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The map label for this gene is hisI

Identifier: 148379539

GI number: 148379539

Start: 1704259

End: 1704591

Strand: Direct

Name: hisI

Synonym: CBO1573

Alternate gene names: 148379539

Gene position: 1704259-1704591 (Clockwise)

Preceding gene: 148379538

Following gene: 148379540

Centisome position: 43.85

GC content: 31.23

Gene sequence:

>333_bases
ATGAATTTACAGAAGATATCAAAGAAAATAGATTTTAAAAAAGGAGCAGGTCTTATACCTACTATTATTCAGGATTTTTG
CTCAGGGGAAGTTTTAATGTTAGCATATATGAACAAAGAGTCTCTAGAAAAAACTATTGAAACTAATACTACTTGGTTTT
GGAGTAGATCTAGAGAAGAACTTTGGAATAAGGGAGCAACTTCAGGTCATTTTCAATATGTTAAAAGTATTCATATAGAT
TGTGATGGAGATACTCTATTGATTAAAGTAGAGCAGCTTGGACCGGCATGTCATACTGGGAATAGAAGTTGCTTTTATAC
AACATTAATATAA

Upstream 100 bases:

>100_bases
GATTATAAATGATTACAAATAGATGTTGTAATTCTCATCTCCATATTTCTAAATAAAGGATGTTAAATTATGTAGTTACA
AATTAAAATGGAGGATAAAA

Downstream 100 bases:

>100_bases
ATGTATTATTTATAAATAGAAAAATTACATATAGAAATTGATGTTATAAAATGGATAGGGGGAAGGATGTGAGTATTTGG
TGGTTTGATGTAATTTATAA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 110; Mature: 110

Protein sequence:

>110_residues
MNLQKISKKIDFKKGAGLIPTIIQDFCSGEVLMLAYMNKESLEKTIETNTTWFWSRSREELWNKGATSGHFQYVKSIHID
CDGDTLLIKVEQLGPACHTGNRSCFYTTLI

Sequences:

>Translated_110_residues
MNLQKISKKIDFKKGAGLIPTIIQDFCSGEVLMLAYMNKESLEKTIETNTTWFWSRSREELWNKGATSGHFQYVKSIHID
CDGDTLLIKVEQLGPACHTGNRSCFYTTLI
>Mature_110_residues
MNLQKISKKIDFKKGAGLIPTIIQDFCSGEVLMLAYMNKESLEKTIETNTTWFWSRSREELWNKGATSGHFQYVKSIHID
CDGDTLLIKVEQLGPACHTGNRSCFYTTLI

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=108, Percent_Identity=49.0740740740741, Blast_Score=115, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6319819, Length=90, Percent_Identity=41.1111111111111, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_CLOB1 (A7FU83)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001383916.1
- ProteinModelPortal:   A7FU83
- SMR:   A7FU83
- STRING:   A7FU83
- GeneID:   5395239
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_1593
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   TQYVHEV
- ProtClustDB:   PRK00051
- BioCyc:   CBOT441770:CLB_1593-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 12536; Mature: 12536

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQKISKKIDFKKGAGLIPTIIQDFCSGEVLMLAYMNKESLEKTIETNTTWFWSRSREE
CCHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCEEEEECCHHH
LWNKGATSGHFQYVKSIHIDCDGDTLLIKVEQLGPACHTGNRSCFYTTLI
HHCCCCCCCCEEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MNLQKISKKIDFKKGAGLIPTIIQDFCSGEVLMLAYMNKESLEKTIETNTTWFWSRSREE
CCHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCEEEEECCHHH
LWNKGATSGHFQYVKSIHIDCDGDTLLIKVEQLGPACHTGNRSCFYTTLI
HHCCCCCCCCEEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA