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The map label for this gene is nprM [H]

Identifier: 148379418

GI number: 148379418

Start: 1576483

End: 1578225

Strand: Reverse

Name: nprM [H]

Synonym: CBO1446

Alternate gene names: 148379418

Gene position: 1578225-1576483 (Counterclockwise)

Preceding gene: 148379419

Following gene: 148379417

Centisome position: 40.6

GC content: 29.95

Gene sequence:

>1743_bases
ATGAAAAGTAAAAAGTTATTAGCTACAGTCTTAAGTGCTGTAATCACTTTTTCCACAGTCTCTGCAGTTTCTGCTGCACC
TGTAGGAAAAGAAAGTAAAAGTGAACCAAAAACCACAACAATATTTTGGGAAAAGAGCGAACAAAATACTAAAAAATCTA
CTACTAGTATAACTCAAGAAAAATTTAGCAATTCTGACGAAATAACTAAATTCTTTGAAAAAAACATCTCTAAATTTGGG
GTAAAGAAAGGTTCTCTTAAAAATACTAAAGCTGTAAAAGATGACAAAGGTAAAACTCACTATCATATGATCTATCAAGT
AGAGGATATCCCTGTATATTATGGAAGAATTGTTTTTACAACAAAAAAAGACTCCTCCTTGGATTCTATAAATGGTAGAA
TTGATACTGCTTTTGAAAATGAAAGTTGGAAAGACAAAGTTAAACTATCAAAGGATAATGCTATAGAAAAAGCTAAAAGT
AGCATAAAATATGATAATTTATCTAAATCAGATGCAGACTTATATTTGTACAATTTTGAAGGAAAACCTTATGTAGTTTA
TTTAGTGGATTTAGTTACAGATGATGGAGATTGGAATGTTTTTGTTAATGCTGAAGATGGTTCTATAGTGAATAAATTTA
ATAACACCCCTACTCTAATTGATAATAAAGATCAAAAATTACCCAATGCTGAAGAAATTAAAAGAAGTTCTGAAAAAGCT
CCTAATATAAACAGTGTCATTAACGTTAATGGACAAAGTACTAAAGGACAAGGTAAAACTAGTCTAGATGGGATAGTGGA
TATTGATTTAACTTATAAAGATGGAAAATATTATTTAAAAGATAGCAATAAAAATATTTATTTATATAATTTAAATAATA
GTTGGGCTCCTACGATTGGTATTTTCTCCAAAGATTATATATTAAGACGTTCAACTCTTGTAGAAAATAACAGTAATAAA
TTTACAGAGGATAAACATGTTACTGCAGTAGATGGTTACGTTAATTTATCAAAAACTTATGATTACTATAAAAATAAATT
TAACAGAAATAGTATAGATAATAAAGGTATGAACGTTGAAGGATTTATTCATACCGGTAAAAATTTCAATAATGCCTTTT
GGAGAGATGACCTTGGTTCTATGTTCTTTGGCGATGGAGATGGGGTAAAATTCTCTTCCTTTGCAAGTGCTTTAGATGTT
GTAGGTCATGAAGTGAGCCATGGTATAACTAGTAAAGAATCCAAGCTTAAATATGAAAAGGAATCTGGTGCTTTAAACGA
ATCCTTCTCTGATATTATGGGAGTAGCTATCGAAGGTAAGAATTTCCAAATAGGTGAAGATTGTTATACACCAAATATTC
CTGGAGATGCATTGAGAGATATGGAGGACCCATCTAAAGGAAATCAACCAGCTCATATGAAAGATTTTCAATATCTTCCT
AATGATAAAGATCATGATTGGGGTGGAGTTCATACAAATTCAGGTATAATAAACCATGCTGCTTATTTAATTGCAGACGG
TATGGAAAAATCTGGAGAGAAAAATAGTAAAGACATTATGGCAAAATTATTTTATAGAGCCAATTGCTATAAATGGGATG
AAACAACAAATTTTGCTAAATGTAGAAATGATGTAGTTCAGGTTACTAAAGACCTTTATGGTGAAAATAGTAAATATGTA
AAAATTGTTGAAAATGCTTTTGACCAAGTTGGAATAACTGCTACACCTCAATTACCATTATAA

Upstream 100 bases:

>100_bases
ATAATTGGTTAATATGTGAAATTGTTATTCATTTTCAATATTGATATAATTAATATTGAAAATTCCAATTAACCATAAAT
TTGTTAGGGGGTAAATATTT

Downstream 100 bases:

>100_bases
TTAAAAATATGCTATACTGGGGGTTATTTATTTATGAAAAGTAAAAAATTATTAGCTACAGTGCTAAGTGCCGTGATCAC
TTTTTCTACTGTTTCTGCAG

Product: secreted protease

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MKSKKLLATVLSAVITFSTVSAVSAAPVGKESKSEPKTTTIFWEKSEQNTKKSTTSITQEKFSNSDEITKFFEKNISKFG
VKKGSLKNTKAVKDDKGKTHYHMIYQVEDIPVYYGRIVFTTKKDSSLDSINGRIDTAFENESWKDKVKLSKDNAIEKAKS
SIKYDNLSKSDADLYLYNFEGKPYVVYLVDLVTDDGDWNVFVNAEDGSIVNKFNNTPTLIDNKDQKLPNAEEIKRSSEKA
PNINSVINVNGQSTKGQGKTSLDGIVDIDLTYKDGKYYLKDSNKNIYLYNLNNSWAPTIGIFSKDYILRRSTLVENNSNK
FTEDKHVTAVDGYVNLSKTYDYYKNKFNRNSIDNKGMNVEGFIHTGKNFNNAFWRDDLGSMFFGDGDGVKFSSFASALDV
VGHEVSHGITSKESKLKYEKESGALNESFSDIMGVAIEGKNFQIGEDCYTPNIPGDALRDMEDPSKGNQPAHMKDFQYLP
NDKDHDWGGVHTNSGIINHAAYLIADGMEKSGEKNSKDIMAKLFYRANCYKWDETTNFAKCRNDVVQVTKDLYGENSKYV
KIVENAFDQVGITATPQLPL

Sequences:

>Translated_580_residues
MKSKKLLATVLSAVITFSTVSAVSAAPVGKESKSEPKTTTIFWEKSEQNTKKSTTSITQEKFSNSDEITKFFEKNISKFG
VKKGSLKNTKAVKDDKGKTHYHMIYQVEDIPVYYGRIVFTTKKDSSLDSINGRIDTAFENESWKDKVKLSKDNAIEKAKS
SIKYDNLSKSDADLYLYNFEGKPYVVYLVDLVTDDGDWNVFVNAEDGSIVNKFNNTPTLIDNKDQKLPNAEEIKRSSEKA
PNINSVINVNGQSTKGQGKTSLDGIVDIDLTYKDGKYYLKDSNKNIYLYNLNNSWAPTIGIFSKDYILRRSTLVENNSNK
FTEDKHVTAVDGYVNLSKTYDYYKNKFNRNSIDNKGMNVEGFIHTGKNFNNAFWRDDLGSMFFGDGDGVKFSSFASALDV
VGHEVSHGITSKESKLKYEKESGALNESFSDIMGVAIEGKNFQIGEDCYTPNIPGDALRDMEDPSKGNQPAHMKDFQYLP
NDKDHDWGGVHTNSGIINHAAYLIADGMEKSGEKNSKDIMAKLFYRANCYKWDETTNFAKCRNDVVQVTKDLYGENSKYV
KIVENAFDQVGITATPQLPL
>Mature_580_residues
MKSKKLLATVLSAVITFSTVSAVSAAPVGKESKSEPKTTTIFWEKSEQNTKKSTTSITQEKFSNSDEITKFFEKNISKFG
VKKGSLKNTKAVKDDKGKTHYHMIYQVEDIPVYYGRIVFTTKKDSSLDSINGRIDTAFENESWKDKVKLSKDNAIEKAKS
SIKYDNLSKSDADLYLYNFEGKPYVVYLVDLVTDDGDWNVFVNAEDGSIVNKFNNTPTLIDNKDQKLPNAEEIKRSSEKA
PNINSVINVNGQSTKGQGKTSLDGIVDIDLTYKDGKYYLKDSNKNIYLYNLNNSWAPTIGIFSKDYILRRSTLVENNSNK
FTEDKHVTAVDGYVNLSKTYDYYKNKFNRNSIDNKGMNVEGFIHTGKNFNNAFWRDDLGSMFFGDGDGVKFSSFASALDV
VGHEVSHGITSKESKLKYEKESGALNESFSDIMGVAIEGKNFQIGEDCYTPNIPGDALRDMEDPSKGNQPAHMKDFQYLP
NDKDHDWGGVHTNSGIINHAAYLIADGMEKSGEKNSKDIMAKLFYRANCYKWDETTNFAKCRNDVVQVTKDLYGENSKYV
KIVENAFDQVGITATPQLPL

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 65154; Mature: 65154

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKKLLATVLSAVITFSTVSAVSAAPVGKESKSEPKTTTIFWEKSEQNTKKSTTSITQE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
KFSNSDEITKFFEKNISKFGVKKGSLKNTKAVKDDKGKTHYHMIYQVEDIPVYYGRIVFT
HCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCEEEEEEEEEE
TKKDSSLDSINGRIDTAFENESWKDKVKLSKDNAIEKAKSSIKYDNLSKSDADLYLYNFE
ECCCCCCHHCCCEEEEEECCCCCHHHEEECCCHHHHHHHHHCCCCCCCCCCCCEEEEEEC
GKPYVVYLVDLVTDDGDWNVFVNAEDGSIVNKFNNTPTLIDNKDQKLPNAEEIKRSSEKA
CCEEEEEEEEEEECCCCEEEEEECCCCCEECCCCCCCCEECCCCCCCCCHHHHHHHHHCC
PNINSVINVNGQSTKGQGKTSLDGIVDIDLTYKDGKYYLKDSNKNIYLYNLNNSWAPTIG
CCCCEEEEECCCCCCCCCCCCCCCEEEEEEEEECCEEEEEECCCEEEEEECCCCCCCEEE
IFSKDYILRRSTLVENNSNKFTEDKHVTAVDGYVNLSKTYDYYKNKFNRNSIDNKGMNVE
ECCCCHHHHHHHHEECCCCCCCCCCCEEEECCEEECHHHHHHHHCCCCCCCCCCCCCCEE
GFIHTGKNFNNAFWRDDLGSMFFGDGDGVKFSSFASALDVVGHEVSHGITSKESKLKYEK
EEEECCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCEECH
ESGALNESFSDIMGVAIEGKNFQIGEDCYTPNIPGDALRDMEDPSKGNQPAHMKDFQYLP
HCCCCCCCHHHHEEEEEECCCEEECCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCC
NDKDHDWGGVHTNSGIINHAAYLIADGMEKSGEKNSKDIMAKLFYRANCYKWDETTNFAK
CCCCCCCCCEECCCCHHHHHHHEEECCHHHCCCCCHHHHHHHHHHHCCCEECCCCCCHHH
CRNDVVQVTKDLYGENSKYVKIVENAFDQVGITATPQLPL
HHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKSKKLLATVLSAVITFSTVSAVSAAPVGKESKSEPKTTTIFWEKSEQNTKKSTTSITQE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
KFSNSDEITKFFEKNISKFGVKKGSLKNTKAVKDDKGKTHYHMIYQVEDIPVYYGRIVFT
HCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCEEEEEEEEEE
TKKDSSLDSINGRIDTAFENESWKDKVKLSKDNAIEKAKSSIKYDNLSKSDADLYLYNFE
ECCCCCCHHCCCEEEEEECCCCCHHHEEECCCHHHHHHHHHCCCCCCCCCCCCEEEEEEC
GKPYVVYLVDLVTDDGDWNVFVNAEDGSIVNKFNNTPTLIDNKDQKLPNAEEIKRSSEKA
CCEEEEEEEEEEECCCCEEEEEECCCCCEECCCCCCCCEECCCCCCCCCHHHHHHHHHCC
PNINSVINVNGQSTKGQGKTSLDGIVDIDLTYKDGKYYLKDSNKNIYLYNLNNSWAPTIG
CCCCEEEEECCCCCCCCCCCCCCCEEEEEEEEECCEEEEEECCCEEEEEECCCCCCCEEE
IFSKDYILRRSTLVENNSNKFTEDKHVTAVDGYVNLSKTYDYYKNKFNRNSIDNKGMNVE
ECCCCHHHHHHHHEECCCCCCCCCCCEEEECCEEECHHHHHHHHCCCCCCCCCCCCCCEE
GFIHTGKNFNNAFWRDDLGSMFFGDGDGVKFSSFASALDVVGHEVSHGITSKESKLKYEK
EEEECCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCEECH
ESGALNESFSDIMGVAIEGKNFQIGEDCYTPNIPGDALRDMEDPSKGNQPAHMKDFQYLP
HCCCCCCCHHHHEEEEEECCCEEECCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCC
NDKDHDWGGVHTNSGIINHAAYLIADGMEKSGEKNSKDIMAKLFYRANCYKWDETTNFAK
CCCCCCCCCEECCCCHHHHHHHEEECCHHHCCCCCHHHHHHHHHHHCCCEECCCCCCHHH
CRNDVVQVTKDLYGENSKYVKIVENAFDQVGITATPQLPL
HHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7764969 [H]