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The map label for this gene is asd

Identifier: 148663573

GI number: 148663573

Start: 4159626

End: 4160663

Strand: Reverse

Name: asd

Synonym: MRA_3745

Alternate gene names: 148663573

Gene position: 4160663-4159626 (Counterclockwise)

Preceding gene: 148663574

Following gene: 148663572

Centisome position: 94.13

GC content: 68.69

Gene sequence:

>1038_bases
ATGGGCCTGTCAATAGGGATCGTGGGGGCCACCGGTCAGGTGGGTCAGGTCATGCGCACGTTGCTCGACGAGCGGGATTT
CCCGGCGAGCGCGGTGCGGTTCTTCGCGTCGGCCCGATCGCAGGGCCGCAAGCTGGCCTTCCGCGGCCAGGAGATCGAAG
TGGAAGACGCCGAGACGGCCGACCCGAGCGGGCTGGATATCGCGTTGTTCTCCGCCGGCTCGGCCATGTCGAAGGTGCAG
GCGCCCCGCTTTGCGGCGGCCGGAGTCACGGTGATCGACAACTCGTCGGCGTGGCGTAAGGACCCCGACGTGCCGTTGGT
GGTGTCCGAGGTGAACTTTGAACGCGACGCGCACCGCCGGCCTAAGGGCATCATCGCCAACCCGAACTGCACCACCATGG
CCGCGATGCCGGTGCTCAAGGTGCTGCACGACGAAGCCCGACTGGTGCGGTTGGTGGTCTCGTCGTATCAGGCGGTGTCC
GGTAGCGGCCTGGCCGGGGTGGCCGAGCTGGCCGAGCAGGCGCGTGCGGTCATCGGTGGGGCCGAGCAGCTGGTGTATGA
CGGCGGCGCGCTCGAGTTCCCGCCGCCGAACACCTACGTCGCCCCGATCGCGTTCAACGTGGTGCCGCTGGCCGGATCCC
TGGTGGACGACGGCTCCGGCGAGACAGACGAGGATCAAAAGTTGCGCTTCGAGAGCCGCAAGATCCTTGGCATCCCCGAC
CTGTTGGTCAGCGGCACCTGTGTGCGGGTTCCGGTGTTCACCGGACACTCTTTGTCGATCAACGCCGAGTTCGCGCAGCC
GCTCTCGCCGGAGCGGGCGCGCGAGCTGCTCGACGGTGCTACGGGCGTGCAGCTGGTCGACGTGCCGACGCCGCTGGCCG
CCGCCGGTGTCGACGAATCTCTGGTCGGCCGGATCCGGCGCGACCCGGGGGTGCCCGACGGGCGTGGTCTGGCGCTGTTC
GTGTCGGGGGATAACCTGCGCAAGGGGGCGGCGCTGAACACCATCCAGATCGCCGAGCTGCTGACCGCCGACTTGTGA

Upstream 100 bases:

>100_bases
CCGCGACACCGAACTGGACAAGGCCGTGGTCGCGCTGCATGAAGCGTTCGGGCTCGGCGGCGACGAGGAGGCCACGGTGT
ACGCGGGGACGGGACGGTAG

Downstream 100 bases:

>100_bases
TATGCGGGTGTGCTCCGCCTGGGTCGTGCGGTGCTCGCTGGTAGTGTCTTTCCTTGTCCCGCAATGTGTTTGGTATGCAC
GCGCCGATCCGCCGGCGCCG

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MGLSIGIVGATGQVGQVMRTLLDERDFPASAVRFFASARSQGRKLAFRGQEIEVEDAETADPSGLDIALFSAGSAMSKVQ
APRFAAAGVTVIDNSSAWRKDPDVPLVVSEVNFERDAHRRPKGIIANPNCTTMAAMPVLKVLHDEARLVRLVVSSYQAVS
GSGLAGVAELAEQARAVIGGAEQLVYDGGALEFPPPNTYVAPIAFNVVPLAGSLVDDGSGETDEDQKLRFESRKILGIPD
LLVSGTCVRVPVFTGHSLSINAEFAQPLSPERARELLDGATGVQLVDVPTPLAAAGVDESLVGRIRRDPGVPDGRGLALF
VSGDNLRKGAALNTIQIAELLTADL

Sequences:

>Translated_345_residues
MGLSIGIVGATGQVGQVMRTLLDERDFPASAVRFFASARSQGRKLAFRGQEIEVEDAETADPSGLDIALFSAGSAMSKVQ
APRFAAAGVTVIDNSSAWRKDPDVPLVVSEVNFERDAHRRPKGIIANPNCTTMAAMPVLKVLHDEARLVRLVVSSYQAVS
GSGLAGVAELAEQARAVIGGAEQLVYDGGALEFPPPNTYVAPIAFNVVPLAGSLVDDGSGETDEDQKLRFESRKILGIPD
LLVSGTCVRVPVFTGHSLSINAEFAQPLSPERARELLDGATGVQLVDVPTPLAAAGVDESLVGRIRRDPGVPDGRGLALF
VSGDNLRKGAALNTIQIAELLTADL
>Mature_344_residues
GLSIGIVGATGQVGQVMRTLLDERDFPASAVRFFASARSQGRKLAFRGQEIEVEDAETADPSGLDIALFSAGSAMSKVQA
PRFAAAGVTVIDNSSAWRKDPDVPLVVSEVNFERDAHRRPKGIIANPNCTTMAAMPVLKVLHDEARLVRLVVSSYQAVSG
SGLAGVAELAEQARAVIGGAEQLVYDGGALEFPPPNTYVAPIAFNVVPLAGSLVDDGSGETDEDQKLRFESRKILGIPDL
LVSGTCVRVPVFTGHSLSINAEFAQPLSPERARELLDGATGVQLVDVPTPLAAAGVDESLVGRIRRDPGVPDGRGLALFV
SGDNLRKGAALNTIQIAELLTADL

Specific function: Unknown

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788658, Length=347, Percent_Identity=32.2766570605187, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789841, Length=360, Percent_Identity=27.2222222222222, Blast_Score=82, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320362, Length=378, Percent_Identity=25.3968253968254, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHAS_MYCBO (P0A543)

Other databases:

- EMBL:   Z18290
- EMBL:   BX248347
- RefSeq:   NP_857373.1
- ProteinModelPortal:   P0A543
- SMR:   P0A543
- EnsemblBacteria:   EBMYCT00000014467
- GeneID:   1093103
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3735c
- GeneTree:   EBGT00050000017367
- HOGENOM:   HBG518238
- OMA:   LELWLCG
- ProtClustDB:   PRK14874
- BioCyc:   MBOV233413:MB3735C-MONOMER
- BRENDA:   1.2.1.11
- GO:   GO:0005737
- InterPro:   IPR000319
- InterPro:   IPR012080
- InterPro:   IPR005986
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000148
- SMART:   SM00859
- TIGRFAMs:   TIGR01296

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC

EC number: =1.2.1.11

Molecular weight: Translated: 36231; Mature: 36099

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS01103 ASD

Important sites: ACT_SITE 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLSIGIVGATGQVGQVMRTLLDERDFPASAVRFFASARSQGRKLAFRGQEIEVEDAETA
CCEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCEEEECCCCCC
DPSGLDIALFSAGSAMSKVQAPRFAAAGVTVIDNSSAWRKDPDVPLVVSEVNFERDAHRR
CCCCCEEEEEECCCHHHHHCCCCEECCCEEEEECCCCCCCCCCCCEEEEECCCCHHHCCC
PKGIIANPNCTTMAAMPVLKVLHDEARLVRLVVSSYQAVSGSGLAGVAELAEQARAVIGG
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
AEQLVYDGGALEFPPPNTYVAPIAFNVVPLAGSLVDDGSGETDEDQKLRFESRKILGIPD
CHHEEECCCEEECCCCCCEEEEEEEEEEECCCCEECCCCCCCCHHHHHHHCCCEECCCCH
LLVSGTCVRVPVFTGHSLSINAEFAQPLSPERARELLDGATGVQLVDVPTPLAAAGVDES
HHHCCCEEEEEEEECCEEEEEHHHCCCCCHHHHHHHHCCCCCCEEEECCCCHHHCCCCHH
LVGRIRRDPGVPDGRGLALFVSGDNLRKGAALNTIQIAELLTADL
HHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
GLSIGIVGATGQVGQVMRTLLDERDFPASAVRFFASARSQGRKLAFRGQEIEVEDAETA
CEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCEEEECCCCCC
DPSGLDIALFSAGSAMSKVQAPRFAAAGVTVIDNSSAWRKDPDVPLVVSEVNFERDAHRR
CCCCCEEEEEECCCHHHHHCCCCEECCCEEEEECCCCCCCCCCCCEEEEECCCCHHHCCC
PKGIIANPNCTTMAAMPVLKVLHDEARLVRLVVSSYQAVSGSGLAGVAELAEQARAVIGG
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
AEQLVYDGGALEFPPPNTYVAPIAFNVVPLAGSLVDDGSGETDEDQKLRFESRKILGIPD
CHHEEECCCEEECCCCCCEEEEEEEEEEECCCCEECCCCCCCCHHHHHHHCCCEECCCCH
LLVSGTCVRVPVFTGHSLSINAEFAQPLSPERARELLDGATGVQLVDVPTPLAAAGVDES
HHHCCCEEEEEEEECCEEEEEHHHCCCCCHHHHHHHHCCCCCCEEEECCCCHHHCCCCHH
LVGRIRRDPGVPDGRGLALFVSGDNLRKGAALNTIQIAELLTADL
HHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7910936; 12788972