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The map label for this gene is thrC

Identifier: 148661083

GI number: 148661083

Start: 1452007

End: 1453089

Strand: Direct

Name: thrC

Synonym: MRA_1303

Alternate gene names: 148661083

Gene position: 1452007-1453089 (Clockwise)

Preceding gene: 148661082

Following gene: 148661084

Centisome position: 32.85

GC content: 65.74

Gene sequence:

>1083_bases
ATGACCGTCCCGCCGACGGCCACTCACCAGCCGTGGCCGGGAGTGATTGCCGCGTACCGTGACCGGCTGCCGGTGGGTGA
CGACTGGACTCCGGTGACCCTGCTCGAGGGTGGTACTCCCCTCATCGCGGCAACTAATCTCTCCAAGCAGACGGGCTGCA
CGATCCACCTCAAAGTGGAGGGCCTCAACCCCACCGGCTCCTTCAAGGATCGTGGCATGACGATGGCGGTCACCGATGCC
CTTGCCCATGGTCAGCGGGCGGTCTTGTGCGCATCGACCGGAAATACCTCGGCGTCGGCGGCGGCCTATGCCGCCCGGGC
CGGCATCACCTGCGCGGTGCTGATACCGCAGGGCAAGATCGCGATGGGCAAGCTCGCACAGGCGGTCATGCACGGCGCCA
AGATCATCCAGATCGACGGTAACTTCGACGACTGCCTGGAACTGGCGCGCAAGATGGCCGCGGACTTCCCGACGATTTCG
TTGGTCAACTCGGTAAACCCGGTGCGCATCGAGGGCCAGAAAACGGCAGCGTTCGAGATCGTCGACGTGCTAGGTACCGC
GCCGGACGTGCATGCTCTGCCGGTTGGCAACGCCGGCAACATCACCGCGTACTGGAAGGGCTACACCGAGTATCACCAGC
TGGGCCTGATCGACAAGTTGCCCCGCATGCTGGGCACTCAGGCCGCGGGCGCGGCGCCCCTGGTGCTCGGCGAACCGGTG
AGCCACCCGGAGACCATCGCAACCGCGATCCGCATCGGCTCGCCGGCGTCGTGGACTTCGGCCGTCGAGGCACAGCAGCA
GTCCAAGGGCCGCTTCTTGGCCGCCTCCGACGAGGAGATACTGGCCGCATATCACCTGGTGGCTCGTGTCGAAGGCGTAT
TCGTGGAGCCCGCGTCCGCAGCCAGCATTGCGGGTCTCCTCAAAGCGATCGACGACGGCTGGGTGGCGCGTGGTTCGACG
GTGGTGTGCACGGTAACCGGCAACGGTCTTAAGGATCCCGACACCGCGCTCAAAGACATGCCGAGCGTGTCTCCGGTTCC
CGTGGACCCGGTAGCCGTCGTCGAGAAGCTAGGGCTGGCCTAG

Upstream 100 bases:

>100_bases
TCGCCACTGACGCCGCACTCTCGGAAACCGTTGATGCACTGGACGACTTGGATGTCGTGCAGGGTGTGTCCAGCGTGATA
CGACTGGAAGGAACCGGCTT

Downstream 100 bases:

>100_bases
TGGCGATCGCAAGCGCGGCGGAGCCGGGTGCGGCGGGTCGGCACGGTTTGGATTGGGTGGCGATCGCAAGCGCGGCGGAG
CCGGGTGCGGCGGGTCGGCA

Product: threonine synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MTVPPTATHQPWPGVIAAYRDRLPVGDDWTPVTLLEGGTPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDA
LAHGQRAVLCASTGNTSASAAAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTIS
LVNSVNPVRIEGQKTAAFEIVDVLGTAPDVHALPVGNAGNITAYWKGYTEYHQLGLIDKLPRMLGTQAAGAAPLVLGEPV
SHPETIATAIRIGSPASWTSAVEAQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDGWVARGST
VVCTVTGNGLKDPDTALKDMPSVSPVPVDPVAVVEKLGLA

Sequences:

>Translated_360_residues
MTVPPTATHQPWPGVIAAYRDRLPVGDDWTPVTLLEGGTPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDA
LAHGQRAVLCASTGNTSASAAAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTIS
LVNSVNPVRIEGQKTAAFEIVDVLGTAPDVHALPVGNAGNITAYWKGYTEYHQLGLIDKLPRMLGTQAAGAAPLVLGEPV
SHPETIATAIRIGSPASWTSAVEAQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDGWVARGST
VVCTVTGNGLKDPDTALKDMPSVSPVPVDPVAVVEKLGLA
>Mature_359_residues
TVPPTATHQPWPGVIAAYRDRLPVGDDWTPVTLLEGGTPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDAL
AHGQRAVLCASTGNTSASAAAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTISL
VNSVNPVRIEGQKTAAFEIVDVLGTAPDVHALPVGNAGNITAYWKGYTEYHQLGLIDKLPRMLGTQAAGAAPLVLGEPVS
HPETIATAIRIGSPASWTSAVEAQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDGWVARGSTV
VCTVTGNGLKDPDTALKDMPSVSPVPVDPVAVVEKLGLA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family

Homologues:

None

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): THRC_MYCBO (P66903)

Other databases:

- EMBL:   BX248338
- RefSeq:   NP_854981.1
- ProteinModelPortal:   P66903
- SMR:   P66903
- EnsemblBacteria:   EBMYCT00000018063
- GeneID:   1090615
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1327
- GeneTree:   EBGT00050000015763
- HOGENOM:   HBG694883
- OMA:   QVDGNFD
- ProtClustDB:   PRK07409
- BioCyc:   MBOV233413:MB1327-MONOMER
- BRENDA:   4.2.3.1
- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450
- TIGRFAMs:   TIGR00260

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.3.1

Molecular weight: Translated: 37322; Mature: 37191

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: BINDING 95-95 BINDING 326-326

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVPPTATHQPWPGVIAAYRDRLPVGDDWTPVTLLEGGTPLIAATNLSKQTGCTIHLKVE
CCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCCEEEEEEE
GLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTGNTSASAAAYAARAGITCAVLIPQGKI
CCCCCCCCCCCCCEEEEHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCC
AMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTISLVNSVNPVRIEGQKTAAFEI
HHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCEEHHCCCCCEEEECCCCHHHHH
VDVLGTAPDVHALPVGNAGNITAYWKGYTEYHQLGLIDKLPRMLGTQAAGAAPLVLGEPV
HHHHCCCCCCEEEECCCCCCEEEEECCCHHHHHHCCHHHHHHHHCCCCCCCCCEEECCCC
SHPETIATAIRIGSPASWTSAVEAQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASA
CCHHHHHHHEECCCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCEEECCCCH
ASIAGLLKAIDDGWVARGSTVVCTVTGNGLKDPDTALKDMPSVSPVPVDPVAVVEKLGLA
HHHHHHHHHHCCCCEECCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
TVPPTATHQPWPGVIAAYRDRLPVGDDWTPVTLLEGGTPLIAATNLSKQTGCTIHLKVE
CCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCCEEEEEEE
GLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTGNTSASAAAYAARAGITCAVLIPQGKI
CCCCCCCCCCCCCEEEEHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCC
AMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTISLVNSVNPVRIEGQKTAAFEI
HHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCEEHHCCCCCEEEECCCCHHHHH
VDVLGTAPDVHALPVGNAGNITAYWKGYTEYHQLGLIDKLPRMLGTQAAGAAPLVLGEPV
HHHHCCCCCCEEEECCCCCCEEEEECCCHHHHHHCCHHHHHHHHCCCCCCCCCEEECCCC
SHPETIATAIRIGSPASWTSAVEAQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASA
CCHHHHHHHEECCCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCEEECCCCH
ASIAGLLKAIDDGWVARGSTVVCTVTGNGLKDPDTALKDMPSVSPVPVDPVAVVEKLGLA
HHHHHHHHHHCCCCEECCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972