| Definition | Mycobacterium tuberculosis H37Ra, complete genome. |
|---|---|
| Accession | NC_009525 |
| Length | 4,419,977 |
Click here to switch to the map view.
The map label for this gene is fabG [H]
Identifier: 148660007
GI number: 148660007
Start: 292027
End: 293391
Strand: Reverse
Name: fabG [H]
Synonym: MRA_0251
Alternate gene names: 148660007
Gene position: 293391-292027 (Counterclockwise)
Preceding gene: 148660009
Following gene: 148660006
Centisome position: 6.64
GC content: 67.99
Gene sequence:
>1365_bases GTGGCTCCCAAGCGTTCGTCCGATCTGTTCTCGCAGGTTGTCAACTCCGGTCCAGGATCGTTTTTGGCCAGGCAATTGGG TGTTCCGCAACCCGAGACGCTTCGCCGCTATCGAGCAGGCGAACCGCCACTGACCGGGTCGCTGCTGATCGGCGGGGCCG GCAGGGTCGTCGAACCACTGCGCGCGGCACTCGAAAAGGACTACGACCTGGTAGGAAACAACCTGGGCGGGCGCTGGGCG GACTCGTTCGGCGGGCTGGTCTTCGACGCCACCGGCATCACAGAGCCGGCCGGGCTCAAGGGGCTGCACGAGTTCTTTAC TCCGGTACTGCGCAATCTCGGCCGTTGCGGGCGCGTGGTGGTTGTTGGCGGCACACCCGAAGCGGCCGCCAGCACGAACG AGCGGATCGCGCAGCGCGCGCTGGAGGGCTTCACCCGCTCGCTGGGCAAGGAACTGCGCCGCGGTGCGACAACGGCGTTG GTCTACCTGTCGCCGGACGCCAAGCCCGCAGCTACCGGCCTCGAGTCGACCATGCGATTCCTGCTGTCGGCCAAGTCGGC CTACGTCGACGGCCAAGTCTTCTCTGTCGGGGCGGACGATTCCACACCGCCGGCCGACTGGGAGAAGCCGCTGGACGGCA AGGTCGCCATTGTGACCGGCGCGGCCCGCGGCATCGGCGCAACCATCGCCGAGGTGTTCGCTCGCGACGGCGCCCACGTG GTCGCCATCGATGTGGAGTCCGCCGCCGAGAACCTGGCCGAAACCGCCAGCAAGGTGGGCGGCACCGCGCTGTGGCTCGA CGTCACCGCCGACGATGCCGTCGACAAGATCAGCGAGCACCTGCGCGACCACCACGGTGGCAAGGCCGACATCCTGGTCA ACAACGCCGGCATCACCCGTGACAAGCTGCTGGCCAACATGGACGATGCGCGTTGGGACGCCGTCCTGGCTGTCAATCTG CTTGCCCCGTTGCGGCTCACCGAGGGTCTGGTGGGCAACGGCAGCATCGGAGAGGGTGGTCGGGTGATCGGGCTGTCGTC GATCGCCGGCATCGCCGGCAACCGCGGCCAGACCAACTACGCCACCACCAAGGCCGGGATGATCGGCATCACCCAGGCGC TGGCACCCGGCCTGGCCGCGAAAGGCATCACGATCAACGCCGTGGCACCGGGATTCATCGAAACCCAGATGACGGCCGCC ATCCCGCTGGCCACCCGTGAGGTAGGCCGCCGGCTGAACTCGCTGCTGCAGGGCGGGCAGCCCGTCGACGTCGCCGAGGC CATCGCCTACTTCGCCAGCCCGGCGTCAAACGCGGTGACCGGCAACGTCATTCGTGTCTGCGGCCAGGCCATGATCGGCG CGTGA
Upstream 100 bases:
>100_bases GCCATACTACCCACTGTTCTTACTCTGAAGTAAGTTAGTCCTCGATACGGTTACGTGTATTGGCGCGCCCGACCCCCACA CGATACGGAAGGCAGCTGAA
Downstream 100 bases:
>100_bases GGGGACAGTAGTGACTCAACCCAGCGGCCTGAAGAACCTGCTGCGCGCGGCGGCCGGGGCGCTACCCGTGGTGCCCCGGA CAGACCAGCTGCCCAACCGG
Product: 3-ketoacyl-(acyl-carrier-protein) reductase
Products: NA
Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]
Number of amino acids: Translated: 454; Mature: 453
Protein sequence:
>454_residues MAPKRSSDLFSQVVNSGPGSFLARQLGVPQPETLRRYRAGEPPLTGSLLIGGAGRVVEPLRAALEKDYDLVGNNLGGRWA DSFGGLVFDATGITEPAGLKGLHEFFTPVLRNLGRCGRVVVVGGTPEAAASTNERIAQRALEGFTRSLGKELRRGATTAL VYLSPDAKPAATGLESTMRFLLSAKSAYVDGQVFSVGADDSTPPADWEKPLDGKVAIVTGAARGIGATIAEVFARDGAHV VAIDVESAAENLAETASKVGGTALWLDVTADDAVDKISEHLRDHHGGKADILVNNAGITRDKLLANMDDARWDAVLAVNL LAPLRLTEGLVGNGSIGEGGRVIGLSSIAGIAGNRGQTNYATTKAGMIGITQALAPGLAAKGITINAVAPGFIETQMTAA IPLATREVGRRLNSLLQGGQPVDVAEAIAYFASPASNAVTGNVIRVCGQAMIGA
Sequences:
>Translated_454_residues MAPKRSSDLFSQVVNSGPGSFLARQLGVPQPETLRRYRAGEPPLTGSLLIGGAGRVVEPLRAALEKDYDLVGNNLGGRWA DSFGGLVFDATGITEPAGLKGLHEFFTPVLRNLGRCGRVVVVGGTPEAAASTNERIAQRALEGFTRSLGKELRRGATTAL VYLSPDAKPAATGLESTMRFLLSAKSAYVDGQVFSVGADDSTPPADWEKPLDGKVAIVTGAARGIGATIAEVFARDGAHV VAIDVESAAENLAETASKVGGTALWLDVTADDAVDKISEHLRDHHGGKADILVNNAGITRDKLLANMDDARWDAVLAVNL LAPLRLTEGLVGNGSIGEGGRVIGLSSIAGIAGNRGQTNYATTKAGMIGITQALAPGLAAKGITINAVAPGFIETQMTAA IPLATREVGRRLNSLLQGGQPVDVAEAIAYFASPASNAVTGNVIRVCGQAMIGA >Mature_453_residues APKRSSDLFSQVVNSGPGSFLARQLGVPQPETLRRYRAGEPPLTGSLLIGGAGRVVEPLRAALEKDYDLVGNNLGGRWAD SFGGLVFDATGITEPAGLKGLHEFFTPVLRNLGRCGRVVVVGGTPEAAASTNERIAQRALEGFTRSLGKELRRGATTALV YLSPDAKPAATGLESTMRFLLSAKSAYVDGQVFSVGADDSTPPADWEKPLDGKVAIVTGAARGIGATIAEVFARDGAHVV AIDVESAAENLAETASKVGGTALWLDVTADDAVDKISEHLRDHHGGKADILVNNAGITRDKLLANMDDARWDAVLAVNLL APLRLTEGLVGNGSIGEGGRVIGLSSIAGIAGNRGQTNYATTKAGMIGITQALAPGLAAKGITINAVAPGFIETQMTAAI PLATREVGRRLNSLLQGGQPVDVAEAIAYFASPASNAVTGNVIRVCGQAMIGA
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=260, Percent_Identity=36.1538461538462, Blast_Score=134, Evalue=1e-31, Organism=Homo sapiens, GI40254992, Length=239, Percent_Identity=33.8912133891213, Blast_Score=109, Evalue=6e-24, Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=30.9236947791165, Blast_Score=100, Evalue=5e-21, Organism=Homo sapiens, GI4504505, Length=193, Percent_Identity=34.7150259067358, Blast_Score=94, Evalue=3e-19, Organism=Homo sapiens, GI31542939, Length=205, Percent_Identity=33.1707317073171, Blast_Score=92, Evalue=1e-18, Organism=Homo sapiens, GI66933014, Length=239, Percent_Identity=29.7071129707113, Blast_Score=86, Evalue=8e-17, Organism=Homo sapiens, GI5031737, Length=260, Percent_Identity=30.3846153846154, Blast_Score=84, Evalue=3e-16, Organism=Homo sapiens, GI33667109, Length=204, Percent_Identity=32.843137254902, Blast_Score=79, Evalue=1e-14, Organism=Homo sapiens, GI4758504, Length=208, Percent_Identity=29.8076923076923, Blast_Score=77, Evalue=4e-14, Organism=Homo sapiens, GI224922801, Length=185, Percent_Identity=31.8918918918919, Blast_Score=77, Evalue=4e-14, Organism=Homo sapiens, GI19923817, Length=256, Percent_Identity=26.953125, Blast_Score=75, Evalue=1e-13, Organism=Homo sapiens, GI126723191, Length=185, Percent_Identity=32.4324324324324, Blast_Score=74, Evalue=3e-13, Organism=Homo sapiens, GI40807363, Length=196, Percent_Identity=27.5510204081633, Blast_Score=72, Evalue=1e-12, Organism=Homo sapiens, GI126723750, Length=252, Percent_Identity=26.984126984127, Blast_Score=71, Evalue=2e-12, Organism=Homo sapiens, GI109715829, Length=243, Percent_Identity=27.9835390946502, Blast_Score=67, Evalue=3e-11, Organism=Homo sapiens, GI59889578, Length=229, Percent_Identity=30.5676855895196, Blast_Score=67, Evalue=3e-11, Organism=Homo sapiens, GI10190704, Length=243, Percent_Identity=27.5720164609054, Blast_Score=67, Evalue=4e-11, Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=41.1290322580645, Blast_Score=159, Evalue=2e-40, Organism=Escherichia coli, GI87082100, Length=247, Percent_Identity=32.7935222672065, Blast_Score=112, Evalue=4e-26, Organism=Escherichia coli, GI87082160, Length=253, Percent_Identity=30.8300395256917, Blast_Score=97, Evalue=2e-21, Organism=Escherichia coli, GI1789208, Length=247, Percent_Identity=30.7692307692308, Blast_Score=97, Evalue=2e-21, Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=28.8, Blast_Score=96, Evalue=6e-21, Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=32.1285140562249, Blast_Score=91, Evalue=2e-19, Organism=Escherichia coli, GI1787905, Length=244, Percent_Identity=31.9672131147541, Blast_Score=90, Evalue=4e-19, Organism=Escherichia coli, GI2367365, Length=245, Percent_Identity=33.469387755102, Blast_Score=89, Evalue=8e-19, Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=27.2030651340996, Blast_Score=82, Evalue=7e-17, Organism=Escherichia coli, GI1789378, Length=259, Percent_Identity=30.5019305019305, Blast_Score=77, Evalue=3e-15, Organism=Escherichia coli, GI1788459, Length=250, Percent_Identity=26, Blast_Score=65, Evalue=7e-12, Organism=Escherichia coli, GI1786812, Length=254, Percent_Identity=25.1968503937008, Blast_Score=63, Evalue=4e-11, Organism=Caenorhabditis elegans, GI25147288, Length=244, Percent_Identity=38.9344262295082, Blast_Score=148, Evalue=5e-36, Organism=Caenorhabditis elegans, GI17555706, Length=247, Percent_Identity=38.0566801619433, Blast_Score=142, Evalue=3e-34, Organism=Caenorhabditis elegans, GI17561402, Length=252, Percent_Identity=32.9365079365079, Blast_Score=100, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17568967, Length=193, Percent_Identity=35.2331606217617, Blast_Score=91, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=29.0322580645161, Blast_Score=86, Evalue=4e-17, Organism=Caenorhabditis elegans, GI17564282, Length=195, Percent_Identity=31.2820512820513, Blast_Score=83, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17559104, Length=261, Percent_Identity=31.8007662835249, Blast_Score=82, Evalue=7e-16, Organism=Caenorhabditis elegans, GI17562908, Length=243, Percent_Identity=29.6296296296296, Blast_Score=81, Evalue=9e-16, Organism=Caenorhabditis elegans, GI17538182, Length=202, Percent_Identity=31.6831683168317, Blast_Score=81, Evalue=1e-15, Organism=Caenorhabditis elegans, GI71994600, Length=246, Percent_Identity=30.0813008130081, Blast_Score=77, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17544670, Length=271, Percent_Identity=27.3062730627306, Blast_Score=75, Evalue=5e-14, Organism=Caenorhabditis elegans, GI17562904, Length=253, Percent_Identity=29.2490118577075, Blast_Score=75, Evalue=9e-14, Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=29.5546558704453, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI193203115, Length=201, Percent_Identity=29.3532338308458, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17560220, Length=247, Percent_Identity=29.1497975708502, Blast_Score=73, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17562906, Length=245, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=6e-13, Organism=Caenorhabditis elegans, GI193203117, Length=196, Percent_Identity=29.0816326530612, Blast_Score=71, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17531453, Length=246, Percent_Identity=28.8617886178862, Blast_Score=69, Evalue=4e-12, Organism=Caenorhabditis elegans, GI193204405, Length=245, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=9e-12, Organism=Caenorhabditis elegans, GI17560332, Length=255, Percent_Identity=29.8039215686275, Blast_Score=68, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17560150, Length=242, Percent_Identity=28.9256198347107, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=26.8199233716475, Blast_Score=66, Evalue=4e-11, Organism=Caenorhabditis elegans, GI115534694, Length=201, Percent_Identity=29.8507462686567, Blast_Score=66, Evalue=4e-11, Organism=Caenorhabditis elegans, GI17508895, Length=205, Percent_Identity=26.3414634146341, Blast_Score=65, Evalue=6e-11, Organism=Caenorhabditis elegans, GI17536025, Length=256, Percent_Identity=29.296875, Blast_Score=65, Evalue=7e-11, Organism=Caenorhabditis elegans, GI17562990, Length=246, Percent_Identity=28.4552845528455, Blast_Score=65, Evalue=8e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=214, Percent_Identity=30.3738317757009, Blast_Score=88, Evalue=3e-18, Organism=Drosophila melanogaster, GI24639444, Length=244, Percent_Identity=38.5245901639344, Blast_Score=142, Evalue=5e-34, Organism=Drosophila melanogaster, GI23397609, Length=248, Percent_Identity=35.8870967741936, Blast_Score=106, Evalue=4e-23, Organism=Drosophila melanogaster, GI18859837, Length=196, Percent_Identity=33.6734693877551, Blast_Score=93, Evalue=4e-19, Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=30.3149606299213, Blast_Score=88, Evalue=1e-17, Organism=Drosophila melanogaster, GI24644339, Length=242, Percent_Identity=33.8842975206612, Blast_Score=86, Evalue=6e-17, Organism=Drosophila melanogaster, GI21357041, Length=241, Percent_Identity=32.7800829875519, Blast_Score=81, Evalue=2e-15, Organism=Drosophila melanogaster, GI28571526, Length=240, Percent_Identity=32.0833333333333, Blast_Score=77, Evalue=2e-14, Organism=Drosophila melanogaster, GI21355319, Length=200, Percent_Identity=32.5, Blast_Score=75, Evalue=1e-13, Organism=Drosophila melanogaster, GI24644337, Length=240, Percent_Identity=29.5833333333333, Blast_Score=72, Evalue=8e-13, Organism=Drosophila melanogaster, GI24649181, Length=227, Percent_Identity=29.9559471365639, Blast_Score=69, Evalue=6e-12, Organism=Drosophila melanogaster, GI24643142, Length=247, Percent_Identity=29.9595141700405, Blast_Score=69, Evalue=6e-12, Organism=Drosophila melanogaster, GI21358495, Length=196, Percent_Identity=27.0408163265306, Blast_Score=68, Evalue=2e-11, Organism=Drosophila melanogaster, GI24581726, Length=200, Percent_Identity=25.5, Blast_Score=65, Evalue=8e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011284 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.100 [H]
Molecular weight: Translated: 46831; Mature: 46700
Theoretical pI: Translated: 6.39; Mature: 6.39
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 1.3 %Met (Translated Protein) 1.8 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 1.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAPKRSSDLFSQVVNSGPGSFLARQLGVPQPETLRRYRAGEPPLTGSLLIGGAGRVVEPL CCCCCHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEECCCCHHHHHH RAALEKDYDLVGNNLGGRWADSFGGLVFDATGITEPAGLKGLHEFFTPVLRNLGRCGRVV HHHHHCCHHHHCCCCCCCHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEE VVGGTPEAAASTNERIAQRALEGFTRSLGKELRRGATTALVYLSPDAKPAATGLESTMRF EECCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHH LLSAKSAYVDGQVFSVGADDSTPPADWEKPLDGKVAIVTGAARGIGATIAEVFARDGAHV HHHHHHHEECCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEE VAIDVESAAENLAETASKVGGTALWLDVTADDAVDKISEHLRDHHGGKADILVNNAGITR EEEEHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH DKLLANMDDARWDAVLAVNLLAPLRLTEGLVGNGSIGEGGRVIGLSSIAGIAGNRGQTNY HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHCCCCCCCCCC ATTKAGMIGITQALAPGLAAKGITINAVAPGFIETQMTAAIPLATREVGRRLNSLLQGGQ CCHHCCHHHHHHHHCCCCHHCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCC PVDVAEAIAYFASPASNAVTGNVIRVCGQAMIGA CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC >Mature Secondary Structure APKRSSDLFSQVVNSGPGSFLARQLGVPQPETLRRYRAGEPPLTGSLLIGGAGRVVEPL CCCCHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEECCCCHHHHHH RAALEKDYDLVGNNLGGRWADSFGGLVFDATGITEPAGLKGLHEFFTPVLRNLGRCGRVV HHHHHCCHHHHCCCCCCCHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEE VVGGTPEAAASTNERIAQRALEGFTRSLGKELRRGATTALVYLSPDAKPAATGLESTMRF EECCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHH LLSAKSAYVDGQVFSVGADDSTPPADWEKPLDGKVAIVTGAARGIGATIAEVFARDGAHV HHHHHHHEECCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEE VAIDVESAAENLAETASKVGGTALWLDVTADDAVDKISEHLRDHHGGKADILVNNAGITR EEEEHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH DKLLANMDDARWDAVLAVNLLAPLRLTEGLVGNGSIGEGGRVIGLSSIAGIAGNRGQTNY HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHCCCCCCCCCC ATTKAGMIGITQALAPGLAAKGITINAVAPGFIETQMTAAIPLATREVGRRLNSLLQGGQ CCHHCCHHHHHHHHCCCCHHCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCC PVDVAEAIAYFASPASNAVTGNVIRVCGQAMIGA CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10360571 [H]