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The map label for this gene is 148661126

Identifier: 148661126

GI number: 148661126

Start: 1505666

End: 1506388

Strand: Direct

Name: 148661126

Synonym: MRA_1345

Alternate gene names: NA

Gene position: 1505666-1506388 (Clockwise)

Preceding gene: 148661125

Following gene: 148661127

Centisome position: 34.07

GC content: 62.93

Gene sequence:

>723_bases
ATGGGCATGACCCCGCGCCGGAAGCGACGGGGAGGAGCGGTGCAGATAACACGGCCCACAGGCCGTCCGCGAACACCGAC
AACGCAGACGACGAAGCGCCCGCGCTGGGTGGTCGGCGGGACGACGATCCTCACCTTCGTCGCGCTGCTCTATCTCGTCG
AACTGATCGACCAGCTGTCCGGGAGTCGGCTGGACGTCAACGGCATCAGGCCGCTGAAAACAGACGGCCTGTGGGGCGTC
ATCTTTGCGCCACTTTTGCACGCGAACTGGCACCACCTAATGGCCAATACCATCCCGCTGCTGGTGCTGGGGTTTCTTAT
GACGCTGGCCGGGCTGTCCCGGTTTGTCTGGGCCACCGCGATCATTTGGATTCTGGGCGGCTTGGGCACTTGGCTGATCG
GCAATGTGGGCAGCAGCTGTGGCCCGACCGACCATATCGGCGCCTCTGGCCTGATCTTTGGCTGGCTGGCCTTCCTATTG
GTGTTCGGGCTTTTTGTGCGCAAGGGATGGGATATCGTCATTGGGCTGGTGGTCTTGTTTGTCTATGGCGGCATCCTGCT
CGGCGCGATGCCGGTGCTGGGCCAGTGTGGTGGCGTGTCATGGCAGGGTCATTTAAGTGGTGCGGTTGCTGGCGTCGTGG
CGGCGTATCTGTTGTCCGCTCCGGAGCGTAAGGCCCGTGCACTGAAAAGGGCCGGCGCGCGTTCCGGGCATCCGAAGTTA
TGA

Upstream 100 bases:

>100_bases
ACATTGCGTTGGTGGTCGCCGACGCCGGGTGGAAGTATCTGTCCACCGGCGCCTACGCCGGTAGCCTGGATGACGCCGAG
ACCGCTCTGGAAGGGCAACT

Downstream 100 bases:

>100_bases
ATTCGCCGTTGGCGCCCGTCGGAGTCTTTGATTCCGGCGTCGGGGGACTGACGGTCGCGCGGGCCATCATCGACCAACTG
CCCGACGAGGACATCGTCTA

Product: putative integral membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MGMTPRRKRRGGAVQITRPTGRPRTPTTQTTKRPRWVVGGTTILTFVALLYLVELIDQLSGSRLDVNGIRPLKTDGLWGV
IFAPLLHANWHHLMANTIPLLVLGFLMTLAGLSRFVWATAIIWILGGLGTWLIGNVGSSCGPTDHIGASGLIFGWLAFLL
VFGLFVRKGWDIVIGLVVLFVYGGILLGAMPVLGQCGGVSWQGHLSGAVAGVVAAYLLSAPERKARALKRAGARSGHPKL

Sequences:

>Translated_240_residues
MGMTPRRKRRGGAVQITRPTGRPRTPTTQTTKRPRWVVGGTTILTFVALLYLVELIDQLSGSRLDVNGIRPLKTDGLWGV
IFAPLLHANWHHLMANTIPLLVLGFLMTLAGLSRFVWATAIIWILGGLGTWLIGNVGSSCGPTDHIGASGLIFGWLAFLL
VFGLFVRKGWDIVIGLVVLFVYGGILLGAMPVLGQCGGVSWQGHLSGAVAGVVAAYLLSAPERKARALKRAGARSGHPKL
>Mature_239_residues
GMTPRRKRRGGAVQITRPTGRPRTPTTQTTKRPRWVVGGTTILTFVALLYLVELIDQLSGSRLDVNGIRPLKTDGLWGVI
FAPLLHANWHHLMANTIPLLVLGFLMTLAGLSRFVWATAIIWILGGLGTWLIGNVGSSCGPTDHIGASGLIFGWLAFLLV
FGLFVRKGWDIVIGLVVLFVYGGILLGAMPVLGQCGGVSWQGHLSGAVAGVVAAYLLSAPERKARALKRAGARSGHPKL

Specific function: Unknown

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To M.leprae ML1171

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1337_MYCTU (P64815)

Other databases:

- EMBL:   BX842576
- EMBL:   AE000516
- PIR:   E70771
- RefSeq:   NP_215853.1
- RefSeq:   NP_335829.1
- ProteinModelPortal:   P64815
- EnsemblBacteria:   EBMYCT00000000450
- EnsemblBacteria:   EBMYCT00000071116
- GeneID:   886870
- GeneID:   924663
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1378
- KEGG:   mtu:Rv1337
- TIGR:   MT1378
- TubercuList:   Rv1337
- GeneTree:   EBGT00050000016384
- HOGENOM:   HBG701304
- OMA:   LFAPFLH
- ProtClustDB:   CLSK791107
- InterPro:   IPR022764

Pfam domain/function: PF01694 Rhomboid

EC number: NA

Molecular weight: Translated: 25703; Mature: 25572

Theoretical pI: Translated: 12.04; Mature: 12.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1debd320)-; HASH(0x1dc852ec)-; HASH(0x1b88754c)-; HASH(0x1dc88f24)-; HASH(0x1e356c1c)-; HASH(0x1e3a57cc)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMTPRRKRRGGAVQITRPTGRPRTPTTQTTKRPRWVVGGTTILTFVALLYLVELIDQLS
CCCCCCCHHCCCEEEEECCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHC
GSRLDVNGIRPLKTDGLWGVIFAPLLHANWHHLMANTIPLLVLGFLMTLAGLSRFVWATA
CCEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIWILGGLGTWLIGNVGSSCGPTDHIGASGLIFGWLAFLLVFGLFVRKGWDIVIGLVVLF
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VYGGILLGAMPVLGQCGGVSWQGHLSGAVAGVVAAYLLSAPERKARALKRAGARSGHPKL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCH
>Mature Secondary Structure 
GMTPRRKRRGGAVQITRPTGRPRTPTTQTTKRPRWVVGGTTILTFVALLYLVELIDQLS
CCCCCCHHCCCEEEEECCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHC
GSRLDVNGIRPLKTDGLWGVIFAPLLHANWHHLMANTIPLLVLGFLMTLAGLSRFVWATA
CCEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIWILGGLGTWLIGNVGSSCGPTDHIGASGLIFGWLAFLLVFGLFVRKGWDIVIGLVVLF
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VYGGILLGAMPVLGQCGGVSWQGHLSGAVAGVVAAYLLSAPERKARALKRAGARSGHPKL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036