Click here to switch to the map view.

The map label for this gene is argH [H]

Identifier: 148360891

GI number: 148360891

Start: 584119

End: 585354

Strand: Direct

Name: argH [H]

Synonym: LPC_2851

Alternate gene names: 148360891

Gene position: 584119-585354 (Clockwise)

Preceding gene: 148360892

Following gene: 148360890

Centisome position: 16.33

GC content: 39.24

Gene sequence:

>1236_bases
ATGACTAATAAGACATGGGGAGGGCGATTTAAGAAATCTTTGGATAGCGGTGTCAACCAGTTTAATGCGTCATTGTCTTT
TGATCATGTGCTTTTTGACCAAGACATTAATGGCAGTCAGGTTCATGTGAAGCAATTAGCTAAACAGAAGATTTTAACAG
AAGTTGAAAGCCAGGCGATTTATTCTGCTCTTGAAGAAATCAGAAGCGAGATAAAACAAGGCCAATATTCATTTAATGTA
CGTGATGAAGAAGACATACATATGTTTATTGAGCAATTACTGATTCAAAAAATAGGCGATTTGGGTAAGAAATTACACAC
CGGCCGTAGTCGTAATGATCAAGTGGCTTTGGATCTTCGTTTATATACCAGAGATAAAGGCTGTCTGATTAATGAACTTT
TGACAAGGCTTATCGATTGTCTAGATGATCTAACCAGTAAACATCAACAGGATTTAATGCCAGGCTATACTCATTTACAG
CAAGCCCAACCTGTTACGTTAGGGGCTTATTTTAACGCGTATCAATGCATGTTTGGCCGAGATAAAAGCAGATTGGAAGA
TTGGTTTAAACGCATGAATTATTCTCCTTTGGGTGCTGGGGCACTGGCTGGAAGTACCTTGCCTCTTGATAGAGAATGGG
TAGCCGAATCCTTGGGATTTGCAGGGATCATTCCTAATACTCTTGATGCAGTCAGTGACAGAGATTTTGTCATCGAGTTA
TGCAGTGTTGCTGCAATGATTATGATGCATCTTTCCAGATTATGTGAAGATTTGATTCTATGGTCTACCCAGGAATTTAA
TTTTGTTATATTGGATGATGCGTTTGCTACAGGCTCTTCACTGATGCCTAACAAGAAAAATCCCGATGTTCCTGAATTGA
TTCGTGGCAAATCAGGACGAGTTTATGGTCATCTAATGGCCATTTTAACGGTAATGAAAGGGTTGCCCTTGGCTTATAAC
AAAGACATGCAGGAGGATAAAGAAGGATTATTTGATACGATTAATACGATAATCGCTTGCCTGCAAATGATAACTCCTTT
CTTGCAAAGTCTGACTTTTAATACCCTGTTAATGAAAACCAAAGCTCAAAGTGGTTACCTTGATGCGACTGCCATTCTGG
AGTCATTAGTGATGAAGGGTATGCCTTTTCGTGATGCACACCATCAAGTTGGGGCATGGATTGCAGAAGCGATAGAAAAA
CAATGTTCACTGAATGAATTATTAAAAGGAGGCTAA

Upstream 100 bases:

>100_bases
GAAGAGGATAATGTATACAACCAAAAGGACGCTGAAGGATTCATTAACCTCTTTTCTTTATCCGCTAAAATCTATAGCCA
GGTACATCAGGAGGGGAATT

Downstream 100 bases:

>100_bases
GAATGTCTTTTTCCACCTCAACCAATTTGACTCCAATTGAAATGCAAGACGATGACCTTGAAAAAATTCAATCTCAGAAT
AGCCCATCTGCAATTAATGA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MTNKTWGGRFKKSLDSGVNQFNASLSFDHVLFDQDINGSQVHVKQLAKQKILTEVESQAIYSALEEIRSEIKQGQYSFNV
RDEEDIHMFIEQLLIQKIGDLGKKLHTGRSRNDQVALDLRLYTRDKGCLINELLTRLIDCLDDLTSKHQQDLMPGYTHLQ
QAQPVTLGAYFNAYQCMFGRDKSRLEDWFKRMNYSPLGAGALAGSTLPLDREWVAESLGFAGIIPNTLDAVSDRDFVIEL
CSVAAMIMMHLSRLCEDLILWSTQEFNFVILDDAFATGSSLMPNKKNPDVPELIRGKSGRVYGHLMAILTVMKGLPLAYN
KDMQEDKEGLFDTINTIIACLQMITPFLQSLTFNTLLMKTKAQSGYLDATAILESLVMKGMPFRDAHHQVGAWIAEAIEK
QCSLNELLKGG

Sequences:

>Translated_411_residues
MTNKTWGGRFKKSLDSGVNQFNASLSFDHVLFDQDINGSQVHVKQLAKQKILTEVESQAIYSALEEIRSEIKQGQYSFNV
RDEEDIHMFIEQLLIQKIGDLGKKLHTGRSRNDQVALDLRLYTRDKGCLINELLTRLIDCLDDLTSKHQQDLMPGYTHLQ
QAQPVTLGAYFNAYQCMFGRDKSRLEDWFKRMNYSPLGAGALAGSTLPLDREWVAESLGFAGIIPNTLDAVSDRDFVIEL
CSVAAMIMMHLSRLCEDLILWSTQEFNFVILDDAFATGSSLMPNKKNPDVPELIRGKSGRVYGHLMAILTVMKGLPLAYN
KDMQEDKEGLFDTINTIIACLQMITPFLQSLTFNTLLMKTKAQSGYLDATAILESLVMKGMPFRDAHHQVGAWIAEAIEK
QCSLNELLKGG
>Mature_410_residues
TNKTWGGRFKKSLDSGVNQFNASLSFDHVLFDQDINGSQVHVKQLAKQKILTEVESQAIYSALEEIRSEIKQGQYSFNVR
DEEDIHMFIEQLLIQKIGDLGKKLHTGRSRNDQVALDLRLYTRDKGCLINELLTRLIDCLDDLTSKHQQDLMPGYTHLQQ
AQPVTLGAYFNAYQCMFGRDKSRLEDWFKRMNYSPLGAGALAGSTLPLDREWVAESLGFAGIIPNTLDAVSDRDFVIELC
SVAAMIMMHLSRLCEDLILWSTQEFNFVILDDAFATGSSLMPNKKNPDVPELIRGKSGRVYGHLMAILTVMKGLPLAYNK
DMQEDKEGLFDTINTIIACLQMITPFLQSLTFNTLLMKTKAQSGYLDATAILESLVMKGMPFRDAHHQVGAWIAEAIEKQ
CSLNELLKGG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=406, Percent_Identity=44.5812807881773, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI68303542, Length=406, Percent_Identity=44.5812807881773, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI68303549, Length=406, Percent_Identity=42.6108374384236, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI68303547, Length=406, Percent_Identity=42.1182266009852, Blast_Score=303, Evalue=2e-82,
Organism=Escherichia coli, GI1790398, Length=405, Percent_Identity=50.1234567901235, Blast_Score=380, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6321806, Length=401, Percent_Identity=45.1371571072319, Blast_Score=332, Evalue=5e-92,
Organism=Drosophila melanogaster, GI221473854, Length=410, Percent_Identity=39.2682926829268, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI78706858, Length=410, Percent_Identity=39.2682926829268, Blast_Score=302, Evalue=3e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 46243; Mature: 46112

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKTWGGRFKKSLDSGVNQFNASLSFDHVLFDQDINGSQVHVKQLAKQKILTEVESQAI
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
YSALEEIRSEIKQGQYSFNVRDEEDIHMFIEQLLIQKIGDLGKKLHTGRSRNDQVALDLR
HHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
LYTRDKGCLINELLTRLIDCLDDLTSKHQQDLMPGYTHLQQAQPVTLGAYFNAYQCMFGR
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEHHHHHHHHHHHCC
DKSRLEDWFKRMNYSPLGAGALAGSTLPLDREWVAESLGFAGIIPNTLDAVSDRDFVIEL
CHHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHCCHHHHHHH
CSVAAMIMMHLSRLCEDLILWSTQEFNFVILDDAFATGSSLMPNKKNPDVPELIRGKSGR
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCC
VYGHLMAILTVMKGLPLAYNKDMQEDKEGLFDTINTIIACLQMITPFLQSLTFNTLLMKT
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAQSGYLDATAILESLVMKGMPFRDAHHQVGAWIAEAIEKQCSLNELLKGG
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure 
TNKTWGGRFKKSLDSGVNQFNASLSFDHVLFDQDINGSQVHVKQLAKQKILTEVESQAI
CCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
YSALEEIRSEIKQGQYSFNVRDEEDIHMFIEQLLIQKIGDLGKKLHTGRSRNDQVALDLR
HHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
LYTRDKGCLINELLTRLIDCLDDLTSKHQQDLMPGYTHLQQAQPVTLGAYFNAYQCMFGR
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEHHHHHHHHHHHCC
DKSRLEDWFKRMNYSPLGAGALAGSTLPLDREWVAESLGFAGIIPNTLDAVSDRDFVIEL
CHHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHCCHHHHHHH
CSVAAMIMMHLSRLCEDLILWSTQEFNFVILDDAFATGSSLMPNKKNPDVPELIRGKSGR
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCC
VYGHLMAILTVMKGLPLAYNKDMQEDKEGLFDTINTIIACLQMITPFLQSLTFNTLLMKT
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAQSGYLDATAILESLVMKGMPFRDAHHQVGAWIAEAIEKQCSLNELLKGG
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA