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The map label for this gene is yjjG [H]

Identifier: 148379013

GI number: 148379013

Start: 1124987

End: 1125676

Strand: Reverse

Name: yjjG [H]

Synonym: CBO1023

Alternate gene names: 148379013

Gene position: 1125676-1124987 (Counterclockwise)

Preceding gene: 148379015

Following gene: 148379009

Centisome position: 28.96

GC content: 25.07

Gene sequence:

>690_bases
ATGAAGTACAAGATTATAATATTTGATGCAGATGAAACCTTATTTGATTTTAAAAAATCTGAAAGAGATGCTTTTAAAAA
TGCTATGCTGGAATTTAATATAAAATATGATGAAAACTATCATCTAAAGGCGTACAAGGATATAAATACAATTATATGGA
AAGAGCTTGAAAATGGACTTATCACTCAAGAAGAATTAAAAATTGAAAGATTTAAAAGATTATCTCATAAATTAAATATT
AAATTTAATGAATATGATTTTGCAAAATCATATATGAAACATTTATCCCATGCATCTTTTTTATATGATGACAGTATAAA
TCTTGTAGAAAGTTTACATAAAAATTATAGACTTTCTATAGTTACTAATGGTCTTAAGGATGTTCAAAATAATAGAATCA
GAAAATCTATTATAGCAAAATACTTTGAAGATATAGTGATATCTGAAGAGGTCAAAGTATCAAAACCAAGCTCTAAAATA
TTTGAACATGCTCTAAATAATATGAATCATACAGATAAGAGAAATGTTTTGATGGTGGGCGATAGCTTAACCTCTGATAT
ACAAGGTGGTATAAATTTTGGTATAGACACCTGCTGGTTTAATTCTAATAAAATTATAAATAAAACAGAAATAAAACCTA
CTTATGAAATCTCTAATATAATGGAACTTAAGGATATGCTTGAAAAATAG

Upstream 100 bases:

>100_bases
AAAATGTTCAAGTGCACTAATTTATTCAACGATCTAAGATTTTTATAAAAAATTTGTATGCTATAATTTAAAAGTTAGAC
ATATCAGAAGGAGGATTATT

Downstream 100 bases:

>100_bases
ATATAAATTAATGGTGCTGTTTCAAAATACGATTAAAGCTATTTTGAAACAGCCCTATCTTTATATTATTTTTATTAACA
TTATCAACTGAATATTTAAA

Product: HAD superfamily (subfamily IA) hydrolase

Products: NA

Alternate protein names: House-cleaning nucleotidase; Non-canonical pyrimidine nucleotide phosphatase; Nucleoside 5'-monophosphate phosphohydrolase; dUMP phosphatase [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MKYKIIIFDADETLFDFKKSERDAFKNAMLEFNIKYDENYHLKAYKDINTIIWKELENGLITQEELKIERFKRLSHKLNI
KFNEYDFAKSYMKHLSHASFLYDDSINLVESLHKNYRLSIVTNGLKDVQNNRIRKSIIAKYFEDIVISEEVKVSKPSSKI
FEHALNNMNHTDKRNVLMVGDSLTSDIQGGINFGIDTCWFNSNKIINKTEIKPTYEISNIMELKDMLEK

Sequences:

>Translated_229_residues
MKYKIIIFDADETLFDFKKSERDAFKNAMLEFNIKYDENYHLKAYKDINTIIWKELENGLITQEELKIERFKRLSHKLNI
KFNEYDFAKSYMKHLSHASFLYDDSINLVESLHKNYRLSIVTNGLKDVQNNRIRKSIIAKYFEDIVISEEVKVSKPSSKI
FEHALNNMNHTDKRNVLMVGDSLTSDIQGGINFGIDTCWFNSNKIINKTEIKPTYEISNIMELKDMLEK
>Mature_229_residues
MKYKIIIFDADETLFDFKKSERDAFKNAMLEFNIKYDENYHLKAYKDINTIIWKELENGLITQEELKIERFKRLSHKLNI
KFNEYDFAKSYMKHLSHASFLYDDSINLVESLHKNYRLSIVTNGLKDVQNNRIRKSIIAKYFEDIVISEEVKVSKPSSKI
FEHALNNMNHTDKRNVLMVGDSLTSDIQGGINFGIDTCWFNSNKIINKTEIKPTYEISNIMELKDMLEK

Specific function: Nucleotidase that shows high phosphatase activity toward non-canonical pyrimidine nucleotides and three canonical nucleoside 5'-monophosphates (UMP, dUMP, and dTMP), and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconat

COG id: COG1011

COG function: function code R; Predicted hydrolase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. YjjG family [H]

Homologues:

Organism=Homo sapiens, GI23308749, Length=246, Percent_Identity=28.4552845528455, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1790833, Length=229, Percent_Identity=33.1877729257642, Blast_Score=154, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR011951 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.5 [H]

Molecular weight: Translated: 27055; Mature: 27055

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYKIIIFDADETLFDFKKSERDAFKNAMLEFNIKYDENYHLKAYKDINTIIWKELENGL
CEEEEEEECCCCHHHHHHHHHHHHHHHCEEEEEEEECCCEEEEEEHHHHHHHHHHHHCCC
ITQEELKIERFKRLSHKLNIKFNEYDFAKSYMKHLSHASFLYDDSINLVESLHKNYRLSI
CCHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCEEEEE
VTNGLKDVQNNRIRKSIIAKYFEDIVISEEVKVSKPSSKIFEHALNNMNHTDKRNVLMVG
EECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEC
DSLTSDIQGGINFGIDTCWFNSNKIINKTEIKPTYEISNIMELKDMLEK
CCHHHHHCCCCCCCEEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKYKIIIFDADETLFDFKKSERDAFKNAMLEFNIKYDENYHLKAYKDINTIIWKELENGL
CEEEEEEECCCCHHHHHHHHHHHHHHHCEEEEEEEECCCEEEEEEHHHHHHHHHHHHCCC
ITQEELKIERFKRLSHKLNIKFNEYDFAKSYMKHLSHASFLYDDSINLVESLHKNYRLSI
CCHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCEEEEE
VTNGLKDVQNNRIRKSIIAKYFEDIVISEEVKVSKPSSKIFEHALNNMNHTDKRNVLMVG
EECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEC
DSLTSDIQGGINFGIDTCWFNSNKIINKTEIKPTYEISNIMELKDMLEK
CCHHHHHCCCCCCCEEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]