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The map label for this gene is argF [H]

Identifier: 148360890

GI number: 148360890

Start: 585357

End: 586472

Strand: Direct

Name: argF [H]

Synonym: LPC_2850

Alternate gene names: 148360890

Gene position: 585357-586472 (Clockwise)

Preceding gene: 148360891

Following gene: 148360888

Centisome position: 16.37

GC content: 39.78

Gene sequence:

>1116_bases
ATGTCTTTTTCCACCTCAACCAATTTGACTCCAATTGAAATGCAAGACGATGACCTTGAAAAAATTCAATCTCAGAATAG
CCCATCTGCAATTAATGAAGTGAAGACCAATACTTTTGTCATTAATTTACAACAAGCTATTTTTGGCTTGGAGACAGGTA
GTGAGGCCGTTGATTTTGATTCTCATAAGAATACAGGCTTTCCATTTCCTGCTGGTGAATACAAACCAAGGCATTTTCTT
ACTGGCACAGAGTTAGCAAGGGAGGAAATTCAGTTTGTCTTAAGCCAGGCTCGCTCTCTAAAACAAAACCCGGGATTATA
TAATCAGGCACTTGCCAATAAAAGTTTGGTAATGATTTTTGAAAAACCTTCCTTTAGAACCCGTTTGAGTTTTGCTTTAG
CGATTCAGAGTATGGGGGGGATCGTTGTTGAAAGCATCGCTAACTCAAGAAAGCAGGAGACTCCAGCTGATATGGCTAGA
GTTTTAAATGGTTATGCTGATTTTGTAATGGTCAGAACACATGAGGACAGTTTTTTGCAAGAAATGGCCGAATATTCCAA
AATCCCTATTATTAATGGCCTCTCCGCATTGCATCACCCTTGTCAGACTCTTGCTGACTTGTTAAGTCTTGAAGAACAAT
TTGGTGCTTTGGAAGGATTAACCCTTACTTACATAGGGGATGGCAATAATATTTTGCATAGTTTGATGCTTTTGGCACCG
CAGCTAGGTGTCACTGTGCATTATTGTTGCCCAAAATCAAATCAGCCTAATGAGGCCATTATTAAGGAAGCCCAAAGCAA
GACAGGGAAACAAATGATTTATTGTTTTGATAAACCGGAGGAAGCTGTGAAGCAAGCGGATGCCGTTTATACCGATGTGT
GGACAAGTATGGGATTTGATAATCCTGAAGCAGGCAAGATTTTTAAAGGGTTTCAGGTTAATGAGACATTAATGTCTCAT
GCAAAACCCGATTCGGTGTTTATGCATTGTATGCCTATGGAAAGGGGAAAAGAGGTTTCTGCTACTTTACCCGACAGCGC
GTCATCTATCATTTTTAGGCAGAGTGAGAATAGAATGCATGTACAAAAGGCTTTGATGCTATTTTTGGATCAATAG

Upstream 100 bases:

>100_bases
GTATGCCTTTTCGTGATGCACACCATCAAGTTGGGGCATGGATTGCAGAAGCGATAGAAAAACAATGTTCACTGAATGAA
TTATTAAAAGGAGGCTAAGA

Downstream 100 bases:

>100_bases
AACTTTGGATTATGAGGCCCATATTTGTTCATGATGAAACGAAATTGCGCATTTCTCCTGATATGGGCTCATGATTTTTG
CAAATTAATTTAGTAATTCT

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MSFSTSTNLTPIEMQDDDLEKIQSQNSPSAINEVKTNTFVINLQQAIFGLETGSEAVDFDSHKNTGFPFPAGEYKPRHFL
TGTELAREEIQFVLSQARSLKQNPGLYNQALANKSLVMIFEKPSFRTRLSFALAIQSMGGIVVESIANSRKQETPADMAR
VLNGYADFVMVRTHEDSFLQEMAEYSKIPIINGLSALHHPCQTLADLLSLEEQFGALEGLTLTYIGDGNNILHSLMLLAP
QLGVTVHYCCPKSNQPNEAIIKEAQSKTGKQMIYCFDKPEEAVKQADAVYTDVWTSMGFDNPEAGKIFKGFQVNETLMSH
AKPDSVFMHCMPMERGKEVSATLPDSASSIIFRQSENRMHVQKALMLFLDQ

Sequences:

>Translated_371_residues
MSFSTSTNLTPIEMQDDDLEKIQSQNSPSAINEVKTNTFVINLQQAIFGLETGSEAVDFDSHKNTGFPFPAGEYKPRHFL
TGTELAREEIQFVLSQARSLKQNPGLYNQALANKSLVMIFEKPSFRTRLSFALAIQSMGGIVVESIANSRKQETPADMAR
VLNGYADFVMVRTHEDSFLQEMAEYSKIPIINGLSALHHPCQTLADLLSLEEQFGALEGLTLTYIGDGNNILHSLMLLAP
QLGVTVHYCCPKSNQPNEAIIKEAQSKTGKQMIYCFDKPEEAVKQADAVYTDVWTSMGFDNPEAGKIFKGFQVNETLMSH
AKPDSVFMHCMPMERGKEVSATLPDSASSIIFRQSENRMHVQKALMLFLDQ
>Mature_370_residues
SFSTSTNLTPIEMQDDDLEKIQSQNSPSAINEVKTNTFVINLQQAIFGLETGSEAVDFDSHKNTGFPFPAGEYKPRHFLT
GTELAREEIQFVLSQARSLKQNPGLYNQALANKSLVMIFEKPSFRTRLSFALAIQSMGGIVVESIANSRKQETPADMARV
LNGYADFVMVRTHEDSFLQEMAEYSKIPIINGLSALHHPCQTLADLLSLEEQFGALEGLTLTYIGDGNNILHSLMLLAPQ
LGVTVHYCCPKSNQPNEAIIKEAQSKTGKQMIYCFDKPEEAVKQADAVYTDVWTSMGFDNPEAGKIFKGFQVNETLMSHA
KPDSVFMHCMPMERGKEVSATLPDSASSIIFRQSENRMHVQKALMLFLDQ

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=308, Percent_Identity=37.3376623376623, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI18105007, Length=263, Percent_Identity=30.7984790874525, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786469, Length=328, Percent_Identity=33.5365853658537, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI1790703, Length=325, Percent_Identity=32.6153846153846, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI2367364, Length=300, Percent_Identity=26.3333333333333, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI193204318, Length=336, Percent_Identity=26.1904761904762, Blast_Score=98, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6322373, Length=309, Percent_Identity=27.5080906148867, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6322331, Length=303, Percent_Identity=26.0726072607261, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24642586, Length=280, Percent_Identity=30.3571428571429, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 41307; Mature: 41175

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSTSTNLTPIEMQDDDLEKIQSQNSPSAINEVKTNTFVINLQQAIFGLETGSEAVDFD
CCCCCCCCCCEEECCCCHHHHHHCCCCCHHHHHCCCCEEEEEHHHHHHCCCCCCCCCCCC
SHKNTGFPFPAGEYKPRHFLTGTELAREEIQFVLSQARSLKQNPGLYNQALANKSLVMIF
CCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEE
EKPSFRTRLSFALAIQSMGGIVVESIANSRKQETPADMARVLNGYADFVMVRTHEDSFLQ
ECCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHCCHHCEEEEEECCHHHHH
EMAEYSKIPIINGLSALHHPCQTLADLLSLEEQFGALEGLTLTYIGDGNNILHSLMLLAP
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHH
QLGVTVHYCCPKSNQPNEAIIKEAQSKTGKQMIYCFDKPEEAVKQADAVYTDVWTSMGFD
HCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCC
NPEAGKIFKGFQVNETLMSHAKPDSVFMHCMPMERGKEVSATLPDSASSIIFRQSENRMH
CCCCCCEECCCCHHHHHHHCCCCCCEEEEEEECCCCCCEEEECCCCCCCEEEECCCCHHH
VQKALMLFLDQ
HHHHHHHHHCC
>Mature Secondary Structure 
SFSTSTNLTPIEMQDDDLEKIQSQNSPSAINEVKTNTFVINLQQAIFGLETGSEAVDFD
CCCCCCCCCEEECCCCHHHHHHCCCCCHHHHHCCCCEEEEEHHHHHHCCCCCCCCCCCC
SHKNTGFPFPAGEYKPRHFLTGTELAREEIQFVLSQARSLKQNPGLYNQALANKSLVMIF
CCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEE
EKPSFRTRLSFALAIQSMGGIVVESIANSRKQETPADMARVLNGYADFVMVRTHEDSFLQ
ECCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHCCHHCEEEEEECCHHHHH
EMAEYSKIPIINGLSALHHPCQTLADLLSLEEQFGALEGLTLTYIGDGNNILHSLMLLAP
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHH
QLGVTVHYCCPKSNQPNEAIIKEAQSKTGKQMIYCFDKPEEAVKQADAVYTDVWTSMGFD
HCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCC
NPEAGKIFKGFQVNETLMSHAKPDSVFMHCMPMERGKEVSATLPDSASSIIFRQSENRMH
CCCCCCEECCCCHHHHHHHCCCCCCEEEEEEECCCCCCEEEECCCCCCCEEEECCCCHHH
VQKALMLFLDQ
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]