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The map label for this gene is pcoR [H]

Identifier: 148360632

GI number: 148360632

Start: 889945

End: 890616

Strand: Reverse

Name: pcoR [H]

Synonym: LPC_2578

Alternate gene names: 148360632

Gene position: 890616-889945 (Counterclockwise)

Preceding gene: 148360629

Following gene: 148360633

Centisome position: 24.9

GC content: 36.61

Gene sequence:

>672_bases
ATGCGATTATTAATTGTTGAAGACCATAAAAGAACGGCTGATTTTATCTGTAAAGGATTTAATGAATATCAATTTCAGGC
AGATGCTGTATACGATGGTGCAGAAGCAATCTATCGAATCTCAGAAATTAACTACGATGCTGTTGTTTTAGACGTTATGT
TACCCATAATGGATGGATGGGCTGTACTTGAAAAGATTCGTGAACTAAAACCCGATTTACCTGTTTTAATGCTTTCTGCC
TGCGACGATGTCGATAGTCGTGTGAAAGGGCTTGAAATGGGTGCCTATGATTATCTTGTTAAACCTTTTTCCTTCAATGA
GCTCCTTGCCCGAGTAAAATCTTTACTACGAAGAAAACCCAAAGAGAGCCCTATCTTATTAAAGATTAATGATTTAACTA
TAAACTTACAAAAGCATACAGCAATACGAGGCGACAAAAAGTTACCTTTAACAGCAAAAGAATTCATGTTATTGACGTTT
ATGTTGAAACGAAGTGGTGAAGTGCTTTCAAGGACAGTCATTGCTGAACAAGTTTGGGATATTAATTTTGACACGAATAC
CAATATCATTGATGTAGCGATCAAGCGTTTAAGGGAAAAAGTGGATAATGATCATCCTACTAAATTGATCCATACCGTCA
GAGGAGTAGGCTATGTATTGGAGATTCGCTAA

Upstream 100 bases:

>100_bases
TCAGAAGAGTGACATCAAGATTACAAAATTGTAATCTAATTCATTATGATAATTAGCATTTTTATGTTAAAATAGAACAT
AATTTAAACACAATGGCATT

Downstream 100 bases:

>100_bases
CTCAATGTCCATTACTAACCGCTTATTACTGATATTTATTGGTTCAACCGTACTGATATTGTCCATTATCACTGGGTTAA
TCTATCCTCCAATGAAAGAA

Product: two component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRLLIVEDHKRTADFICKGFNEYQFQADAVYDGAEAIYRISEINYDAVVLDVMLPIMDGWAVLEKIRELKPDLPVLMLSA
CDDVDSRVKGLEMGAYDYLVKPFSFNELLARVKSLLRRKPKESPILLKINDLTINLQKHTAIRGDKKLPLTAKEFMLLTF
MLKRSGEVLSRTVIAEQVWDINFDTNTNIIDVAIKRLREKVDNDHPTKLIHTVRGVGYVLEIR

Sequences:

>Translated_223_residues
MRLLIVEDHKRTADFICKGFNEYQFQADAVYDGAEAIYRISEINYDAVVLDVMLPIMDGWAVLEKIRELKPDLPVLMLSA
CDDVDSRVKGLEMGAYDYLVKPFSFNELLARVKSLLRRKPKESPILLKINDLTINLQKHTAIRGDKKLPLTAKEFMLLTF
MLKRSGEVLSRTVIAEQVWDINFDTNTNIIDVAIKRLREKVDNDHPTKLIHTVRGVGYVLEIR
>Mature_223_residues
MRLLIVEDHKRTADFICKGFNEYQFQADAVYDGAEAIYRISEINYDAVVLDVMLPIMDGWAVLEKIRELKPDLPVLMLSA
CDDVDSRVKGLEMGAYDYLVKPFSFNELLARVKSLLRRKPKESPILLKINDLTINLQKHTAIRGDKKLPLTAKEFMLLTF
MLKRSGEVLSRTVIAEQVWDINFDTNTNIIDVAIKRLREKVDNDHPTKLIHTVRGVGYVLEIR

Specific function: Probable member of a two-component regulatory system pcoS/pcoR. May be involved in the activation of copper resistance gene operon pcoABCD by binding to a specific site on the cop operon promoter (copper box) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=48.8888888888889, Blast_Score=223, Evalue=8e-60,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=47.2477064220183, Blast_Score=211, Evalue=4e-56,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=35.9090909090909, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=35.4545454545455, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=32.4444444444444, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=32.0175438596491, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=30.0448430493274, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=35.9090909090909, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=33.0434782608696, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=33.6283185840708, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=29.8701298701299, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=29.1304347826087, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=26.5486725663717, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=31.7757009345794, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=27.4678111587983, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790299, Length=106, Percent_Identity=32.0754716981132, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=30.4347826086957, Blast_Score=64, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25649; Mature: 25649

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLIVEDHKRTADFICKGFNEYQFQADAVYDGAEAIYRISEINYDAVVLDVMLPIMDGW
CEEEEEECCCHHHHHHHCCCCHHEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCH
AVLEKIRELKPDLPVLMLSACDDVDSRVKGLEMGAYDYLVKPFSFNELLARVKSLLRRKP
HHHHHHHHHCCCCCEEEEHHCCCHHHHHHHCCCCCHHHEECCCCHHHHHHHHHHHHHCCC
KESPILLKINDLTINLQKHTAIRGDKKLPLTAKEFMLLTFMLKRSGEVLSRTVIAEQVWD
CCCCEEEEEECEEEEEEHHHEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
INFDTNTNIIDVAIKRLREKVDNDHPTKLIHTVRGVGYVLEIR
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure
MRLLIVEDHKRTADFICKGFNEYQFQADAVYDGAEAIYRISEINYDAVVLDVMLPIMDGW
CEEEEEECCCHHHHHHHCCCCHHEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCH
AVLEKIRELKPDLPVLMLSACDDVDSRVKGLEMGAYDYLVKPFSFNELLARVKSLLRRKP
HHHHHHHHHCCCCCEEEEHHCCCHHHHHHHCCCCCHHHEECCCCHHHHHHHHHHHHHCCC
KESPILLKINDLTINLQKHTAIRGDKKLPLTAKEFMLLTFMLKRSGEVLSRTVIAEQVWD
CCCCEEEEEECEEEEEEHHHEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
INFDTNTNIIDVAIKRLREKVDNDHPTKLIHTVRGVGYVLEIR
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8594334; 9141682 [H]