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The map label for this gene is fadD7 [H]

Identifier: 148659883

GI number: 148659883

Start: 145408

End: 146985

Strand: Direct

Name: fadD7 [H]

Synonym: MRA_0126

Alternate gene names: 148659883

Gene position: 145408-146985 (Clockwise)

Preceding gene: 148659881

Following gene: 148659886

Centisome position: 3.29

GC content: 68.57

Gene sequence:

>1578_bases
ATGGCATCCGACTTCGGCCCGCGCATCGCCGATCTTGTCGAGGTGGCGGCGACCCGGCTGCCCGAGGCTCCGGCGCTCGT
CGTCACCGCGGATCGCATCGCGATCAGCCACCGCGACCTGGCCCGTCTGGTTGATGAGCTGGCCGGCCAGCTGACGCGGT
CCGGCCTGCTGCCCGGTGACCGGGTCGCGCTGCGCATGGGCAGCAACGCCGAATTCGTCGTCGCCTTGCTGGCGGCGTCG
CGTGCGGATCTCGTCGTCGTGCCGCTGGATCCGGCGCTGCCCATCACCGAGCAACGCGTCCGAAGCCAGGCCGCGGGAGC
CCGGGTGGTGCTGATTGACGCGGATGGGCCGCACGACAGGGCAGAACCCACCACCCGGTGGTGGCCGCTCACGGTGAACG
TCGGCGGTGACAGCGGCCCCTCGGGTGGCACCTTGTCGGTCCACCTGGACGCCGCCACCGAGCCGAACCCCGCAACCTCG
ACGCCCGAGGGACTGCGACCCGATGACGCCATGATCATGTTCACCGGCGGGACGACCGGCCTGCCGAAGATGGTCCCCTG
GACGCACGCAAACATCGCCAGCTCGGTCCGCGCCATCATCACCGGGTACCGGCTGAGCCCGCGGGACGCCACCGTTGCGG
TGATGCCGCTCTACCATGGCCACGGGCTGATCGCGTCGTTGCTTGCCACCCTGGCGTCCGGCGGCGCGGTGTCGCTGCCC
GCACGCGGGCGATTCTCCGCGCACACCTTCTGGGACGACATCAAAGCCGTTGGAGCCACCTGGTATACGGCGGTTCCGAC
GATTCACCAAATCCTGCTGGAGCGATCGGCAACCGAACCGTCGGGGCGCAAACCTGCCGCACTGCGTTTCATCCGCAGCT
GCAGCGCACCGCTCACTGCCCAAGCCGCGCTAGCACTGCAAACCGAGTTCGCGGCACCGGTCGTGTGTGCCTTCGGCATG
ACCGAAGCCACCCACCAGGTAACGACAACGCAGATTGAGGGTATCGACCAAACCGAAACTCCCGTCGTGTCAACCGGTCT
GGTCGGCCGGTCGACGGGAGCGCAAATCCGGATCGTCGGGTCCGACGGGCTGCCACTGCCCGCGGGCGCGGTCGGGGAGA
TCTGGCTGCGGGGGACCACCGTGGTACGCGGGTATCTGGGTGACCCGACGATAACCGCCGCGAATTTCACCGACGGTTGG
TTGCGTACCGGTGATCTCGGGTCCCTGTCGGCGGCCGGTGACCTGAGCATCCGCGGCCGCATCAAGGAACTCATCAACCG
AGGTGGTGAAAAGATCTCGCCCGAGCGCGTCGAGGGCGTGCTGGCCAGCCATCCAAACGTCATGGAGGCAGCCGTATTCG
GCGTCCCGCACCAGCTCTACGGCGAGGCGGTCGCGGCGGTGATTGTGCCTCGTGAGTCCGCCCCGCCGACTCGCGAGGAG
CTTGTCCAGTTCTGCCGGGAACGGTTGGCGGCCTTCGAGATCCCGGCCTCCTTCCAGGAGGCCAGCGGGCTGCCGCACAC
CGCGAAGGGTTCGCTCGACCGCCGCGCTGTCGCCGAACGGTTCGGCCATTCGGTGTAG

Upstream 100 bases:

>100_bases
CAACCGTTAGCGGATCGGTATTGGACGCCGGGCAGGCGAGCCCGGCACTGTGCTGATCGTGCCGAACCCGCACACCGAAC
ACATGGAAGGAGCGTTCGCG

Downstream 100 bases:

>100_bases
CTAGCCGGCCCCGGCCTTTACCCGGGCGGCGGCGGATTCCGGCATCGGTTCGTAGCGGGCAAACGAACGGGTGAAGGATG
CGGCCCCATGCGCCAGCGAG

Product: acyl-CoA synthetase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MASDFGPRIADLVEVAATRLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGDRVALRMGSNAEFVVALLAAS
RADLVVVPLDPALPITEQRVRSQAAGARVVLIDADGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATS
TPEGLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYRLSPRDATVAVMPLYHGHGLIASLLATLASGGAVSLP
ARGRFSAHTFWDDIKAVGATWYTAVPTIHQILLERSATEPSGRKPAALRFIRSCSAPLTAQAALALQTEFAAPVVCAFGM
TEATHQVTTTQIEGIDQTETPVVSTGLVGRSTGAQIRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTITAANFTDGW
LRTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPHQLYGEAVAAVIVPRESAPPTREE
LVQFCRERLAAFEIPASFQEASGLPHTAKGSLDRRAVAERFGHSV

Sequences:

>Translated_525_residues
MASDFGPRIADLVEVAATRLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGDRVALRMGSNAEFVVALLAAS
RADLVVVPLDPALPITEQRVRSQAAGARVVLIDADGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATS
TPEGLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYRLSPRDATVAVMPLYHGHGLIASLLATLASGGAVSLP
ARGRFSAHTFWDDIKAVGATWYTAVPTIHQILLERSATEPSGRKPAALRFIRSCSAPLTAQAALALQTEFAAPVVCAFGM
TEATHQVTTTQIEGIDQTETPVVSTGLVGRSTGAQIRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTITAANFTDGW
LRTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPHQLYGEAVAAVIVPRESAPPTREE
LVQFCRERLAAFEIPASFQEASGLPHTAKGSLDRRAVAERFGHSV
>Mature_524_residues
ASDFGPRIADLVEVAATRLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGDRVALRMGSNAEFVVALLAASR
ADLVVVPLDPALPITEQRVRSQAAGARVVLIDADGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATST
PEGLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYRLSPRDATVAVMPLYHGHGLIASLLATLASGGAVSLPA
RGRFSAHTFWDDIKAVGATWYTAVPTIHQILLERSATEPSGRKPAALRFIRSCSAPLTAQAALALQTEFAAPVVCAFGMT
EATHQVTTTQIEGIDQTETPVVSTGLVGRSTGAQIRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTITAANFTDGWL
RTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPHQLYGEAVAAVIVPRESAPPTREEL
VQFCRERLAAFEIPASFQEASGLPHTAKGSLDRRAVAERFGHSV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=541, Percent_Identity=28.0961182994455, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI187761343, Length=541, Percent_Identity=28.0961182994455, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI156151445, Length=555, Percent_Identity=26.6666666666667, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI115511026, Length=521, Percent_Identity=24.1842610364683, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI58082049, Length=538, Percent_Identity=23.4200743494424, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI42544132, Length=529, Percent_Identity=22.4952741020794, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI38505220, Length=487, Percent_Identity=25.8726899383984, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI157311624, Length=538, Percent_Identity=23.0483271375465, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI157311622, Length=538, Percent_Identity=23.0483271375465, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI122937307, Length=520, Percent_Identity=24.0384615384615, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI28416953, Length=562, Percent_Identity=23.8434163701068, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI40807357, Length=467, Percent_Identity=24.1970021413276, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI38524616, Length=476, Percent_Identity=24.7899159663866, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI62865631, Length=283, Percent_Identity=25.4416961130742, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI13325055, Length=283, Percent_Identity=25.4416961130742, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI8923896, Length=122, Percent_Identity=34.4262295081967, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI253970489, Length=122, Percent_Identity=34.4262295081967, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786810, Length=519, Percent_Identity=27.5529865125241, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI221142682, Length=503, Percent_Identity=27.037773359841, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1788107, Length=548, Percent_Identity=27.007299270073, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI145693145, Length=531, Percent_Identity=27.4952919020716, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI1788595, Length=468, Percent_Identity=23.9316239316239, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1786801, Length=538, Percent_Identity=24.7211895910781, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790505, Length=529, Percent_Identity=24.007561436673, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786529, Length=551, Percent_Identity=22.8675136116152, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558820, Length=478, Percent_Identity=28.0334728033473, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71994694, Length=547, Percent_Identity=26.3254113345521, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71994690, Length=547, Percent_Identity=26.3254113345521, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI71994703, Length=547, Percent_Identity=26.3254113345521, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI32563687, Length=500, Percent_Identity=25.6, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17557194, Length=516, Percent_Identity=25.968992248062, Blast_Score=141, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17538037, Length=513, Percent_Identity=25.7309941520468, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17560308, Length=547, Percent_Identity=24.8628884826325, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17559526, Length=383, Percent_Identity=26.8929503916449, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17531443, Length=527, Percent_Identity=22.5806451612903, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17560140, Length=510, Percent_Identity=22.5490196078431, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71996755, Length=474, Percent_Identity=24.4725738396624, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71985884, Length=413, Percent_Identity=24.455205811138, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17564090, Length=375, Percent_Identity=23.2, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71982997, Length=371, Percent_Identity=25.3369272237197, Blast_Score=65, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6319699, Length=534, Percent_Identity=34.0823970037453, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6319264, Length=562, Percent_Identity=22.4199288256228, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320852, Length=183, Percent_Identity=28.9617486338798, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24581924, Length=544, Percent_Identity=28.3088235294118, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI18859661, Length=494, Percent_Identity=27.7327935222672, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI21355181, Length=498, Percent_Identity=23.0923694779116, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI20130357, Length=506, Percent_Identity=23.9130434782609, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24653035, Length=544, Percent_Identity=24.2647058823529, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21358303, Length=158, Percent_Identity=33.5443037974684, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648253, Length=370, Percent_Identity=25.4054054054054, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI62472339, Length=544, Percent_Identity=24.8161764705882, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24667955, Length=544, Percent_Identity=24.8161764705882, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21356947, Length=450, Percent_Identity=24.2222222222222, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24648255, Length=370, Percent_Identity=25.4054054054054, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24648257, Length=394, Percent_Identity=27.6649746192893, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19922652, Length=556, Percent_Identity=25.8992805755396, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281365686, Length=440, Percent_Identity=24.3181818181818, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355225, Length=542, Percent_Identity=23.8007380073801, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24667959, Length=378, Percent_Identity=25.3968253968254, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24648260, Length=320, Percent_Identity=25.3125, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24656500, Length=361, Percent_Identity=26.5927977839335, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI161076582, Length=552, Percent_Identity=23.731884057971, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356441, Length=337, Percent_Identity=23.1454005934718, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020459
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 55159; Mature: 55028

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASDFGPRIADLVEVAATRLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGD
CCCCCCCHHHHHHHHHHHHCCCCCEEEEEECHHEECHHHHHHHHHHHHHHHHHHCCCCCC
RVALRMGSNAEFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLIDADGPHDR
CEEEEECCCCCEEHHEECCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCCC
AEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATSTPEGLRPDDAMIMFTGGTTG
CCCCCEEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCC
LPKMVPWTHANIASSVRAIITGYRLSPRDATVAVMPLYHGHGLIASLLATLASGGAVSLP
CCCCCCCCHHHHHHHHHHHHHCCEECCCCCEEEEEEEECCCHHHHHHHHHHHCCCEEECC
ARGRFSAHTFWDDIKAVGATWYTAVPTIHQILLERSATEPSGRKPAALRFIRSCSAPLTA
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHH
QAALALQTEFAAPVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGRSTGAQIRIVG
HHHHHHHHHHCCCCCEECCCCHHHHEEEEEEECCCCCCCCCEEECCCEECCCCCEEEEEC
SDGLPLPAGAVGEIWLRGTTVVRGYLGDPTITAANFTDGWLRTGDLGSLSAAGDLSIRGR
CCCCCCCCCCCCCEEEECEEEEEEECCCCCEEEECCCCCCEECCCCCCCCCCCCCHHHHH
IKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPHQLYGEAVAAVIVPRESAPPTREE
HHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHEEEEEEEECCCCCCCHHH
LVQFCRERLAAFEIPASFQEASGLPHTAKGSLDRRAVAERFGHSV
HHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
ASDFGPRIADLVEVAATRLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGD
CCCCCCHHHHHHHHHHHHCCCCCEEEEEECHHEECHHHHHHHHHHHHHHHHHHCCCCCC
RVALRMGSNAEFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLIDADGPHDR
CEEEEECCCCCEEHHEECCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCCC
AEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATSTPEGLRPDDAMIMFTGGTTG
CCCCCEEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCC
LPKMVPWTHANIASSVRAIITGYRLSPRDATVAVMPLYHGHGLIASLLATLASGGAVSLP
CCCCCCCCHHHHHHHHHHHHHCCEECCCCCEEEEEEEECCCHHHHHHHHHHHCCCEEECC
ARGRFSAHTFWDDIKAVGATWYTAVPTIHQILLERSATEPSGRKPAALRFIRSCSAPLTA
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHH
QAALALQTEFAAPVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGRSTGAQIRIVG
HHHHHHHHHHCCCCCEECCCCHHHHEEEEEEECCCCCCCCCEEECCCEECCCCCEEEEEC
SDGLPLPAGAVGEIWLRGTTVVRGYLGDPTITAANFTDGWLRTGDLGSLSAAGDLSIRGR
CCCCCCCCCCCCCEEEECEEEEEEECCCCCEEEECCCCCCEECCCCCCCCCCCCCHHHHH
IKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPHQLYGEAVAAVIVPRESAPPTREE
HHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHEEEEEEEECCCCCCCHHH
LVQFCRERLAAFEIPASFQEASGLPHTAKGSLDRRAVAERFGHSV
HHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]