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The map label for this gene is gabP [H]

Identifier: 148660291

GI number: 148660291

Start: 614348

End: 615652

Strand: Direct

Name: gabP [H]

Synonym: MRA_0529

Alternate gene names: 148660291

Gene position: 614348-615652 (Clockwise)

Preceding gene: 148660290

Following gene: 148660293

Centisome position: 13.9

GC content: 62.22

Gene sequence:

>1305_bases
ATGATCGCTATCGGCGGCGTCATCGGTGCTGGCTTGTTCGTCGGGTCTGGTGTGGTTATCCGTGCGACCGGTCCGGCGGC
ATTCCTGACCTATGCGCTGTGCGGCGCACTGATCGTTCTGGTGATGCGCATGCTGGGCGAGATGGCCGCCGCCAATCCGT
CGACTGGAGCGTTCGCCGACTACGCGGCAAAAGCCCTGGGCGGCTGGGCGGGATTCTCGGTTGGCTGGCTGTACTGGTAC
TTCTGGGTAATCGTCGTGGGGTTCGAGGCGGTTGCCGGCGGGAAGGTTCTAACCTACTGGATCGATGCGCCGCTGTGGTT
GGCGTCGCTGTGTCTGATGATGATGATGACCGCGACGAACTTGGTCTCGGTGTCATCCTTCGGTGAGTTCGAGTTCTGGT
TCGCCGGAGTCAAGGTTGCCACCATCGTCGGCTTCCTGGTCCTTGGCACCGCTTTCGCCTTCGGGCTGCTGCCGGGCCAT
GGCATGGATTTCAGCAACCTCAGCGCGCACGGTGGCTTCTTTCCCGACGGGGTAGGTGCCGTCTTCGCTGCCATCGTGGT
CGCGATCTTCTCCATGACTGGCACGGAAGTAGTCACCATCGCCGCGGCTGAAGCGCCGGACCCTCAACGAGCGGTCCAAC
GCGCGATGAGCACGGTGGTGGCACGCATCGTGATCTTCTTCGTCGGCTCGGTCTTCCTGCTCACGGTGATCCTGCCGTGG
AACTCGTTGGAGCTTGGCGCCTCCCCGTACGTTGCCGCGCTGCGGCACATGGGTATTGGGGGTGCTGATCAGATCATGAA
TGCCGTCGTGCTTACCGCGGTGCTGTCCTGCTTGAACTCGGGCCTGTATACCGCGTCGCGGATGCTGTTCGTGCTCGCCG
CCCGGCAGGAGGCGCCGGCCCAGCTGGTCAAAGTCAACCGGCGTGGAGTCCCCACCTTCGCGATCATGGGATCGTCCGTG
GTGGGATTCCTGTGCGTGATCATGGCATGGGTCTCACCCGCAACGGTATTCGTTTTCCTGCTCAACTCGTCGGGCGCTGT
GATTTTGTTCGTCTACCTGCTTATCGCGCTGTCGCAGATCGTGTTGCGTCGCCAGACATCTGGCCAAAATCTGGGGGTAC
GGATGTGGCTTTTCCCGGGGCTGTCGATCGTCACGGTGACCGGAATTGTCGCCGTGCTGGCGCGGATGGCGTTCGACTAC
GCCGCGCGCAGCCAGCTCTGGCTCAGCCTGCTGTCCTGGGCAGTGGTCGTTGGGTGTTATTTGGTCACCACATTGGTGCG
ACGTCCCCTTAATCGGCCTTGGTGA

Upstream 100 bases:

>100_bases
TTGCCCGGCGGCGCCAGTACTGCCCCCGACGGACCGGAAGGCAGGTGCCATAGCTACCACTTCAGGACTGCGCCCAGGAC
TGTCGCAGCGTCAGCTCAAC

Downstream 100 bases:

>100_bases
GCAGTACGGCCTCGTCGAACGGCAGTCTGGCAAAGACCGGCCGCCATCGGCTGCTGACATACGGCGCCGCCTCGGCCTTG
GTGAGCCGCCGCGGGTTGGC

Product: gaba permease GabP

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MIAIGGVIGAGLFVGSGVVIRATGPAAFLTYALCGALIVLVMRMLGEMAAANPSTGAFADYAAKALGGWAGFSVGWLYWY
FWVIVVGFEAVAGGKVLTYWIDAPLWLASLCLMMMMTATNLVSVSSFGEFEFWFAGVKVATIVGFLVLGTAFAFGLLPGH
GMDFSNLSAHGGFFPDGVGAVFAAIVVAIFSMTGTEVVTIAAAEAPDPQRAVQRAMSTVVARIVIFFVGSVFLLTVILPW
NSLELGASPYVAALRHMGIGGADQIMNAVVLTAVLSCLNSGLYTASRMLFVLAARQEAPAQLVKVNRRGVPTFAIMGSSV
VGFLCVIMAWVSPATVFVFLLNSSGAVILFVYLLIALSQIVLRRQTSGQNLGVRMWLFPGLSIVTVTGIVAVLARMAFDY
AARSQLWLSLLSWAVVVGCYLVTTLVRRPLNRPW

Sequences:

>Translated_434_residues
MIAIGGVIGAGLFVGSGVVIRATGPAAFLTYALCGALIVLVMRMLGEMAAANPSTGAFADYAAKALGGWAGFSVGWLYWY
FWVIVVGFEAVAGGKVLTYWIDAPLWLASLCLMMMMTATNLVSVSSFGEFEFWFAGVKVATIVGFLVLGTAFAFGLLPGH
GMDFSNLSAHGGFFPDGVGAVFAAIVVAIFSMTGTEVVTIAAAEAPDPQRAVQRAMSTVVARIVIFFVGSVFLLTVILPW
NSLELGASPYVAALRHMGIGGADQIMNAVVLTAVLSCLNSGLYTASRMLFVLAARQEAPAQLVKVNRRGVPTFAIMGSSV
VGFLCVIMAWVSPATVFVFLLNSSGAVILFVYLLIALSQIVLRRQTSGQNLGVRMWLFPGLSIVTVTGIVAVLARMAFDY
AARSQLWLSLLSWAVVVGCYLVTTLVRRPLNRPW
>Mature_434_residues
MIAIGGVIGAGLFVGSGVVIRATGPAAFLTYALCGALIVLVMRMLGEMAAANPSTGAFADYAAKALGGWAGFSVGWLYWY
FWVIVVGFEAVAGGKVLTYWIDAPLWLASLCLMMMMTATNLVSVSSFGEFEFWFAGVKVATIVGFLVLGTAFAFGLLPGH
GMDFSNLSAHGGFFPDGVGAVFAAIVVAIFSMTGTEVVTIAAAEAPDPQRAVQRAMSTVVARIVIFFVGSVFLLTVILPW
NSLELGASPYVAALRHMGIGGADQIMNAVVLTAVLSCLNSGLYTASRMLFVLAARQEAPAQLVKVNRRGVPTFAIMGSSV
VGFLCVIMAWVSPATVFVFLLNSSGAVILFVYLLIALSQIVLRRQTSGQNLGVRMWLFPGLSIVTVTGIVAVLARMAFDY
AARSQLWLSLLSWAVVVGCYLVTTLVRRPLNRPW

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=414, Percent_Identity=23.6714975845411, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1789017, Length=411, Percent_Identity=45.0121654501217, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI87081708, Length=442, Percent_Identity=38.6877828054299, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1786302, Length=382, Percent_Identity=37.696335078534, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1786789, Length=384, Percent_Identity=37.2395833333333, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI48994972, Length=436, Percent_Identity=34.8623853211009, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1790653, Length=371, Percent_Identity=36.1185983827493, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1788480, Length=375, Percent_Identity=36.8, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI87081915, Length=408, Percent_Identity=36.7647058823529, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI1786602, Length=395, Percent_Identity=34.6835443037975, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17532491, Length=395, Percent_Identity=24.5569620253165, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=416, Percent_Identity=32.6923076923077, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324061, Length=404, Percent_Identity=33.4158415841584, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324059, Length=387, Percent_Identity=32.0413436692506, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322892, Length=405, Percent_Identity=32.3456790123457, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324553, Length=379, Percent_Identity=32.9815303430079, Blast_Score=162, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6324990, Length=368, Percent_Identity=33.4239130434783, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324924, Length=371, Percent_Identity=31.5363881401617, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6319824, Length=394, Percent_Identity=30.2030456852792, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321629, Length=406, Percent_Identity=29.5566502463054, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320717, Length=395, Percent_Identity=29.1139240506329, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319543, Length=380, Percent_Identity=28.1578947368421, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6319608, Length=425, Percent_Identity=26.8235294117647, Blast_Score=136, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6321053, Length=379, Percent_Identity=29.023746701847, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322967, Length=386, Percent_Identity=28.7564766839378, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319542, Length=394, Percent_Identity=28.1725888324873, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320251, Length=395, Percent_Identity=27.5949367088608, Blast_Score=120, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6324981, Length=386, Percent_Identity=29.7927461139896, Blast_Score=113, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46031; Mature: 46031

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAIGGVIGAGLFVGSGVVIRATGPAAFLTYALCGALIVLVMRMLGEMAAANPSTGAFAD
CEEECHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YAAKALGGWAGFSVGWLYWYFWVIVVGFEAVAGGKVLTYWIDAPLWLASLCLMMMMTATN
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHH
LVSVSSFGEFEFWFAGVKVATIVGFLVLGTAFAFGLLPGHGMDFSNLSAHGGFFPDGVGA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHH
VFAAIVVAIFSMTGTEVVTIAAAEAPDPQRAVQRAMSTVVARIVIFFVGSVFLLTVILPW
HHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NSLELGASPYVAALRHMGIGGADQIMNAVVLTAVLSCLNSGLYTASRMLFVLAARQEAPA
CCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHH
QLVKVNRRGVPTFAIMGSSVVGFLCVIMAWVSPATVFVFLLNSSGAVILFVYLLIALSQI
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VLRRQTSGQNLGVRMWLFPGLSIVTVTGIVAVLARMAFDYAARSQLWLSLLSWAVVVGCY
HHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVTTLVRRPLNRPW
HHHHHHHCCCCCCC
>Mature Secondary Structure
MIAIGGVIGAGLFVGSGVVIRATGPAAFLTYALCGALIVLVMRMLGEMAAANPSTGAFAD
CEEECHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YAAKALGGWAGFSVGWLYWYFWVIVVGFEAVAGGKVLTYWIDAPLWLASLCLMMMMTATN
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHH
LVSVSSFGEFEFWFAGVKVATIVGFLVLGTAFAFGLLPGHGMDFSNLSAHGGFFPDGVGA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHH
VFAAIVVAIFSMTGTEVVTIAAAEAPDPQRAVQRAMSTVVARIVIFFVGSVFLLTVILPW
HHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NSLELGASPYVAALRHMGIGGADQIMNAVVLTAVLSCLNSGLYTASRMLFVLAARQEAPA
CCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHH
QLVKVNRRGVPTFAIMGSSVVGFLCVIMAWVSPATVFVFLLNSSGAVILFVYLLIALSQI
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VLRRQTSGQNLGVRMWLFPGLSIVTVTGIVAVLARMAFDYAARSQLWLSLLSWAVVVGCY
HHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVTTLVRRPLNRPW
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377 [H]