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The map label for this gene is oxc [H]

Identifier: 148659882

GI number: 148659882

Start: 143487

End: 145235

Strand: Reverse

Name: oxc [H]

Synonym: MRA_0125

Alternate gene names: 148659882

Gene position: 145235-143487 (Counterclockwise)

Preceding gene: 148659884

Following gene: 148659880

Centisome position: 3.29

GC content: 66.67

Gene sequence:

>1749_bases
ATGACCACACGATCGGCATCTCCCTGCACAGTGCTGACCGACGGCTGCCACCTGGTGGTGGACGCCCTCAAAGCCAACGA
CGTCGACACCATCTACGGCGTTGTCGGCATCCCGATCACCGACCTGGCTCGCGCCGCCCAAGCCTCGGGGATCCGCTATA
TCGGTTTCCGCCACGAAGCATCAGCGGGCAATGCGGCGGCCGCCGCGGGGTTCCTCACCGCACGGCCCGGCGTGTGTCTG
ACGACGTCCGGCCCCGGCTTTCTCAACGGCCTGCCCGCGCTGGCGAACGCCACCACGAACTGCTTCCCGATGATCCAGAT
CTCCGGATCGAGCAGCCGGCCGATGGTCGACCTGCAGCGCGGCGACTATCAGGACCTCGACCAGCTCAACGCCGCTCGAC
CGTTCGTGAAGGCGGCGTATCGGATCGGCCAAGTCCAGGACATCGGGCGCGGCGTCGCGCGCGCCATTCGCACCGCGACC
TCCGGGCGGCCCGGCGGTGTATACCTCGATATCCCCGGCGATGTGCTGGGCCAGGCCGTTGAGGCATCGGCTGCTTCCGG
CGCCATTTGGCGGCCGGTGGACCCGGCTCCCCGACTACTGCCGGCACCGGAGGCGATTGATCGCGCGCTGGACGTGCTCG
CCCAAGCGCAGCGACCGCTGCTCGTGCTCAGCAAGGGCGCGGCATATGCGCAGGCCGACAACGTTATTCGGGAGTTTGTG
GAGCACACCGGCATTCCCTTCCTGCCGATGTCGATGGCCAAGGGGCTGCTGCCCGACTCACACCCGCAGTCGGCGGCTGC
GGCTCGTTCGCTGGCGATGGCCCGCGCCGACGTGGTGCTGCTGGTTGGCGCTCGGCTGAATTGGCTACTAGGCAACGGAG
AGTCGCCGCAATGGTCGGCCGATGCCAAGTTCATCCAGGTCGATATCGAGGCGTCGGAGTTTGACAGCAACCGGCCGATC
GTGGCACCGCTGACCGGCGACATCGGCTCGGTAATGTCGGCGCTCCTCGAAGCTGCGGCCGATCGTTCGAGCGTGGCCTC
GGCGGCGTGGACCGGCGAGCTCGCCGACCGCAAGGCCCGCAACAGTGCCAAGATGCGTCGGCGGTTGGCCGACGATCATC
ATCCGATGCGGTTCTACAACGCGCTTGGTGCCATTAGGTCTGTGCTGCAACGCAACCCGGATGTCTATGTGGTCAACGAA
GGCGCCAACGCGCTGGACCTCGCCCGCAACATCATCGACATGCACCTACCGCGGCACCGGCTCGACAGCGGAACCTGGGG
CGTGATGGGCATCGGCATGGGCTACGCCATCGCGGCCGCCGTCGAGACCGGGCGACCTGTCGTGGCGATCGAGGGCGACA
GCGCATTTGGCTTCAGCGGCATGGAGTTCGAGACCATCTGCCGATACCGACTCCCGGTCACCGTCGTCATCCTCAACAAC
GGCGGCGTCTACCGCGGCGACGAGGCAACGATCTTTAGGTCGGCCGCCCCGGTGTGGCGACACGACCCAGCGCCCACCGT
GCTGAACGCTCATGCACGTCACGAACTGATCGCAGAGGCGTTCGGCGGCAAAGGATATCACGTAAGCACCCCAACCGAAC
TGGAGTCGGCGCTGACCGATGCACTGGCATCGAACGGACCGTCACTCATCGACTGCGAACTCGACCCTGCAGACGGGGTG
GAGAGCGGCCACCTGGCGAAGCTGAACACTACCAGCGCAGCGACGCCCGCGATCAGCGGCGACGGGTGA

Upstream 100 bases:

>100_bases
GCGTCCAATACCGATCCGCTAACGGTTGATAGACCGCGTAAATCGCTGCATAGTGACTCGGTCTTGGACACGGCCGGCGC
CCCGGACAACAGTGAACACC

Downstream 100 bases:

>100_bases
TCCCCCGCAGCTGCGTGTCAAAGAATTCGTTCAGCGCCAGCGCCTGCGCGCATGTTATGAGCGCTCGGGCAACCGGAGAT
CCCGGTCCCAAGGCGTTGGT

Product: putative oxalyl-CoA decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 582; Mature: 581

Protein sequence:

>582_residues
MTTRSASPCTVLTDGCHLVVDALKANDVDTIYGVVGIPITDLARAAQASGIRYIGFRHEASAGNAAAAAGFLTARPGVCL
TTSGPGFLNGLPALANATTNCFPMIQISGSSSRPMVDLQRGDYQDLDQLNAARPFVKAAYRIGQVQDIGRGVARAIRTAT
SGRPGGVYLDIPGDVLGQAVEASAASGAIWRPVDPAPRLLPAPEAIDRALDVLAQAQRPLLVLSKGAAYAQADNVIREFV
EHTGIPFLPMSMAKGLLPDSHPQSAAAARSLAMARADVVLLVGARLNWLLGNGESPQWSADAKFIQVDIEASEFDSNRPI
VAPLTGDIGSVMSALLEAAADRSSVASAAWTGELADRKARNSAKMRRRLADDHHPMRFYNALGAIRSVLQRNPDVYVVNE
GANALDLARNIIDMHLPRHRLDSGTWGVMGIGMGYAIAAAVETGRPVVAIEGDSAFGFSGMEFETICRYRLPVTVVILNN
GGVYRGDEATIFRSAAPVWRHDPAPTVLNAHARHELIAEAFGGKGYHVSTPTELESALTDALASNGPSLIDCELDPADGV
ESGHLAKLNTTSAATPAISGDG

Sequences:

>Translated_582_residues
MTTRSASPCTVLTDGCHLVVDALKANDVDTIYGVVGIPITDLARAAQASGIRYIGFRHEASAGNAAAAAGFLTARPGVCL
TTSGPGFLNGLPALANATTNCFPMIQISGSSSRPMVDLQRGDYQDLDQLNAARPFVKAAYRIGQVQDIGRGVARAIRTAT
SGRPGGVYLDIPGDVLGQAVEASAASGAIWRPVDPAPRLLPAPEAIDRALDVLAQAQRPLLVLSKGAAYAQADNVIREFV
EHTGIPFLPMSMAKGLLPDSHPQSAAAARSLAMARADVVLLVGARLNWLLGNGESPQWSADAKFIQVDIEASEFDSNRPI
VAPLTGDIGSVMSALLEAAADRSSVASAAWTGELADRKARNSAKMRRRLADDHHPMRFYNALGAIRSVLQRNPDVYVVNE
GANALDLARNIIDMHLPRHRLDSGTWGVMGIGMGYAIAAAVETGRPVVAIEGDSAFGFSGMEFETICRYRLPVTVVILNN
GGVYRGDEATIFRSAAPVWRHDPAPTVLNAHARHELIAEAFGGKGYHVSTPTELESALTDALASNGPSLIDCELDPADGV
ESGHLAKLNTTSAATPAISGDG
>Mature_581_residues
TTRSASPCTVLTDGCHLVVDALKANDVDTIYGVVGIPITDLARAAQASGIRYIGFRHEASAGNAAAAAGFLTARPGVCLT
TSGPGFLNGLPALANATTNCFPMIQISGSSSRPMVDLQRGDYQDLDQLNAARPFVKAAYRIGQVQDIGRGVARAIRTATS
GRPGGVYLDIPGDVLGQAVEASAASGAIWRPVDPAPRLLPAPEAIDRALDVLAQAQRPLLVLSKGAAYAQADNVIREFVE
HTGIPFLPMSMAKGLLPDSHPQSAAAARSLAMARADVVLLVGARLNWLLGNGESPQWSADAKFIQVDIEASEFDSNRPIV
APLTGDIGSVMSALLEAAADRSSVASAAWTGELADRKARNSAKMRRRLADDHHPMRFYNALGAIRSVLQRNPDVYVVNEG
ANALDLARNIIDMHLPRHRLDSGTWGVMGIGMGYAIAAAVETGRPVVAIEGDSAFGFSGMEFETICRYRLPVTVVILNNG
GVYRGDEATIFRSAAPVWRHDPAPTVLNAHARHELIAEAFGGKGYHVSTPTELESALTDALASNGPSLIDCELDPADGVE
SGHLAKLNTTSAATPAISGDG

Specific function: Oxalic acid catabolism; second step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=559, Percent_Identity=41.5026833631485, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI21361361, Length=505, Percent_Identity=29.9009900990099, Blast_Score=184, Evalue=2e-46,
Organism=Escherichia coli, GI1788716, Length=563, Percent_Identity=59.6802841918295, Blast_Score=666, Evalue=0.0,
Organism=Escherichia coli, GI87081685, Length=577, Percent_Identity=26.8630849220104, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1790104, Length=559, Percent_Identity=25.2236135957066, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI1786717, Length=549, Percent_Identity=26.5938069216758, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1787096, Length=545, Percent_Identity=25.1376146788991, Blast_Score=99, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17531301, Length=553, Percent_Identity=39.0596745027125, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17531299, Length=553, Percent_Identity=39.0596745027125, Blast_Score=371, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17542570, Length=574, Percent_Identity=28.397212543554, Blast_Score=188, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6320816, Length=552, Percent_Identity=33.3333333333333, Blast_Score=296, Evalue=8e-81,
Organism=Saccharomyces cerevisiae, GI6323755, Length=590, Percent_Identity=23.8983050847458, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI19922626, Length=558, Percent_Identity=38.8888888888889, Blast_Score=411, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017660
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.8 [H]

Molecular weight: Translated: 61172; Mature: 61041

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRSASPCTVLTDGCHLVVDALKANDVDTIYGVVGIPITDLARAAQASGIRYIGFRHEA
CCCCCCCCCEEEECCCEEEHHHHHCCCCHHHHEEECCCHHHHHHHHHHCCEEEEEEEECC
SAGNAAAAAGFLTARPGVCLTTSGPGFLNGLPALANATTNCFPMIQISGSSSRPMVDLQR
CCCCHHHHHHHEECCCCEEEEECCCCHHCCCCHHHCCCCCCEEEEEECCCCCCCEEEECC
GDYQDLDQLNAARPFVKAAYRIGQVQDIGRGVARAIRTATSGRPGGVYLDIPGDVLGQAV
CCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHH
EASAASGAIWRPVDPAPRLLPAPEAIDRALDVLAQAQRPLLVLSKGAAYAQADNVIREFV
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHH
EHTGIPFLPMSMAKGLLPDSHPQSAAAARSLAMARADVVLLVGARLNWLLGNGESPQWSA
HHCCCCEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHCEEEEECCCEEEEECCCCCCCCCC
DAKFIQVDIEASEFDSNRPIVAPLTGDIGSVMSALLEAAADRSSVASAAWTGELADRKAR
CCEEEEEEEEHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHH
NSAKMRRRLADDHHPMRFYNALGAIRSVLQRNPDVYVVNEGANALDLARNIIDMHLPRHR
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCHHH
LDSGTWGVMGIGMGYAIAAAVETGRPVVAIEGDSAFGFSGMEFETICRYRLPVTVVILNN
CCCCCCEEEECCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHEEECCEEEEEECC
GGVYRGDEATIFRSAAPVWRHDPAPTVLNAHARHELIAEAFGGKGYHVSTPTELESALTD
CCEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHH
ALASNGPSLIDCELDPADGVESGHLAKLNTTSAATPAISGDG
HHHCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TTRSASPCTVLTDGCHLVVDALKANDVDTIYGVVGIPITDLARAAQASGIRYIGFRHEA
CCCCCCCCEEEECCCEEEHHHHHCCCCHHHHEEECCCHHHHHHHHHHCCEEEEEEEECC
SAGNAAAAAGFLTARPGVCLTTSGPGFLNGLPALANATTNCFPMIQISGSSSRPMVDLQR
CCCCHHHHHHHEECCCCEEEEECCCCHHCCCCHHHCCCCCCEEEEEECCCCCCCEEEECC
GDYQDLDQLNAARPFVKAAYRIGQVQDIGRGVARAIRTATSGRPGGVYLDIPGDVLGQAV
CCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHH
EASAASGAIWRPVDPAPRLLPAPEAIDRALDVLAQAQRPLLVLSKGAAYAQADNVIREFV
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHH
EHTGIPFLPMSMAKGLLPDSHPQSAAAARSLAMARADVVLLVGARLNWLLGNGESPQWSA
HHCCCCEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHCEEEEECCCEEEEECCCCCCCCCC
DAKFIQVDIEASEFDSNRPIVAPLTGDIGSVMSALLEAAADRSSVASAAWTGELADRKAR
CCEEEEEEEEHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHH
NSAKMRRRLADDHHPMRFYNALGAIRSVLQRNPDVYVVNEGANALDLARNIIDMHLPRHR
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCHHH
LDSGTWGVMGIGMGYAIAAAVETGRPVVAIEGDSAFGFSGMEFETICRYRLPVTVVILNN
CCCCCCEEEECCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHEEECCEEEEEECC
GGVYRGDEATIFRSAAPVWRHDPAPTVLNAHARHELIAEAFGGKGYHVSTPTELESALTD
CCEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHH
ALASNGPSLIDCELDPADGVESGHLAKLNTTSAATPAISGDG
HHHCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]