| Definition | Legionella pneumophila str. Corby chromosome, complete genome. |
|---|---|
| Accession | NC_009494 |
| Length | 3,576,470 |
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The map label for this gene is ponA [H]
Identifier: 148360427
GI number: 148360427
Start: 1105381
End: 1107765
Strand: Reverse
Name: ponA [H]
Synonym: LPC_2366
Alternate gene names: 148360427
Gene position: 1107765-1105381 (Counterclockwise)
Preceding gene: 148360426
Following gene: 148360433
Centisome position: 30.97
GC content: 40.71
Gene sequence:
>2385_bases ATGAAAAAAATGGCATACTTCTGGCGTAAAGGTCTTTGGGCGCTGATGAGCCTGTTTTTTCTCCTAATAGTGGCTGGCAG CCTTCTATATCTTTATCTCGAAAGCCAATTGCCTAATGTTGATTCATTAAAAACTGTACAACTACAAGTGCCATTACAGA TTTTCAGCAAAGAAGGTTTATTAATTCAGGAATACGGTGAAAAAAAACGTATTCCCGTAACTTATGACGAAATTCCCCCT ACTCTGATCCATGCATTAATTGCAACAGAAGATCAACGATTTTTTGAACACCCTGGTGTAGACGTTATGGGATTGGGCCG AGCTGCAGTAAGCATGCTCAAAACTGGAACCAAATCTCAAGGTGGCAGTACGATCACCATGCAAGTAGCTCGTAATTTTT TCTTAAGCCGTAAAAAAACATTTTTACGGAAATTCAATGAAATTATGCTTGCTATCAAAATTGACCGGGAATTAAGTAAA GAAAAGATTTTGGAACTTTACTTAAACAGAGTTTATCTGGGTAACCGGGCTTACGGTGTTGGTGCGGCAGCCATGGTTTA TTTTGGAAAATCCCTTAAAGACCTTAATCTGGCTGAACTGGCTATGATAGCAGGACTTCCTCAAGCTCCCTCAACTCAGA ATCCTATCGCTAACCCGCTTGCTGCAAAAAAACGTCGTGACCATGTACTGGAGCGATTACTGGAAGAACATTATATCAAT GAAGAACAATACCAAAATGCAGTCAATCAACCAATTACTGCAAAATACCATGGAACTAATATCAAGGTGAAAGCGCCTTA TGTTGCTGAAATGATTCGTCAGTCCCTGTACGACAATTTTGGCCCCGAAGCGTACACTAAAGGCTATAAGGTATATACAA CCATTGATGGCAAATTACAAAATACTGCCAATGAAGTGGTAGAAAAAAATCTGATTGCTTACGATCATCGACATGGTTAC AGAGGGCCAATTGCCAATATAGGTGAAAAAGACAGTCAATCTCCCAAGATTAGGCAAAAATACTTGCGGCAATATCCAGA GCTGAACAGCCTGATTCCAGCAGTAGTCACTGAAGTAAGAGAAAAAGAAGCGACTGCGGCATTACAAAACGGGCAAATAA TTATTATTCCCTGGGAGGGTATGTCCTGGGCCAGGCCGGCACTGAAAAGAGGAGGCTGGGTTGGGAAATCACCGACCAAA GCACAACAAGTGGTGGCAGCAGGCGATATAATTTATGTACACCCCACGGAAAAATCCTGGCAACTCGCCCAAATTCCTGA AGCAGAATCTGCAATGGTTGCTATGAATCCTAAAAATGGCGCCATTGAAGTTTTGGTCGGAGGATTTAACTTCTCAAAAA GTAAATTCAACCGAGCTACCCAATCCAGCAGGCAACCAGGCTCCAGTTTCAAACCATTTGTTTACGCTGCGGCTTTGAAC AATGGTTATAATCTTGCTACCTTAATTAATGATGCCCCCATCGTTGTAGACGATCCCAGCCAACCGAATTTATGGCGGCC ACACAATGTGAATCTAAAATTCAATGGCCCTACCCGCCTGAAACAGGCATTAGTTCAATCTAAAAATTTGGTATCTATAA GAATTCTTGATGATATAGGTATTGATTATACGATAGATTTCTTAACTCGTTTTGGCTTTAATAAAAAATCATTGCCTAGA GCCTTATCACTTGCTTTAGGAAGTTTGTCCATTAGCCCTATGGATTTAACCACTGCTTATGCAGTCTTTGCTAATGGTGG TTATAAAGTAGAGCCCTACCTCATTGACCATATAACAGATGCTGATGGTAAAATTCTGTTACAAGCCAAACCAAGTGTTG TATGTGACCCTTGTGATAAAGACAAAATTGATGCTTCTACCTTGGCACCGCGCGTTATTTCTGAAGACATTGCCTTTTTA ATGAATACGGCATTGCGCGATGTAATACAGCATGGCACTGGACGTGCTGCACGAGTATTAAATCGTCAAGACATCGCCGG TAAAACAGGGACTACTAATGATCAAGTAGATGCGTGGTTTGCCGGATTTAACCCTAATTTGGTAGTAACAACCTGGATTG GTTTTGATAATCCCAAATCATTGCATGAATATGCTGCAAATCTTGCTCTTCCACTATGGATTGATTTTATGAAAGTAGCA TTAAAAGACAAACCTGAAACTGAATTGAAGCAGCCTGAAAATGTTATAGCGGTTCGAATAGATCCAGTAAGTGGTTTGCT TGCTAAGCCTAACCAGGAAAATGGCATCATTGAGTATTTTCGACAAAATGAGGTTCCATCTGAAGAGGATCAAGGTCCTG TCTATAATGCACATAATGATCAGCAAGAAGAAGAGCTAGCACCAGTGGAAGAAAGTCTGTTTTAA
Upstream 100 bases:
>100_bases TAGCATTTAAATCAGGTTTTTTTCCCTTGTAAACCTCGCAATATTATATAGATTCGCTGTATAATATTGCACTACTCACA TTTAACGAAAACGAAATTCT
Downstream 100 bases:
>100_bases TTTGAAGATTTATATTCTGATGAAGCACAAAACCCGTATTCAATTTGTGTAATACGGGTTTTAATCTAATAATTATCGTC CTGATAAAGCAGCTGCAGCT
Product: penicillin binding protein 1A
Products: NA
Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 794; Mature: 794
Protein sequence:
>794_residues MKKMAYFWRKGLWALMSLFFLLIVAGSLLYLYLESQLPNVDSLKTVQLQVPLQIFSKEGLLIQEYGEKKRIPVTYDEIPP TLIHALIATEDQRFFEHPGVDVMGLGRAAVSMLKTGTKSQGGSTITMQVARNFFLSRKKTFLRKFNEIMLAIKIDRELSK EKILELYLNRVYLGNRAYGVGAAAMVYFGKSLKDLNLAELAMIAGLPQAPSTQNPIANPLAAKKRRDHVLERLLEEHYIN EEQYQNAVNQPITAKYHGTNIKVKAPYVAEMIRQSLYDNFGPEAYTKGYKVYTTIDGKLQNTANEVVEKNLIAYDHRHGY RGPIANIGEKDSQSPKIRQKYLRQYPELNSLIPAVVTEVREKEATAALQNGQIIIIPWEGMSWARPALKRGGWVGKSPTK AQQVVAAGDIIYVHPTEKSWQLAQIPEAESAMVAMNPKNGAIEVLVGGFNFSKSKFNRATQSSRQPGSSFKPFVYAAALN NGYNLATLINDAPIVVDDPSQPNLWRPHNVNLKFNGPTRLKQALVQSKNLVSIRILDDIGIDYTIDFLTRFGFNKKSLPR ALSLALGSLSISPMDLTTAYAVFANGGYKVEPYLIDHITDADGKILLQAKPSVVCDPCDKDKIDASTLAPRVISEDIAFL MNTALRDVIQHGTGRAARVLNRQDIAGKTGTTNDQVDAWFAGFNPNLVVTTWIGFDNPKSLHEYAANLALPLWIDFMKVA LKDKPETELKQPENVIAVRIDPVSGLLAKPNQENGIIEYFRQNEVPSEEDQGPVYNAHNDQQEEELAPVEESLF
Sequences:
>Translated_794_residues MKKMAYFWRKGLWALMSLFFLLIVAGSLLYLYLESQLPNVDSLKTVQLQVPLQIFSKEGLLIQEYGEKKRIPVTYDEIPP TLIHALIATEDQRFFEHPGVDVMGLGRAAVSMLKTGTKSQGGSTITMQVARNFFLSRKKTFLRKFNEIMLAIKIDRELSK EKILELYLNRVYLGNRAYGVGAAAMVYFGKSLKDLNLAELAMIAGLPQAPSTQNPIANPLAAKKRRDHVLERLLEEHYIN EEQYQNAVNQPITAKYHGTNIKVKAPYVAEMIRQSLYDNFGPEAYTKGYKVYTTIDGKLQNTANEVVEKNLIAYDHRHGY RGPIANIGEKDSQSPKIRQKYLRQYPELNSLIPAVVTEVREKEATAALQNGQIIIIPWEGMSWARPALKRGGWVGKSPTK AQQVVAAGDIIYVHPTEKSWQLAQIPEAESAMVAMNPKNGAIEVLVGGFNFSKSKFNRATQSSRQPGSSFKPFVYAAALN NGYNLATLINDAPIVVDDPSQPNLWRPHNVNLKFNGPTRLKQALVQSKNLVSIRILDDIGIDYTIDFLTRFGFNKKSLPR ALSLALGSLSISPMDLTTAYAVFANGGYKVEPYLIDHITDADGKILLQAKPSVVCDPCDKDKIDASTLAPRVISEDIAFL MNTALRDVIQHGTGRAARVLNRQDIAGKTGTTNDQVDAWFAGFNPNLVVTTWIGFDNPKSLHEYAANLALPLWIDFMKVA LKDKPETELKQPENVIAVRIDPVSGLLAKPNQENGIIEYFRQNEVPSEEDQGPVYNAHNDQQEEELAPVEESLF >Mature_794_residues MKKMAYFWRKGLWALMSLFFLLIVAGSLLYLYLESQLPNVDSLKTVQLQVPLQIFSKEGLLIQEYGEKKRIPVTYDEIPP TLIHALIATEDQRFFEHPGVDVMGLGRAAVSMLKTGTKSQGGSTITMQVARNFFLSRKKTFLRKFNEIMLAIKIDRELSK EKILELYLNRVYLGNRAYGVGAAAMVYFGKSLKDLNLAELAMIAGLPQAPSTQNPIANPLAAKKRRDHVLERLLEEHYIN EEQYQNAVNQPITAKYHGTNIKVKAPYVAEMIRQSLYDNFGPEAYTKGYKVYTTIDGKLQNTANEVVEKNLIAYDHRHGY RGPIANIGEKDSQSPKIRQKYLRQYPELNSLIPAVVTEVREKEATAALQNGQIIIIPWEGMSWARPALKRGGWVGKSPTK AQQVVAAGDIIYVHPTEKSWQLAQIPEAESAMVAMNPKNGAIEVLVGGFNFSKSKFNRATQSSRQPGSSFKPFVYAAALN NGYNLATLINDAPIVVDDPSQPNLWRPHNVNLKFNGPTRLKQALVQSKNLVSIRILDDIGIDYTIDFLTRFGFNKKSLPR ALSLALGSLSISPMDLTTAYAVFANGGYKVEPYLIDHITDADGKILLQAKPSVVCDPCDKDKIDASTLAPRVISEDIAFL MNTALRDVIQHGTGRAARVLNRQDIAGKTGTTNDQVDAWFAGFNPNLVVTTWIGFDNPKSLHEYAANLALPLWIDFMKVA LKDKPETELKQPENVIAVRIDPVSGLLAKPNQENGIIEYFRQNEVPSEEDQGPVYNAHNDQQEEELAPVEESLF
Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal
COG id: COG5009
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI87082258, Length=841, Percent_Identity=43.4007134363853, Blast_Score=677, Evalue=0.0, Organism=Escherichia coli, GI1786343, Length=258, Percent_Identity=33.7209302325581, Blast_Score=143, Evalue=3e-35, Organism=Escherichia coli, GI1788867, Length=239, Percent_Identity=36.4016736401674, Blast_Score=142, Evalue=7e-35, Organism=Escherichia coli, GI1789601, Length=138, Percent_Identity=37.6811594202899, Blast_Score=91, Evalue=4e-19,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011816 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-; 3.4.-.- [C]
Molecular weight: Translated: 88695; Mature: 88695
Theoretical pI: Translated: 8.96; Mature: 8.96
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 2.3 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKKMAYFWRKGLWALMSLFFLLIVAGSLLYLYLESQLPNVDSLKTVQLQVPLQIFSKEGL CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHCCCCE LIQEYGEKKRIPVTYDEIPPTLIHALIATEDQRFFEHPGVDVMGLGRAAVSMLKTGTKSQ EEEECCCCCCCCEEHHCCCHHHHHHHHHCCCHHHHHCCCCCEEECCHHHHHHHHCCCCCC GGSTITMQVARNFFLSRKKTFLRKFNEIMLAIKIDRELSKEKILELYLNRVYLGNRAYGV CCCEEEHHHHHHHHHHHHHHHHHHHHHEEEEEEECHHHHHHHHHHHHHHHHEECCCCCCC GAAAMVYFGKSLKDLNLAELAMIAGLPQAPSTQNPIANPLAAKKRRDHVLERLLEEHYIN HHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC EEQYQNAVNQPITAKYHGTNIKVKAPYVAEMIRQSLYDNFGPEAYTKGYKVYTTIDGKLQ HHHHHHHHCCCCEEEECCCEEEEECCHHHHHHHHHHHHCCCCHHHHCCEEEEEEECCHHH NTANEVVEKNLIAYDHRHGYRGPIANIGEKDSQSPKIRQKYLRQYPELNSLIPAVVTEVR HHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH EKEATAALQNGQIIIIPWEGMSWARPALKRGGWVGKSPTKAQQVVAAGDIIYVHPTEKSW HHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCHHHHHEEECCEEEEECCCCCC QLAQIPEAESAMVAMNPKNGAIEVLVGGFNFSKSKFNRATQSSRQPGSSFKPFVYAAALN EEECCCCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEC NGYNLATLINDAPIVVDDPSQPNLWRPHNVNLKFNGPTRLKQALVQSKNLVSIRILDDIG CCCEEEEEECCCCEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCEEEEEEEECCC IDYTIDFLTRFGFNKKSLPRALSLALGSLSISPMDLTTAYAVFANGGYKVEPYLIDHITD CCEEHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCCEEECCEEEEEECC ADGKILLQAKPSVVCDPCDKDKIDASTLAPRVISEDIAFLMNTALRDVIQHGTGRAARVL CCCEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH NRQDIAGKTGTTNDQVDAWFAGFNPNLVVTTWIGFDNPKSLHEYAANLALPLWIDFMKVA CHHHCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHH LKDKPETELKQPENVIAVRIDPVSGLLAKPNQENGIIEYFRQNEVPSEEDQGPVYNAHND HCCCCCHHHCCCCCEEEEEECCCCCHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCC QQEEELAPVEESLF CCHHHHCCHHHHCC >Mature Secondary Structure MKKMAYFWRKGLWALMSLFFLLIVAGSLLYLYLESQLPNVDSLKTVQLQVPLQIFSKEGL CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHCCCCE LIQEYGEKKRIPVTYDEIPPTLIHALIATEDQRFFEHPGVDVMGLGRAAVSMLKTGTKSQ EEEECCCCCCCCEEHHCCCHHHHHHHHHCCCHHHHHCCCCCEEECCHHHHHHHHCCCCCC GGSTITMQVARNFFLSRKKTFLRKFNEIMLAIKIDRELSKEKILELYLNRVYLGNRAYGV CCCEEEHHHHHHHHHHHHHHHHHHHHHEEEEEEECHHHHHHHHHHHHHHHHEECCCCCCC GAAAMVYFGKSLKDLNLAELAMIAGLPQAPSTQNPIANPLAAKKRRDHVLERLLEEHYIN HHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC EEQYQNAVNQPITAKYHGTNIKVKAPYVAEMIRQSLYDNFGPEAYTKGYKVYTTIDGKLQ HHHHHHHHCCCCEEEECCCEEEEECCHHHHHHHHHHHHCCCCHHHHCCEEEEEEECCHHH NTANEVVEKNLIAYDHRHGYRGPIANIGEKDSQSPKIRQKYLRQYPELNSLIPAVVTEVR HHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH EKEATAALQNGQIIIIPWEGMSWARPALKRGGWVGKSPTKAQQVVAAGDIIYVHPTEKSW HHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCHHHHHEEECCEEEEECCCCCC QLAQIPEAESAMVAMNPKNGAIEVLVGGFNFSKSKFNRATQSSRQPGSSFKPFVYAAALN EEECCCCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEC NGYNLATLINDAPIVVDDPSQPNLWRPHNVNLKFNGPTRLKQALVQSKNLVSIRILDDIG CCCEEEEEECCCCEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCEEEEEEEECCC IDYTIDFLTRFGFNKKSLPRALSLALGSLSISPMDLTTAYAVFANGGYKVEPYLIDHITD CCEEHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCCEEECCEEEEEECC ADGKILLQAKPSVVCDPCDKDKIDASTLAPRVISEDIAFLMNTALRDVIQHGTGRAARVL CCCEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH NRQDIAGKTGTTNDQVDAWFAGFNPNLVVTTWIGFDNPKSLHEYAANLALPLWIDFMKVA CHHHCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHH LKDKPETELKQPENVIAVRIDPVSGLLAKPNQENGIIEYFRQNEVPSEEDQGPVYNAHND HCCCCCHHHCCCCCEEEEEECCCCCHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCC QQEEELAPVEESLF CCHHHHCCHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10984043; 7901733 [H]