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The map label for this gene is hisE

Identifier: 148379540

GI number: 148379540

Start: 1704716

End: 1705048

Strand: Direct

Name: hisE

Synonym: CBO1574

Alternate gene names: 148379540

Gene position: 1704716-1705048 (Clockwise)

Preceding gene: 148379539

Following gene: 148379541

Centisome position: 43.86

GC content: 24.32

Gene sequence:

>333_bases
ATGAATAGAAATAATGTTATAGATAGTTTATTTAATATAATAGAGGACAGAAAAGATAAGCCCATAGAAGGTTCTTATAC
TGGATATTTATTTGAAAAAGGATTGGATAAAATATTAAAAAAGGTTGGAGAAGAAAGTTCAGAGGTAATTATAGCTGCTA
AAAATGAAGACGAAGAGGAACTGATAAAAGAAATATGTGATTTAACCTATCACATAATGGTTTTAATGGTAGAAAAACAA
ATAAAATTAGATGATATAGAAAAAGAATTAGAAAAGAGAAGAGAAAGAATATGCAATAAAAAAAATGAAAGAAAAACAAT
AGAGAAATTATAA

Upstream 100 bases:

>100_bases
TTACATATAGAAATTGATGTTATAAAATGGATAGGGGGAAGGATGTGAGTATTTGGTGGTTTGATGTAATTTATAAACAT
CTGATCACTAAGGACAAATT

Downstream 100 bases:

>100_bases
AAATAGGAAGAGTCAGTATAATTATTGTAATTTGAACTATTTTTATTAATATATTAAAATAAATGTATATTTATAAATTT
CAAATAATGAATAAATAAAA

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 110; Mature: 110

Protein sequence:

>110_residues
MNRNNVIDSLFNIIEDRKDKPIEGSYTGYLFEKGLDKILKKVGEESSEVIIAAKNEDEEELIKEICDLTYHIMVLMVEKQ
IKLDDIEKELEKRRERICNKKNERKTIEKL

Sequences:

>Translated_110_residues
MNRNNVIDSLFNIIEDRKDKPIEGSYTGYLFEKGLDKILKKVGEESSEVIIAAKNEDEEELIKEICDLTYHIMVLMVEKQ
IKLDDIEKELEKRRERICNKKNERKTIEKL
>Mature_110_residues
MNRNNVIDSLFNIIEDRKDKPIEGSYTGYLFEKGLDKILKKVGEESSEVIIAAKNEDEEELIKEICDLTYHIMVLMVEKQ
IKLDDIEKELEKRRERICNKKNERKTIEKL

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=83, Percent_Identity=37.3493975903614, Blast_Score=62, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_CLOB1 (A7FU84)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001383917.1
- ProteinModelPortal:   A7FU84
- SMR:   A7FU84
- STRING:   A7FU84
- GeneID:   5394642
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_1594
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   EMRRREN
- ProtClustDB:   PRK00400
- BioCyc:   CBOT441770:CLB_1594-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 13029; Mature: 13029

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRNNVIDSLFNIIEDRKDKPIEGSYTGYLFEKGLDKILKKVGEESSEVIIAAKNEDEEE
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHH
LIKEICDLTYHIMVLMVEKQIKLDDIEKELEKRRERICNKKNERKTIEKL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure
MNRNNVIDSLFNIIEDRKDKPIEGSYTGYLFEKGLDKILKKVGEESSEVIIAAKNEDEEE
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHH
LIKEICDLTYHIMVLMVEKQIKLDDIEKELEKRRERICNKKNERKTIEKL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA