Click here to switch to the map view.

The map label for this gene is cls [H]

Identifier: 148652674

GI number: 148652674

Start: 1023457

End: 1025226

Strand: Direct

Name: cls [H]

Synonym: PsycPRwf_0865

Alternate gene names: 148652674

Gene position: 1023457-1025226 (Clockwise)

Preceding gene: 148652673

Following gene: 148652675

Centisome position: 34.36

GC content: 45.99

Gene sequence:

>1770_bases
ATGACTCGCTTTATTTTTGTCCCTGCGACATCGACTTCCACGTATCCGGCTTTAAGCGAAGAGCTTGAGGCGGCATCTGT
GTGGCTACAGACCGTGTCGGCGGGCGACTGGGCTTGGCTTGGGGTCGCTATTCATATCACCCTAACGGTGTTTATGATCG
TGCGTATCTTATCTACTCAGCGCAATAATGGGATTGCCATTGCGTGGTTGGTATTGTTATTTGCCATCCCTTTTTTGAGT
ATTATTGCTTATGTCTTGGTGGGTGAACCCTATTTGGGCAAAAGCTATAAATCACGTAACTCACAAGCCCAAAAAATGCT
AAAGGCTGTCGCCAAACGTGAAGCGATTCAGTTGGCCAAAGTCGATGATACCTTGCCGCAGCGCTATCAAGGAGTCAGTC
GTATTGGTACTTTTGATACTGGATTTGGGGTGTATGATAAGCACAAGATGCAGCTACTGACCTCAGCACAGGCCACATTT
GAGTCGCTAATTTCTGATATTAACCATGCCACCACCTTAATTTTGATGGAGTTTTATATCATCTATCCCAAAGGCCGGGT
CCAAGAGGTCTTTGAGGCTTTAATTGCCGCAGCACACAGAGGCGTGGAGTGTCAGATATTAGCAGATAGTGTGGGCAGCT
TTAGCTTCTTTACCGATGACTGGCATAAGCGGCTAACGCAAGCAGGTGTGACCATCCATCAGTCGCTGCCAGTGGGGTTA
TTTAAGACCTTATTTAAACGTACGGATCTACGCAATCACCGCAAGATTGTGGTTATAGATGATGATATTGGCTATACCGG
TAGCTTCAACTTGGTTGATCCTGAGTTTTTTAAACAAGACAAGGCGGTAGGTCAGTGGATTGACTTAATTATGCGCATTG
AAAGTGAGAAATCGGTAAGTGTGGTGACCGCTTTGGCCGCAGTGAATGTGACTGATATTGGTGCTGAGAGCCTAACTAAT
TTAAAAGAGCTTGGCTTGCGCATTGATAACAATATTAATATTTATACACGCAAACTGTATCGTCCCAAGCCGGCCATTAA
TGATATAAATGATAAGGCATCGGGTTATCTATCGCGGCAAATCGCCTCTTTTAACTTAAGTGATGAATATGGTCATGACT
TTAAGGCCTCTGATCAAAAAGTACAGGAGGGGGCAGACGAGAGGTTGCCGCAGAAGCTGGCAGGCTATATGCAGCAAATT
GCCAACTTGCCAGCAATAGATAATGTCATGGCGCAGCTCATTCCTTCAGCGCCGCGCATTACAGAGCATGTGATTTATAA
CACCTTATTGACTGTGTTTCACCGCGCAGATCGACGCATTCAAATTACCACCCCCTATTTTGTCCCTGATGAGGCGCTGT
TAGCGGCGTTAACTACCGCGGCAAAACGAGGCGTGGAGGTGACCTTAATTTTACCCAAAAAGGTCGACTCGTTTTTTGTG
CAGCATGCCTCACAAGCGTCGTACTCTATTTTGATGGAGGCTGGGGTTAATATTGCCTTATTTAATGGCGGTTTGTTGCA
TGCAAAGACGGTGGTGATTGATGATGACTACTGCTTATTTGGCACCGTCAATATGGACATGCGCAGCTTTTATCTGAATA
TGGAGATTAGCTTAGCGCTTTATACCCCAAGTATTGTGGCACAAGTGGTGCGCTGCCAGCAGGCGTATTTGACCCAGTGT
GAGATGCTGGATCTGGCACACTGGGAGAGTCGGCCGACTTATAAGCGTTTATTTGATTCGGGCATACGTTTGTTTAGCCC
GTTATTGTAG

Upstream 100 bases:

>100_bases
GCAGTGTTGGCATTGTTAACCACAAACGAGTAATCTATCTCACTTTAATCTTGAATAGTACTTCTTCTTTTAACGGCATT
AATTTTTTAGACACTCGACC

Downstream 100 bases:

>100_bases
ATATATTATTGATAGCAATCGCTATTTTAAACATTTTAAATGGGGTAAAATAACGCCTATTTTTTCCGCCATTGGTTTTA
TTTCTTTTTATAAGGTGATA

Product: cardiolipin synthetase

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 589; Mature: 588

Protein sequence:

>589_residues
MTRFIFVPATSTSTYPALSEELEAASVWLQTVSAGDWAWLGVAIHITLTVFMIVRILSTQRNNGIAIAWLVLLFAIPFLS
IIAYVLVGEPYLGKSYKSRNSQAQKMLKAVAKREAIQLAKVDDTLPQRYQGVSRIGTFDTGFGVYDKHKMQLLTSAQATF
ESLISDINHATTLILMEFYIIYPKGRVQEVFEALIAAAHRGVECQILADSVGSFSFFTDDWHKRLTQAGVTIHQSLPVGL
FKTLFKRTDLRNHRKIVVIDDDIGYTGSFNLVDPEFFKQDKAVGQWIDLIMRIESEKSVSVVTALAAVNVTDIGAESLTN
LKELGLRIDNNINIYTRKLYRPKPAINDINDKASGYLSRQIASFNLSDEYGHDFKASDQKVQEGADERLPQKLAGYMQQI
ANLPAIDNVMAQLIPSAPRITEHVIYNTLLTVFHRADRRIQITTPYFVPDEALLAALTTAAKRGVEVTLILPKKVDSFFV
QHASQASYSILMEAGVNIALFNGGLLHAKTVVIDDDYCLFGTVNMDMRSFYLNMEISLALYTPSIVAQVVRCQQAYLTQC
EMLDLAHWESRPTYKRLFDSGIRLFSPLL

Sequences:

>Translated_589_residues
MTRFIFVPATSTSTYPALSEELEAASVWLQTVSAGDWAWLGVAIHITLTVFMIVRILSTQRNNGIAIAWLVLLFAIPFLS
IIAYVLVGEPYLGKSYKSRNSQAQKMLKAVAKREAIQLAKVDDTLPQRYQGVSRIGTFDTGFGVYDKHKMQLLTSAQATF
ESLISDINHATTLILMEFYIIYPKGRVQEVFEALIAAAHRGVECQILADSVGSFSFFTDDWHKRLTQAGVTIHQSLPVGL
FKTLFKRTDLRNHRKIVVIDDDIGYTGSFNLVDPEFFKQDKAVGQWIDLIMRIESEKSVSVVTALAAVNVTDIGAESLTN
LKELGLRIDNNINIYTRKLYRPKPAINDINDKASGYLSRQIASFNLSDEYGHDFKASDQKVQEGADERLPQKLAGYMQQI
ANLPAIDNVMAQLIPSAPRITEHVIYNTLLTVFHRADRRIQITTPYFVPDEALLAALTTAAKRGVEVTLILPKKVDSFFV
QHASQASYSILMEAGVNIALFNGGLLHAKTVVIDDDYCLFGTVNMDMRSFYLNMEISLALYTPSIVAQVVRCQQAYLTQC
EMLDLAHWESRPTYKRLFDSGIRLFSPLL
>Mature_588_residues
TRFIFVPATSTSTYPALSEELEAASVWLQTVSAGDWAWLGVAIHITLTVFMIVRILSTQRNNGIAIAWLVLLFAIPFLSI
IAYVLVGEPYLGKSYKSRNSQAQKMLKAVAKREAIQLAKVDDTLPQRYQGVSRIGTFDTGFGVYDKHKMQLLTSAQATFE
SLISDINHATTLILMEFYIIYPKGRVQEVFEALIAAAHRGVECQILADSVGSFSFFTDDWHKRLTQAGVTIHQSLPVGLF
KTLFKRTDLRNHRKIVVIDDDIGYTGSFNLVDPEFFKQDKAVGQWIDLIMRIESEKSVSVVTALAAVNVTDIGAESLTNL
KELGLRIDNNINIYTRKLYRPKPAINDINDKASGYLSRQIASFNLSDEYGHDFKASDQKVQEGADERLPQKLAGYMQQIA
NLPAIDNVMAQLIPSAPRITEHVIYNTLLTVFHRADRRIQITTPYFVPDEALLAALTTAAKRGVEVTLILPKKVDSFFVQ
HASQASYSILMEAGVNIALFNGGLLHAKTVVIDDDYCLFGTVNMDMRSFYLNMEISLALYTPSIVAQVVRCQQAYLTQCE
MLDLAHWESRPTYKRLFDSGIRLFSPLL

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=566, Percent_Identity=33.5689045936396, Blast_Score=310, Evalue=2e-85,
Organism=Escherichia coli, GI1787007, Length=112, Percent_Identity=31.25, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 66006; Mature: 65875

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRFIFVPATSTSTYPALSEELEAASVWLQTVSAGDWAWLGVAIHITLTVFMIVRILSTQ
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
RNNGIAIAWLVLLFAIPFLSIIAYVLVGEPYLGKSYKSRNSQAQKMLKAVAKREAIQLAK
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHH
VDDTLPQRYQGVSRIGTFDTGFGVYDKHKMQLLTSAQATFESLISDINHATTLILMEFYI
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYPKGRVQEVFEALIAAAHRGVECQILADSVGSFSFFTDDWHKRLTQAGVTIHQSLPVGL
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCEEECCCCHHH
FKTLFKRTDLRNHRKIVVIDDDIGYTGSFNLVDPEFFKQDKAVGQWIDLIMRIESEKSVS
HHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHH
VVTALAAVNVTDIGAESLTNLKELGLRIDNNINIYTRKLYRPKPAINDINDKASGYLSRQ
HHHHHHHHCHHHCCHHHHHHHHHCCCEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
IASFNLSDEYGHDFKASDQKVQEGADERLPQKLAGYMQQIANLPAIDNVMAQLIPSAPRI
HHCCCCCHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHH
TEHVIYNTLLTVFHRADRRIQITTPYFVPDEALLAALTTAAKRGVEVTLILPKKVDSFFV
HHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHH
QHASQASYSILMEAGVNIALFNGGLLHAKTVVIDDDYCLFGTVNMDMRSFYLNMEISLAL
HHHCCHHHHHHHHCCCEEEEECCCEEEEEEEEEECCEEEEEEECCCCEEEEEEEEEEEEE
YTPSIVAQVVRCQQAYLTQCEMLDLAHWESRPTYKRLFDSGIRLFSPLL
ECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRFIFVPATSTSTYPALSEELEAASVWLQTVSAGDWAWLGVAIHITLTVFMIVRILSTQ
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
RNNGIAIAWLVLLFAIPFLSIIAYVLVGEPYLGKSYKSRNSQAQKMLKAVAKREAIQLAK
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHH
VDDTLPQRYQGVSRIGTFDTGFGVYDKHKMQLLTSAQATFESLISDINHATTLILMEFYI
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYPKGRVQEVFEALIAAAHRGVECQILADSVGSFSFFTDDWHKRLTQAGVTIHQSLPVGL
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCEEECCCCHHH
FKTLFKRTDLRNHRKIVVIDDDIGYTGSFNLVDPEFFKQDKAVGQWIDLIMRIESEKSVS
HHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHH
VVTALAAVNVTDIGAESLTNLKELGLRIDNNINIYTRKLYRPKPAINDINDKASGYLSRQ
HHHHHHHHCHHHCCHHHHHHHHHCCCEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
IASFNLSDEYGHDFKASDQKVQEGADERLPQKLAGYMQQIANLPAIDNVMAQLIPSAPRI
HHCCCCCHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHH
TEHVIYNTLLTVFHRADRRIQITTPYFVPDEALLAALTTAAKRGVEVTLILPKKVDSFFV
HHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHH
QHASQASYSILMEAGVNIALFNGGLLHAKTVVIDDDYCLFGTVNMDMRSFYLNMEISLAL
HHHCCHHHHHHHHCCCEEEEECCCEEEEEEEEEECCEEEEEEECCCCEEEEEEEEEEEEE
YTPSIVAQVVRCQQAYLTQCEMLDLAHWESRPTYKRLFDSGIRLFSPLL
ECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA