCCGAAGCCCCCTGGCGGA
CCTCAAGGTGTTGCGCGAGGGCCCGGTCGACGACGATCACCTGCGCTTTACGACGTCGGCTTCGGCGAGCCGGCTGACGG
TGAAGCGCATCACCAGGAGCACGCCATGGAACTGA

Upstream 100 bases:

>100_bases
GTCACCATGAGCTGCGGATGGTGATCATCGGCAGCGGCGCGACCGCGGTCACGCTGGTGCCGGCCATGGCCCAGACCGCC
GGCGCGGTAACCATGCCCAA

Downstream 100 bases:

>100_bases
TGTCACCGATCGATGCGCTGTTCTTATCAGCCGAGTCGCGAGAGCATCCGCTGCATGTCGGCGCGCTGCAACTGTTCGAG
CCACCCGCGGGGGCGGGACG

Product: putative oxidoreductase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MIGRDRAYAVTRRKDIAKQRLVWRLCQRYPRAARRLIRHLNAKQLAAGYPADEHFKPVYNPWDQRLCAVPDADMFKAIRD
GRASVVTEAIDTFTENGIRLQSGRELAADISITATGLNLLAFGGINLSVDGVAVDVAEKVAFKGFLLSDVSNFAGPHGRT
RAHHLLSAAARSHADPAAAGRRSPLADLKVLREGPVDDDHLRFTTSASASRLTVKRITRSTPWN

Sequences:

>Translated_224_residues
MIGRDRAYAVTRRKDIAKQRLVWRLCQRYPRAARRLIRHLNAKQLAAGYPADEHFKPVYNPWDQRLCAVPDADMFKAIRD
GRASVVTEAIDTFTENGIRLQSGRELAADISITATGLNLLAFGGINLSVDGVAVDVAEKVAFKGFLLSDVSNFAGPHGRT
RAHHLLSAAARSHADPAAAGRRSPLADLKVLREGPVDDDHLRFTTSASASRLTVKRITRSTPWN
>Mature_224_residues
MIGRDRAYAVTRRKDIAKQRLVWRLCQRYPRAARRLIRHLNAKQLAAGYPADEHFKPVYNPWDQRLCAVPDADMFKAIRD
GRASVVTEAIDTFTENGIRLQSGRELAADISITATGLNLLAFGGINLSVDGVAVDVAEKVAFKGFLLSDVSNFAGPHGRT
RAHHLLSAAARSHADPAAAGRRSPLADLKVLREGPVDDDHLRFTTSASASRLTVKRITRSTPWN

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 24676; Mature: 24676

Theoretical pI: Translated: 10.89; Mature: 10.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGRDRAYAVTRRKDIAKQRLVWRLCQRYPRAARRLIRHLNAKQLAAGYPADEHFKPVYN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCC
PWDQRLCAVPDADMFKAIRDGRASVVTEAIDTFTENGIRLQSGRELAADISITATGLNLL
HHHHHEECCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEECCCCCCHHCEEEEECCCEEE
AFGGINLSVDGVAVDVAEKVAFKGFLLSDVSNFAGPHGRTRAHHLLSAAARSHADPAAAG
EECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHCC
RRSPLADLKVLREGPVDDDHLRFTTSASASRLTVKRITRSTPWN
CCCCHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIGRDRAYAVTRRKDIAKQRLVWRLCQRYPRAARRLIRHLNAKQLAAGYPADEHFKPVYN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCC
PWDQRLCAVPDADMFKAIRDGRASVVTEAIDTFTENGIRLQSGRELAADISITATGLNLL
HHHHHEECCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEECCCCCCHHCEEEEECCCEEE
AFGGINLSVDGVAVDVAEKVAFKGFLLSDVSNFAGPHGRTRAHHLLSAAARSHADPAAAG
EECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHCC
RRSPLADLKVLREGPVDDDHLRFTTSASASRLTVKRITRSTPWN
CCCCHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]