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The map label for this gene is lysA [H]

Identifier: 148652160

GI number: 148652160

Start: 419924

End: 421261

Strand: Direct

Name: lysA [H]

Synonym: PsycPRwf_0348

Alternate gene names: 148652160

Gene position: 419924-421261 (Clockwise)

Preceding gene: 148652159

Following gene: 148652161

Centisome position: 14.1

GC content: 48.06

Gene sequence:

>1338_bases
ATGAGCAACCCCGACTTATCTCAAGCCGCCGTACAACATAGCGAATCTGGTCTACGCATCAATCCTGAAGTCTTTGTCAA
AAAACTGCCCACTTTAAGCTATCAGCAAGGGACCTTGTTTGTGGAGCAAGCCTCTGTACAGCAGTTGGCTGAGCAGTATG
GTACGCCTTTGTATGTGTATTCAAAGCAGGCAATTTTGGATGCTTATACGGCATACACTACCAGTTTTGCAGCCATTGAC
CATCAGGTCTGCTATGCGGTCAAAGCCAACTCAAACTTAGCGGTGTTGTCAGTATTGGCCAAAGCCGGTGCAGGCTTTGA
TTTGGTGTCCTCAGGGGAGCTGGCTCGAGTACTGGCCGTGGGCGCTGACCCCAGTAAAATTGTATTCTCAGGTGTGGGCA
AAACCGTCACTGAACTCACAGCGGCGCTTAAAGCAGGTATTGGCTGCTTTAACGTAGAGTCATTAAGTGAGCTTGATACG
CTAAATGCGGTGGCAGCAGAGCTGAATGTTAAGGCGCCGATCTCCATTCGGGTCAACCCAGATGTCGATGCCAAAACCCA
TCCTTATATTTCAACCGGCCTAAAAGACAATAAATTTGGTATCAGTCATGACATCGCTGTGGCAGCATATCAACATGCCG
CAAGCTTAGAGCACTTACAGATTGTCGGTATTGACTGCCATATTGGCTCACAGTTGACCGAAATTGATCCGTTTGTGGCC
GCTTTGGATAAGGTGTGTGAGCTGATTGAAGCGCTCAAACAAGTAGGTATTGAGCTACAGCACATTGATTTGGGCGGTGG
TTTGGGCGTTATCTATATTGATGAAGAGGTGGCTAAGGTCAGTGAGTTTGCCGCCGCTTTATTACCAAAACTACAAGAGC
TTGGGTTAAAAGTATTTTTTGAGCCGGGTCGCAGTATTGTTGCCAACGCTGGCATGCTGGTTACCAAGGTTGAGGTGTTA
AAACCCACTGAGCATAGAGACTTTGCTATTGTTGATGCGGCCATGAATGATTTAATTCGTCCAGCGCTGTATCAAGCCGA
AATGGCGGTCATTCCGGTACAAACAGCGTCGCAAGCATCACAGAAGAGCTGGGATATTGTCGGTGCTGTGTGCGAAACCG
GCGACTTTTTGGCCAAAAAACGTCTGTTAAGCCTAGCGGTTGGCGATATCTTGGCCATTACTGGTGCTGGCGCTTATGGC
TTTGTGATGAGTAGCAACTACAATTCGCGCCCACGTCCTGCTGAAGTTATGGTGTCAGGGGATAAGCACCAAGTGGTACG
CGCCCGTGAGACCGTAGCACAGTTATTTGAGACGGAATCAACGTTTGATATAGATTAA

Upstream 100 bases:

>100_bases
TGGGTGCACCGCTTTACCTGTTTTGACATTAATGGTTTAATAAGTTGATTAAACTGCTTTTTTGTTGATTTATACTCTCT
GACTTGGACACCTTTATATT

Downstream 100 bases:

>100_bases
GTCATCAACGCATTAAAAAAATTAATCATAATTATCTGCTCAACGTGCATTGATAATTGACAAAAAAACCTGCATTTACT
GTGCAGGTTTTTTTATTTTT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSNPDLSQAAVQHSESGLRINPEVFVKKLPTLSYQQGTLFVEQASVQQLAEQYGTPLYVYSKQAILDAYTAYTTSFAAID
HQVCYAVKANSNLAVLSVLAKAGAGFDLVSSGELARVLAVGADPSKIVFSGVGKTVTELTAALKAGIGCFNVESLSELDT
LNAVAAELNVKAPISIRVNPDVDAKTHPYISTGLKDNKFGISHDIAVAAYQHAASLEHLQIVGIDCHIGSQLTEIDPFVA
ALDKVCELIEALKQVGIELQHIDLGGGLGVIYIDEEVAKVSEFAAALLPKLQELGLKVFFEPGRSIVANAGMLVTKVEVL
KPTEHRDFAIVDAAMNDLIRPALYQAEMAVIPVQTASQASQKSWDIVGAVCETGDFLAKKRLLSLAVGDILAITGAGAYG
FVMSSNYNSRPRPAEVMVSGDKHQVVRARETVAQLFETESTFDID

Sequences:

>Translated_445_residues
MSNPDLSQAAVQHSESGLRINPEVFVKKLPTLSYQQGTLFVEQASVQQLAEQYGTPLYVYSKQAILDAYTAYTTSFAAID
HQVCYAVKANSNLAVLSVLAKAGAGFDLVSSGELARVLAVGADPSKIVFSGVGKTVTELTAALKAGIGCFNVESLSELDT
LNAVAAELNVKAPISIRVNPDVDAKTHPYISTGLKDNKFGISHDIAVAAYQHAASLEHLQIVGIDCHIGSQLTEIDPFVA
ALDKVCELIEALKQVGIELQHIDLGGGLGVIYIDEEVAKVSEFAAALLPKLQELGLKVFFEPGRSIVANAGMLVTKVEVL
KPTEHRDFAIVDAAMNDLIRPALYQAEMAVIPVQTASQASQKSWDIVGAVCETGDFLAKKRLLSLAVGDILAITGAGAYG
FVMSSNYNSRPRPAEVMVSGDKHQVVRARETVAQLFETESTFDID
>Mature_444_residues
SNPDLSQAAVQHSESGLRINPEVFVKKLPTLSYQQGTLFVEQASVQQLAEQYGTPLYVYSKQAILDAYTAYTTSFAAIDH
QVCYAVKANSNLAVLSVLAKAGAGFDLVSSGELARVLAVGADPSKIVFSGVGKTVTELTAALKAGIGCFNVESLSELDTL
NAVAAELNVKAPISIRVNPDVDAKTHPYISTGLKDNKFGISHDIAVAAYQHAASLEHLQIVGIDCHIGSQLTEIDPFVAA
LDKVCELIEALKQVGIELQHIDLGGGLGVIYIDEEVAKVSEFAAALLPKLQELGLKVFFEPGRSIVANAGMLVTKVEVLK
PTEHRDFAIVDAAMNDLIRPALYQAEMAVIPVQTASQASQKSWDIVGAVCETGDFLAKKRLLSLAVGDILAITGAGAYGF
VMSSNYNSRPRPAEVMVSGDKHQVVRARETVAQLFETESTFDID

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=367, Percent_Identity=26.158038147139, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI22538418, Length=350, Percent_Identity=26.2857142857143, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI21361583, Length=350, Percent_Identity=26.2857142857143, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI16506287, Length=351, Percent_Identity=25.3561253561254, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1789203, Length=411, Percent_Identity=32.360097323601, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17562780, Length=353, Percent_Identity=26.0623229461756, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322664, Length=369, Percent_Identity=24.1192411924119, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24586474, Length=337, Percent_Identity=25.5192878338279, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24586472, Length=342, Percent_Identity=24.8538011695906, Blast_Score=85, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47506; Mature: 47375

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPDLSQAAVQHSESGLRINPEVFVKKLPTLSYQQGTLFVEQASVQQLAEQYGTPLYVY
CCCCCHHHHHHHHCCCCCEECHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHCCEEEEE
SKQAILDAYTAYTTSFAAIDHQVCYAVKANSNLAVLSVLAKAGAGFDLVSSGELARVLAV
EHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHCCCCCEEECCCCEEEEEEE
GADPSKIVFSGVGKTVTELTAALKAGIGCFNVESLSELDTLNAVAAELNVKAPISIRVNP
CCCCCCEEEECCCHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHCCCCCCEEEEECC
DVDAKTHPYISTGLKDNKFGISHDIAVAAYQHAASLEHLQIVGIDCHIGSQLTEIDPFVA
CCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCHHHCCHHHH
ALDKVCELIEALKQVGIELQHIDLGGGLGVIYIDEEVAKVSEFAAALLPKLQELGLKVFF
HHHHHHHHHHHHHHHCCEEEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHCCEEEEE
EPGRSIVANAGMLVTKVEVLKPTEHRDFAIVDAAMNDLIRPALYQAEMAVIPVQTASQAS
CCCCHHHHCCCEEEEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHCCEEEEEECCHHHHH
QKSWDIVGAVCETGDFLAKKRLLSLAVGDILAITGAGAYGFVMSSNYNSRPRPAEVMVSG
CCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCCCCCCCEEEEEC
DKHQVVRARETVAQLFETESTFDID
CHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SNPDLSQAAVQHSESGLRINPEVFVKKLPTLSYQQGTLFVEQASVQQLAEQYGTPLYVY
CCCCHHHHHHHHCCCCCEECHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHCCEEEEE
SKQAILDAYTAYTTSFAAIDHQVCYAVKANSNLAVLSVLAKAGAGFDLVSSGELARVLAV
EHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHCCCCCEEECCCCEEEEEEE
GADPSKIVFSGVGKTVTELTAALKAGIGCFNVESLSELDTLNAVAAELNVKAPISIRVNP
CCCCCCEEEECCCHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHCCCCCCEEEEECC
DVDAKTHPYISTGLKDNKFGISHDIAVAAYQHAASLEHLQIVGIDCHIGSQLTEIDPFVA
CCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCHHHCCHHHH
ALDKVCELIEALKQVGIELQHIDLGGGLGVIYIDEEVAKVSEFAAALLPKLQELGLKVFF
HHHHHHHHHHHHHHHCCEEEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHCCEEEEE
EPGRSIVANAGMLVTKVEVLKPTEHRDFAIVDAAMNDLIRPALYQAEMAVIPVQTASQAS
CCCCHHHHCCCEEEEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHCCEEEEEECCHHHHH
QKSWDIVGAVCETGDFLAKKRLLSLAVGDILAITGAGAYGFVMSSNYNSRPRPAEVMVSG
CCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCCCCCCCEEEEEC
DKHQVVRARETVAQLFETESTFDID
CHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]