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The map label for this gene is hemL [H]

Identifier: 148652142

GI number: 148652142

Start: 397233

End: 398561

Strand: Direct

Name: hemL [H]

Synonym: PsycPRwf_0330

Alternate gene names: 148652142

Gene position: 397233-398561 (Clockwise)

Preceding gene: 148652141

Following gene: 148652143

Centisome position: 13.33

GC content: 48.16

Gene sequence:

>1329_bases
ATGAGTGAGACTATGAATATAAAAATGAGTACAAAGAACGAACAACTTTTTTTGCAAGCCAAAAAACACATTCCAGGTGG
GGTAAACTCTCCTGTGCGCGCTTTCGCTGGCGTGGGCGGCACACCAGTATTTATGCACAAAGCAGCAGGTAGCAAAATCT
ATGATACCGAAGACAATGAGTATATTGATTATGTCGGCTCATGGGGCCCTATGATCTTGGGTCATGCCCATCCTAAAGTG
ATTGAAGCGGTAAAAGCTGCGGCCGATGATGGTCTAAGCTTTGGTACCCCAACCACGTTTGAGACCTCAGTGGCGGACAT
CATTTGTGATATCGTTCCAAGCGTTGAGATGATTCGTATGACCAGCTCTGGCACAGAGGCCACCATGAGTGCCATTCGTT
TGGCTCGTGGCTACACTGGCCGTGACAAGATTGTTAAATTTGAGGGCTGTTATCATGGTCACTCAGACAGCCTATTGGTA
AAAGCGGGCTCTGGCATGTTAGATATTGGCGAGCCTACCTCACAAGGGGTGCCTGCAGACTTTGCCAAGCACACCATCAC
CTTGCCATACAATGACCCACAAGCGATTAAAGACTGCTTTGAGAAATGGGGTGATGAGATTGCCTGTGTGATTGTTGAGC
CTATTGCGGGCAACATGAACATGATCGTACCGAGTCAAGAATTCCACGATACTTTACGTGCGCAGTGTACTCAAGGCGGC
GCTGTGTTGATTTTTGATGAAGTAATGACGGGCTTTCGCGTGGGCCTAAAAGGCGCGCAAGCACATTTTGGTATTGAGCC
AGATTTAATCTGTTTTGGTAAAATCATCGGTGCTGGCCTGCCAGTAGGTGCCTTTGGCGGTAAGCGTGAAATCATGGAGT
GTATAGCACCTATGGGCGGCGTGTATCAAGCAGGTACGCTGTCAGGCAACCCATTGGCGATGCGTGCCGGTATCGCTATG
TTTGAAGATTTAACTGTGGAAGGCTTCTATGAGGGCGTGGCTGATAAAGTCACTTATCTGGTAGAGGGTATCCAAGCGGC
GGCACACAAGCATGGCATTAAGCTACGCTCAACTAAGCTTGGCGGTATGTTTGGCCTGTTCTTCGTCAAAGATGAGGCCA
CGGGTGTTCCCCAAAACTTCGATGAGGTGACCGCTTGTGATATGGATAAATTTAACACCTTCTTCCATGGTATGTTAGAT
CGTGGTATTTATCTGGCACCATCGGCTTATGAAGTGGGCTTTATGTCTTCAAAACACACGACCGAAGACTTAGATGCGAC
CATCAAAGCCGCTGATGACGTGTTCGCTGAGATGTCAGCTGCGTCATAA

Upstream 100 bases:

>100_bases
ATTGATGCCCTTTTTTTAGCCCCTGTTTTTAGAACCCGTAACCTTTAAAATCAAAAAAGATAATAAGGTTTTTTTATCCA
TAAAATTAAGAGTGACTGTG

Downstream 100 bases:

>100_bases
ATCGCTGATGCGCTGTTGGGCCTTTTTTGTTCTAGTCACTTGCATGTTTTTTGCGGATTGGAATAAAAAAGGCCTTTTTT
TTAAAGCAGTAATAGGCGCT

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSETMNIKMSTKNEQLFLQAKKHIPGGVNSPVRAFAGVGGTPVFMHKAAGSKIYDTEDNEYIDYVGSWGPMILGHAHPKV
IEAVKAAADDGLSFGTPTTFETSVADIICDIVPSVEMIRMTSSGTEATMSAIRLARGYTGRDKIVKFEGCYHGHSDSLLV
KAGSGMLDIGEPTSQGVPADFAKHTITLPYNDPQAIKDCFEKWGDEIACVIVEPIAGNMNMIVPSQEFHDTLRAQCTQGG
AVLIFDEVMTGFRVGLKGAQAHFGIEPDLICFGKIIGAGLPVGAFGGKREIMECIAPMGGVYQAGTLSGNPLAMRAGIAM
FEDLTVEGFYEGVADKVTYLVEGIQAAAHKHGIKLRSTKLGGMFGLFFVKDEATGVPQNFDEVTACDMDKFNTFFHGMLD
RGIYLAPSAYEVGFMSSKHTTEDLDATIKAADDVFAEMSAAS

Sequences:

>Translated_442_residues
MSETMNIKMSTKNEQLFLQAKKHIPGGVNSPVRAFAGVGGTPVFMHKAAGSKIYDTEDNEYIDYVGSWGPMILGHAHPKV
IEAVKAAADDGLSFGTPTTFETSVADIICDIVPSVEMIRMTSSGTEATMSAIRLARGYTGRDKIVKFEGCYHGHSDSLLV
KAGSGMLDIGEPTSQGVPADFAKHTITLPYNDPQAIKDCFEKWGDEIACVIVEPIAGNMNMIVPSQEFHDTLRAQCTQGG
AVLIFDEVMTGFRVGLKGAQAHFGIEPDLICFGKIIGAGLPVGAFGGKREIMECIAPMGGVYQAGTLSGNPLAMRAGIAM
FEDLTVEGFYEGVADKVTYLVEGIQAAAHKHGIKLRSTKLGGMFGLFFVKDEATGVPQNFDEVTACDMDKFNTFFHGMLD
RGIYLAPSAYEVGFMSSKHTTEDLDATIKAADDVFAEMSAAS
>Mature_441_residues
SETMNIKMSTKNEQLFLQAKKHIPGGVNSPVRAFAGVGGTPVFMHKAAGSKIYDTEDNEYIDYVGSWGPMILGHAHPKVI
EAVKAAADDGLSFGTPTTFETSVADIICDIVPSVEMIRMTSSGTEATMSAIRLARGYTGRDKIVKFEGCYHGHSDSLLVK
AGSGMLDIGEPTSQGVPADFAKHTITLPYNDPQAIKDCFEKWGDEIACVIVEPIAGNMNMIVPSQEFHDTLRAQCTQGGA
VLIFDEVMTGFRVGLKGAQAHFGIEPDLICFGKIIGAGLPVGAFGGKREIMECIAPMGGVYQAGTLSGNPLAMRAGIAMF
EDLTVEGFYEGVADKVTYLVEGIQAAAHKHGIKLRSTKLGGMFGLFFVKDEATGVPQNFDEVTACDMDKFNTFFHGMLDR
GIYLAPSAYEVGFMSSKHTTEDLDATIKAADDVFAEMSAAS

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=310, Percent_Identity=30.3225806451613, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI24119277, Length=362, Percent_Identity=25.414364640884, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI13994255, Length=388, Percent_Identity=26.2886597938144, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI37574042, Length=363, Percent_Identity=26.1707988980716, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI226442709, Length=332, Percent_Identity=27.1084337349398, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI284507298, Length=226, Percent_Identity=31.858407079646, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI226442705, Length=363, Percent_Identity=25.068870523416, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1786349, Length=428, Percent_Identity=57.9439252336449, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI1789016, Length=385, Percent_Identity=28.3116883116883, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1788044, Length=350, Percent_Identity=31.1428571428571, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789759, Length=312, Percent_Identity=31.4102564102564, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI145693181, Length=450, Percent_Identity=26, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787560, Length=285, Percent_Identity=29.4736842105263, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1786991, Length=325, Percent_Identity=28, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71992977, Length=364, Percent_Identity=26.0989010989011, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=306, Percent_Identity=28.4313725490196, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25144274, Length=150, Percent_Identity=31.3333333333333, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=354, Percent_Identity=28.2485875706215, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324432, Length=345, Percent_Identity=26.0869565217391, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21357415, Length=304, Percent_Identity=26.3157894736842, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356575, Length=370, Percent_Identity=24.8648648648649, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 47338; Mature: 47206

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETMNIKMSTKNEQLFLQAKKHIPGGVNSPVRAFAGVGGTPVFMHKAAGSKIYDTEDNE
CCCCEEEEEECCCCEEEEEEHHCCCCCCCCHHHHHHCCCCCEEEEEECCCCEEEECCCCC
YIDYVGSWGPMILGHAHPKVIEAVKAAADDGLSFGTPTTFETSVADIICDIVPSVEMIRM
EEEECCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEE
TSSGTEATMSAIRLARGYTGRDKIVKFEGCYHGHSDSLLVKAGSGMLDIGEPTSQGVPAD
ECCCCHHHHHHHHHHCCCCCCCCEEEEECEECCCCCCEEEEECCCEEECCCCCCCCCCCC
FAKHTITLPYNDPQAIKDCFEKWGDEIACVIVEPIAGNMNMIVPSQEFHDTLRAQCTQGG
CCCCEEEECCCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCHHHHHHHHHHHCCCC
AVLIFDEVMTGFRVGLKGAQAHFGIEPDLICFGKIIGAGLPVGAFGGKREIMECIAPMGG
EEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCC
VYQAGTLSGNPLAMRAGIAMFEDLTVEGFYEGVADKVTYLVEGIQAAAHKHGIKLRSTKL
CEECCCCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GGMFGLFFVKDEATGVPQNFDEVTACDMDKFNTFFHGMLDRGIYLAPSAYEVGFMSSKHT
CCEEEEEEEECCCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCEEECCCCEEECCCCCCCC
TEDLDATIKAADDVFAEMSAAS
CHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SETMNIKMSTKNEQLFLQAKKHIPGGVNSPVRAFAGVGGTPVFMHKAAGSKIYDTEDNE
CCCEEEEEECCCCEEEEEEHHCCCCCCCCHHHHHHCCCCCEEEEEECCCCEEEECCCCC
YIDYVGSWGPMILGHAHPKVIEAVKAAADDGLSFGTPTTFETSVADIICDIVPSVEMIRM
EEEECCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEE
TSSGTEATMSAIRLARGYTGRDKIVKFEGCYHGHSDSLLVKAGSGMLDIGEPTSQGVPAD
ECCCCHHHHHHHHHHCCCCCCCCEEEEECEECCCCCCEEEEECCCEEECCCCCCCCCCCC
FAKHTITLPYNDPQAIKDCFEKWGDEIACVIVEPIAGNMNMIVPSQEFHDTLRAQCTQGG
CCCCEEEECCCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCHHHHHHHHHHHCCCC
AVLIFDEVMTGFRVGLKGAQAHFGIEPDLICFGKIIGAGLPVGAFGGKREIMECIAPMGG
EEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCC
VYQAGTLSGNPLAMRAGIAMFEDLTVEGFYEGVADKVTYLVEGIQAAAHKHGIKLRSTKL
CEECCCCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GGMFGLFFVKDEATGVPQNFDEVTACDMDKFNTFFHGMLDRGIYLAPSAYEVGFMSSKHT
CCEEEEEEEECCCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCEEECCCCEEECCCCCCCC
TEDLDATIKAADDVFAEMSAAS
CHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA