Click here to switch to the map view.

The map label for this gene is add [H]

Identifier: 148360773

GI number: 148360773

Start: 708604

End: 709584

Strand: Reverse

Name: add [H]

Synonym: LPC_2723

Alternate gene names: 148360773

Gene position: 709584-708604 (Counterclockwise)

Preceding gene: 148360770

Following gene: 148360774

Centisome position: 19.84

GC content: 37.41

Gene sequence:

>981_bases
ATGAATTTAAAAAAAGCAGAATTACACGTACATTTAGAAGGAACTATTTCCCCAGACCTGGCCAAAAAATTAGCAAAAAG
AAACCATTTAACTCTCCCTGATGGTCTTATTGCTTTCGATGAGAAAAGTTACTTATCAAAAGACTTTCTCGATTTTCTTA
AGGTTTATGATACGCTGGCATCCGTAATTAAAAATCCACAAGATTATTATGATATTACCTTTGATTATCTTAAATCAAAC
GCTCAAGAACATGCTATCTACATTGAAATGATGTACTCTCCGGACCATGCCGAGCAATCCAGTGGAATTCCTTCAAAAGA
GCATTTAGCAGCAATTCAACAGGCTATTGATGATGCTAAAAGTCAATTTGATATTGTTGGACGTATTATTATCACTGCAG
TACGCCATTTTGGCGTAGAAGCATGCGAACGCGTAGCAAAACAAGCTTCTATAGATAAATTTCCTTGTGTAACAGGATTT
GGATTAGGAGGAGATGAAGCAAAATTTCCTCCTCAATTGTTTGCCAAAACTTATCAGATAGCAGCAGACTCCGGATTGGA
ATGCACCGTTCATGCCGGCGAATTTGATTCAGCCAAAGGAATGGAAGAAGCAATGAAAACTCTGCCTATTAAAAGAATTG
GACATGGGGTTCGAGTGATTGACTCACCTGACATCATGGCCATGGTTAAAGACCAGGGTATTGCATTGGAAGTGTGCCCA
ACCAGTAACATATTTTTGGGATTATTCAAAGACATGAATAGCCACCCTTTTCCAAAGCTTTATGAAGCAGGGATTAAAGT
CAGTATTAATTCCGATGATCCTCCTTTTATGAGCACTACACTTGCTCAAGAGTACAAAAGAGTTCAAAAAGCTTATGGCT
ATAGCAATGACACAATGAATAATATTACGCGTATGGCTATTGAAGCTGCTTTTGTTGATGAAAAAACCCGGAAGGAACTT
TTAACAAAATTAGAACAATAA

Upstream 100 bases:

>100_bases
CATACTCAATCCAAAATAACTTTATTTAAAAAATATATTTTATCGTTTTTTTATCTAAGTTACCATTAATCTTCTTTCAA
GTAAGATAATAGGCTATATC

Downstream 100 bases:

>100_bases
TCTCAGTCTTATATTCCTGTTGTCAGTACTAATTCCCTGCTGACTTGAGGCGATAATGATACTGTTATATTTTTACAGGT
TGGTGTTGATACATGGCTTA

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MNLKKAELHVHLEGTISPDLAKKLAKRNHLTLPDGLIAFDEKSYLSKDFLDFLKVYDTLASVIKNPQDYYDITFDYLKSN
AQEHAIYIEMMYSPDHAEQSSGIPSKEHLAAIQQAIDDAKSQFDIVGRIIITAVRHFGVEACERVAKQASIDKFPCVTGF
GLGGDEAKFPPQLFAKTYQIAADSGLECTVHAGEFDSAKGMEEAMKTLPIKRIGHGVRVIDSPDIMAMVKDQGIALEVCP
TSNIFLGLFKDMNSHPFPKLYEAGIKVSINSDDPPFMSTTLAQEYKRVQKAYGYSNDTMNNITRMAIEAAFVDEKTRKEL
LTKLEQ

Sequences:

>Translated_326_residues
MNLKKAELHVHLEGTISPDLAKKLAKRNHLTLPDGLIAFDEKSYLSKDFLDFLKVYDTLASVIKNPQDYYDITFDYLKSN
AQEHAIYIEMMYSPDHAEQSSGIPSKEHLAAIQQAIDDAKSQFDIVGRIIITAVRHFGVEACERVAKQASIDKFPCVTGF
GLGGDEAKFPPQLFAKTYQIAADSGLECTVHAGEFDSAKGMEEAMKTLPIKRIGHGVRVIDSPDIMAMVKDQGIALEVCP
TSNIFLGLFKDMNSHPFPKLYEAGIKVSINSDDPPFMSTTLAQEYKRVQKAYGYSNDTMNNITRMAIEAAFVDEKTRKEL
LTKLEQ
>Mature_326_residues
MNLKKAELHVHLEGTISPDLAKKLAKRNHLTLPDGLIAFDEKSYLSKDFLDFLKVYDTLASVIKNPQDYYDITFDYLKSN
AQEHAIYIEMMYSPDHAEQSSGIPSKEHLAAIQQAIDDAKSQFDIVGRIIITAVRHFGVEACERVAKQASIDKFPCVTGF
GLGGDEAKFPPQLFAKTYQIAADSGLECTVHAGEFDSAKGMEEAMKTLPIKRIGHGVRVIDSPDIMAMVKDQGIALEVCP
TSNIFLGLFKDMNSHPFPKLYEAGIKVSINSDDPPFMSTTLAQEYKRVQKAYGYSNDTMNNITRMAIEAAFVDEKTRKEL
LTKLEQ

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family [H]

Homologues:

Organism=Homo sapiens, GI47078295, Length=348, Percent_Identity=27.2988505747126, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI226693318, Length=331, Percent_Identity=25.9818731117825, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI61175224, Length=220, Percent_Identity=26.3636363636364, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1787910, Length=327, Percent_Identity=27.5229357798165, Blast_Score=149, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI32565969, Length=349, Percent_Identity=24.0687679083095, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17538512, Length=349, Percent_Identity=24.0687679083095, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI115537133, Length=322, Percent_Identity=20.4968944099379, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324188, Length=332, Percent_Identity=30.7228915662651, Blast_Score=173, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24645260, Length=327, Percent_Identity=23.2415902140673, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45553183, Length=244, Percent_Identity=26.6393442622951, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17737615, Length=244, Percent_Identity=26.6393442622951, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24666073, Length=244, Percent_Identity=26.2295081967213, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001365
- InterPro:   IPR006330 [H]

Pfam domain/function: PF00962 A_deaminase [H]

EC number: =3.5.4.4 [H]

Molecular weight: Translated: 36352; Mature: 36352

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00485 A_DEAMINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKKAELHVHLEGTISPDLAKKLAKRNHLTLPDGLIAFDEKSYLSKDFLDFLKVYDTLA
CCCCEEEEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHH
SVIKNPQDYYDITFDYLKSNAQEHAIYIEMMYSPDHAEQSSGIPSKEHLAAIQQAIDDAK
HHHCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHH
SQFDIVGRIIITAVRHFGVEACERVAKQASIDKFPCVTGFGLGGDEAKFPPQLFAKTYQI
HHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHH
AADSGLECTVHAGEFDSAKGMEEAMKTLPIKRIGHGVRVIDSPDIMAMVKDQGIALEVCP
HCCCCCEEEEECCCCCCCCCHHHHHHHCCHHHHCCCEEEECCCCEEEEEECCCEEEEECC
TSNIFLGLFKDMNSHPFPKLYEAGIKVSINSDDPPFMSTTLAQEYKRVQKAYGYSNDTMN
CCCHHHHHHHHCCCCCCHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
NITRMAIEAAFVDEKTRKELLTKLEQ
HHHHHHHHHHHHCHHHHHHHHHHHCC
>Mature Secondary Structure
MNLKKAELHVHLEGTISPDLAKKLAKRNHLTLPDGLIAFDEKSYLSKDFLDFLKVYDTLA
CCCCEEEEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHH
SVIKNPQDYYDITFDYLKSNAQEHAIYIEMMYSPDHAEQSSGIPSKEHLAAIQQAIDDAK
HHHCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHH
SQFDIVGRIIITAVRHFGVEACERVAKQASIDKFPCVTGFGLGGDEAKFPPQLFAKTYQI
HHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHH
AADSGLECTVHAGEFDSAKGMEEAMKTLPIKRIGHGVRVIDSPDIMAMVKDQGIALEVCP
HCCCCCEEEEECCCCCCCCCHHHHHHHCCHHHHCCCEEEECCCCEEEEEECCCEEEEECC
TSNIFLGLFKDMNSHPFPKLYEAGIKVSINSDDPPFMSTTLAQEYKRVQKAYGYSNDTMN
CCCHHHHHHHHCCCCCCHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
NITRMAIEAAFVDEKTRKELLTKLEQ
HHHHHHHHHHHHCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA