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The map label for this gene is fabH [H]

Identifier: 148359775

GI number: 148359775

Start: 2640430

End: 2641440

Strand: Direct

Name: fabH [H]

Synonym: LPC_1700

Alternate gene names: 148359775

Gene position: 2640430-2641440 (Clockwise)

Preceding gene: 148359774

Following gene: 148359778

Centisome position: 73.83

GC content: 42.73

Gene sequence:

>1011_bases
ATGAATTTTTTCCGTTGTGAAAAACCCATCTATATAAAAGGCCCTTTTGTTGCGCTTCCCGAGAGAGTCATGAGCAACCA
AGATGTTCTCAATTGGATGAACAGTACCCAAAATCCAGCCGTGATTGGATTTTCAACTGGAATTAAAAACCGGCATTGGG
TAAATGAGGATCAAGCTTGTAGCGATCTGGCTGTGCGAGCGGCAGAACATTTGTTTATGGAAAAACCCAGGGAAAAACAT
AAAGTGAACCAAGTGATCCTGGCCACTATCTCAGGGGATTACCCCTCCCCGCCAAGCAGCCCTCTCGTACAGTACAGACT
TGGCCTACAAAACGCCGGAGCTTTTGATATAGGAGCTGCCTGTGCCGGATTTGTTGTCGGTTTGCATACAAGTGCTGCTT
TAGCACAGACCAATGATGGTTCGGTATTACTCATAGCCAGCGAAATTCGCTCCAAATTTTTAAATAAAAACAATTTTGCA
ACCAGTGTTTTATTCGGTGATGGGGCAGCAGCATGTTGTGTTTCTCAAGATAAAGAAGAAGCAGACTTTCGTTTTATAGC
GTCTGCGTTGTTTGCTGACGGTGAAGTATATGATGCCGTCTCAACTCCGGCAGGAGGTTCCCGCTTGCCCGCCGCAGTTT
GTAATGATAATGAGCAATTTTACATTACCATAAAGGAAAGTACTGCTTTATTTGTAAAAGCAGTGCATGGAATGGCAGAT
AGCGCCAAAGATTTTCTAAAAGAATTAAATCTGACAATCTCTGATATCCAATGGCTTGTTCCTCATCAGGGAAATAAAAA
TCTGGTTTTGTCGGTAGCAAAACAATTAGGTTTTCCTGAAGAAAAAACGATAAAAACTGTTGAAGAAACAGGAAATACTT
CAGGATCCAGTGTAGGCATCGCTTTGGATCGACTGAGGTCGGATGGCAAAATAAAATCTGGAGAAAAGGTACTTTTGGTG
GCAGCAGGTGGAGGAGGAATTGCAGCCTGTTCTTTATTGGAAGTTATCTGA

Upstream 100 bases:

>100_bases
AAGCCATTGATCCACTTTTGTCAAAAACCTCGTTTATGACGGGATCAGTTGTAACAGTCAGTGGTGGTCTGCCTTTAATG
CGTTCAGAAGGATTGTTGTC

Downstream 100 bases:

>100_bases
TTTGATCATTGTTTGTTGAGGCATTTTACCCATAGGCGTCAAGCTAAAACTAATTACACTATCCGTTCAGGCTGAGGAGG
CGTTTACTCCGTCTCGAAGC

Product: 3-oxoacyl-(acyl carrier protein) synthase III FabH

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MNFFRCEKPIYIKGPFVALPERVMSNQDVLNWMNSTQNPAVIGFSTGIKNRHWVNEDQACSDLAVRAAEHLFMEKPREKH
KVNQVILATISGDYPSPPSSPLVQYRLGLQNAGAFDIGAACAGFVVGLHTSAALAQTNDGSVLLIASEIRSKFLNKNNFA
TSVLFGDGAAACCVSQDKEEADFRFIASALFADGEVYDAVSTPAGGSRLPAAVCNDNEQFYITIKESTALFVKAVHGMAD
SAKDFLKELNLTISDIQWLVPHQGNKNLVLSVAKQLGFPEEKTIKTVEETGNTSGSSVGIALDRLRSDGKIKSGEKVLLV
AAGGGGIAACSLLEVI

Sequences:

>Translated_336_residues
MNFFRCEKPIYIKGPFVALPERVMSNQDVLNWMNSTQNPAVIGFSTGIKNRHWVNEDQACSDLAVRAAEHLFMEKPREKH
KVNQVILATISGDYPSPPSSPLVQYRLGLQNAGAFDIGAACAGFVVGLHTSAALAQTNDGSVLLIASEIRSKFLNKNNFA
TSVLFGDGAAACCVSQDKEEADFRFIASALFADGEVYDAVSTPAGGSRLPAAVCNDNEQFYITIKESTALFVKAVHGMAD
SAKDFLKELNLTISDIQWLVPHQGNKNLVLSVAKQLGFPEEKTIKTVEETGNTSGSSVGIALDRLRSDGKIKSGEKVLLV
AAGGGGIAACSLLEVI
>Mature_336_residues
MNFFRCEKPIYIKGPFVALPERVMSNQDVLNWMNSTQNPAVIGFSTGIKNRHWVNEDQACSDLAVRAAEHLFMEKPREKH
KVNQVILATISGDYPSPPSSPLVQYRLGLQNAGAFDIGAACAGFVVGLHTSAALAQTNDGSVLLIASEIRSKFLNKNNFA
TSVLFGDGAAACCVSQDKEEADFRFIASALFADGEVYDAVSTPAGGSRLPAAVCNDNEQFYITIKESTALFVKAVHGMAD
SAKDFLKELNLTISDIQWLVPHQGNKNLVLSVAKQLGFPEEKTIKTVEETGNTSGSSVGIALDRLRSDGKIKSGEKVLLV
AAGGGGIAACSLLEVI

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family [H]

Homologues:

Organism=Escherichia coli, GI1787333, Length=310, Percent_Identity=31.6129032258064, Blast_Score=144, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C [H]

EC number: =2.3.1.180 [H]

Molecular weight: Translated: 35984; Mature: 35984

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFFRCEKPIYIKGPFVALPERVMSNQDVLNWMNSTQNPAVIGFSTGIKNRHWVNEDQAC
CCCEECCCCEEEECCHHHHHHHHHCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHH
SDLAVRAAEHLFMEKPREKHKVNQVILATISGDYPSPPSSPLVQYRLGLQNAGAFDIGAA
HHHHHHHHHHHHHCCCHHHHHHCEEEEEEECCCCCCCCCCCHHHEEECCCCCCCCCHHHH
CAGFVVGLHTSAALAQTNDGSVLLIASEIRSKFLNKNNFATSVLFGDGAAACCVSQDKEE
HHHHHHHHCCCHHEEECCCCCEEEEHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCH
ADFRFIASALFADGEVYDAVSTPAGGSRLPAAVCNDNEQFYITIKESTALFVKAVHGMAD
HHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHEECCCCEEEEEEECCCEEEHHHHHCCHH
SAKDFLKELNLTISDIQWLVPHQGNKNLVLSVAKQLGFPEEKTIKTVEETGNTSGSSVGI
HHHHHHHHCCCCHHHEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHH
ALDRLRSDGKIKSGEKVLLVAAGGGGIAACSLLEVI
HHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHC
>Mature Secondary Structure
MNFFRCEKPIYIKGPFVALPERVMSNQDVLNWMNSTQNPAVIGFSTGIKNRHWVNEDQAC
CCCEECCCCEEEECCHHHHHHHHHCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHH
SDLAVRAAEHLFMEKPREKHKVNQVILATISGDYPSPPSSPLVQYRLGLQNAGAFDIGAA
HHHHHHHHHHHHHCCCHHHHHHCEEEEEEECCCCCCCCCCCHHHEEECCCCCCCCCHHHH
CAGFVVGLHTSAALAQTNDGSVLLIASEIRSKFLNKNNFATSVLFGDGAAACCVSQDKEE
HHHHHHHHCCCHHEEECCCCCEEEEHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCH
ADFRFIASALFADGEVYDAVSTPAGGSRLPAAVCNDNEQFYITIKESTALFVKAVHGMAD
HHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHEECCCCEEEEEEECCCEEEHHHHHCCHH
SAKDFLKELNLTISDIQWLVPHQGNKNLVLSVAKQLGFPEEKTIKTVEETGNTSGSSVGI
HHHHHHHHCCCCHHHEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHH
ALDRLRSDGKIKSGEKVLLVAAGGGGIAACSLLEVI
HHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]