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The map label for this gene is ethA [H]

Identifier: 148660334

GI number: 148660334

Start: 657320

End: 658780

Strand: Reverse

Name: ethA [H]

Synonym: MRA_0572

Alternate gene names: 148660334

Gene position: 658780-657320 (Counterclockwise)

Preceding gene: 148660335

Following gene: 148660333

Centisome position: 14.9

GC content: 62.56

Gene sequence:

>1461_bases
ATGAGCGTGACTCCAAACGCCGGCTGTGTCGACGTCGTCATCGTCGGCGCCGGCATCTCCGGACTGGGCGCGGCCTACCG
GATCATCGAACGCAACCCGCAGCTGACCTACACCATCCTGGAAAGGCGTGCGCGGATCGGCGGCACCTGGGATCTGTTCC
GCTACCCCGGCGTGCGCTCCGACAGCAGCATCTTCACGCTGTCGTTTCCCTACGAGCCGTGGACCCGCGAAGAAGGCATC
GCCGACGGCGCCCACATCCGCGAGTACCTCACCGACATGGCCCACAAGTACGGCATCGATCGCCACATCGAGTTCAACAG
CTACGTTCGCGCAGCGGACTGGGACTCATCCACCGATACCTGGACCGTCACCTTCGAGCAGAACGGCGTGCACAAGCACT
ACCGCAGCCGGTTCGTGTTCTTCGGCAGCGGCTACTACAACTATGACGAGGGCTACACCCCCGACTTCGGAGGCATCGAG
AAGTTTGGCGGCGCGGTAGTGCATCCCCAGCACTGGCCAGAGGATCTGGACTACACCGGCAAGAAGATCGTGGTGATCGG
CAGCGGGGCCACCGCGGTCACACTGATCCCCTCGCTGACCGACCGGGCCGAAAAGGTAACCATGCTGCAGCGATCCCCGA
CCTACCTGATCTCGGCATCCAAATACAGCACGTTCGCCGCCGTTGTTCGTAAAGCGTTGCCTCCCAAAACTTCTCACTTG
ATTGTCCGAATGTACAACGCGTTATTGGAAGCGGTGTTCTGGTTCTTGTCCCGCAAGACACCGGTGTTCGTGAAATGGCT
GCTGCGCCGTACCGCGATCAAAAATCTGCCCGAGGGCTACGACATCGAAACCCACTTCACGCCGCGGTACAACCCGTGGG
ATCAGCGACTGTGCCTGATCCCGGACGCCGACCTGTACAACGCCATCACCAGCGGCCGCGCCGAGGTGGTCACCGACCAT
ATCGACCACTTCGACGCCACCGGTATTGCACTCAAATCCGGTGGGCACCTCGATGCGGACATTATCGTCACCGCCACCGG
CCTGCAGTTGCAAGCGCTTGGCGGGGCCGCGATCAGCCTCGACGGCGTCGAGATCGACCCTCGGGATCGCTTTGTCTACA
AGGCGCACATGCTCGAAGACGTGCCCAACCTGTTCTGGTGTGTGGGTTACACGAACGCGTCCTGGACGCTGCGCGCCGAC
ATGACGGCCCGGGCGACGGCAAAACTACTGGCACACATGGCCGCCCATGGACACACGCGCGCCGCCCCGCACCTGGGCGA
CGAGCCGATGGACGAGAAACCGTCCTGGGACATTCAGGCCGGCTATGTGAAGCGGGCGCCGTACGCGCTGCCCAAGTCCG
GCACCAAGCGGCCGTGGAATGTACGACAGAACTACTTGGCCGACGCCATCGACTACCGATTCGACCGCATCGAGGAGGCA
ATGGTGTTCGGCGCGGCATGA

Upstream 100 bases:

>100_bases
TGCAGTTTGTGAACTACCGCTAGTCGCGGCGATCTGGAGGGGCTGGCTGGATGTCCTGGCTACCCTGGTCGCTGATCCAG
GATTTCAAGCGAGGTTCACG

Downstream 100 bases:

>100_bases
TTGCTCCTGCGGTTCGTCGACGGATATCAAATGTCCGGTTGCCGCAATACGCTGAACGCCATGGCAGCCAACAAGCGCGA
ACCCAAAGTCGTTGTCCTCG

Product: putative monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MSVTPNAGCVDVVIVGAGISGLGAAYRIIERNPQLTYTILERRARIGGTWDLFRYPGVRSDSSIFTLSFPYEPWTREEGI
ADGAHIREYLTDMAHKYGIDRHIEFNSYVRAADWDSSTDTWTVTFEQNGVHKHYRSRFVFFGSGYYNYDEGYTPDFGGIE
KFGGAVVHPQHWPEDLDYTGKKIVVIGSGATAVTLIPSLTDRAEKVTMLQRSPTYLISASKYSTFAAVVRKALPPKTSHL
IVRMYNALLEAVFWFLSRKTPVFVKWLLRRTAIKNLPEGYDIETHFTPRYNPWDQRLCLIPDADLYNAITSGRAEVVTDH
IDHFDATGIALKSGGHLDADIIVTATGLQLQALGGAAISLDGVEIDPRDRFVYKAHMLEDVPNLFWCVGYTNASWTLRAD
MTARATAKLLAHMAAHGHTRAAPHLGDEPMDEKPSWDIQAGYVKRAPYALPKSGTKRPWNVRQNYLADAIDYRFDRIEEA
MVFGAA

Sequences:

>Translated_486_residues
MSVTPNAGCVDVVIVGAGISGLGAAYRIIERNPQLTYTILERRARIGGTWDLFRYPGVRSDSSIFTLSFPYEPWTREEGI
ADGAHIREYLTDMAHKYGIDRHIEFNSYVRAADWDSSTDTWTVTFEQNGVHKHYRSRFVFFGSGYYNYDEGYTPDFGGIE
KFGGAVVHPQHWPEDLDYTGKKIVVIGSGATAVTLIPSLTDRAEKVTMLQRSPTYLISASKYSTFAAVVRKALPPKTSHL
IVRMYNALLEAVFWFLSRKTPVFVKWLLRRTAIKNLPEGYDIETHFTPRYNPWDQRLCLIPDADLYNAITSGRAEVVTDH
IDHFDATGIALKSGGHLDADIIVTATGLQLQALGGAAISLDGVEIDPRDRFVYKAHMLEDVPNLFWCVGYTNASWTLRAD
MTARATAKLLAHMAAHGHTRAAPHLGDEPMDEKPSWDIQAGYVKRAPYALPKSGTKRPWNVRQNYLADAIDYRFDRIEEA
MVFGAA
>Mature_485_residues
SVTPNAGCVDVVIVGAGISGLGAAYRIIERNPQLTYTILERRARIGGTWDLFRYPGVRSDSSIFTLSFPYEPWTREEGIA
DGAHIREYLTDMAHKYGIDRHIEFNSYVRAADWDSSTDTWTVTFEQNGVHKHYRSRFVFFGSGYYNYDEGYTPDFGGIEK
FGGAVVHPQHWPEDLDYTGKKIVVIGSGATAVTLIPSLTDRAEKVTMLQRSPTYLISASKYSTFAAVVRKALPPKTSHLI
VRMYNALLEAVFWFLSRKTPVFVKWLLRRTAIKNLPEGYDIETHFTPRYNPWDQRLCLIPDADLYNAITSGRAEVVTDHI
DHFDATGIALKSGGHLDADIIVTATGLQLQALGGAAISLDGVEIDPRDRFVYKAHMLEDVPNLFWCVGYTNASWTLRADM
TARATAKLLAHMAAHGHTRAAPHLGDEPMDEKPSWDIQAGYVKRAPYALPKSGTKRPWNVRQNYLADAIDYRFDRIEEAM
VFGAA

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI50541965, Length=285, Percent_Identity=24.9122807017544, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI50541961, Length=285, Percent_Identity=24.9122807017544, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI193202226, Length=235, Percent_Identity=24.6808510638298, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 54526; Mature: 54395

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTPNAGCVDVVIVGAGISGLGAAYRIIERNPQLTYTILERRARIGGTWDLFRYPGVRS
CCCCCCCCCEEEEEEECCCHHHHHHHHEECCCCCEEHHHHHHHHHCCCCEEHHCCCCCCC
DSSIFTLSFPYEPWTREEGIADGAHIREYLTDMAHKYGIDRHIEFNSYVRAADWDSSTDT
CCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCEEEECCCCCCCCE
WTVTFEQNGVHKHYRSRFVFFGSGYYNYDEGYTPDFGGIEKFGGAVVHPQHWPEDLDYTG
EEEEEECCCCHHHHHCEEEEEECCEEECCCCCCCCCCCHHHHCCEEECCCCCCCCCCCCC
KKIVVIGSGATAVTLIPSLTDRAEKVTMLQRSPTYLISASKYSTFAAVVRKALPPKTSHL
CEEEEEECCCEEEEEECCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCHHHH
IVRMYNALLEAVFWFLSRKTPVFVKWLLRRTAIKNLPEGYDIETHFTPRYNPWDQRLCLI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHCEEEEE
PDADLYNAITSGRAEVVTDHIDHFDATGIALKSGGHLDADIIVTATGLQLQALGGAAISL
CCCHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEECCEEEEECCCEEEEE
DGVEIDPRDRFVYKAHMLEDVPNLFWCVGYTNASWTLRADMTARATAKLLAHMAAHGHTR
CCCEECCCCCEEEHHHHHHHCCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHCCCCC
AAPHLGDEPMDEKPSWDIQAGYVKRAPYALPKSGTKRPWNVRQNYLADAIDYRFDRIEEA
CCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MVFGAA
HHCCCC
>Mature Secondary Structure 
SVTPNAGCVDVVIVGAGISGLGAAYRIIERNPQLTYTILERRARIGGTWDLFRYPGVRS
CCCCCCCCEEEEEEECCCHHHHHHHHEECCCCCEEHHHHHHHHHCCCCEEHHCCCCCCC
DSSIFTLSFPYEPWTREEGIADGAHIREYLTDMAHKYGIDRHIEFNSYVRAADWDSSTDT
CCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCEEEECCCCCCCCE
WTVTFEQNGVHKHYRSRFVFFGSGYYNYDEGYTPDFGGIEKFGGAVVHPQHWPEDLDYTG
EEEEEECCCCHHHHHCEEEEEECCEEECCCCCCCCCCCHHHHCCEEECCCCCCCCCCCCC
KKIVVIGSGATAVTLIPSLTDRAEKVTMLQRSPTYLISASKYSTFAAVVRKALPPKTSHL
CEEEEEECCCEEEEEECCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCHHHH
IVRMYNALLEAVFWFLSRKTPVFVKWLLRRTAIKNLPEGYDIETHFTPRYNPWDQRLCLI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHCEEEEE
PDADLYNAITSGRAEVVTDHIDHFDATGIALKSGGHLDADIIVTATGLQLQALGGAAISL
CCCHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEECCEEEEECCCEEEEE
DGVEIDPRDRFVYKAHMLEDVPNLFWCVGYTNASWTLRADMTARATAKLLAHMAAHGHTR
CCCEECCCCCEEEHHHHHHHCCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHCCCCC
AAPHLGDEPMDEKPSWDIQAGYVKRAPYALPKSGTKRPWNVRQNYLADAIDYRFDRIEEA
CCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MVFGAA
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA