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The map label for this gene is prs [H]

Identifier: 148360319

GI number: 148360319

Start: 1228944

End: 1229849

Strand: Direct

Name: prs [H]

Synonym: LPC_2256

Alternate gene names: 148360319

Gene position: 1228944-1229849 (Clockwise)

Preceding gene: 148360320

Following gene: 148360318

Centisome position: 34.36

GC content: 39.96

Gene sequence:

>906_bases
TTGAAGCCTCTGTTATTTTCATTATTTGATTCTTCAGAAATCGCCGGACAATTACAAAAGACACTTCAAGTGGAGGTGGG
TAGGGTCACTTTTCATCGTTTCCCTGATAGAGAGTGGTACTTAAAAATTGATTCAGAGGTTAAAAATCGCAGCCTTATTG
TAGTGGACAGTTTAAACCAGCCGGATGAAAAAATACTGCCTTTGTTGTTTTTTGCCAAAACAGCTAAAGAATTGGGTGCT
CAAAAAATCGGCTTAATTGCCCCTTATCTTTCCTACCTACGGCAAGATAAACGTTTTCATGAAGGCGAAGGAATTACATC
ACGCTATTTTGCAGACATTTTATCCACTTCATTCGATTGGCTCATGACGATTGATCCGCACTTGCATCGCTATCATTCTT
TAGATGAAATCTACTCAATTCCCACTTTTGTTTTGCATGCCACAGCTCCTATTGCCACATGGATTAAACATCATGTTCCT
AAGCCAGTTCTTATTGGTCCTGATATGGAAAGTGAGCAGTGGGTGGCAGACATTGCAGAAAAAGGTTCTTTTCCTTATGT
CATTTTGGAAAAAGTTCGTCATGGTGATAAAGAGGTGGCTATTTCAGTACCCAATCTACTTAAGCTTGAATCGTCAACCC
CCATATTGGTGGATGACATTATCTCTACCGCGAGAACCATGGTAGAGACGGTGAAGCATTTACACCAAGCAGGAGTTAAG
TCCGTTGTTTGTATTGGGGTGCATGCATTGTTTGCACAAGACGCTTATTCCCTATTATCAGGAATAGAAGGGGTGCAAAT
CATTACGTGTAACACCATTCGTCATGTCACCAATGCGATTGATGTCAGTGATTTGATTGCGAAGGATTTAGCACAATATA
AGTTGGCAAAGACTTATAAAAAATAA

Upstream 100 bases:

>100_bases
AACCTTTGTTTACAATTCATTCGGAGTCCTCAGGGGAGCTCAATTACGCTTGTGATTTACTTCGCGATAAACAAGACATC
ATTATTTTAGGAGAAAATTC

Downstream 100 bases:

>100_bases
GTTGGAAAAGTCTTAATAGAGAAGGAGTATTTCATGTCATTTTTTAAAGTAATCAGGATCATTATGGTGTTCATTGGGCT
GGTTTTTGCGACTTCCTTTT

Product: phosphoribosylpyrophosphate synthetase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MKPLLFSLFDSSEIAGQLQKTLQVEVGRVTFHRFPDREWYLKIDSEVKNRSLIVVDSLNQPDEKILPLLFFAKTAKELGA
QKIGLIAPYLSYLRQDKRFHEGEGITSRYFADILSTSFDWLMTIDPHLHRYHSLDEIYSIPTFVLHATAPIATWIKHHVP
KPVLIGPDMESEQWVADIAEKGSFPYVILEKVRHGDKEVAISVPNLLKLESSTPILVDDIISTARTMVETVKHLHQAGVK
SVVCIGVHALFAQDAYSLLSGIEGVQIITCNTIRHVTNAIDVSDLIAKDLAQYKLAKTYKK

Sequences:

>Translated_301_residues
MKPLLFSLFDSSEIAGQLQKTLQVEVGRVTFHRFPDREWYLKIDSEVKNRSLIVVDSLNQPDEKILPLLFFAKTAKELGA
QKIGLIAPYLSYLRQDKRFHEGEGITSRYFADILSTSFDWLMTIDPHLHRYHSLDEIYSIPTFVLHATAPIATWIKHHVP
KPVLIGPDMESEQWVADIAEKGSFPYVILEKVRHGDKEVAISVPNLLKLESSTPILVDDIISTARTMVETVKHLHQAGVK
SVVCIGVHALFAQDAYSLLSGIEGVQIITCNTIRHVTNAIDVSDLIAKDLAQYKLAKTYKK
>Mature_301_residues
MKPLLFSLFDSSEIAGQLQKTLQVEVGRVTFHRFPDREWYLKIDSEVKNRSLIVVDSLNQPDEKILPLLFFAKTAKELGA
QKIGLIAPYLSYLRQDKRFHEGEGITSRYFADILSTSFDWLMTIDPHLHRYHSLDEIYSIPTFVLHATAPIATWIKHHVP
KPVLIGPDMESEQWVADIAEKGSFPYVILEKVRHGDKEVAISVPNLLKLESSTPILVDDIISTARTMVETVKHLHQAGVK
SVVCIGVHALFAQDAYSLLSGIEGVQIITCNTIRHVTNAIDVSDLIAKDLAQYKLAKTYKK

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI28557709, Length=297, Percent_Identity=24.2424242424242, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI84875539, Length=301, Percent_Identity=23.9202657807309, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4506129, Length=298, Percent_Identity=23.489932885906, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI4506127, Length=297, Percent_Identity=23.5690235690236, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1787458, Length=278, Percent_Identity=22.6618705035971, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17554704, Length=301, Percent_Identity=23.9202657807309, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25149168, Length=297, Percent_Identity=23.5690235690236, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17554702, Length=297, Percent_Identity=23.5690235690236, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71989924, Length=292, Percent_Identity=23.2876712328767, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319403, Length=268, Percent_Identity=23.8805970149254, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321776, Length=265, Percent_Identity=23.0188679245283, Blast_Score=82, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320946, Length=286, Percent_Identity=22.027972027972, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355239, Length=274, Percent_Identity=25.1824817518248, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45551540, Length=297, Percent_Identity=23.5690235690236, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33972; Mature: 33972

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00196 COPPER_BLUE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLLFSLFDSSEIAGQLQKTLQVEVGRVTFHRFPDREWYLKIDSEVKNRSLIVVDSLNQ
CCCHHHHHHCCHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCCCEEEEEECCCC
PDEKILPLLFFAKTAKELGAQKIGLIAPYLSYLRQDKRFHEGEGITSRYFADILSTSFDW
CHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCE
LMTIDPHLHRYHSLDEIYSIPTFVLHATAPIATWIKHHVPKPVLIGPDMESEQWVADIAE
EEEECHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHH
KGSFPYVILEKVRHGDKEVAISVPNLLKLESSTPILVDDIISTARTMVETVKHLHQAGVK
CCCCCHHHHHHHHCCCCEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCHH
SVVCIGVHALFAQDAYSLLSGIEGVQIITCNTIRHVTNAIDVSDLIAKDLAQYKLAKTYK
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
K
C
>Mature Secondary Structure
MKPLLFSLFDSSEIAGQLQKTLQVEVGRVTFHRFPDREWYLKIDSEVKNRSLIVVDSLNQ
CCCHHHHHHCCHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCCCEEEEEECCCC
PDEKILPLLFFAKTAKELGAQKIGLIAPYLSYLRQDKRFHEGEGITSRYFADILSTSFDW
CHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCE
LMTIDPHLHRYHSLDEIYSIPTFVLHATAPIATWIKHHVPKPVLIGPDMESEQWVADIAE
EEEECHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHH
KGSFPYVILEKVRHGDKEVAISVPNLLKLESSTPILVDDIISTARTMVETVKHLHQAGVK
CCCCCHHHHHHHHCCCCEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCHH
SVVCIGVHALFAQDAYSLLSGIEGVQIITCNTIRHVTNAIDVSDLIAKDLAQYKLAKTYK
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]