Click here to switch to the map view.

The map label for this gene is hemA

Identifier: 148652123

GI number: 148652123

Start: 371286

End: 372641

Strand: Direct

Name: hemA

Synonym: PsycPRwf_0311

Alternate gene names: 148652123

Gene position: 371286-372641 (Clockwise)

Preceding gene: 148652121

Following gene: 148652125

Centisome position: 12.46

GC content: 49.34

Gene sequence:

>1356_bases
ATGAATCTTGTTGTCATCGGTGTGAACCATAAAACTGCCCCCGTCGCCTTGCGTGAACGGTTAGCATTTGTGGGCGGCGA
CATCCAGGTGGCGCAAGCACAATTGCAACAAATCACCGCAGGCAGTTTGATCATCTCAACGTGTAACCGTACTGAGATTT
ATGCTTTAGCGCCCAGCACCCAGTTACTTGCCAATTCTGATGCTGCCTTGAGTAAGCAAAGCGATTTGTCGCTGGCTGAT
GAGCCTGTGAGCACCGTTGATTTAACGGAGCAACTGATCACGTGGCTGGCAGACTTTAAGCAAGTACCTCTTGAAGAGAC
CCGCCCTTATTTATATGACTATGTCGATGGTCAAGCGCTCACCCATATGCTGCGCGTAGCAGCCGGTCTGGACTCTATGA
TTTTAGGGGAGCCACAAATCTTCGGTCAGATCAAACGATCGGTCAACCAGGCCAAAGAACAAGGTTTTTTGACCAATCAG
CTAAACTGGGTAGTGGAGCAAATATTCGCTGCGGCAAAAAGAGTGCGAAATGAGACGGATGTGGGTACTCAGGCTATCTC
CTTGGGCTACGCGGCCTCTAAGCTTGTCACCCAAATTTTTGATCGTCCGGAAGAAACCACCTTTTTATTGATTGCCGCAG
GTGAAATGAACCGCTTGGTGGCACAGAATATCGCTGGGCTTGGGGTTAAACGTATCTTAATCTGTAACCGTACGCCGGAG
CGTGCCAATCTTCTGGCGCAAGAGCTTGCGCACTTGGGTATACAGATTGAAGTGCACCCGCTCACAGAGCTGGACTCTTT
GTTGTATCAAGCCGATATCGTGAGCAGCTGTAGCGGTAGTATGGACATGCTCATTGACAAGGCCATGACTCGCCGCGCAT
TAAAAAAACGCCGCTATAAACCCATGCTCATGGTAGATTTAGCGGTGCCTAGAGACATCGACTCAAGCGTAGGTAAGCTT
GATGATGTGTACTTGTATTCTATTGATGACTTGCAACATGTGATTGCCGGCAACCTAGAGAAGCGTCGTCAGGCGGCGGT
AGAGGCAGAGCTTTTGGTTAGTCACTTGGTGGTTGAGATTGAGCGCCGTTTCCAGGTACGCAAAGTAGGTCAAGATATCC
ATGATTACCGTGCCCTTGCTGCACAAAAGGCCGAAGCTGTATTAAATGAAGCATTGCATGAGCTGAGAACCTCAGAGGCG
ACTGCAGAGGAGGTCATGACAGAGTTGACCCGCCGTCTTACTCAGACGTTAGTGCATGCGCCATCTTCTTTAATGCGCCG
AGCTGCTCGTGACGGCAATAACGAAGCGATTGATTTGATCATTCTGGGTCTGAAAGATGCTTATCGCAAAAAGTAA

Upstream 100 bases:

>100_bases
ACAGGTATCACAGTGAATGCCCATTCATGGTATGCAGTTAGCAAAGGCTAATTGCACGGAATGTTGACGGCTTAATCTCT
AACTAATGGGTAGATTTTAC

Downstream 100 bases:

>100_bases
GCTGGTCACATCACGCCTTTAAGTCGCCGAGTCAAACGCTAAATTAATAAACACACCCATTGTCCACAAAAAAGGAGCGC
TAAGCGCTCCTTTTTTTGTG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MNLVVIGVNHKTAPVALRERLAFVGGDIQVAQAQLQQITAGSLIISTCNRTEIYALAPSTQLLANSDAALSKQSDLSLAD
EPVSTVDLTEQLITWLADFKQVPLEETRPYLYDYVDGQALTHMLRVAAGLDSMILGEPQIFGQIKRSVNQAKEQGFLTNQ
LNWVVEQIFAAAKRVRNETDVGTQAISLGYAASKLVTQIFDRPEETTFLLIAAGEMNRLVAQNIAGLGVKRILICNRTPE
RANLLAQELAHLGIQIEVHPLTELDSLLYQADIVSSCSGSMDMLIDKAMTRRALKKRRYKPMLMVDLAVPRDIDSSVGKL
DDVYLYSIDDLQHVIAGNLEKRRQAAVEAELLVSHLVVEIERRFQVRKVGQDIHDYRALAAQKAEAVLNEALHELRTSEA
TAEEVMTELTRRLTQTLVHAPSSLMRRAARDGNNEAIDLIILGLKDAYRKK

Sequences:

>Translated_451_residues
MNLVVIGVNHKTAPVALRERLAFVGGDIQVAQAQLQQITAGSLIISTCNRTEIYALAPSTQLLANSDAALSKQSDLSLAD
EPVSTVDLTEQLITWLADFKQVPLEETRPYLYDYVDGQALTHMLRVAAGLDSMILGEPQIFGQIKRSVNQAKEQGFLTNQ
LNWVVEQIFAAAKRVRNETDVGTQAISLGYAASKLVTQIFDRPEETTFLLIAAGEMNRLVAQNIAGLGVKRILICNRTPE
RANLLAQELAHLGIQIEVHPLTELDSLLYQADIVSSCSGSMDMLIDKAMTRRALKKRRYKPMLMVDLAVPRDIDSSVGKL
DDVYLYSIDDLQHVIAGNLEKRRQAAVEAELLVSHLVVEIERRFQVRKVGQDIHDYRALAAQKAEAVLNEALHELRTSEA
TAEEVMTELTRRLTQTLVHAPSSLMRRAARDGNNEAIDLIILGLKDAYRKK
>Mature_451_residues
MNLVVIGVNHKTAPVALRERLAFVGGDIQVAQAQLQQITAGSLIISTCNRTEIYALAPSTQLLANSDAALSKQSDLSLAD
EPVSTVDLTEQLITWLADFKQVPLEETRPYLYDYVDGQALTHMLRVAAGLDSMILGEPQIFGQIKRSVNQAKEQGFLTNQ
LNWVVEQIFAAAKRVRNETDVGTQAISLGYAASKLVTQIFDRPEETTFLLIAAGEMNRLVAQNIAGLGVKRILICNRTPE
RANLLAQELAHLGIQIEVHPLTELDSLLYQADIVSSCSGSMDMLIDKAMTRRALKKRRYKPMLMVDLAVPRDIDSSVGKL
DDVYLYSIDDLQHVIAGNLEKRRQAAVEAELLVSHLVVEIERRFQVRKVGQDIHDYRALAAQKAEAVLNEALHELRTSEA
TAEEVMTELTRRLTQTLVHAPSSLMRRAARDGNNEAIDLIILGLKDAYRKK

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=449, Percent_Identity=39.6436525612472, Blast_Score=304, Evalue=7e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_PSYWF (A5WC75)

Other databases:

- EMBL:   CP000713
- RefSeq:   YP_001279216.1
- ProteinModelPortal:   A5WC75
- SMR:   A5WC75
- STRING:   A5WC75
- GeneID:   5204520
- GenomeReviews:   CP000713_GR
- KEGG:   prw:PsycPRwf_0311
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- BioCyc:   PSP56811:PSYCPRWF_0311-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 50055; Mature: 50055

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 48-48 BINDING 132-132 BINDING 143-143

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLVVIGVNHKTAPVALRERLAFVGGDIQVAQAQLQQITAGSLIISTCNRTEIYALAPST
CCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHEEEECCCCEEEEECCCH
QLLANSDAALSKQSDLSLADEPVSTVDLTEQLITWLADFKQVPLEETRPYLYDYVDGQAL
HHHCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHCCCHHHH
THMLRVAAGLDSMILGEPQIFGQIKRSVNQAKEQGFLTNQLNWVVEQIFAAAKRVRNETD
HHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
VGTQAISLGYAASKLVTQIFDRPEETTFLLIAAGEMNRLVAQNIAGLGVKRILICNRTPE
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCH
RANLLAQELAHLGIQIEVHPLTELDSLLYQADIVSSCSGSMDMLIDKAMTRRALKKRRYK
HHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
PMLMVDLAVPRDIDSSVGKLDDVYLYSIDDLQHVIAGNLEKRRQAAVEAELLVSHLVVEI
CEEEEEECCCCCCCHHHCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ERRFQVRKVGQDIHDYRALAAQKAEAVLNEALHELRTSEATAEEVMTELTRRLTQTLVHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
PSSLMRRAARDGNNEAIDLIILGLKDAYRKK
CHHHHHHHHHCCCCCEEEEEEECCCHHHCCC
>Mature Secondary Structure
MNLVVIGVNHKTAPVALRERLAFVGGDIQVAQAQLQQITAGSLIISTCNRTEIYALAPST
CCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHEEEECCCCEEEEECCCH
QLLANSDAALSKQSDLSLADEPVSTVDLTEQLITWLADFKQVPLEETRPYLYDYVDGQAL
HHHCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHCCCHHHH
THMLRVAAGLDSMILGEPQIFGQIKRSVNQAKEQGFLTNQLNWVVEQIFAAAKRVRNETD
HHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
VGTQAISLGYAASKLVTQIFDRPEETTFLLIAAGEMNRLVAQNIAGLGVKRILICNRTPE
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCH
RANLLAQELAHLGIQIEVHPLTELDSLLYQADIVSSCSGSMDMLIDKAMTRRALKKRRYK
HHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
PMLMVDLAVPRDIDSSVGKLDDVYLYSIDDLQHVIAGNLEKRRQAAVEAELLVSHLVVEI
CEEEEEECCCCCCCHHHCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ERRFQVRKVGQDIHDYRALAAQKAEAVLNEALHELRTSEATAEEVMTELTRRLTQTLVHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
PSSLMRRAARDGNNEAIDLIILGLKDAYRKK
CHHHHHHHHHCCCCCEEEEEEECCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA