Click here to switch to the map view.

The map label for this gene is panB [H]

Identifier: 148378428

GI number: 148378428

Start: 506533

End: 507360

Strand: Reverse

Name: panB [H]

Synonym: CBO0425

Alternate gene names: 148378428

Gene position: 507360-506533 (Counterclockwise)

Preceding gene: 148378430

Following gene: 148378427

Centisome position: 13.05

GC content: 33.09

Gene sequence:

>828_bases
ATGCGTAATACTGTATCAACTTTTCAAGAATTAAAAAACAAAGGTGAAAAAATAACTATGTTAACTGCCTATGATTATTC
TATGGCAAAGCTTATAGACTCCTCTGGAATCAATGGAATACTAGTTGGGGACTCTTTAGGAATGGTATGCTTAGGATATG
AAAACACACTAAGTGTAACTATGGAAGATATGCTCCATCATACTAAGGCTGTAGTAAGAGGAACTTCTAACGCTTTAGTT
GTGGGAGATATGCCCTTTATGTCTTACCAAACTTCTATTTATGATGCGGTTTATAATGCAGGAAGATTTATAAAAGAAGC
TGGCGCTCACGCTGTAAAATTAGAGGGTGGTGCCACTGTAGCTGAAGAAATTAAAGCTATAGTTAAAGCTCAAATCCCTG
TAATGGGACATATAGGTTTAACCCCTCAATCTGTAAATATGTTTGGAGGATTCAAAGTTCAGGGGAAAAACGAAAAAGTA
GCAAAGAAACTAATAGAAGATGCTAAAATTTTAGAAGAGGCGGGAGCTTTTTCTATAGTTCTAGAATGTATCCCTGAAAA
ATTATCAAAGATAATATCAGAATCCATTTCCATCCCAACCATAGGCATAGGTGCAGGAAAATATTGTGATGGTCAAATAC
TAGTTTATCAAGATATGCTTTCTATGTTTTCAGATTTCAAACCTAAATTTGTTAAGTCCTTTGGAAATATAGGAGAATCT
ATAAAAGATGGTGTTTCACAATATATAAAAGAAGTTAAAGAAGCTAAGTTTCCTGAAGAAAAACATGCTTTTAAAATAGA
TGATGATGTAATAAATAAATTATATTAG

Upstream 100 bases:

>100_bases
TTTATAAAAACAATTCGGATGCACATTGGTATTCTATCCATCCTAATAAATTTTTACAAAATTATTTACAATATAATATT
AATATTTTAGGAGGGATACG

Downstream 100 bases:

>100_bases
TTTTTAAATAACCAGCAGAGGGGGGTAAAGGCTGATTTTCTCAGCTGAACAATATGAATATAGTTAATACAATAAAAGAT
GTTAGATTAATCATAAAAAA

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MRNTVSTFQELKNKGEKITMLTAYDYSMAKLIDSSGINGILVGDSLGMVCLGYENTLSVTMEDMLHHTKAVVRGTSNALV
VGDMPFMSYQTSIYDAVYNAGRFIKEAGAHAVKLEGGATVAEEIKAIVKAQIPVMGHIGLTPQSVNMFGGFKVQGKNEKV
AKKLIEDAKILEEAGAFSIVLECIPEKLSKIISESISIPTIGIGAGKYCDGQILVYQDMLSMFSDFKPKFVKSFGNIGES
IKDGVSQYIKEVKEAKFPEEKHAFKIDDDVINKLY

Sequences:

>Translated_275_residues
MRNTVSTFQELKNKGEKITMLTAYDYSMAKLIDSSGINGILVGDSLGMVCLGYENTLSVTMEDMLHHTKAVVRGTSNALV
VGDMPFMSYQTSIYDAVYNAGRFIKEAGAHAVKLEGGATVAEEIKAIVKAQIPVMGHIGLTPQSVNMFGGFKVQGKNEKV
AKKLIEDAKILEEAGAFSIVLECIPEKLSKIISESISIPTIGIGAGKYCDGQILVYQDMLSMFSDFKPKFVKSFGNIGES
IKDGVSQYIKEVKEAKFPEEKHAFKIDDDVINKLY
>Mature_275_residues
MRNTVSTFQELKNKGEKITMLTAYDYSMAKLIDSSGINGILVGDSLGMVCLGYENTLSVTMEDMLHHTKAVVRGTSNALV
VGDMPFMSYQTSIYDAVYNAGRFIKEAGAHAVKLEGGATVAEEIKAIVKAQIPVMGHIGLTPQSVNMFGGFKVQGKNEKV
AKKLIEDAKILEEAGAFSIVLECIPEKLSKIISESISIPTIGIGAGKYCDGQILVYQDMLSMFSDFKPKFVKSFGNIGES
IKDGVSQYIKEVKEAKFPEEKHAFKIDDDVINKLY

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=262, Percent_Identity=46.1832061068702, Blast_Score=244, Evalue=6e-66,
Organism=Saccharomyces cerevisiae, GI6319653, Length=280, Percent_Identity=37.8571428571429, Blast_Score=204, Evalue=1e-53,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 30045; Mature: 30045

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNTVSTFQELKNKGEKITMLTAYDYSMAKLIDSSGINGILVGDSLGMVCLGYENTLSVT
CCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCCEEEEECCCCEEEECCCCHHHHH
MEDMLHHTKAVVRGTSNALVVGDMPFMSYQTSIYDAVYNAGRFIKEAGAHAVKLEGGATV
HHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHH
AEEIKAIVKAQIPVMGHIGLTPQSVNMFGGFKVQGKNEKVAKKLIEDAKILEEAGAFSIV
HHHHHHHHHHCCCEEEECCCCCCCCHHCCCEEEECCCHHHHHHHHHHHHHHHHCCHHHHH
LECIPEKLSKIISESISIPTIGIGAGKYCDGQILVYQDMLSMFSDFKPKFVKSFGNIGES
HHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHH
IKDGVSQYIKEVKEAKFPEEKHAFKIDDDVINKLY
HHHHHHHHHHHHHHCCCCCHHCCEECCHHHHHHCC
>Mature Secondary Structure
MRNTVSTFQELKNKGEKITMLTAYDYSMAKLIDSSGINGILVGDSLGMVCLGYENTLSVT
CCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCCEEEEECCCCEEEECCCCHHHHH
MEDMLHHTKAVVRGTSNALVVGDMPFMSYQTSIYDAVYNAGRFIKEAGAHAVKLEGGATV
HHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHH
AEEIKAIVKAQIPVMGHIGLTPQSVNMFGGFKVQGKNEKVAKKLIEDAKILEEAGAFSIV
HHHHHHHHHHCCCEEEECCCCCCCCHHCCCEEEECCCHHHHHHHHHHHHHHHHCCHHHHH
LECIPEKLSKIISESISIPTIGIGAGKYCDGQILVYQDMLSMFSDFKPKFVKSFGNIGES
HHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHH
IKDGVSQYIKEVKEAKFPEEKHAFKIDDDVINKLY
HHHHHHHHHHHHHHCCCCCHHCCEECCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA