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The map label for this gene is pepA [H]

Identifier: 148659889

GI number: 148659889

Start: 152507

End: 153574

Strand: Direct

Name: pepA [H]

Synonym: MRA_0132

Alternate gene names: 148659889

Gene position: 152507-153574 (Clockwise)

Preceding gene: 148659888

Following gene: 148659890

Centisome position: 3.45

GC content: 68.07

Gene sequence:

>1068_bases
ATGAGCAATTCGCGCCGCCGCTCACTCAGGTGGTCATGGTTGCTGAGCGTGCTGGCTGCCGTCGGGCTGGGCCTGGCCAC
GGCGCCGGCCCAGGCGGCCCCGCCGGCCTTGTCGCAGGACCGGTTCGCCGACTTCCCCGCGCTGCCCCTCGACCCGTCCG
CGATGGTCGCCCAAGTGGGGCCACAGGTGGTCAACATCAACACCAAACTGGGCTACAACAACGCCGTGGGCGCCGGGACC
GGCATCGTCATCGATCCCAACGGTGTCGTGCTGACCAACAACCACGTGATCGCGGGCGCCACCGACATCAATGCGTTCAG
CGTCGGCTCCGGCCAAACCTACGGCGTCGATGTGGTCGGGTATGACCGCACCCAGGATGTCGCGGTGCTGCAGCTGCGCG
GTGCCGGTGGCCTGCCGTCGGCGGCGATCGGTGGCGGCGTCGCGGTTGGTGAGCCCGTCGTCGCGATGGGCAACAGCGGT
GGGCAGGGCGGAACGCCCCGTGCGGTGCCTGGCAGGGTGGTCGCGCTCGGCCAAACCGTGCAGGCGTCGGATTCGCTGAC
CGGTGCCGAAGAGACATTGAACGGGTTGATCCAGTTCGATGCCGCGATCCAGCCCGGTGATTCGGGCGGGCCCGTCGTCA
ACGGCCTAGGACAGGTGGTCGGTATGAACACGGCCGCGTCCGATAACTTCCAGCTGTCCCAGGGTGGGCAGGGATTCGCC
ATTCCGATCGGGCAGGCGATGGCGATCGCGGGCCAGATCCGATCGGGTGGGGGGTCACCCACCGTTCATATCGGGCCTAC
CGCCTTCCTCGGCTTGGGTGTTGTCGACAACAACGGCAACGGCGCACGAGTCCAACGCGTGGTCGGGAGCGCTCCGGCGG
CAAGTCTCGGCATCTCCACCGGCGACGTGATCACCGCGGTCGACGGCGCTCCGATCAACTCGGCCACCGCGATGGCGGAC
GCGCTTAACGGGCATCATCCCGGTGACGTCATCTCGGTGACCTGGCAAACCAAGTCGGGCGGCACGCGTACAGGGAACGT
GACATTGGCCGAGGGACCCCCGGCCTGA

Upstream 100 bases:

>100_bases
GCTGGCGATCTGGACTACGTTGGTGTAGAAAAATCCTGCCGCCCGGACCCTTAAGGCTGGGACAATTTCTGATAGCTACC
CCGACACAGGAGGTTACGGG

Downstream 100 bases:

>100_bases
TTTCGTCGCGGATACCACCCGCCGGCCGGCCAATTGGATTGGCGCCAGCCGTGATTGCCGCGTGAGCCCCCGAGTTCCGT
CTCCCGTGCGCGTGGCATCG

Product: putative serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MSNSRRRSLRWSWLLSVLAAVGLGLATAPAQAAPPALSQDRFADFPALPLDPSAMVAQVGPQVVNINTKLGYNNAVGAGT
GIVIDPNGVVLTNNHVIAGATDINAFSVGSGQTYGVDVVGYDRTQDVAVLQLRGAGGLPSAAIGGGVAVGEPVVAMGNSG
GQGGTPRAVPGRVVALGQTVQASDSLTGAEETLNGLIQFDAAIQPGDSGGPVVNGLGQVVGMNTAASDNFQLSQGGQGFA
IPIGQAMAIAGQIRSGGGSPTVHIGPTAFLGLGVVDNNGNGARVQRVVGSAPAASLGISTGDVITAVDGAPINSATAMAD
ALNGHHPGDVISVTWQTKSGGTRTGNVTLAEGPPA

Sequences:

>Translated_355_residues
MSNSRRRSLRWSWLLSVLAAVGLGLATAPAQAAPPALSQDRFADFPALPLDPSAMVAQVGPQVVNINTKLGYNNAVGAGT
GIVIDPNGVVLTNNHVIAGATDINAFSVGSGQTYGVDVVGYDRTQDVAVLQLRGAGGLPSAAIGGGVAVGEPVVAMGNSG
GQGGTPRAVPGRVVALGQTVQASDSLTGAEETLNGLIQFDAAIQPGDSGGPVVNGLGQVVGMNTAASDNFQLSQGGQGFA
IPIGQAMAIAGQIRSGGGSPTVHIGPTAFLGLGVVDNNGNGARVQRVVGSAPAASLGISTGDVITAVDGAPINSATAMAD
ALNGHHPGDVISVTWQTKSGGTRTGNVTLAEGPPA
>Mature_354_residues
SNSRRRSLRWSWLLSVLAAVGLGLATAPAQAAPPALSQDRFADFPALPLDPSAMVAQVGPQVVNINTKLGYNNAVGAGTG
IVIDPNGVVLTNNHVIAGATDINAFSVGSGQTYGVDVVGYDRTQDVAVLQLRGAGGLPSAAIGGGVAVGEPVVAMGNSGG
QGGTPRAVPGRVVALGQTVQASDSLTGAEETLNGLIQFDAAIQPGDSGGPVVNGLGQVVGMNTAASDNFQLSQGGQGFAI
PIGQAMAIAGQIRSGGGSPTVHIGPTAFLGLGVVDNNGNGARVQRVVGSAPAASLGISTGDVITAVDGAPINSATAMADA
LNGHHPGDVISVTWQTKSGGTRTGNVTLAEGPPA

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoB and HtrA [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=297, Percent_Identity=25.5892255892256, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI22129776, Length=304, Percent_Identity=25.3289473684211, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI24308541, Length=298, Percent_Identity=26.510067114094, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI7019477, Length=294, Percent_Identity=27.891156462585, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1789630, Length=366, Percent_Identity=29.5081967213115, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789629, Length=275, Percent_Identity=32.7272727272727, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786356, Length=251, Percent_Identity=34.2629482071713, Blast_Score=93, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646839, Length=270, Percent_Identity=27.7777777777778, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 34927; Mature: 34795

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50106 PDZ ; PS00135 TRYPSIN_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSRRRSLRWSWLLSVLAAVGLGLATAPAQAAPPALSQDRFADFPALPLDPSAMVAQVG
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCC
PQVVNINTKLGYNNAVGAGTGIVIDPNGVVLTNNHVIAGATDINAFSVGSGQTYGVDVVG
CEEEEEEEECCCCCCCCCCCEEEECCCCEEEECCEEEEECCCCCEEECCCCCEEEEEEEE
YDRTQDVAVLQLRGAGGLPSAAIGGGVAVGEPVVAMGNSGGQGGTPRAVPGRVVALGQTV
CCCCCCEEEEEEECCCCCCCHHCCCCEECCCCEEEECCCCCCCCCCCCCCCEEEEECCEE
QASDSLTGAEETLNGLIQFDAAIQPGDSGGPVVNGLGQVVGMNTAASDNFQLSQGGQGFA
ECCCCCCCHHHHHHHEEEECCEECCCCCCCHHHHHHHHHEECCCCCCCCEEECCCCCEEE
IPIGQAMAIAGQIRSGGGSPTVHIGPTAFLGLGVVDNNGNGARVQRVVGSAPAASLGIST
EECCCCEEEEEHHCCCCCCCEEEECCHHEEEEEEEECCCCCCEEHEECCCCCCHHCCCCC
GDVITAVDGAPINSATAMADALNGHHPGDVISVTWQTKSGGTRTGNVTLAEGPPA
CCEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCEEECCCCCC
>Mature Secondary Structure 
SNSRRRSLRWSWLLSVLAAVGLGLATAPAQAAPPALSQDRFADFPALPLDPSAMVAQVG
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCC
PQVVNINTKLGYNNAVGAGTGIVIDPNGVVLTNNHVIAGATDINAFSVGSGQTYGVDVVG
CEEEEEEEECCCCCCCCCCCEEEECCCCEEEECCEEEEECCCCCEEECCCCCEEEEEEEE
YDRTQDVAVLQLRGAGGLPSAAIGGGVAVGEPVVAMGNSGGQGGTPRAVPGRVVALGQTV
CCCCCCEEEEEEECCCCCCCHHCCCCEECCCCEEEECCCCCCCCCCCCCCCEEEEECCEE
QASDSLTGAEETLNGLIQFDAAIQPGDSGGPVVNGLGQVVGMNTAASDNFQLSQGGQGFA
ECCCCCCCHHHHHHHEEEECCEECCCCCCCHHHHHHHHHEECCCCCCCCEEECCCCCEEE
IPIGQAMAIAGQIRSGGGSPTVHIGPTAFLGLGVVDNNGNGARVQRVVGSAPAASLGIST
EECCCCEEEEEHHCCCCCCCEEEECCHHEEEEEEEECCCCCCEEHEECCCCCCHHCCCCC
GDVITAVDGAPINSATAMADALNGHHPGDVISVTWQTKSGGTRTGNVTLAEGPPA
CCEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]