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The map label for this gene is nprM [H]

Identifier: 148379417

GI number: 148379417

Start: 1574704

End: 1576449

Strand: Reverse

Name: nprM [H]

Synonym: CBO1445

Alternate gene names: 148379417

Gene position: 1576449-1574704 (Counterclockwise)

Preceding gene: 148379418

Following gene: 148379416

Centisome position: 40.56

GC content: 30.07

Gene sequence:

>1746_bases
ATGAAAAGTAAAAAATTATTAGCTACAGTGCTAAGTGCCGTGATCACTTTTTCTACTGTTTCTGCAGTTTATGCTGCGCC
TGTAGGAAAAGAAAGTAAAGTTGAACCAAAAACTACAACAATAACTTGGGAAAAAAATGAACAAAATACTAAAAAAGCTG
CTACTGATATAACTGAAAAGAAATTTAACAATTCTGAGGAGATAACTAAATTCTTTGAAAAAAATATATCTAAATTTGGT
GTACAAAAAGGTTCTCTTAAAAACACCAAGACTGTAAAAGACGAAAAAGGTAAAACTAACTATCATATGATTTATGAAGT
AGAAGGTATACCTGTATACTATGGAAGAATTGTTTTTACAACTGAAAAAGACTCCTCCATGGATTCTATAAACGGTAGAA
TTGATACTGTTTTTGAAAATGGGAATTGGAAAAACAAAATCAAACTATCAAAAGAAGATGCTATAGCAAAAGCTAAAAAT
GATATTAAAGATGAAAAAGCAACTAGTAAAAAGACCGATTTATATCTGTATAATTTTGAGGGCAAACCTTATGTAGTTTA
TTTAGTAGATCTAATTACAGACAACGGGAGTTGGACGGTTTTCGTTAATGCTGAGGATGGTTCTATAGTAAATAAATTTA
ATAATACTCCTACTTTAATTGATACTAAAGATCAAAAATTACCCAATGCTAAAAAAATTAAAGATGAAGCTAAAAAAGCT
AGTAATGCAAATAATGTAATTGATGTTCAAGGTCAAAGCGTTAAAGGAGTAGGAAAAACTAGCTTGGATGGACTAGTAAA
TATTGATGTAACTTATGGAAATGGAAAATACTATTTAAAAGATAGCAACAAAAATATTTATCTATATGACTTAAAAAATC
AAGTTGATGAATATGATCTATACAATTATCTTAGTAGACCTAACTATAAACAAATATTAATGAGCAAATCTGAATTAATA
TCTAATTACAATAATAATTTTATAGCCAACAATCAGGTTAATTCTGTAGATGCTTATGTAAACACAAATAAAACCTATGA
TTATTATAAAAACAAATTAAATAGAAACAGTATTGATAATAAGGGTATGAATATTAATGGGTTTGTTCATGTAGGTAGAA
ATTATGGTAATGCTTTTTGGTACGGTCCATATGATGGGATGTTCTTTGGCGATGGCGACGGAATATACTTCTCTTCCCTT
GCAAAATCTTTAGATGTTGTAGGCCACGAATTAAGTCATGGTGTAACAAATAAAGAGTCTAATCTTAAATATGAAAATGA
ATCTGGTGCCCTAAATGAATCTTTCTCAGATATTATGGGAGTAGCTGTTGAGGGTAAAAACTTTGTACTAGGTGAAGATT
GCTGGGTTGCTGGAGGAGTAATGAGAGATATGGAAAATCCATCCAGAGGAGGCCAACCAGCTCATATGAAAGATTATAAA
TACAAAACTATGAATGACGATAACGGTGGTGTTCATACAAATTCAGGTATAATAAACCATGCTGCTTATTTAGTTGCAGA
TGGAATAGAAAAAACTGGTGCAAAAAATAGTAAAGATATTATGGGAAAAATATTCTATACAGCTAATTGCTATAAATGGG
ATGAAACAACAAATTTTGCTAAGTGCAGAAATGATGTAGTCCAAGTTACTAAAGAACTTTATGGCGAAAATAGCAACTAT
GTAAAAATTGTTGAAAAAGCTTTTGACCAAGTTGGAATAACTGCTACACCTCAATTACCATTATAA

Upstream 100 bases:

>100_bases
TGTAAAAATTGTTGAAAATGCTTTTGACCAAGTTGGAATAACTGCTACACCTCAATTACCATTATAATTAAAAATATGCT
ATACTGGGGGTTATTTATTT

Downstream 100 bases:

>100_bases
TAAAAGCCCTATTGAAGCTATAAATATATCTATATAAAATTATAAACCTATTGATATTTTGCTATATAAATATCAATAGG
TTTATAAGTAAAAATATATT

Product: secreted protease

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MKSKKLLATVLSAVITFSTVSAVYAAPVGKESKVEPKTTTITWEKNEQNTKKAATDITEKKFNNSEEITKFFEKNISKFG
VQKGSLKNTKTVKDEKGKTNYHMIYEVEGIPVYYGRIVFTTEKDSSMDSINGRIDTVFENGNWKNKIKLSKEDAIAKAKN
DIKDEKATSKKTDLYLYNFEGKPYVVYLVDLITDNGSWTVFVNAEDGSIVNKFNNTPTLIDTKDQKLPNAKKIKDEAKKA
SNANNVIDVQGQSVKGVGKTSLDGLVNIDVTYGNGKYYLKDSNKNIYLYDLKNQVDEYDLYNYLSRPNYKQILMSKSELI
SNYNNNFIANNQVNSVDAYVNTNKTYDYYKNKLNRNSIDNKGMNINGFVHVGRNYGNAFWYGPYDGMFFGDGDGIYFSSL
AKSLDVVGHELSHGVTNKESNLKYENESGALNESFSDIMGVAVEGKNFVLGEDCWVAGGVMRDMENPSRGGQPAHMKDYK
YKTMNDDNGGVHTNSGIINHAAYLVADGIEKTGAKNSKDIMGKIFYTANCYKWDETTNFAKCRNDVVQVTKELYGENSNY
VKIVEKAFDQVGITATPQLPL

Sequences:

>Translated_581_residues
MKSKKLLATVLSAVITFSTVSAVYAAPVGKESKVEPKTTTITWEKNEQNTKKAATDITEKKFNNSEEITKFFEKNISKFG
VQKGSLKNTKTVKDEKGKTNYHMIYEVEGIPVYYGRIVFTTEKDSSMDSINGRIDTVFENGNWKNKIKLSKEDAIAKAKN
DIKDEKATSKKTDLYLYNFEGKPYVVYLVDLITDNGSWTVFVNAEDGSIVNKFNNTPTLIDTKDQKLPNAKKIKDEAKKA
SNANNVIDVQGQSVKGVGKTSLDGLVNIDVTYGNGKYYLKDSNKNIYLYDLKNQVDEYDLYNYLSRPNYKQILMSKSELI
SNYNNNFIANNQVNSVDAYVNTNKTYDYYKNKLNRNSIDNKGMNINGFVHVGRNYGNAFWYGPYDGMFFGDGDGIYFSSL
AKSLDVVGHELSHGVTNKESNLKYENESGALNESFSDIMGVAVEGKNFVLGEDCWVAGGVMRDMENPSRGGQPAHMKDYK
YKTMNDDNGGVHTNSGIINHAAYLVADGIEKTGAKNSKDIMGKIFYTANCYKWDETTNFAKCRNDVVQVTKELYGENSNY
VKIVEKAFDQVGITATPQLPL
>Mature_581_residues
MKSKKLLATVLSAVITFSTVSAVYAAPVGKESKVEPKTTTITWEKNEQNTKKAATDITEKKFNNSEEITKFFEKNISKFG
VQKGSLKNTKTVKDEKGKTNYHMIYEVEGIPVYYGRIVFTTEKDSSMDSINGRIDTVFENGNWKNKIKLSKEDAIAKAKN
DIKDEKATSKKTDLYLYNFEGKPYVVYLVDLITDNGSWTVFVNAEDGSIVNKFNNTPTLIDTKDQKLPNAKKIKDEAKKA
SNANNVIDVQGQSVKGVGKTSLDGLVNIDVTYGNGKYYLKDSNKNIYLYDLKNQVDEYDLYNYLSRPNYKQILMSKSELI
SNYNNNFIANNQVNSVDAYVNTNKTYDYYKNKLNRNSIDNKGMNINGFVHVGRNYGNAFWYGPYDGMFFGDGDGIYFSSL
AKSLDVVGHELSHGVTNKESNLKYENESGALNESFSDIMGVAVEGKNFVLGEDCWVAGGVMRDMENPSRGGQPAHMKDYK
YKTMNDDNGGVHTNSGIINHAAYLVADGIEKTGAKNSKDIMGKIFYTANCYKWDETTNFAKCRNDVVQVTKELYGENSNY
VKIVEKAFDQVGITATPQLPL

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 65153; Mature: 65153

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKKLLATVLSAVITFSTVSAVYAAPVGKESKVEPKTTTITWEKNEQNTKKAATDITEK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHH
KFNNSEEITKFFEKNISKFGVQKGSLKNTKTVKDEKGKTNYHMIYEVEGIPVYYGRIVFT
HCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEEEEE
TEKDSSMDSINGRIDTVFENGNWKNKIKLSKEDAIAKAKNDIKDEKATSKKTDLYLYNFE
ECCCCCHHHCCCEEEEEEECCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
GKPYVVYLVDLITDNGSWTVFVNAEDGSIVNKFNNTPTLIDTKDQKLPNAKKIKDEAKKA
CCEEEEEEEEEEECCCCEEEEEECCCCCEEECCCCCCCEEECCCCCCCCHHHHHHHHHHC
SNANNVIDVQGQSVKGVGKTSLDGLVNIDVTYGNGKYYLKDSNKNIYLYDLKNQVDEYDL
CCCCCEEEECCCCCCCCCCCCCCCEEEEEEEECCCEEEEEECCCEEEEEECCCCCCHHHH
YNYLSRPNYKQILMSKSELISNYNNNFIANNQVNSVDAYVNTNKTYDYYKNKLNRNSIDN
HHHHCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEECCCCHHHHHHCCCCCCCCC
KGMNINGFVHVGRNYGNAFWYGPYDGMFFGDGDGIYFSSLAKSLDVVGHELSHGVTNKES
CCCCEEEEEEECCCCCCEEEECCCCCCEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCCC
NLKYENESGALNESFSDIMGVAVEGKNFVLGEDCWVAGGVMRDMENPSRGGQPAHMKDYK
CCEECCCCCCCCCCHHHHHEEEECCCCEEECCCCEEECCHHHHCCCCCCCCCCCCCCCCE
YKTMNDDNGGVHTNSGIINHAAYLVADGIEKTGAKNSKDIMGKIFYTANCYKWDETTNFA
EEECCCCCCCEECCCCHHHHHHHHHCCCHHHCCCCCCHHHEEEEEEEEEEEECCCCCCHH
KCRNDVVQVTKELYGENSNYVKIVEKAFDQVGITATPQLPL
HHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKSKKLLATVLSAVITFSTVSAVYAAPVGKESKVEPKTTTITWEKNEQNTKKAATDITEK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHH
KFNNSEEITKFFEKNISKFGVQKGSLKNTKTVKDEKGKTNYHMIYEVEGIPVYYGRIVFT
HCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEEEEE
TEKDSSMDSINGRIDTVFENGNWKNKIKLSKEDAIAKAKNDIKDEKATSKKTDLYLYNFE
ECCCCCHHHCCCEEEEEEECCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
GKPYVVYLVDLITDNGSWTVFVNAEDGSIVNKFNNTPTLIDTKDQKLPNAKKIKDEAKKA
CCEEEEEEEEEEECCCCEEEEEECCCCCEEECCCCCCCEEECCCCCCCCHHHHHHHHHHC
SNANNVIDVQGQSVKGVGKTSLDGLVNIDVTYGNGKYYLKDSNKNIYLYDLKNQVDEYDL
CCCCCEEEECCCCCCCCCCCCCCCEEEEEEEECCCEEEEEECCCEEEEEECCCCCCHHHH
YNYLSRPNYKQILMSKSELISNYNNNFIANNQVNSVDAYVNTNKTYDYYKNKLNRNSIDN
HHHHCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEECCCCHHHHHHCCCCCCCCC
KGMNINGFVHVGRNYGNAFWYGPYDGMFFGDGDGIYFSSLAKSLDVVGHELSHGVTNKES
CCCCEEEEEEECCCCCCEEEECCCCCCEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCCC
NLKYENESGALNESFSDIMGVAVEGKNFVLGEDCWVAGGVMRDMENPSRGGQPAHMKDYK
CCEECCCCCCCCCCHHHHHEEEECCCCEEECCCCEEECCHHHHCCCCCCCCCCCCCCCCE
YKTMNDDNGGVHTNSGIINHAAYLVADGIEKTGAKNSKDIMGKIFYTANCYKWDETTNFA
EEECCCCCCCEECCCCHHHHHHHHHCCCHHHCCCCCCHHHEEEEEEEEEEEECCCCCCHH
KCRNDVVQVTKELYGENSNYVKIVEKAFDQVGITATPQLPL
HHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7764969 [H]