BacMap

Definition	Psychrobacter sp. PRwf-1 chromosome, complete genome.
Accession	NC_009524
Length	2,978,976

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The map label for this gene is fabG2 [H]

Identifier: 148652672

GI number: 148652672

Start: 1021247

End: 1022023

Strand: Direct

Name: fabG2 [H]

Synonym: PsycPRwf_0863

Alternate gene names: 148652672

Gene position: 1021247-1022023 (Clockwise)

Preceding gene: 148652671

Following gene: 148652673

Centisome position: 34.28

GC content: 49.29

Gene sequence:

>777_bases
ATGAAGATTGCATCACAAGCTTTTATCGTAACCGGCGGCGCTTCAGGATTGGGTGCGGCCACCACACGTGAATTGGTCCA
ACGCGGTGCCAAAGTGGTTGTTGCAGATCTAAATGCACAAGCCGGTGAGGCACTGGTTAGCGAGCTTGGTGACAGTGTGC
GCTTTGTGGCCTGTGATATTACAAAAAGTGAAGATGTGGAGCATGCCGTACAGACTGCCGAAAAAGAGTTTGGCGGGCTA
GCTGGCAGTATCAACTGTGCTGGTATCGCTATCGTTCAAAAGCTGCTTGATCGTGATAATAACCCTGCTGACCTTGAGCA
GTTTAACAAAGGGGTTCAGGTCAATTTGATCGGTAGCTTTAATGTGGCGCGCTTAGTGGCAGCAAGTATTGCCAAACGTG
TGGCGGCCAGCGGCGGTCCTAACAATGAAGATCAAGGTATTATTATCAATACCGCATCTATCGCCGCCTTTGATGGCCAA
GTGGGACAAGGCAGCTATGCCTCCTCAAAATCTGGGGTAGTGGGCTTGACCCTGCCTTTGGCACGTGAGCTGACTCGCCA
TGGTATTCGTGTGATGACCATTGCACCAGGTATTTTTGAAACCCCCATGATGGCAGGTTTACCAGAAAAGGCGCAAGAGC
AGCTTAAAGCAAGCGTACCTTATCCTAAACGTTTGGGCATGCCTGCAGAGTACGCCAATTTGGTCGCTCATATTATTGAA
AATGCCTACCTTAATGGTGAGGTAATTCGTCTTGATGGTGCCATTCGTATGACCTAA

Upstream 100 bases:

>100_bases
AATTGATAAATATGACTAAACCTGTTTAAATAAATGCTAAAGTTGTTTGACTGTTTGTTCGAGTAATAACTCATAATTTA
ACCATAAAAAAGGATTTTAA

Downstream 100 bases:

>100_bases
TAGGCGATGATAATGAGCGTCTAAAATTAGCCCAGTGTCGATAATAAGCTGTCTTCTTAACCGAAGGCGGCTTTTTTTGT
GTGTTAAGGGGTTCACTTAC

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MKIASQAFIVTGGASGLGAATTRELVQRGAKVVVADLNAQAGEALVSELGDSVRFVACDITKSEDVEHAVQTAEKEFGGL
AGSINCAGIAIVQKLLDRDNNPADLEQFNKGVQVNLIGSFNVARLVAASIAKRVAASGGPNNEDQGIIINTASIAAFDGQ
VGQGSYASSKSGVVGLTLPLARELTRHGIRVMTIAPGIFETPMMAGLPEKAQEQLKASVPYPKRLGMPAEYANLVAHIIE
NAYLNGEVIRLDGAIRMT

Sequences:

>Translated_258_residues
MKIASQAFIVTGGASGLGAATTRELVQRGAKVVVADLNAQAGEALVSELGDSVRFVACDITKSEDVEHAVQTAEKEFGGL
AGSINCAGIAIVQKLLDRDNNPADLEQFNKGVQVNLIGSFNVARLVAASIAKRVAASGGPNNEDQGIIINTASIAAFDGQ
VGQGSYASSKSGVVGLTLPLARELTRHGIRVMTIAPGIFETPMMAGLPEKAQEQLKASVPYPKRLGMPAEYANLVAHIIE
NAYLNGEVIRLDGAIRMT
>Mature_258_residues
MKIASQAFIVTGGASGLGAATTRELVQRGAKVVVADLNAQAGEALVSELGDSVRFVACDITKSEDVEHAVQTAEKEFGGL
AGSINCAGIAIVQKLLDRDNNPADLEQFNKGVQVNLIGSFNVARLVAASIAKRVAASGGPNNEDQGIIINTASIAAFDGQ
VGQGSYASSKSGVVGLTLPLARELTRHGIRVMTIAPGIFETPMMAGLPEKAQEQLKASVPYPKRLGMPAEYANLVAHIIE
NAYLNGEVIRLDGAIRMT

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=250, Percent_Identity=52, Blast_Score=250, Evalue=7e-67,
Organism=Homo sapiens, GI83715985, Length=251, Percent_Identity=49.003984063745, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI40254992, Length=248, Percent_Identity=31.0483870967742, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI15277342, Length=270, Percent_Identity=30.7407407407407, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI32483357, Length=259, Percent_Identity=30.1158301158301, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI31542939, Length=266, Percent_Identity=27.0676691729323, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI59889578, Length=221, Percent_Identity=28.5067873303167, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI40548397, Length=201, Percent_Identity=30.8457711442786, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI214010158, Length=201, Percent_Identity=30.8457711442786, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI214010156, Length=201, Percent_Identity=30.8457711442786, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI22758144, Length=201, Percent_Identity=30.8457711442786, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI19743808, Length=245, Percent_Identity=28.9795918367347, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI150247226, Length=198, Percent_Identity=30.8080808080808, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI19923817, Length=267, Percent_Identity=26.9662921348315, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4504505, Length=239, Percent_Identity=29.2887029288703, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI22507405, Length=245, Percent_Identity=25.3061224489796, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI210032110, Length=205, Percent_Identity=25.3658536585366, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI126723750, Length=261, Percent_Identity=27.5862068965517, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI224922801, Length=182, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI50726952, Length=206, Percent_Identity=28.6407766990291, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=261, Percent_Identity=30.2681992337165, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082100, Length=265, Percent_Identity=26.4150943396226, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1790717, Length=261, Percent_Identity=27.9693486590038, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789208, Length=252, Percent_Identity=28.968253968254, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI2367175, Length=253, Percent_Identity=28.8537549407115, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787905, Length=262, Percent_Identity=28.2442748091603, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082160, Length=252, Percent_Identity=26.984126984127, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789378, Length=260, Percent_Identity=26.9230769230769, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789057, Length=272, Percent_Identity=27.2058823529412, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787820, Length=190, Percent_Identity=25.2631578947368, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=250, Percent_Identity=44.8, Blast_Score=211, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=33.0708661417323, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17555706, Length=263, Percent_Identity=33.8403041825095, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17563726, Length=277, Percent_Identity=27.7978339350181, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17561402, Length=265, Percent_Identity=28.3018867924528, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17567345, Length=205, Percent_Identity=29.2682926829268, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=275, Percent_Identity=26.1818181818182, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=275, Percent_Identity=24.7272727272727, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=210, Percent_Identity=26.1904761904762, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17507613, Length=214, Percent_Identity=28.0373831775701, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI32563809, Length=214, Percent_Identity=28.0373831775701, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI115534660, Length=205, Percent_Identity=25.8536585365854, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=270, Percent_Identity=23.3333333333333, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=225, Percent_Identity=26.2222222222222, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=273, Percent_Identity=25.6410256410256, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=273, Percent_Identity=26.3736263736264, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320089, Length=211, Percent_Identity=27.4881516587678, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322861, Length=208, Percent_Identity=33.1730769230769, Blast_Score=79, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6324126, Length=260, Percent_Identity=28.0769230769231, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI17737361, Length=251, Percent_Identity=51.792828685259, Blast_Score=259, Evalue=9e-70,
Organism=Drosophila melanogaster, GI24639444, Length=262, Percent_Identity=32.824427480916, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI21355319, Length=262, Percent_Identity=27.0992366412214, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI221331218, Length=207, Percent_Identity=28.0193236714976, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24665243, Length=207, Percent_Identity=28.0193236714976, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI23397609, Length=261, Percent_Identity=27.2030651340996, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221331216, Length=208, Percent_Identity=28.3653846153846, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24665247, Length=208, Percent_Identity=28.3653846153846, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356301, Length=208, Percent_Identity=27.8846153846154, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24663911, Length=229, Percent_Identity=25.764192139738, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28571387, Length=217, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 26897; Mature: 26897

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIASQAFIVTGGASGLGAATTRELVQRGAKVVVADLNAQAGEALVSELGDSVRFVACDI
CCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCEEEEEEEC
TKSEDVEHAVQTAEKEFGGLAGSINCAGIAIVQKLLDRDNNPADLEQFNKGVQVNLIGSF
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCEEEEEEECC
NVARLVAASIAKRVAASGGPNNEDQGIIINTASIAAFDGQVGQGSYASSKSGVVGLTLPL
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECEEEEECCCCCCCCCCCCCCCEEEEEHHH
ARELTRHGIRVMTIAPGIFETPMMAGLPEKAQEQLKASVPYPKRLGMPAEYANLVAHIIE
HHHHHHCCEEEEEECCCHHHCCHHCCCCHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHH
NAYLNGEVIRLDGAIRMT
HHCCCCEEEEECCEEECC
>Mature Secondary Structure
MKIASQAFIVTGGASGLGAATTRELVQRGAKVVVADLNAQAGEALVSELGDSVRFVACDI
CCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCEEEEEEEC
TKSEDVEHAVQTAEKEFGGLAGSINCAGIAIVQKLLDRDNNPADLEQFNKGVQVNLIGSF
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCEEEEEEECC
NVARLVAASIAKRVAASGGPNNEDQGIIINTASIAAFDGQVGQGSYASSKSGVVGLTLPL
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECEEEEECCCCCCCCCCCCCCCEEEEEHHH
ARELTRHGIRVMTIAPGIFETPMMAGLPEKAQEQLKASVPYPKRLGMPAEYANLVAHIIE
HHHHHHCCEEEEEECCCHHHCCHHCCCCHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHH
NAYLNGEVIRLDGAIRMT
HHCCCCEEEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]