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The map label for this gene is tyrP [H]

Identifier: 148360692

GI number: 148360692

Start: 808532

End: 809794

Strand: Reverse

Name: tyrP [H]

Synonym: LPC_2639

Alternate gene names: 148360692

Gene position: 809794-808532 (Counterclockwise)

Preceding gene: 148360691

Following gene: 148360693

Centisome position: 22.64

GC content: 41.33

Gene sequence:

>1263_bases
TTGACTTTTTTTGAGGAACAAAGTATCATTTTGTTCTATATTTGTACTGTTTTTGGGTTATACTTCGTGATCAATTCAAA
ATTAATTGGTGGTATATTACTCATAGTAGGCACTTCGATTGGTGGTGGGATGCTAGCGCTACCTGTTTCTACAGCCGAGG
TGGGATTTGCTAACTCATTATTTTTCCTGTTTTTTTGCTGGTTGGTGATGACCGCTGGAGCTTTATTAATTCTTGAGGTA
AATCTACGACTCCCGGCAGGAAGCAATATGATTTCAATGGCGAAATCAACCTTGGGCCTGCCAGGTCAGGTAATTGCCTG
GATAACCTACCTTCTTCTTCTTTATACCCTCCTGGCAGCTTATATTTCAGGTGGAAGCGATGTATTTAGCAGCCTGCTGC
ATAAGGCCCACATTGATTTACCGAATTGGATAACGTCTGTAATATTTACTGCCATGTTCAGCCTTATTGTATATAGTGGT
ATACGCTCTGTAGACTACGTTAATCGTGGACTTATGTTTGGCAAACTGGGCGTCTATATTTTATTGGTTATCATTATCAG
TCCCCATGTATCCGCAGCAGGATTAACAGGCGGCTCAGCGAAAGCCTTTACTGGTACTCTCATGATCTTGGTCACTTCTT
TTGGATTTGCATCCATCGTGCCGAGCTTACGTGATTATTTTAACGATGATATACGTAGCTTACGTCGTGTTATTTTGTTT
GGCTCTCTTATACCATTATTCTGCTACATAGTCTGGGATGCAGTGATTATGGGCGTTATCTCACGCGAGGGAGAAAATGG
TTTATTGTCCCTAATGAACTCGGATCATGCGACCAGCGGCCTCACTGAAGCACTTAGTCAATCGGTAAGCAGCCAGTGGA
TCAGTGGATTTTTTGGTTTTTTCACTTCGATCTGTATGGTTACTGCATTTCTGGGAGTTTCATTAGGACTATTTGATTTT
CTTGCTGATGGATTAAAGCTTAAAAAATCTGGTAATCAAGGCAAGTATACGCTGGCTCTCACTTTTATCCCTCCATTGGC
CGTGGTGTTGTTTAACCCAGGTATCTACCTGCATGCATTAAGTTATGCAGGGGTTTGTTGTGTCATTTTACTGCTGTTAT
TACCTGCTATCATGGCATGGAAAGGAAGACAAACCTGTAGCCAATCTCCATCAGAAACTCATTTGATTCCTGGAGGAAAC
CCAGCTTTAAGCCTTATAGGATTTATCGCCATTGGTTTGCTTATCATTGCGATCATGTATTAA

Upstream 100 bases:

>100_bases
TTTGATAGCAGTAAAACATTAAAACCTGATAAACAGGATGTATAAATTGAACGCCAGGTCATTTGCGAAAAGAAAATGAT
CGAGGTATACAATAAGGAAG

Downstream 100 bases:

>100_bases
TTAAAGCCTGAATATCAGCGTTAAAAAGTACAAATTTGATATATTTTAAAATAAAGCGAAGCCAGTACAAGGGCTATTTT
GTAAATCAGATAAGGAACCT

Product: tryptophan/tyrosine permease

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTFFEEQSIILFYICTVFGLYFVINSKLIGGILLIVGTSIGGGMLALPVSTAEVGFANSLFFLFFCWLVMTAGALLILEV
NLRLPAGSNMISMAKSTLGLPGQVIAWITYLLLLYTLLAAYISGGSDVFSSLLHKAHIDLPNWITSVIFTAMFSLIVYSG
IRSVDYVNRGLMFGKLGVYILLVIIISPHVSAAGLTGGSAKAFTGTLMILVTSFGFASIVPSLRDYFNDDIRSLRRVILF
GSLIPLFCYIVWDAVIMGVISREGENGLLSLMNSDHATSGLTEALSQSVSSQWISGFFGFFTSICMVTAFLGVSLGLFDF
LADGLKLKKSGNQGKYTLALTFIPPLAVVLFNPGIYLHALSYAGVCCVILLLLLPAIMAWKGRQTCSQSPSETHLIPGGN
PALSLIGFIAIGLLIIAIMY

Sequences:

>Translated_420_residues
MTFFEEQSIILFYICTVFGLYFVINSKLIGGILLIVGTSIGGGMLALPVSTAEVGFANSLFFLFFCWLVMTAGALLILEV
NLRLPAGSNMISMAKSTLGLPGQVIAWITYLLLLYTLLAAYISGGSDVFSSLLHKAHIDLPNWITSVIFTAMFSLIVYSG
IRSVDYVNRGLMFGKLGVYILLVIIISPHVSAAGLTGGSAKAFTGTLMILVTSFGFASIVPSLRDYFNDDIRSLRRVILF
GSLIPLFCYIVWDAVIMGVISREGENGLLSLMNSDHATSGLTEALSQSVSSQWISGFFGFFTSICMVTAFLGVSLGLFDF
LADGLKLKKSGNQGKYTLALTFIPPLAVVLFNPGIYLHALSYAGVCCVILLLLLPAIMAWKGRQTCSQSPSETHLIPGGN
PALSLIGFIAIGLLIIAIMY
>Mature_419_residues
TFFEEQSIILFYICTVFGLYFVINSKLIGGILLIVGTSIGGGMLALPVSTAEVGFANSLFFLFFCWLVMTAGALLILEVN
LRLPAGSNMISMAKSTLGLPGQVIAWITYLLLLYTLLAAYISGGSDVFSSLLHKAHIDLPNWITSVIFTAMFSLIVYSGI
RSVDYVNRGLMFGKLGVYILLVIIISPHVSAAGLTGGSAKAFTGTLMILVTSFGFASIVPSLRDYFNDDIRSLRRVILFG
SLIPLFCYIVWDAVIMGVISREGENGLLSLMNSDHATSGLTEALSQSVSSQWISGFFGFFTSICMVTAFLGVSLGLFDFL
ADGLKLKKSGNQGKYTLALTFIPPLAVVLFNPGIYLHALSYAGVCCVILLLLLPAIMAWKGRQTCSQSPSETHLIPGGNP
ALSLIGFIAIGLLIIAIMY

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=390, Percent_Identity=34.8717948717949, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1790145, Length=395, Percent_Identity=30.6329113924051, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789552, Length=382, Percent_Identity=27.7486910994764, Blast_Score=131, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 45186; Mature: 45055

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFFEEQSIILFYICTVFGLYFVINSKLIGGILLIVGTSIGGGMLALPVSTAEVGFANSL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHCHHHHH
FFLFFCWLVMTAGALLILEVNLRLPAGSNMISMAKSTLGLPGQVIAWITYLLLLYTLLAA
HHHHHHHHHHHCCEEEEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YISGGSDVFSSLLHKAHIDLPNWITSVIFTAMFSLIVYSGIRSVDYVNRGLMFGKLGVYI
HHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LLVIIISPHVSAAGLTGGSAKAFTGTLMILVTSFGFASIVPSLRDYFNDDIRSLRRVILF
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
GSLIPLFCYIVWDAVIMGVISREGENGLLSLMNSDHATSGLTEALSQSVSSQWISGFFGF
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FTSICMVTAFLGVSLGLFDFLADGLKLKKSGNQGKYTLALTFIPPLAVVLFNPGIYLHAL
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEEEHHHHHHHHCCCCHHHHHH
SYAGVCCVILLLLLPAIMAWKGRQTCSQSPSETHLIPGGNPALSLIGFIAIGLLIIAIMY
HHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TFFEEQSIILFYICTVFGLYFVINSKLIGGILLIVGTSIGGGMLALPVSTAEVGFANSL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHCHHHHH
FFLFFCWLVMTAGALLILEVNLRLPAGSNMISMAKSTLGLPGQVIAWITYLLLLYTLLAA
HHHHHHHHHHHCCEEEEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YISGGSDVFSSLLHKAHIDLPNWITSVIFTAMFSLIVYSGIRSVDYVNRGLMFGKLGVYI
HHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LLVIIISPHVSAAGLTGGSAKAFTGTLMILVTSFGFASIVPSLRDYFNDDIRSLRRVILF
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
GSLIPLFCYIVWDAVIMGVISREGENGLLSLMNSDHATSGLTEALSQSVSSQWISGFFGF
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FTSICMVTAFLGVSLGLFDFLADGLKLKKSGNQGKYTLALTFIPPLAVVLFNPGIYLHAL
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEEEHHHHHHHHCCCCHHHHHH
SYAGVCCVILLLLLPAIMAWKGRQTCSQSPSETHLIPGGNPALSLIGFIAIGLLIIAIMY
HHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]