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The map label for this gene is pta

Identifier: 148660173

GI number: 148660173

Start: 493096

End: 495168

Strand: Direct

Name: pta

Synonym: MRA_0414

Alternate gene names: 148660173

Gene position: 493096-495168 (Clockwise)

Preceding gene: 148660172

Following gene: 148660174

Centisome position: 11.16

GC content: 64.21

Gene sequence:

>2073_bases
TTGGCTGACTCCTCGGCGATCTACCTCGCCGCACCAGAATCGCAGACGGGTAAGTCGACGATTGCACTGGGGCTTTTGCA
CCGACTGACCGCGATGGTCGCCAAAGTCGGTGTGTTCCGGCCGATTACGCGGCTCTCTGCGGAGCGGGACTACATCCTGG
AACTACTGCTCGCGCACACCAGTGCGGGCCTGCCCTATGAGCGGTGTGTTGGCGTGACCTACCAGCAGCTGCATGCTGAC
CGCGACGACGCGATCGCCGAAATTGTCGATTCGTATCACGCAATGGCCGACGAGTGTGACGCGGTGGTGGTCGTCGGCAG
TGACTACACCGACGTCACCAGCCCCACCGAGCTCTCGGTCAACGGCCGGATCGCGGTGAACCTCGGCGCGCCAGTGTTGT
TGACGGTTCGGGCGAAGGACCGCACCCCCGATCAGGTCGCCAGCGTCGTCGAGGTCTGCTTGGCCGAGCTGGACACCCAG
CGCGCTCATACCGCGGCGGTAGTGGCGAACCGGTGCGAGCTGTCCGCGATACCGGCCGTGACCGACGCGCTGCGCAGGTT
CACCCCGCCTAGCTATGTAGTGCCCGAGGAACCACTGCTGTCGGCGCCGACCGTTGCCGAGTTAACGCAGGCTGTGAACG
GGGCGGTGGTAAGCGGTGATGTTGCGCTGCGCGAACGTGAGGTGATGGGCGTGCTGGCCGCGGGTATGACCGCCGACCAT
GTGTTGGAGCGGCTGACCGATGGCATGGCGGTGATTACTCCCGGCGACCGCTCGGACGTGGTGTTGGCCGTCGCTAGCGC
CCATGCGGCCGAAGGGTTTCCGTCATTGTCATGCATCGTCCTCAATGGCGGGTTCCAGTTGCATCCGGCGATCGCCGCCC
TGGTTTCCGGCCTGCGATTGCGGTTACCTGTCATCGCCACCGCGTTGGGCACCTACGACACCGCCAGCGCTGCCGCGTCG
GCCCGCGGGCTGGTAACGGCGACGTCGCAACGCAAGATCGACACCGCGTTGGAGCTGATGGACCGCCACGTGGACGTCGC
CGGTCTATTGGCGCAGCTGACCATTCCCATCCCTACGGTCACTACACCACAGATGTTCACTTATCGGCTGCTGCAGCAGG
CCCGTTCGGACCTCATGCGCATCGTCCTTCCCGAAGGGGACGACGATCGCATCCTCAAATCGGCGGGCCGCCTGCTTCAG
CGCGGCATCGTCGACCTGACCATCCTGGGCGATGAAGCCAAAGTCCGTCTGCGGGCAGCGGAACTCGGTGTGGACCTGGA
CGGCGCCACGGTAATCGAGCCATGCGCAAGCGAACTGCACGATCAATTCGCCGACCAGTATGCGCAGTTGCGTAAGGCGA
AGGGAATCACCGTGGAGCATGCCCGCGAAATCATGAACGATGCCACATATTTCGGCACCATGCTGGTGCACAACTGTCAT
GCCGACGGCATGGTATCGGGTGCTGCTCACACCACGGCGCACACCGTTCGTCCGGCGCTGGAGATCATCAAGACCGTTCC
GGGCATATCCACCGTGTCCAGCATTTTCCTGATGTGTCTGCCGGATCGGGTACTGGCGTACGGCGACTGCGCGATCATCC
CGAACCCGACGGTGGAGCAGCTCGCTGATATCGCCATCTGCTCGGCACGCACCGCCGCACAGTTCGGCATCGAGCCCCGG
GTGGCCATGCTGTCCTACTCCACCGGTGACTCGGGGAAAGGTGCCGACGTCGACAAGGTCAGAGCGGCAACGGAGTTGGT
GCGCGCTCGGGAGCCGCAGCTGCCGGTCGAGGGTCCCATTCAATACGACGCCGCAGTGGAACCGTCGGTCGCGGCCACCA
AGTTGCGCGATTCGCCGGTGGCCGGCCGCGCGACGGTGCTGATCTTCCCCGATCTCAATACCGGCAACAACACCTACAAA
GCGGTGCAGCGTTCTGCGGGTGCGATCGCGATCGGCCCGGTGCTGCAGGGCTTACGCAAGCCGGTGAACGACCTATCTCG
GGGTGCACTGGTCGACGACATAGTCAACACCGTGGCCATCACGGCGATTCAGGCGCAGGGCGTCCATGAGTAG

Upstream 100 bases:

>100_bases
ACATGGGGCCTGAACCACCTGGTATTTCACGCACCAGGACATGACCAGCGCCGGTTTCTGGAGCTCTTCCAGTCGGACCT
GGCACCCAGGTTGCGGCGAC

Downstream 100 bases:

>100_bases
CACCGTGCTGGTGATCAATTCCGGCTCGTCGTCGCTGAAGTTCCAGCTCGTCGAGCCGGTCGCCGGCATGTCACGTGCCG
CCGGGATTGTCGAGCGGATC

Product: phosphate acetyltransferase

Products: NA

Alternate protein names: Phosphotransacetylase

Number of amino acids: Translated: 690; Mature: 689

Protein sequence:

>690_residues
MADSSAIYLAAPESQTGKSTIALGLLHRLTAMVAKVGVFRPITRLSAERDYILELLLAHTSAGLPYERCVGVTYQQLHAD
RDDAIAEIVDSYHAMADECDAVVVVGSDYTDVTSPTELSVNGRIAVNLGAPVLLTVRAKDRTPDQVASVVEVCLAELDTQ
RAHTAAVVANRCELSAIPAVTDALRRFTPPSYVVPEEPLLSAPTVAELTQAVNGAVVSGDVALREREVMGVLAAGMTADH
VLERLTDGMAVITPGDRSDVVLAVASAHAAEGFPSLSCIVLNGGFQLHPAIAALVSGLRLRLPVIATALGTYDTASAAAS
ARGLVTATSQRKIDTALELMDRHVDVAGLLAQLTIPIPTVTTPQMFTYRLLQQARSDLMRIVLPEGDDDRILKSAGRLLQ
RGIVDLTILGDEAKVRLRAAELGVDLDGATVIEPCASELHDQFADQYAQLRKAKGITVEHAREIMNDATYFGTMLVHNCH
ADGMVSGAAHTTAHTVRPALEIIKTVPGISTVSSIFLMCLPDRVLAYGDCAIIPNPTVEQLADIAICSARTAAQFGIEPR
VAMLSYSTGDSGKGADVDKVRAATELVRAREPQLPVEGPIQYDAAVEPSVAATKLRDSPVAGRATVLIFPDLNTGNNTYK
AVQRSAGAIAIGPVLQGLRKPVNDLSRGALVDDIVNTVAITAIQAQGVHE

Sequences:

>Translated_690_residues
MADSSAIYLAAPESQTGKSTIALGLLHRLTAMVAKVGVFRPITRLSAERDYILELLLAHTSAGLPYERCVGVTYQQLHAD
RDDAIAEIVDSYHAMADECDAVVVVGSDYTDVTSPTELSVNGRIAVNLGAPVLLTVRAKDRTPDQVASVVEVCLAELDTQ
RAHTAAVVANRCELSAIPAVTDALRRFTPPSYVVPEEPLLSAPTVAELTQAVNGAVVSGDVALREREVMGVLAAGMTADH
VLERLTDGMAVITPGDRSDVVLAVASAHAAEGFPSLSCIVLNGGFQLHPAIAALVSGLRLRLPVIATALGTYDTASAAAS
ARGLVTATSQRKIDTALELMDRHVDVAGLLAQLTIPIPTVTTPQMFTYRLLQQARSDLMRIVLPEGDDDRILKSAGRLLQ
RGIVDLTILGDEAKVRLRAAELGVDLDGATVIEPCASELHDQFADQYAQLRKAKGITVEHAREIMNDATYFGTMLVHNCH
ADGMVSGAAHTTAHTVRPALEIIKTVPGISTVSSIFLMCLPDRVLAYGDCAIIPNPTVEQLADIAICSARTAAQFGIEPR
VAMLSYSTGDSGKGADVDKVRAATELVRAREPQLPVEGPIQYDAAVEPSVAATKLRDSPVAGRATVLIFPDLNTGNNTYK
AVQRSAGAIAIGPVLQGLRKPVNDLSRGALVDDIVNTVAITAIQAQGVHE
>Mature_689_residues
ADSSAIYLAAPESQTGKSTIALGLLHRLTAMVAKVGVFRPITRLSAERDYILELLLAHTSAGLPYERCVGVTYQQLHADR
DDAIAEIVDSYHAMADECDAVVVVGSDYTDVTSPTELSVNGRIAVNLGAPVLLTVRAKDRTPDQVASVVEVCLAELDTQR
AHTAAVVANRCELSAIPAVTDALRRFTPPSYVVPEEPLLSAPTVAELTQAVNGAVVSGDVALREREVMGVLAAGMTADHV
LERLTDGMAVITPGDRSDVVLAVASAHAAEGFPSLSCIVLNGGFQLHPAIAALVSGLRLRLPVIATALGTYDTASAAASA
RGLVTATSQRKIDTALELMDRHVDVAGLLAQLTIPIPTVTTPQMFTYRLLQQARSDLMRIVLPEGDDDRILKSAGRLLQR
GIVDLTILGDEAKVRLRAAELGVDLDGATVIEPCASELHDQFADQYAQLRKAKGITVEHAREIMNDATYFGTMLVHNCHA
DGMVSGAAHTTAHTVRPALEIIKTVPGISTVSSIFLMCLPDRVLAYGDCAIIPNPTVEQLADIAICSARTAAQFGIEPRV
AMLSYSTGDSGKGADVDKVRAATELVRAREPQLPVEGPIQYDAAVEPSVAATKLRDSPVAGRATVLIFPDLNTGNNTYKA
VQRSAGAIAIGPVLQGLRKPVNDLSRGALVDDIVNTVAITAIQAQGVHE

Specific function: Conversion of acetate to acetyl-CoA; second step. [C]

COG id: COG0857

COG function: function code R; BioD-like N-terminal domain of phosphotransacetylase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family

Homologues:

Organism=Escherichia coli, GI1788635, Length=721, Percent_Identity=37.7253814147018, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1788800, Length=312, Percent_Identity=41.3461538461538, Blast_Score=218, Evalue=1e-57,
Organism=Escherichia coli, GI1788806, Length=336, Percent_Identity=30.952380952381, Blast_Score=164, Evalue=2e-41,

Paralogues:

None

Copy number: 1420 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1250 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PTA_MYCTU (P96254)

Other databases:

- EMBL:   BX842573
- EMBL:   AE000516
- PIR:   F70628
- RefSeq:   NP_214922.1
- RefSeq:   NP_334831.1
- ProteinModelPortal:   P96254
- EnsemblBacteria:   EBMYCT00000001685
- EnsemblBacteria:   EBMYCT00000072202
- GeneID:   886401
- GeneID:   923688
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0421
- KEGG:   mtu:Rv0408
- TIGR:   MT0421
- TubercuList:   Rv0408
- GeneTree:   EBGT00050000017507
- HOGENOM:   HBG576804
- OMA:   QFGVEPR
- ProtClustDB:   PRK05632
- BRENDA:   2.3.1.8
- GO:   GO:0005737
- InterPro:   IPR010766
- InterPro:   IPR016475
- InterPro:   IPR004614
- InterPro:   IPR002505
- PIRSF:   PIRSF006107
- TIGRFAMs:   TIGR00651

Pfam domain/function: PF07085 DRTGG; PF01515 PTA_PTB

EC number: =2.3.1.8

Molecular weight: Translated: 72949; Mature: 72818

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSSAIYLAAPESQTGKSTIALGLLHRLTAMVAKVGVFRPITRLSAERDYILELLLAHT
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SAGLPYERCVGVTYQQLHADRDDAIAEIVDSYHAMADECDAVVVVGSDYTDVTSPTELSV
CCCCCHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEE
NGRIAVNLGAPVLLTVRAKDRTPDQVASVVEVCLAELDTQRAHTAAVVANRCELSAIPAV
CCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
TDALRRFTPPSYVVPEEPLLSAPTVAELTQAVNGAVVSGDVALREREVMGVLAAGMTADH
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCHHHHHHHHHHHHHHCCCHHH
VLERLTDGMAVITPGDRSDVVLAVASAHAAEGFPSLSCIVLNGGFQLHPAIAALVSGLRL
HHHHHHCCEEEECCCCCCCEEEEEECHHHCCCCCCEEEEEEECCCEEHHHHHHHHCCHHH
RLPVIATALGTYDTASAAASARGLVTATSQRKIDTALELMDRHVDVAGLLAQLTIPIPTV
HHHHHHHHHCCCCCHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCHHHHHHHHEECCCCC
TTPQMFTYRLLQQARSDLMRIVLPEGDDDRILKSAGRLLQRGIVDLTILGDEAKVRLRAA
CCCHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEHH
ELGVDLDGATVIEPCASELHDQFADQYAQLRKAKGITVEHAREIMNDATYFGTMLVHNCH
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
ADGMVSGAAHTTAHTVRPALEIIKTVPGISTVSSIFLMCLPDRVLAYGDCAIIPNPTVEQ
CCCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHEECCEEECCCCCHHH
LADIAICSARTAAQFGIEPRVAMLSYSTGDSGKGADVDKVRAATELVRAREPQLPVEGPI
HHHHHHHCCHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
QYDAAVEPSVAATKLRDSPVAGRATVLIFPDLNTGNNTYKAVQRSAGAIAIGPVLQGLRK
CCCCCCCCCHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEHHHHHHHHHH
PVNDLSRGALVDDIVNTVAITAIQAQGVHE
HHHHHHCCHHHHHHHHHHHHHHEECCCCCC
>Mature Secondary Structure 
ADSSAIYLAAPESQTGKSTIALGLLHRLTAMVAKVGVFRPITRLSAERDYILELLLAHT
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SAGLPYERCVGVTYQQLHADRDDAIAEIVDSYHAMADECDAVVVVGSDYTDVTSPTELSV
CCCCCHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEE
NGRIAVNLGAPVLLTVRAKDRTPDQVASVVEVCLAELDTQRAHTAAVVANRCELSAIPAV
CCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
TDALRRFTPPSYVVPEEPLLSAPTVAELTQAVNGAVVSGDVALREREVMGVLAAGMTADH
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCHHHHHHHHHHHHHHCCCHHH
VLERLTDGMAVITPGDRSDVVLAVASAHAAEGFPSLSCIVLNGGFQLHPAIAALVSGLRL
HHHHHHCCEEEECCCCCCCEEEEEECHHHCCCCCCEEEEEEECCCEEHHHHHHHHCCHHH
RLPVIATALGTYDTASAAASARGLVTATSQRKIDTALELMDRHVDVAGLLAQLTIPIPTV
HHHHHHHHHCCCCCHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCHHHHHHHHEECCCCC
TTPQMFTYRLLQQARSDLMRIVLPEGDDDRILKSAGRLLQRGIVDLTILGDEAKVRLRAA
CCCHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEHH
ELGVDLDGATVIEPCASELHDQFADQYAQLRKAKGITVEHAREIMNDATYFGTMLVHNCH
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
ADGMVSGAAHTTAHTVRPALEIIKTVPGISTVSSIFLMCLPDRVLAYGDCAIIPNPTVEQ
CCCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHEECCEEECCCCCHHH
LADIAICSARTAAQFGIEPRVAMLSYSTGDSGKGADVDKVRAATELVRAREPQLPVEGPI
HHHHHHHCCHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
QYDAAVEPSVAATKLRDSPVAGRATVLIFPDLNTGNNTYKAVQRSAGAIAIGPVLQGLRK
CCCCCCCCCHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEHHHHHHHHHH
PVNDLSRGALVDDIVNTVAITAIQAQGVHE
HHHHHHCCHHHHHHHHHHHHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036