BacMap

Definition	Mycobacterium tuberculosis H37Ra, complete genome.
Accession	NC_009525
Length	4,419,977

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The map label for this gene is hdhA [C]

Identifier: 148660546

GI number: 148660546

Start: 863718

End: 864464

Strand: Direct

Name: hdhA [C]

Synonym: MRA_0778

Alternate gene names: 148660546

Gene position: 863718-864464 (Clockwise)

Preceding gene: 148660545

Following gene: 148660547

Centisome position: 19.54

GC content: 61.71

Gene sequence:

>747_bases
ATGTTCGACAGCAAGGTGGCTATCGTCACCGGGGCTGCCCAGGGTATCGGGCAGGCCTACGCTCAGGCGTTGGCCCGCGA
AGGTGCCTCGGTGGTCGTCGCTGACATCAACGCCGACGGTGCCGCGGCGGTAGCCAAGCAGATTGTCGCCGACGGCGGTA
CTGCGATTCATGTGCCCGTTGACGTGTCCGACGAGGATTCCGCTAAAGCCATGGTCGACCGCGCCGTCGGTGCTTTCGGC
GGCATCGACTATCTGGTGAACAATGCGGCGATCTACGGTGGCATGAAGCTCGATCTGTTGTTGACCGTGCCGTTGGACTA
CTACAAGAAATTCATGAGCGTCAACCACGACGGCGTGCTGGTGTGTACCCGCGCGGTGTACAAGCACATGGCCAAACGGG
GCGGCGGCGCGATTGTCAACCAGTCCTCGACCGCGGCCTGGCTGTATTCCAACTTCTACGGCCTGGCCAAGGTCGGTGTC
AACGGGCTGACGCAGCAGCTGGCCCGCGAGCTGGGCGGAATGAAGATAAGGATCAATGCGATCGCACCCGGACCGATCGA
CACCGAAGCTACCCGCACCGTCACCCCCGCAGAGCTGGTCAAGAACATGGTGCAGACCATCCCGCTGTCGCGGATGGGTA
CACCGGAGGATCTGGTGGGCATGTGCCTGTTCCTGCTGTCGGATTCGGCATCGTGGATCACCGGGCAGATCTTCAATGTC
GATGGCGGACAGATCATCCGGTCATGA

Upstream 100 bases:

>100_bases
ACGCGAGATGGGTCTCCTCGGCTTCGAGGAGTACTTAGAAGCCAAACTCATTGCTACCGCTGCAAATTAGCTAGCGGGTT
GACAGCGCAGAAAGGAAGCC

Downstream 100 bases:

>100_bases
CCGGCGCCGGCGCCGATGCAGAGCGGGGCGATGAGGTGGGGGCACGCCCCCACAAGTGGGAGGTACCCCCATCCGCTGGC
GGGGGAGAGCGGCGCTCATG

Product: short chain dehydrogenase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MFDSKVAIVTGAAQGIGQAYAQALAREGASVVVADINADGAAAVAKQIVADGGTAIHVPVDVSDEDSAKAMVDRAVGAFG
GIDYLVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAVYKHMAKRGGGAIVNQSSTAAWLYSNFYGLAKVGV
NGLTQQLARELGGMKIRINAIAPGPIDTEATRTVTPAELVKNMVQTIPLSRMGTPEDLVGMCLFLLSDSASWITGQIFNV
DGGQIIRS

Sequences:

>Translated_248_residues
MFDSKVAIVTGAAQGIGQAYAQALAREGASVVVADINADGAAAVAKQIVADGGTAIHVPVDVSDEDSAKAMVDRAVGAFG
GIDYLVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAVYKHMAKRGGGAIVNQSSTAAWLYSNFYGLAKVGV
NGLTQQLARELGGMKIRINAIAPGPIDTEATRTVTPAELVKNMVQTIPLSRMGTPEDLVGMCLFLLSDSASWITGQIFNV
DGGQIIRS
>Mature_248_residues
MFDSKVAIVTGAAQGIGQAYAQALAREGASVVVADINADGAAAVAKQIVADGGTAIHVPVDVSDEDSAKAMVDRAVGAFG
GIDYLVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAVYKHMAKRGGGAIVNQSSTAAWLYSNFYGLAKVGV
NGLTQQLARELGGMKIRINAIAPGPIDTEATRTVTPAELVKNMVQTIPLSRMGTPEDLVGMCLFLLSDSASWITGQIFNV
DGGQIIRS

Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=254, Percent_Identity=37.7952755905512, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI19923817, Length=254, Percent_Identity=31.8897637795276, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI15277342, Length=251, Percent_Identity=32.6693227091633, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI10190704, Length=249, Percent_Identity=31.7269076305221, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=31.7073170731707, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI126723750, Length=257, Percent_Identity=33.0739299610895, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI4503301, Length=250, Percent_Identity=31.6, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4504505, Length=257, Percent_Identity=32.6848249027237, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI7705925, Length=242, Percent_Identity=34.7107438016529, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI5031737, Length=243, Percent_Identity=30.4526748971193, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI4758504, Length=250, Percent_Identity=30.4, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI31542939, Length=217, Percent_Identity=31.7972350230415, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI40254986, Length=188, Percent_Identity=32.9787234042553, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI7706318, Length=244, Percent_Identity=28.2786885245902, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI109715829, Length=247, Percent_Identity=28.7449392712551, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI126723191, Length=190, Percent_Identity=36.3157894736842, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI83715985, Length=252, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI66933014, Length=252, Percent_Identity=30.1587301587302, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI33667109, Length=197, Percent_Identity=28.9340101522843, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4557649, Length=207, Percent_Identity=28.0193236714976, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI20149619, Length=193, Percent_Identity=29.5336787564767, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI224922801, Length=176, Percent_Identity=31.25, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI59889578, Length=230, Percent_Identity=25.6521739130435, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI209862901, Length=240, Percent_Identity=27.0833333333333, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI19923983, Length=240, Percent_Identity=27.0833333333333, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787905, Length=245, Percent_Identity=37.9591836734694, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI1787335, Length=245, Percent_Identity=31.8367346938775, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790717, Length=246, Percent_Identity=30.4878048780488, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI87082100, Length=253, Percent_Identity=32.8063241106719, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=33.4661354581673, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=31.4285714285714, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI87082160, Length=248, Percent_Identity=30.6451612903226, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=34.6456692913386, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1789057, Length=260, Percent_Identity=30.7692307692308, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1789378, Length=251, Percent_Identity=28.6852589641434, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786812, Length=257, Percent_Identity=28.7937743190661, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI2367365, Length=248, Percent_Identity=27.0161290322581, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787526, Length=253, Percent_Identity=24.1106719367589, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787820, Length=182, Percent_Identity=27.4725274725275, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1787545, Length=247, Percent_Identity=26.7206477732794, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=35.6, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=34.2741935483871, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=34.136546184739, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17562910, Length=259, Percent_Identity=29.7297297297297, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=31.4741035856574, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71994604, Length=249, Percent_Identity=30.9236947791165, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=29.3893129770992, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17560676, Length=254, Percent_Identity=31.8897637795276, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17559104, Length=259, Percent_Identity=30.8880308880309, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=32.183908045977, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17560332, Length=260, Percent_Identity=32.3076923076923, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17531453, Length=259, Percent_Identity=30.1158301158301, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562908, Length=262, Percent_Identity=30.1526717557252, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562904, Length=266, Percent_Identity=30.0751879699248, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=28.4090909090909, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17551412, Length=260, Percent_Identity=29.6153846153846, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI115534694, Length=247, Percent_Identity=31.5789473684211, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17538182, Length=250, Percent_Identity=30.4, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17544670, Length=264, Percent_Identity=28.7878787878788, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI72000259, Length=261, Percent_Identity=29.1187739463602, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17536025, Length=251, Percent_Identity=31.4741035856574, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17536651, Length=253, Percent_Identity=28.8537549407115, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=30.6513409961686, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560220, Length=262, Percent_Identity=28.2442748091603, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538486, Length=260, Percent_Identity=30.7692307692308, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17568967, Length=257, Percent_Identity=31.1284046692607, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=28.5171102661597, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17561272, Length=253, Percent_Identity=31.2252964426877, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=27.3764258555133, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71982365, Length=194, Percent_Identity=30.4123711340206, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565030, Length=266, Percent_Identity=29.3233082706767, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17564282, Length=201, Percent_Identity=30.3482587064677, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17567345, Length=170, Percent_Identity=28.8235294117647, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558628, Length=195, Percent_Identity=31.7948717948718, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=191, Percent_Identity=30.3664921465969, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=191, Percent_Identity=30.3664921465969, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=251, Percent_Identity=26.2948207171315, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=251, Percent_Identity=29.8804780876494, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6322861, Length=255, Percent_Identity=29.8039215686275, Blast_Score=93, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=35.5102040816327, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=33.7301587301587, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21357041, Length=254, Percent_Identity=32.2834645669291, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21355319, Length=256, Percent_Identity=30.078125, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17737361, Length=255, Percent_Identity=29.0196078431373, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=31.7460317460317, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI116007236, Length=240, Percent_Identity=27.0833333333333, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI18859837, Length=195, Percent_Identity=33.8461538461538, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI116007234, Length=202, Percent_Identity=34.6534653465347, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=30.1960784313725, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21357673, Length=247, Percent_Identity=27.9352226720648, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24644337, Length=253, Percent_Identity=28.8537549407115, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI116007232, Length=189, Percent_Identity=33.8624338624339, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI116007238, Length=185, Percent_Identity=27.5675675675676, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281364494, Length=224, Percent_Identity=29.0178571428571, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24643142, Length=246, Percent_Identity=29.6747967479675, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21358495, Length=192, Percent_Identity=27.6041666666667, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641232, Length=202, Percent_Identity=28.2178217821782, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24648693, Length=203, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355889, Length=203, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24663911, Length=221, Percent_Identity=25.3393665158371, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 25966; Mature: 25966

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDSKVAIVTGAAQGIGQAYAQALAREGASVVVADINADGAAAVAKQIVADGGTAIHVPV
CCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEE
DVSDEDSAKAMVDRAVGAFGGIDYLVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVL
ECCCCCHHHHHHHHHHHHHCCHHHHHCCEEEECCEEEEEEEECCHHHHHHHHCCCCCCEE
VCTRAVYKHMAKRGGGAIVNQSSTAAWLYSNFYGLAKVGVNGLTQQLARELGGMKIRINA
EHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEE
IAPGPIDTEATRTVTPAELVKNMVQTIPLSRMGTPEDLVGMCLFLLSDSASWITGQIFNV
ECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEC
DGGQIIRS
CCCCEECC
>Mature Secondary Structure
MFDSKVAIVTGAAQGIGQAYAQALAREGASVVVADINADGAAAVAKQIVADGGTAIHVPV
CCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEE
DVSDEDSAKAMVDRAVGAFGGIDYLVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVL
ECCCCCHHHHHHHHHHHHHCCHHHHHCCEEEECCEEEEEEEECCHHHHHHHHCCCCCCEE
VCTRAVYKHMAKRGGGAIVNQSSTAAWLYSNFYGLAKVGVNGLTQQLARELGGMKIRINA
EHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEE
IAPGPIDTEATRTVTPAELVKNMVQTIPLSRMGTPEDLVGMCLFLLSDSASWITGQIFNV
ECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEC
DGGQIIRS
CCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9655913; 12597275 [H]