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The map label for this gene is gor [H]

Identifier: 148360774

GI number: 148360774

Start: 707015

End: 708373

Strand: Reverse

Name: gor [H]

Synonym: LPC_2724

Alternate gene names: 148360774

Gene position: 708373-707015 (Counterclockwise)

Preceding gene: 148360773

Following gene: 148360775

Centisome position: 19.81

GC content: 38.41

Gene sequence:

>1359_bases
ATGAAAACAAAACATTTTGACCTTATAGTTCTTGGAGGAGGAAGTGGCGGAATAGCCAGTGCTGTTCGTGCTGCTCAGTA
TGGAGCCAAAGTAGCGGTTATTGAGCAAAGCCACTTGGGAGGGACCTGCGTGAATTTAGGATGTGTCCCCAAAAAAATTA
TGTACAATGCTTCATCAATTGCAGAAACACTCCATAAATCTCCTGATTACGGTTTTTTCCTGGAAAATAATGCCAAGTTA
GATTGGAAGCGACTAGTGAATAAACGCAATGCGTATATTGAACGTTTAAGAGAAAATTATGCGAAACGATTTTCACAGCA
CAAAATTACTCTAATTCAAGGTAAGGGTATTTTCCACGATCAAAGTTCTATCACGATAGATCATACTATTTATCAAGCAG
AACATATTATTATTGCAACTGGTGGTGAGCCAGCTCTACCAGCAATTAATGGCATTAAGCATGCTATTGATTCTGATGGT
TTCTTTTCATTAACCAAATTACCAGCTAAAGTAGCTGTTATTGGTAGCGGTTACATAGGTGTTGAATTAGCAGGAATCCT
TAACTCTCTTGGTAGTGAAACTCACTTATTAATGAGAGGTACACGGCCACTGAGTCGCTTTGATCATATGATTGGCGATA
CTTTAATGGAAATTATGCAAAAACAAGGAATCTGTATTCATCAAAACCATAAAGCCCAAGCTATCCATCTTCATAGCGAC
GGCAGAAAAAGTATTTTGTGCCAAAGTGGCTCTATTATTGAAAATATTGATGTGATTATATCTGCTGTAGGTCGAAAACC
GCGGACTGGCAATTTAAATCTTGATAAAATAAACGTTAACATGGATGACAAAGGATTAATCCTGGTTGATGCATTTCAAA
ATACATCGGTTAAAGGTATTTATGCTATTGGCGATGTCACTAATGCTCCCGCACTAACACCCGTTGCAATAGCGGCAGGG
AGGCGTTTGGCAGACCGAATTTTCGGGAATCAACCTGATGCCTGCTTAAATTATGATAATATTTGTTCAGTAGTATTCTC
TCATCCTCCATCTGGTTCTGTCGGTTTAACCGAGCATGAAGCCATTGAAAAATATGGTAAGAATAAAATTAAAATATATC
AAACCCGTTTCATCCCTATGTATGATGCCTTGAGTATTGATAAAACCCCTACTGCGATGAAATTGGTTACCTTGGGTAAA
AAGGAAAAGATTATTGGTTTACATGTCGTCGGATACAGCGCCGATGAAATGCTACAAGGCTTTGGGGTTGCCATAAAAAT
GGGCGCATGTAAAAAGGACTTCGATAATACAATAGCAATTCATCCAACCAGTGCTGAAGAATTTGTAACTATGGTGTAA

Upstream 100 bases:

>100_bases
GAAATTAAAAAATATTTTAGTTTTTTATAAAATTCAGTTTAATCCCTTGGTAGACCAAGCACGACCTGCTACTATTATTT
TATTTTCCTATTAATTGACT

Downstream 100 bases:

>100_bases
ATATACATGAACTATTCCATTCGTAAATTTGAAGACAAGTATCCTGAATTAGGTGAACGAGTTTATATTGATCCGCAATC
CACTGTCATTGGTAACGTAA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MKTKHFDLIVLGGGSGGIASAVRAAQYGAKVAVIEQSHLGGTCVNLGCVPKKIMYNASSIAETLHKSPDYGFFLENNAKL
DWKRLVNKRNAYIERLRENYAKRFSQHKITLIQGKGIFHDQSSITIDHTIYQAEHIIIATGGEPALPAINGIKHAIDSDG
FFSLTKLPAKVAVIGSGYIGVELAGILNSLGSETHLLMRGTRPLSRFDHMIGDTLMEIMQKQGICIHQNHKAQAIHLHSD
GRKSILCQSGSIIENIDVIISAVGRKPRTGNLNLDKINVNMDDKGLILVDAFQNTSVKGIYAIGDVTNAPALTPVAIAAG
RRLADRIFGNQPDACLNYDNICSVVFSHPPSGSVGLTEHEAIEKYGKNKIKIYQTRFIPMYDALSIDKTPTAMKLVTLGK
KEKIIGLHVVGYSADEMLQGFGVAIKMGACKKDFDNTIAIHPTSAEEFVTMV

Sequences:

>Translated_452_residues
MKTKHFDLIVLGGGSGGIASAVRAAQYGAKVAVIEQSHLGGTCVNLGCVPKKIMYNASSIAETLHKSPDYGFFLENNAKL
DWKRLVNKRNAYIERLRENYAKRFSQHKITLIQGKGIFHDQSSITIDHTIYQAEHIIIATGGEPALPAINGIKHAIDSDG
FFSLTKLPAKVAVIGSGYIGVELAGILNSLGSETHLLMRGTRPLSRFDHMIGDTLMEIMQKQGICIHQNHKAQAIHLHSD
GRKSILCQSGSIIENIDVIISAVGRKPRTGNLNLDKINVNMDDKGLILVDAFQNTSVKGIYAIGDVTNAPALTPVAIAAG
RRLADRIFGNQPDACLNYDNICSVVFSHPPSGSVGLTEHEAIEKYGKNKIKIYQTRFIPMYDALSIDKTPTAMKLVTLGK
KEKIIGLHVVGYSADEMLQGFGVAIKMGACKKDFDNTIAIHPTSAEEFVTMV
>Mature_452_residues
MKTKHFDLIVLGGGSGGIASAVRAAQYGAKVAVIEQSHLGGTCVNLGCVPKKIMYNASSIAETLHKSPDYGFFLENNAKL
DWKRLVNKRNAYIERLRENYAKRFSQHKITLIQGKGIFHDQSSITIDHTIYQAEHIIIATGGEPALPAINGIKHAIDSDG
FFSLTKLPAKVAVIGSGYIGVELAGILNSLGSETHLLMRGTRPLSRFDHMIGDTLMEIMQKQGICIHQNHKAQAIHLHSD
GRKSILCQSGSIIENIDVIISAVGRKPRTGNLNLDKINVNMDDKGLILVDAFQNTSVKGIYAIGDVTNAPALTPVAIAAG
RRLADRIFGNQPDACLNYDNICSVVFSHPPSGSVGLTEHEAIEKYGKNKIKIYQTRFIPMYDALSIDKTPTAMKLVTLGK
KEKIIGLHVVGYSADEMLQGFGVAIKMGACKKDFDNTIAIHPTSAEEFVTMV

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=458, Percent_Identity=47.3799126637555, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI22035672, Length=457, Percent_Identity=33.6980306345733, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI148277065, Length=455, Percent_Identity=34.9450549450549, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI33519430, Length=455, Percent_Identity=34.9450549450549, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI33519428, Length=455, Percent_Identity=34.9450549450549, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI33519426, Length=455, Percent_Identity=34.9450549450549, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI148277071, Length=455, Percent_Identity=34.9450549450549, Blast_Score=248, Evalue=7e-66,
Organism=Homo sapiens, GI291045266, Length=457, Percent_Identity=31.9474835886214, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI291045268, Length=457, Percent_Identity=29.1028446389497, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI91199540, Length=456, Percent_Identity=30.4824561403509, Blast_Score=185, Evalue=6e-47,
Organism=Escherichia coli, GI1789915, Length=450, Percent_Identity=51.5555555555556, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1786307, Length=451, Percent_Identity=27.9379157427938, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=26.4900662251656, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI87082354, Length=461, Percent_Identity=27.114967462039, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=49.1111111111111, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=49.1111111111111, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=34.1772151898734, Blast_Score=275, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=33.3333333333333, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI32565766, Length=473, Percent_Identity=28.5412262156448, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=46.3519313304721, Blast_Score=401, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=28.5407725321888, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=25.531914893617, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24640549, Length=472, Percent_Identity=33.8983050847458, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24640553, Length=472, Percent_Identity=33.8983050847458, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24640551, Length=472, Percent_Identity=33.8983050847458, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=33.7552742616034, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=29.4117647058824, Blast_Score=172, Evalue=4e-43,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49145; Mature: 49145

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKHFDLIVLGGGSGGIASAVRAAQYGAKVAVIEQSHLGGTCVNLGCVPKKIMYNASSI
CCCCEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCHHHHCCHHHH
AETLHKSPDYGFFLENNAKLDWKRLVNKRNAYIERLRENYAKRFSQHKITLIQGKGIFHD
HHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEC
QSSITIDHTIYQAEHIIIATGGEPALPAINGIKHAIDSDGFFSLTKLPAKVAVIGSGYIG
CCCEEEEEEEEEEEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEECCCEEEEEEECCCHH
VELAGILNSLGSETHLLMRGTRPLSRFDHMIGDTLMEIMQKQGICIHQNHKAQAIHLHSD
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEECC
GRKSILCQSGSIIENIDVIISAVGRKPRTGNLNLDKINVNMDDKGLILVDAFQNTSVKGI
CCCEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCEEE
YAIGDVTNAPALTPVAIAAGRRLADRIFGNQPDACLNYDNICSVVFSHPPSGSVGLTEHE
EEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHEECCCCCCCCCCCHHH
AIEKYGKNKIKIYQTRFIPMYDALSIDKTPTAMKLVTLGKKEKIIGLHVVGYSADEMLQG
HHHHHCCCEEEEEEEEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEEECCCHHHHHHC
FGVAIKMGACKKDFDNTIAIHPTSAEEFVTMV
CCEEEEECCCCCCCCCEEEEECCCHHHHEECC
>Mature Secondary Structure
MKTKHFDLIVLGGGSGGIASAVRAAQYGAKVAVIEQSHLGGTCVNLGCVPKKIMYNASSI
CCCCEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCHHHHCCHHHH
AETLHKSPDYGFFLENNAKLDWKRLVNKRNAYIERLRENYAKRFSQHKITLIQGKGIFHD
HHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEC
QSSITIDHTIYQAEHIIIATGGEPALPAINGIKHAIDSDGFFSLTKLPAKVAVIGSGYIG
CCCEEEEEEEEEEEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEECCCEEEEEEECCCHH
VELAGILNSLGSETHLLMRGTRPLSRFDHMIGDTLMEIMQKQGICIHQNHKAQAIHLHSD
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEECC
GRKSILCQSGSIIENIDVIISAVGRKPRTGNLNLDKINVNMDDKGLILVDAFQNTSVKGI
CCCEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCEEE
YAIGDVTNAPALTPVAIAAGRRLADRIFGNQPDACLNYDNICSVVFSHPPSGSVGLTEHE
EEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHEECCCCCCCCCCCHHH
AIEKYGKNKIKIYQTRFIPMYDALSIDKTPTAMKLVTLGKKEKIIGLHVVGYSADEMLQG
HHHHHCCCEEEEEEEEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEEECCCHHHHHHC
FGVAIKMGACKKDFDNTIAIHPTSAEEFVTMV
CCEEEEECCCCCCCCCEEEEECCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]